Online citations, reference lists, and bibliographies.
← Back to Search

Cerebral Cortical Representation Of Automatic And Volitional Swallowing In Humans.

R. Martin, B. Goodyear, J. Gati, R. Menon
Published 2001 · Medicine, Psychology

Cite This
Download PDF
Analyze on Scholarcy
Share
Although the cerebral cortex has been implicated in the control of swallowing, the functional organization of the human cortical swallowing representation has not been fully documented. Therefore, the present study determined the cortical representation of swallowing in fourteen healthy right-handed female subjects using single-event-related functional magnetic resonance imaging (fMRI). Subjects were scanned during three swallowing activation tasks: a naïve saliva swallow, a voluntary saliva swallow, and a water bolus swallow. Swallow-related laryngeal movement was recorded simultaneously from the output of a bellows positioned over the thyroid cartilage. Statistical maps were generated by computing the difference between the magnitude of the voxel time course during 1) a single swallowing trial and 2) the corresponding control period. Automatic and volitional swallowing produced activation within several common cortical regions, the most prominent and consistent being located within the lateral precentral gyrus, lateral postcentral gyrus, and right insula. Activation foci within the superior temporal gyrus, middle and inferior frontal gyri, and frontal operculum also were identified for all swallowing tasks. In contrast, activation of the caudal anterior cingulate cortex was significantly more likely in association with the voluntary saliva swallow and water bolus swallow than the naïve swallow. These findings support the view that, in addition to known brain stem areas, human swallowing is represented within a number of spatially and functionally distinct cortical loci which may participate differentially in the regulation of swallowing. Activation of the insula was significantly lateralized to the right hemisphere for the voluntary saliva swallow, suggesting a functional hemispheric dominance of the insula for the processing of swallowing.
This paper references
10.1016/0028-3932(71)90067-4
The assessment and analysis of handedness: the Edinburgh inventory.
R. Oldfield (1971)
10.1002/MRM.1910330508
Improved Assessment of Significant Activation in Functional Magnetic Resonance Imaging (fMRI): Use of a Cluster‐Size Threshold
S. Forman (1995)
10.1016/0304-3940(96)12798-1
The primary gustatory area in human cerebral cortex studied by magnetoencephalography
T. Kobayakawa (1996)
10.1136/jnnp.36.5.853
Dysphagia in unilateral cerebral lesions
J. Meadows (1973)
Physiol Rev
Miller Aj Deglutition (1982)
A GUI based fMRI analysis software package (Abstract )
Strupp Jp Stimulate (1996)
10.1152/JN.1997.78.3.1516
Functional properties of neurons in the primate tongue primary motor cortex during swallowing.
R. Martin (1997)
Functional MRI activation pattern of motor and language tasks in Broca ’ s area
P ERHARD (1978)
10.1093/BRAIN/78.4.445
The insula; further observations on its function.
W. Penfield (1955)
10.1097/00004691-199811000-00009
Cortical activation during fast repetitive finger movements in humans: dipole sources of steady-state movement-related cortical potentials.
C. Gerloff (1998)
10.3109/14417040008996802
The Neuroscientific Principles of Swallowing and Dysphagia
A. Miller (2000)
10.1016/0165-0270(94)90191-0
Functional magnetic resonance imaging (FMRI) of the human brain
E. DeYoe (1994)
10.1097/00001756-199612200-00005
Transient brain activity used in magnetic resonance imaging to detect functional areas
S. Konishi (1996)
10.1073/PNAS.93.25.14878
Detection of cortical activation during averaged single trials of a cognitive task using functional magnetic resonance imaging.
R. Buckner (1996)
10.1152/JN.1993.70.2.453
Role of the human anterior cingulate cortex in the control of oculomotor, manual, and speech responses: a positron emission tomography study.
T. Paus (1993)
10.1007/978-1-349-08964-2_9
Brainstem Control of Swallowing: Localization and Organization of the Central Pattern Generator for Swallowing
A. Jean (1990)
Cerebral glucose comsumption following verbal auditory stimulation.Brain
MJ KUSHNER (1987)
10.1001/ARCHNEUR.1960.03840090124020
Handbook of Physiology.
F. Plum (1960)
Central nervous system mechanisms in deglutition and emesis In: Handbook of Physiology. Gastrointestinal System. Control of Food and Water Intake
Do Carpenter (1989)
10.1016/S0165-0173(96)00011-2
Circuitry and functional aspects of the insular lobe in primates including humans
J. Augustine (1996)
Control of food and water intake
C. F. Code (1967)
10.1152/JN.1995.74.5.1856
Neurons of the anterior mesial cortex related to faciovocal activity in the awake monkey.
