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Cerebral Cortical Representation Of Automatic And Volitional Swallowing In Humans.
R. Martin, B. Goodyear, J. Gati, R. Menon
Published 2001 · Medicine, Psychology
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Although the cerebral cortex has been implicated in the control of swallowing, the functional organization of the human cortical swallowing representation has not been fully documented. Therefore, the present study determined the cortical representation of swallowing in fourteen healthy right-handed female subjects using single-event-related functional magnetic resonance imaging (fMRI). Subjects were scanned during three swallowing activation tasks: a naïve saliva swallow, a voluntary saliva swallow, and a water bolus swallow. Swallow-related laryngeal movement was recorded simultaneously from the output of a bellows positioned over the thyroid cartilage. Statistical maps were generated by computing the difference between the magnitude of the voxel time course during 1) a single swallowing trial and 2) the corresponding control period. Automatic and volitional swallowing produced activation within several common cortical regions, the most prominent and consistent being located within the lateral precentral gyrus, lateral postcentral gyrus, and right insula. Activation foci within the superior temporal gyrus, middle and inferior frontal gyri, and frontal operculum also were identified for all swallowing tasks. In contrast, activation of the caudal anterior cingulate cortex was significantly more likely in association with the voluntary saliva swallow and water bolus swallow than the naïve swallow. These findings support the view that, in addition to known brain stem areas, human swallowing is represented within a number of spatially and functionally distinct cortical loci which may participate differentially in the regulation of swallowing. Activation of the insula was significantly lateralized to the right hemisphere for the voluntary saliva swallow, suggesting a functional hemispheric dominance of the insula for the processing of swallowing.
This paper references
The assessment and analysis of handedness: the Edinburgh inventory.
R. Oldfield (1971)
Improved Assessment of Significant Activation in Functional Magnetic Resonance Imaging (fMRI): Use of a Cluster‐Size Threshold
S. Forman (1995)
The primary gustatory area in human cerebral cortex studied by magnetoencephalography
T. Kobayakawa (1996)
Dysphagia in unilateral cerebral lesions
J. Meadows (1973)
Miller Aj Deglutition (1982)
A GUI based fMRI analysis software package (Abstract )
Strupp Jp Stimulate (1996)
Functional properties of neurons in the primate tongue primary motor cortex during swallowing.
R. Martin (1997)
Functional MRI activation pattern of motor and language tasks in Broca ’ s area
P ERHARD (1978)
The insula; further observations on its function.
W. Penfield (1955)
Cortical activation during fast repetitive finger movements in humans: dipole sources of steady-state movement-related cortical potentials.
C. Gerloff (1998)
The Neuroscientific Principles of Swallowing and Dysphagia
A. Miller (2000)
Functional magnetic resonance imaging (FMRI) of the human brain
E. DeYoe (1994)
Transient brain activity used in magnetic resonance imaging to detect functional areas
S. Konishi (1996)
Detection of cortical activation during averaged single trials of a cognitive task using functional magnetic resonance imaging.
R. Buckner (1996)
Role of the human anterior cingulate cortex in the control of oculomotor, manual, and speech responses: a positron emission tomography study.
T. Paus (1993)
Brainstem Control of Swallowing: Localization and Organization of the Central Pattern Generator for Swallowing
A. Jean (1990)
Cerebral glucose comsumption following verbal auditory stimulation.Brain
MJ KUSHNER (1987)
Handbook of Physiology.
F. Plum (1960)
Central nervous system mechanisms in deglutition and emesis In: Handbook of Physiology. Gastrointestinal System. Control of Food and Water Intake
Do Carpenter (1989)
Circuitry and functional aspects of the insular lobe in primates including humans
J. Augustine (1996)
Control of food and water intake
C. F. Code (1967)
Neurons of the anterior mesial cortex related to faciovocal activity in the awake monkey.
R. West (1995)
The assessment and analysis of handedness: the Edinburgh Inventory.Neuropsychologia9
RC OLDFIELD (1971)
Alterations in the pattern of mastication after ablations of the lateral precentral cortex in rhesus macaques
C. Larson (1980)
The Role of the Insular Cortex in Dysphagia
S. Daniels (1997)
Functional magnetic resonance imaging of Broca's area during internal speech.
R. Hinke (1993)
Functional anatomy of taste perception in the human brain studied with positron emission tomography
S. Kinomura (1994)
REVIEW ARTICLE: Contributions of anterior cingulate cortex to behaviour
O. Devinsky (1995)
Handbook of Sensory Physiology
M. D. Sanders (1975)
The topographic representation of esophageal motor function on the human cerebral cortex.
