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Motor Unit Recruitment In A Distributed Model Of Extraocular Muscle.

P. Dean
Published 1996 · Psychology, Medicine

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1. Eye position commands frequently are treated as a lumped, single-valued variable that is related linearly to eye position. As a step toward investigating how system-level linearity might be achieved despite nonlinear components, a distributed model of motor units in the abducens nucleus and lateral rectus muscle was constructed. 2. Parameters in the model were estimated using data from three main sources: measurement of length-tension curves for eye muscle in people, electrophysiological recording of ocular motoneuron properties in monkeys, and investigations of oculomotor unit properties in cat. Units (n = 100) in the distributed model were assigned equal strengths and for a given fixation command, the force developed by each unit was calculated, and the sum of unit forces compared with the active force in the entire muscle as measured experimentally. 3. The properties of the active units then were adjusted to reduce the size of any resultant error in a manner related to gradient descent methods for neural-net training. Distributed models were "trained" in this fashion for a series of eye positions drawn at random from the oculomotor range until performance stabilized. The goal of the training procedure was to obtain a good match between the output of the model and the experimental data on muscle force as a function of eye position. 4. Plots of trained motor-unit strength against ocular motoneuron threshold revealed a U-shaped pattern with the strongest units being recruited at both extremes of the oculomotor range and the weakest units recruited in the middle. The pattern remained unaltered qualitatively over a range of assumptions about the distribution of ocular motoneuron parameters and the relation between motoneuron firing rate and unit force. 5. The right-hand limb of the U-shaped pattern is similar to that observed in spinal motoneurons, where stronger units tend to have higher recruitment thresholds. The left-hand limb may reflect the two specializations of eye muscle: the functional need for very precise control of eye position in the middle of the oculomotor range and the use of multiply innervated muscle fibers to provide ripple-free control of eye position at low firing frequencies.
This paper references
10.1001/ARCHOPHT.1973.01000050321017
Division of labor in human extraocular muscle.
A. B. Scott (1973)
Extraocular muscle fibers: ultrastructural identification of iontophoretically labeled fibers contracting in response to succinylcholine.
P. Bach-y-rita (1977)
10.1002/JMOR.1051740211
Fiber composition of the superior rectus extraocular muscle of the rhesus macaque
B. Pachter (1982)
10.1212/WNL.18.4.403
Motor nerve endings in human extraocular muscle
Tatsuji Namba (1968)
10.1146/ANNUREV.NE.18.030195.002205
Learning and memory in the vestibulo-ocular reflex.
S. du Lac (1995)
The behavior of eye movement motoneurons in the alert monkey.
Robinson Da (1972)
10.1152/JN.1991.65.4.952
Computer simulation of the steady-state input-output function of the cat medial gastrocnemius motoneuron pool.
C. Heckman (1991)
10.1016/0014-4886(78)90159-0
Laminar organization of the extraocular muscles of the rabbit
N. Barmack (1978)
10.1007/BF00344390
Effects of muscle model parameter dispersion and multi-loop segmental interaction on the neuromuscular system performance
G. Inbar (2004)
10.1016/0959-4388(93)90177-Z
How different afferent inputs control motoneuron discharge and the output of the motoneuron pool
M. D. Binder (1993)
10.21236/ad0241531
Adaptive switching circuits
B. Widrow (1988)
10.1002/JMOR.1052130204
Neuromuscular organization of feline anterior sartorius: II. Intramuscular length changes and complex length‐tension relationships during stimulation of individual nerve branches
S. Scott (1992)
10.1002/MUS.880180905
Lateral rectus emg and contractile responses elicited by cat abducens motoneurons
M. Shall (1995)
10.1126/SCIENCE.1891718
Autoassociation and novelty detection by neuromechanics.
W. Daunicht (1991)
Muscle and tendon: properties, models, scaling, and application to biomechanics and motor control.
F. Zajac (1989)
10.1152/JN.1977.40.4.779
Recruitment and suprathreshold frequency modulation of single extraocular muscle fibers in the rabbit.
N. Barmack (1977)
Prenatal morphogenesis of primate extraocular muscle: neuromuscular junction formation and fiber type differentiation.
