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NF-kappaB Signaling: A Tale Of Two Pathways In Skeletal Myogenesis.

N. Bakkar, D. Guttridge
Published 2010 · Biology, Medicine

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NF-kappaB is a ubiquitiously expressed transcription factor that plays vital roles in innate immunity and other processes involving cellular survival, proliferation, and differentiation. Activation of NF-kappaB is controlled by an IkappaB kinase (IKK) complex that can direct either canonical (classical) NF-kappaB signaling by degrading the IkappaB inhibitor and releasing p65/p50 dimers to the nucleus, or causes p100 processing and nuclear translocation of RelB/p52 via a noncanonical (alternative) pathway. Under physiological conditions, NF-kappaB activity is transiently regulated, whereas constitutive activation of this transcription factor typically in the classical pathway is associated with a multitude of disease conditions, including those related to skeletal muscle. How NF-kappaB functions in muscle diseases is currently under intense investigation. Insight into this role of NF-kappaB may be gained by understanding at a more basic level how this transcription factor contributes to skeletal muscle cell differentiation. Recent data from knockout mice support that the classical NF-kappaB pathway functions as an inhibitor of skeletal myogenesis and muscle regeneration acting through multiple mechanisms. In contrast, alternative NF-kappaB signaling does not appear to be required for myofiber conversion, but instead functions in myotube homeostasis by regulating mitochondrial biogenesis. Additional knowledge of these signaling pathways in skeletal myogenesis should aid in the development of specific inhibitors that may be useful in treatments of muscle disorders.
This paper references
Differential Requirement for TANK-binding Kinase-1 in Type I Interferon Responses to Toll-like Receptor Activation and Viral Infection
Andrea K. Perry (2004)
The role of tumor necrosis factor-alpha (TNF-alpha) in skeletal muscle regeneration. Studies in TNF-alpha(-/-) and TNF-alpha(-/-)/LT-alpha(-/-) mice.
R. Collins (2001)
Tumor necrosis factor-α inhibits myogenesis through redox-dependent and -independent pathways
R. Langen (2002)
Negative Regulation of Toll-Like Receptor Signaling by NF-κB p50 Ubiquitination Blockade
R. Carmody (2007)
Activators and target genes of Rel/NF-kappaB transcription factors.
H. Pahl (1999)
TNF-dependent recruitment of the protein kinase RIP to the TNF receptor-1 signaling complex.
H. Hsu (1996)
TNF-α regulates myogenesis and muscle regeneration by activating p38 MAPK
S. E. Chen (2007)
The alternative NF-kappaB pathway from biochemistry to biology: pitfalls and promises for future drug development.
E. Dejardin (2006)
Mechanism of PP2A-mediated IKKbeta dephos 510 NADINE BAKKAR AND DENIS C
J Witt (2010)
NF-kappaB-induced loss of MyoD messenger RNA: possible role in muscle decay and cachexia.
D. Guttridge (2000)
Mitochondrial biogenesis during cellular differentiation.
C. Moyes (1997)
The p38 MAPK signaling pathway: A major regulator of skeletal muscle development
A. Keren (2006)
Two Pathways to NF-κB
J. Pomerantz (2002)
IKKbeta phosphorylates p65 at S468 in transactivaton domain 2.
R. Schwabe (2005)
Two pathways to NF-kappaB.
J. Pomerantz (2002)
Satellite and stem cells in muscle growth and repair
F. Le Grand (2007)
Role for IkappaBalpha, but not c-Rel, in skeletal muscle atrophy.
A. Judge (2007)
ferential requirement for TANKbinding kinase1 in type I Interferon responses to Toll - like receptor activation and viral infection
AK Perry (2004)
A novel IkappaB protein, IkappaB-zeta, induced by proinflammatory stimuli, negatively regulates nuclear factor-kappaB in the nuclei.
S. Yamazaki (2001)
SMRT derepression by the IkappaB kinase alpha: a prerequisite to NF-kappaB transcription and survival.
Jamie E. Hoberg (2004)
One nucleotide in a kappaB site can determine cofactor specificity for NF-kappaB dimers.
Thomas H Leung (2004)
Modulation of life and death by the tumor necrosis factor receptor-associated factors (TRAFs).
Na Kyung Lee (2002)
IκB Kinase Promotes Tumorigenesis through Inhibition of Forkhead FOXO3a
Mickey C.-T. Hu (2004)
Mechanism of PP2A-mediated IKKβ dephosphorylation: a systems biological approach
J. Witt (2009)
RelA/p65 promotes osteoclast differentiation by blocking a RANKL-induced apoptotic JNK pathway in mice.
S. Vaira (2008)
The Polycomb Ezh2 methyltransferase regulates muscle gene expression and skeletal muscle differentiation.
G. Caretti (2004)
Clinorotation prevents differentiation of rat myoblastic L6 cells in association with reduced NF-kappa B signaling.
K. Hirasaka (2005)
The p50-p50 NF-kappaB complex as a stimulus-specific repressor of gene activation.
X. Tong (2004)
A fourth IkappaB protein within the NF-kappaB signaling module.
S. Basak (2007)
Posttranslational modifications of NEMO and its partners in NF-kappaB signaling.
Hélène Sebban (2006)
NF-κB signaling in skeletal muscle: prospects for intervention in muscle diseases
F. Mourkioti (2008)
Post-translational modifications regulating the activity and function of the nuclear factor kappa B pathway
N. Perkins (2006)
Regulation of RelA Subcellular Localization by a Putative Nuclear Export Signal and p50
E. Harhaj (1999)
Notch Function in Myogenesis
E. Vasyutina (2007)
Structure of a NEMO/IKK-associating domain reveals architecture of the interaction site.