Q. Aziz (1996)
Human Cortical Activation During Single Swallowing Trials Measured by functional Magnetic Resonance Imaging (fMRI).
R. Martin (1998)
Co-Planar Sterotaxic Atlas of the Human Brain
Talairach J Tournoux (1988)
Reticular ascending activation of frontal cortical neurons in rabbits, with special reference to the regulation of deglutition.
T. Sumi (1972)
Somatic and limbic cortex activation in esophageal distention: A functional imaging study
F. Binkofski (1998)
Cortical mechanisms controlling mastication and swallowing in the awake monkey
Bj Sessle (1995)
cortical activation associated with human swallowing : a fMRI study
RE MARTIN (1971)
Cardiovascular effects of human insular cortex stimulation
S. Oppenheimer (1992)
Explaining oropharyngeal dysphagia after unilateral hemispheric stroke
S. Hamdy (1997)
Input-output relationships of the primary face motor cortex in the monkey (Macaca fascicularis).
C. Huang (1989)
Relationship of firing patterns of units in face area of monkey precentral cortex to conditioned jaw movements.
E. Luschei (1971)
The functional neuroanatomy of voluntary swallowing
D. Zald (1999)
Stimulate: A GUI based fMRI analysis software package
J. P. Strupp (1996)
Somatic and limbic cortex activation in esophageal distention: a functional magnetic resonance imaging study.
F. Binkofski (1998)
Precentral Cortical Modulation of Mastication and Swallowing
A. Miller (1977)
Identification and characterization of cerebral cortical response to esophageal mucosal acid exposure and distention.
M. Kern (1998)
The Neural Basis of Oral and Facial Function
R. Dubner (1978)
Identification of the cerebral loci processing human swallowing with H2(15)O PET activation.
S. Hamdy (1999)
Patterns of lateral sensory cortical activation determined using functional magnetic resonance imaging.
C. Hodge (1998)
Activities of the Primary and Supplementary Motor Areas Increase in Preparation and Execution of Voluntary Muscle Relaxation: An Event-Related fMRI Study
K. Toma (1999)
The Cerebral Cortex of Man
W. Penfield (1950)
Magnetic resonance imaging.
J. Hogg (1994)
Functional magnetic resonance imaging of Broca’s area during internal speech.Neuroreport4: 675–678
RM HINKE (1993)
Submillimeter functional localization in human striate cortex using BOLD contrast at 4 Tesla: Implications for the vascular point‐spread function
R. Menon (1999)
Cortical activation during human volitional swallowing: an event-related fMRI study.
S. Hamdy (1999)
SESSLEBJ, AND STOREY AT
R DUBNER (1978)
Cortical Representation of Swallowing in Normal Adults: Functional Implications
K. Mosier (1999)
Reduction of signal fluctuation in functional MRI using navigator echoes
X. Hu (1994)
Central Projections of the Gustatory System
H. Burton (1971)
Features of cortically evoked swallowing in the awake primate (Macaca fascicularis).
R. Martin (1999)
Two movement-related foci in the primate cingulate cortex observed in signal-triggered and self-paced forelimb movements.
K. Shima (1991)
Topographical distribution and functional properties of cortically induced rhythmical jaw movements in the monkey (Macaca fascicularis).
C. Huang (1989)
The cortical topography of human swallowing musculature in health and disease
S. Hamdy (1996)
Functional Lateralization of Human Gustatory Cortex Related to Handedness Disclosed by fMRI Study a
B. Cerf (1998)
fMRI Study of Taste Cortical Areas in Humans
A. Faurion (1998)
Effects of functional disruption of lateral pericentral cerebral cortex on primate swallowing
N. Narita (1999)
A Role for the Right Anterior Temporal Lobe in Taste Quality Recognition
D. Small (1997)
Identification of the cerebral loci processing human swallowing with H215
S HAMDY (1999)
cortical activation associated with human swallowing: a fMRI study
Martin Re (1997)
Contributions of anterior cingulate cortex to behaviour.
O. Devinsky (1995)
A new brain region for coordinating speech articulation
N. Dronkers (1996)
In vivo morphometry of the intrasulcal gray matter in the human cingulate, paracingulate, and superior‐rostral sulci: Hemispheric asymmetries, gender differences and probability maps
T. Paus (1996)
Event‐related fMRI of tasks involving brief motion
R. Birn (1999)
Selective averaging of rapidly presented individual trials using fMRI
A. Dale (1997)
Cerebral glucose consumption following verbal auditory stimulation
M. Kushner (1987)
Closure mechanisms of laryngeal vestibule during swallow.