J. Porter (1992)
10.1016/0042-6989(85)90187-7
Reconstruction of neural control signals for saccades based on an inverse method
A. J. Opstal (1985)
10.1113/jphysiol.1975.sp010850
Muscle tension during unrestrained human eye movements.
C. Collins (1975)
10.7551/MITPRESS/5236.001.0001
Parallel distributed processing: explorations in the microstructure of cognition, vol. 1: foundations
D. E. Rumelhart (1986)
10.1016/0306-4522(92)90035-Z
Identification models of the nervous system
D. Zipser (1992)
10.1016/0020-7101(89)90031-7
Computer simulation of the neural discharge carried by the abducens nerve during eye fixation in the cat.
C. Gómez (1989)
10.1007/BF00799651
Varieties of tonic muscle fibers in the oculomotor apparatus of the rabbit
D. Matyushkin (2004)
10.1152/JN.1986.56.1.50
Contractile differences between muscle units in the medial rectus and lateral rectus muscles in the cat.
M. A. Meredith (1986)
10.1152/JN.1993.70.5.1827
Computer simulations of the effects of different synaptic input systems on motor unit recruitment.
C. Heckman (1993)
10.1109/TSMC.1983.6313103
Parallel nonlinear neuronal channels: The generalized steady-state analysis
G. Inbar (1983)
10.1152/JN.1991.66.6.2125
Discharge characteristics of medial rectus and abducens motoneurons in the goldfish.
A. Pastor (1991)
10.1016/0010-4809(84)90012-0
A model of the mechanics of binocular alignment.
J. Miller (1984)
10.1017/CBO9780511529788.005
Movement control: Implications of neural networks for how we think about brain function
D. Robinson (1992)
10.1016/0006-8993(92)91010-C
Extraocular motor units: type classification and motoneuron stimulation frequency-muscle unit force relationships
M. Shall (1992)
10.1016/0014-4886(68)90130-1
Conduction velocities in the abducens nerve correlated with vestibular nystagmus in cats.
Y. Yamanaka (1968)
10.1152/JN.1970.33.3.393
Oculomotor unit behavior in the monkey.
D. Robinson (1970)
10.1016/0022-510X(86)90099-7
Motor innervation and acetylcholine receptor distribution of human extraocular muscle fibres
K. Oda (1986)
10.1016/0025-5564(74)90001-7
Control of human eye movements: I. modelling of extraocular muscle
M. Clark (1974)
10.1007/BF00943976
Correlation of potential and fiber type in extraocular muscle
T. Ozawa (1969)
10.1152/JN.1986.55.4.715
Motoneuron electrophysiological and muscle contractile properties of superior oblique motor units in cat.
J. S. Nelson (1986)
10.1152/JN.1988.60.6.1874
Discharge patterns and recruitment order of identified motoneurons and internuclear neurons in the monkey abducens nucleus.
A. Fuchs (1988)
10.1152/JN.1973.36.4.724
Role of abducens neurons in vestibuloocular reflex.
A. A. Skavenski (1973)
The Segmental motor system
M. D. Binder (1990)
10.1113/jphysiol.1976.sp011245
The contractile properties of slow muscle fibres in sheep extraocular muscle.
J. S. Browne (1976)
10.1016/S0959-4388(05)80046-7
Organization of voluntary movement
C. Ghez (1991)
10.1109/10.32097
Methods for estimating isometric recruitment curves of electrically stimulated muscle
W.K. Durfee (1989)
10.1016/0306-4522(86)90072-2
Behavior of neurons in the abducens nucleus of the alert cat—I. Motoneurons
J. Delgado-García (1986)
10.1109/5.58328
Neural network model for control of muscle force based on the size principle of motor unit
K. Akazawa (1990)



This paper is referenced by
10.1159/000047836
Motoneurons of the Lateral and Medial Rectus Extraocular Muscles in Squirrel Monkey and Cat
J. McClung (2001)
10.1523/JNEUROSCI.18-24-10629.1998
Extraocular Motor Unit and Whole-Muscle Responses in the Lateral Rectus Muscle of the Squirrel Monkey
S. Goldberg (1998)
10.1152/jn.91045.2008
Dynamics of primate oculomotor plant revealed by effects of abducens microstimulation.