R. West (1995)
The assessment and analysis of handedness: the Edinburgh Inventory.Neuropsychologia9
RC OLDFIELD (1971)
10.1016/0014-4886(80)90189-2
Alterations in the pattern of mastication after ablations of the lateral precentral cortex in rhesus macaques
C. Larson (1980)
10.1007/PL00009529
The Role of the Insular Cortex in Dysphagia
S. Daniels (1997)
10.1097/00001756-199306000-00018
Functional magnetic resonance imaging of Broca's area during internal speech.
R. Hinke (1993)
10.1016/0006-8993(94)90890-7
Functional anatomy of taste perception in the human brain studied with positron emission tomography
S. Kinomura (1994)
REVIEW ARTICLE: Contributions of anterior cingulate cortex to behaviour
O. Devinsky (1995)
10.1136/BJO.59.2.111-C
Handbook of Sensory Physiology
M. D. Sanders (1975)
10.1016/S0016-5085(96)70053-7
The topographic representation of esophageal motor function on the human cerebral cortex.
Q. Aziz (1996)
10.1016/S1053-8119(18)31822-6
Human Cortical Activation During Single Swallowing Trials Measured by functional Magnetic Resonance Imaging (fMRI).
R. Martin (1998)
Co-Planar Sterotaxic Atlas of the Human Brain
Talairach J Tournoux (1988)
10.1016/0006-8993(72)90004-2
Reticular ascending activation of frontal cortical neurons in rabbits, with special reference to the regulation of deglutition.
T. Sumi (1972)
10.1002/ANA.410440516
Somatic and limbic cortex activation in esophageal distention: A functional imaging study
F. Binkofski (1998)
Cortical mechanisms controlling mastication and swallowing in the awake monkey
Bj Sessle (1995)
cortical activation associated with human swallowing : a fMRI study
RE MARTIN (1971)
10.1212/WNL.42.9.1727
Cardiovascular effects of human insular cortex stimulation
S. Oppenheimer (1992)
10.1016/S0140-6736(97)02068-0
Explaining oropharyngeal dysphagia after unilateral hemispheric stroke
S. Hamdy (1997)
10.1152/JN.1989.61.2.350
Input-output relationships of the primary face motor cortex in the monkey (Macaca fascicularis).
C. Huang (1989)
10.1152/JN.1971.34.4.552
Relationship of firing patterns of units in face area of monkey precentral cortex to conditioned jaw movements.
E. Luschei (1971)
10.1002/1531-8249(199909)46:3<281::AID-ANA2>3.0.CO;2-L
The functional neuroanatomy of voluntary swallowing
D. Zald (1999)
10.1016/S1053-8119(96)80609-4
Stimulate: A GUI based fMRI analysis software package
J. P. Strupp (1996)
Somatic and limbic cortex activation in esophageal distention: a functional magnetic resonance imaging study.
F. Binkofski (1998)
10.1177/00220345770560100401
Precentral Cortical Modulation of Mastication and Swallowing
A. Miller (1977)
10.1016/S0016-5085(98)70013-7
Identification and characterization of cerebral cortical response to esophageal mucosal acid exposure and distention.
M. Kern (1998)
10.1016/B978-0-12-801238-3.00035-0
The Neural Basis of Oral and Facial Function
R. Dubner (1978)
10.1152/JN.1999.81.4.1917
Identification of the cerebral loci processing human swallowing with H2(15)O PET activation.
S. Hamdy (1999)
10.3171/JNS.1998.89.5.0769
Patterns of lateral sensory cortical activation determined using functional magnetic resonance imaging.
C. Hodge (1998)
10.1523/JNEUROSCI.19-09-03527.1999
Activities of the Primary and Supplementary Motor Areas Increase in Preparation and Execution of Voluntary Muscle Relaxation: An Event-Related fMRI Study
K. Toma (1999)
10.1016/s0140-6736(00)47063-7
The Cerebral Cortex of Man
W. Penfield (1950)
10.1201/9781420030679.ch5
Magnetic resonance imaging.
J. Hogg (1994)
Functional magnetic resonance imaging of Broca’s area during internal speech.Neuroreport4: 675–678
RM HINKE (1993)
10.1002/(SICI)1522-2594(199902)41:2<230::AID-MRM3>3.0.CO;2-O
Submillimeter functional localization in human striate cortex using BOLD contrast at 4 Tesla: Implications for the vascular point‐spread function
R. Menon (1999)
10.1152/ajpgi.1999.277.1.G219
Cortical activation during human volitional swallowing: an event-related fMRI study.