J. Logemann (1992)
Functional MRI activation pattern of motor and language tasks in Broca's area
Erhard P Kato (1996)
Cortical activation during fast repetitive finger movements in humans: steady-state movement-related magnetic fields and their cortical generators.
C. Gerloff (1998)
Neurophysiology of the Jaws and Teeth
A. Taylor (1990)
High order gustatory projections in the human brain studied with positron emission tomography
H FUKUDA (1995)
Memory mechanisms in the processing of words and word-like symbols.
M. Raichle (1991)
A modality-specific somatosensory area within the insula of the rhesus monkey
R. Schneider (1993)
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A Study of Brain Networks Associated with Swallowing Using Graph-Theoretical Approaches
Bo Luan (2013)
Swallowing Physiology and Impairment in Individuals with Amyotrophic Lateral Sclerosis (ALS)
Ashley A Waito (2019)
Cortical swallowing processing in early subacute stroke
I. Teismann (2011)
Modulation of Activity in Swallowing Motor Cortex Following Esophageal Acidification: A Functional Magnetic Resonance Imaging Study
P. Paine (2007)
Foix-Chavany-Marie syndrome caused by a disconnection between the right pars opercularis of the inferior frontal gyrus and the supplementary motor area.
J. Martino (2012)
Modulation of spontaneous and volitional swallowing : methodological and behavioural analyses
K. Lamvik (2016)
Predictors of Percutaneous Endoscopic Gastrostomy Tube Placement after Stroke.
Jian Li (2014)
Effect of Age on Cortical Activation during Swallowing: An fMRI Study
Hyun Im Moon (2016)
Drinking speed using a Pat Saunders valved straw, wide-bore straw and a narrow-bore straw in a normal adult population
Celia Harding (2014)
Experimental device for detecting laryngeal movement during swallowing.
Shinichi Abe (2002)
Differences in swallow physiology in patients with left and right hemispheric strokes
J. Wilmskoetter (2018)
Functional changes of neural circuits in stroke patients with dysphagia: A meta‐analysis
L. Liu (2017)
Excitability of the lower-limb area of the motor cortex in Parkinson's disease
F. Vacherot (2010)
Effects of music therapy on involuntary swallowing
I. Jomori (2010)
LES CARTES SENSORIMOTRICES DE LA PAROLE : Corrélats neurocognitifs et couplage fonctionnel des systèmes de perception et de production des voyelles du Français
Krystyna Grabski (2012)
Décision kinésithérapique : Louis F. hémiplégique dysphagique
Thomas Gallice (2017)
Alterations of the amplitude of low-frequency fluctuation in healthy subjects with theta-burst stimulation of the cortex of the suprahyoid muscles
Xiuhang Ruan (2017)
Pharyngeal electrical stimulation can modulate swallowing in cortical processing and behavior — Magnetoencephalographic evidence
S. Suntrup (2015)
Evidence for adaptive cortical changes in swallowing in Parkinson's disease.
S. Suntrup (2013)
THE EFFECTS OF CARBONATED FLUIDS ON THE HUMAN CORTICAL SWALLOWING MOTOR SYSTEM
O. Elshukri (2013)
Dysphagiemanagement verbessert Lebensqualität und senkt Mortalität
Bendix Labeit (2019)
Age-related differences in the within-session trainability of hemodynamic parameters: a near-infrared spectroscopy–based neurofeedback study
Silvia Erika Kober (2019)
Emergence of deglutology: a transdisciplinary field.
A. Babaei (2014)
Influence of command on tongue elevation during swallowing: examination of tongue pressure and ultrasound imaging
K. Nomura (2011)
Functional imaging during speech production.
K. Munhall (2001)
Cerebral areas processing swallowing and tongue movement are overlapping but distinct: a functional magnetic resonance imaging study.
R. Martin (2004)
Gastroenterology and Hepatology Research
Y. Yağmur (2015)
Short and Long-term effects of pharyngeal electrical stimulation on swallowing performance in healthy humans
R. Takeishi (2015)
Cortical regulation during the early stage of initiation of voluntary swallowing
S. Abe (2004)
Dementia and dysphagia.
Caryn S. Easterling (2008)
Sensory stimulation activates both motor and sensory components of the swallowing system
Soren Y. Lowell (2008)
Supratentorial Regions of Acute Ischemia Associated With Clinically Important Swallowing Disorders: A Pilot Study
M. González-Fernández (2008)See more