S. Anderson (2009)
10.1016/B978-0-323-05714-1.00007-8
The Extraocular Muscles
L. McLoon (2011)
10.1038/nrn986
The brainstem control of saccadic eye movements
D. L. Sparks (2002)
The organization and function of medial rectus and inferior rectus non-twitch motoneurons in the oculomotor nucleus of monkey
Xiaofang Tang (2007)
10.1007/s00221-002-1176-8
Estimation of premotor synaptic drives to simulated abducens motoneurons for control of eye position
T. Hazel (2002)
10.1111/j.1460-9568.2007.05516.x
Phasic and tonic firing properties in rat oculomotor nucleus motoneurons, studied in vitro
J. L. Nieto-Gonzalez (2007)
The superfast extraocular myosin (MYH13) is localized to the innervation zone in both the global and orbital layers of rabbit extraocular muscle.
M. Briggs (2002)
10.1002/cne.1318
Motoneurons of twitch and nontwitch extraocular muscle fibers in the abducens, trochlear, and oculomotor nuclei of monkeys
J. Büttner-Ennever (2001)
10.1002/cne.20296
Twitch and nontwitch motoneuron subgroups in the oculomotor nucleus of monkeys receive different afferent projections
R. Wasicky (2004)
Innervated myotendinous cylinders in human extraocular muscles.
J. Lukas (2000)
10.1152/JN.00402.2003
Recruitment order of cat abducens motoneurons and internuclear neurons.
A. Pastor (2003)
An investigation of the sensory and motor innervation of extraocular muscles in monkey and rat with combined tract-tracing and immunofluorescence methods: evidence for a dual motor innervation as common concept in mammals
A. Eberhorn (2005)
10.1007/s00422-006-0105-5
Response linearity determined by recruitment strategy in detailed model of nictitating membrane control
E. Mavritsaki (2006)
10.1007/s00221-003-1506-5
Extraocular motor unit and whole-muscle contractile properties in the squirrel monkey
M. Shall (2003)
10.1109/TBME.2010.2044574
Nonlinear Dynamic Modeling of Isometric Force Production in Primate Eye Muscle
S. Anderson (2010)
10.1007/s00422-011-0420-3
Modeling trade-off between time-optimal and minimum energy in saccade main sequence
Xuezhong Wang (2011)
10.1007/s00221-001-0912-9
The brainstem burst generator for saccadic eye movements
C. Scudder (2002)
10.1016/S0893-6080(98)00072-0
Pseudo-inverse control in biological systems: a learning mechanism for fixation stability
P. Dean (1998)
10.1111/APHA.13535
Myosin heavy chains in extraocular muscle fibres: Distribution, regulation and function.
J. Hoh (2020)
10.1152/JN.1997.78.3.1531
Simulated recruitment of medial rectus motoneurons by abducens internuclear neurons: synaptic specificity vs. intrinsic motoneuron properties.
P. Dean (1997)
10.1016/S0079-6123(03)42005-0
Single cell signals: an oculomotor perspective.
D. Sparks (2003)
10.1111/j.1749-6632.2003.tb00240.x
Motor and Sensory Innervation of Extraocular Eye Muscles
J. Büttner-Ennever (2003)
10.1098/rsif.2016.0547
Cerebellar-inspired algorithm for adaptive control of nonlinear dielectric elastomer-based artificial muscle
Emma D. Wilson (2016)
10.5384/SJOVS.VOL5I1P1-14
The Oculomotor Systems Ability to Adapt to Structural Changes Caused by the Process of Senescence: A Review
J. R. Bruenech (2012)
Application of Deterministic and Stochastic Components of the Ocular Dynamic System.
Xuezhong Wang (2010)
10.3389/fnbeh.2017.00061
Response Properties of Motor Equivalence Neurons of the Primate Premotor Cortex
E. Neromyliotis (2017)
10.1007/s004220050469
A framework for considering the role of afference and efference in the control and perception of ocular position
M. Mon-Williams (1998)
10.1016/S0079-6123(08)62859-9
Motor units of extraocular muscles: recent findings.
S. Goldberg (1999)
10.1152/JN.1999.81.2.735
Optimality of position commands to horizontal eye muscles: A test of the minimum-norm rule.
P. Dean (1999)
10.1016/j.neunet.2012.12.005
Adaptive filters and internal models: Multilevel description of cerebellar function
J. Porrill (2013)
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