S. Hamdy (1999)
SESSLEBJ, AND STOREY AT
R DUBNER (1978)
10.1097/00005537-199909000-00011
Cortical Representation of Swallowing in Normal Adults: Functional Implications
K. Mosier (1999)
10.1002/MRM.1910310505
Reduction of signal fluctuation in functional MRI using navigator echoes
X. Hu (1994)
10.1007/978-3-642-65245-5_8
Central Projections of the Gustatory System
H. Burton (1971)
10.1152/JN.1999.82.3.1529
Features of cortically evoked swallowing in the awake primate (Macaca fascicularis).
R. Martin (1999)
10.1152/JN.1991.65.2.188
Two movement-related foci in the primate cingulate cortex observed in signal-triggered and self-paced forelimb movements.
K. Shima (1991)
10.1152/JN.1989.61.3.635
Topographical distribution and functional properties of cortically induced rhythmical jaw movements in the monkey (Macaca fascicularis).
C. Huang (1989)
10.1038/nm1196-1217
The cortical topography of human swallowing musculature in health and disease
S. Hamdy (1996)
10.1111/J.1749-6632.1998.TB10627.X
Functional Lateralization of Human Gustatory Cortex Related to Handedness Disclosed by fMRI Study a
B. Cerf (1998)
10.1111/J.1749-6632.1998.TB10623.X
fMRI Study of Taste Cortical Areas in Humans
A. Faurion (1998)
10.1016/S0006-8993(99)01151-8
Effects of functional disruption of lateral pericentral cerebral cortex on primate swallowing
N. Narita (1999)
10.1523/JNEUROSCI.17-13-05136.1997
A Role for the Right Anterior Temporal Lobe in Taste Quality Recognition
D. Small (1997)
Identification of the cerebral loci processing human swallowing with H215
S HAMDY (1999)
cortical activation associated with human swallowing: a fMRI study
Martin Re (1997)
10.1093/BRAIN/118.1.279
Contributions of anterior cingulate cortex to behaviour.
O. Devinsky (1995)
10.1038/384159A0
A new brain region for coordinating speech articulation
N. Dronkers (1996)
10.1002/(SICI)1096-9861(19961223)376:4<664::AID-CNE12>3.0.CO;2-M
In vivo morphometry of the intrasulcal gray matter in the human cingulate, paracingulate, and superior‐rostral sulci: Hemispheric asymmetries, gender differences and probability maps
T. Paus (1996)
10.1002/(SICI)1097-0193(1999)7:2<106::AID-HBM4>3.0.CO;2-O
Event‐related fMRI of tasks involving brief motion
R. Birn (1999)
10.1002/(SICI)1097-0193(1997)5:5<329::AID-HBM1>3.0.CO;2-5
Selective averaging of rapidly presented individual trials using fMRI
A. Dale (1997)
10.1016/0006-8993(87)90743-8
Cerebral glucose consumption following verbal auditory stimulation
M. Kushner (1987)
10.1152/AJPGI.1992.262.2.G338
Closure mechanisms of laryngeal vestibule during swallow.
J. Logemann (1992)
Functional MRI activation pattern of motor and language tasks in Broca's area
Erhard P Kato (1996)
10.1016/S0924-980X(98)00045-9
Cortical activation during fast repetitive finger movements in humans: steady-state movement-related magnetic fields and their cortical generators.
C. Gerloff (1998)
10.1007/978-1-349-08964-2
Neurophysiology of the Jaws and Teeth
A. Taylor (1990)
High order gustatory projections in the human brain studied with positron emission tomography
H FUKUDA (1995)
10.1002/9780470514184.CH12
Memory mechanisms in the processing of words and word-like symbols.
M. Raichle (1991)
10.1016/0006-8993(93)90305-7
A modality-specific somatosensory area within the insula of the rhesus monkey
R. Schneider (1993)



This paper is referenced by
10.1371/journal.pone.0073577
A Study of Brain Networks Associated with Swallowing Using Graph-Theoretical Approaches
Bo Luan (2013)
Swallowing Physiology and Impairment in Individuals with Amyotrophic Lateral Sclerosis (ALS)
Ashley A Waito (2019)
10.1186/1471-2377-11-34
Cortical swallowing processing in early subacute stroke
I. Teismann (2011)
10.1007/s00455-007-9114-3
Modulation of Activity in Swallowing Motor Cortex Following Esophageal Acidification: A Functional Magnetic Resonance Imaging Study
P. Paine (2007)
10.3171/2012.7.JNS12404
Foix-Chavany-Marie syndrome caused by a disconnection between the right pars opercularis of the inferior frontal gyrus and the supplementary motor area.
J. Martino (2012)
Modulation of spontaneous and volitional swallowing : methodological and behavioural analyses
K. Lamvik (2016)
10.1017/S0317167100016218
Predictors of Percutaneous Endoscopic Gastrostomy Tube Placement after Stroke.
Jian Li (2014)
10.34160/JKDS.2016.6.1.005
Effect of Age on Cortical Activation during Swallowing: An fMRI Study
Hyun Im Moon (2016)
10.1097/XEB.0000000000000021
Drinking speed using a Pat Saunders valved straw, wide-bore straw and a narrow-bore straw in a normal adult population
Celia Harding (2014)
10.2209/tdcpublication.43.199
Experimental device for detecting laryngeal movement during swallowing.
Shinichi Abe (2002)
10.1016/j.physbeh.2018.05.010
Differences in swallow physiology in patients with left and right hemispheric strokes
J. Wilmskoetter (2018)
10.1111/jebm.12242
Functional changes of neural circuits in stroke patients with dysphagia: A meta‐analysis
L. Liu (2017)
10.1016/j.neucli.2010.04.002
Excitability of the lower-limb area of the motor cortex in Parkinson's disease
F. Vacherot (2010)
10.1080/08098130903086354
Effects of music therapy on involuntary swallowing
I. Jomori (2010)
LES CARTES SENSORIMOTRICES DE LA PAROLE : Corrélats neurocognitifs et couplage fonctionnel des systèmes de perception et de production des voyelles du Français
Krystyna Grabski (2012)
10.1016/J.KINE.2017.04.005
Décision kinésithérapique : Louis F. hémiplégique dysphagique
Thomas Gallice (2017)
10.1016/j.neuroscience.2017.09.027
Alterations of the amplitude of low-frequency fluctuation in healthy subjects with theta-burst stimulation of the cortex of the suprahyoid muscles
Xiuhang Ruan (2017)
10.1016/j.neuroimage.2014.10.016
Pharyngeal electrical stimulation can modulate swallowing in cortical processing and behavior — Magnetoencephalographic evidence
S. Suntrup (2015)
10.1093/brain/awt004
Evidence for adaptive cortical changes in swallowing in Parkinson's disease.
S. Suntrup (2013)
THE EFFECTS OF CARBONATED FLUIDS ON THE HUMAN CORTICAL SWALLOWING MOTOR SYSTEM
O. Elshukri (2013)
10.1007/s15005-019-0026-1
Dysphagiemanagement verbessert Lebensqualität und senkt Mortalität
Bendix Labeit (2019)
10.1016/j.neurobiolaging.2019.05.022
Age-related differences in the within-session trainability of hemodynamic parameters: a near-infrared spectroscopy–based neurofeedback study
Silvia Erika Kober (2019)
10.1016/j.cgh.2014.08.031
Emergence of deglutology: a transdisciplinary field.
A. Babaei (2014)
Influence of command on tongue elevation during swallowing: examination of tongue pressure and ultrasound imaging
K. Nomura (2011)
10.1016/S0001-6918(01)00026-9
Functional imaging during speech production.
K. Munhall (2001)
10.1152/JN.01144.2003
Cerebral areas processing swallowing and tongue movement are overlapping but distinct: a functional magnetic resonance imaging study.
R. Martin (2004)
Gastroenterology and Hepatology Research
Y. Yağmur (2015)
Short and Long-term effects of pharyngeal electrical stimulation on swallowing performance in healthy humans
R. Takeishi (2015)
10.1016/J.ICS.2004.04.048
Cortical regulation during the early stage of initiation of voluntary swallowing
S. Abe (2004)
10.1016/j.gerinurse.2007.10.015
Dementia and dysphagia.
Caryn S. Easterling (2008)
10.1016/j.neuroimage.2008.04.234
Sensory stimulation activates both motor and sensory components of the swallowing system
Soren Y. Lowell (2008)
10.1161/STROKEAHA.108.518969
Supratentorial Regions of Acute Ischemia Associated With Clinically Important Swallowing Disorders: A Pilot Study
M. González-Fernández (2008)
See more
Semantic Scholar Logo Some data provided by SemanticScholar