M. Rushe (2008)
Phosphorylation of serine 68 in the IkappaB kinase (IKK)-binding domain of NEMO interferes with the structure of the IKK complex and tumor necrosis factor-alpha-induced NF-kappaB activity.
Lysann Palkowitsch (2008)
Activation of an alternative NF‐ΚB pathway in skeletal muscle during disuse atrophy
R. B. Hunter (2002)
p38 MAPK-induced nuclear factor-kappaB activity is required for skeletal muscle differentiation: role of interleukin-6.
Bernat Baeza-Raja (2004)
Skeletal muscle satellite cells and adult myogenesis.
F. Le Grand (2007)
NF-κB p50 and p52 Regulate Receptor Activator of NF-κB Ligand (RANKL) and Tumor Necrosis Factor-induced Osteoclast Precursor Differentiation by Activating c-Fos and NFATc1*
T. Yamashita (2007)
Induction of p100 processing by NF-kappaB-inducing kinase involves docking IkappaB kinase alpha (IKKalpha) to p100 and IKKalpha-mediated phosphorylation.
G. Xiao (2004)
Tumor Necrosis Factor-like Weak Inducer of Apoptosis Inhibits Skeletal Myogenesis through Sustained Activation of Nuclear Factor-κB and Degradation of MyoD Protein*
Charu Dogra (2006)
Nuclear factor-kappa B signaling in skeletal muscle atrophy
Hong Li (2008)
Differential roles of p300 and PCAF acetyltransferases in muscle differentiation.
P. L. Puri (1997)
Myostatin and NF-κB Regulate Skeletal Myogenesis Through Distinct Signaling Pathways
N. Bakkar (2005)
Skeletal muscle development and regeneration.
S. Grefte (2007)
Shared Principles in NF-κB Signaling
M. Hayden (2008)
Nuclear exclusion of forkhead box O and Elk1 and activation of nuclear factor-kappaB are required for C2C12-RasV12C40 myoblast differentiation.
C. de Álvaro (2008)
WIP1 phosphatase is a negative regulator of NF-κB signalling
J. Chew (2009)
Tumors secreting human TNF/cachectin induce cachexia in mice
A. Oliff (1987)
Post-translational modification of RelA(p65) NF-κB
K. Campbell (2004)
Alterations in NF-kappaB function in transgenic epithelial tissue demonstrate a growth inhibitory role for NF-kappaB.
C. S. Seitz (1998)
Differential activation of Myf5 and MyoD by different Wnts in explants of mouse paraxial mesoderm and the later activation of myogenesis in the absence of Myf5.
S. Tajbakhsh (1998)
Redefining the Genetic Hierarchies Controlling Skeletal Myogenesis: Pax-3 and Myf-5 Act Upstream of MyoD
S. Tajbakhsh (1997)
NAK is an IκB kinase-activating kinase
Y. Tojima (2000)
Phosphorylation of MRF4 transactivation domain by p38 mediates repression of specific myogenic genes
M. Suelves (2004)
Oncogenic Ras Enhances NF-κB Transcriptional Activity through Raf-dependent and Raf-independent Mitogen-activated Protein Kinase Signaling Pathways*
J. Norris (1999)
Phosphorylation of Serine 68 in the IκB Kinase (IKK)-binding Domain of NEMO Interferes with the Structure of the IKK Complex and Tumor Necrosis Factor-α-induced NF-κB Activity*
Lysann Palkowitsch (2008)
RelB is the NF-κB subunit downstream of NIK responsible for osteoclast differentiation
S. Vaira (2008)
Targeted ablation of IKK2 improves skeletal muscle strength, maintains mass, and promotes regeneration.
F. Mourkioti (2006)
Systemic administration of the NF-kappaB inhibitor curcumin stimulates muscle regeneration after traumatic injury.
D. Thaloor (1999)
The Role of Tumor Necrosis Factor-alpha (TNF-α) in Skeletal Muscle Regeneration
R. Collins (2001)
Activation of IKKα target genes depends on recognition of specific κB binding sites by RelB:p52 dimers
G. Bonizzi (2004)
Skeletal Muscle Diseases, Inflammation, and NF-κB Signaling: Insights and Opportunities for Therapeutic Intervention
J. M. Peterson (2008)
Genetic approaches in mice to understand Rel/NF-κB and IκB function: transgenics and knockouts
S. Gerondakis (1999)
Nuclear factor κB and activating protein 1 are involved in differentiation-related resistance to oxidative stress in skeletal muscle cells
M. Catani (2004)
Are fibroblast growth factors regulators of myogenesis in vivo?
B. Olwin (1994)
NF-κB Controls Cell Growth and Differentiation through Transcriptional Regulation of Cyclin D1
D. Guttridge (1999)
Inhibition of myogenic differentiation in proliferating myoblasts by cyclin D1-dependent kinase
S. Skapek (1995)
Inhibition of osteoblastic bone formation by nuclear factor-κB
J. Chang (2009)
Akt Stimulates the Transactivation Potential of the RelA/p65 Subunit of NF-κB through Utilization of the IκB Kinase and Activation of the Mitogen-activated Protein Kinase p38*
L. V. Madrid (2001)
Systemic administration of the NF-κB inhibitor curcumin stimulates muscle regeneration after traumatic injury.
D. Thaloor (1999)
Postrepression Activation of NF-κB Requires the Amino-Terminal Nuclear Export Signal Specific to IκBα
T. T. Huang (2001)
Functional interdependence at the chromatin level between the MKK6/p38 and IGF1/PI3K/AKT pathways during muscle differentiation.
C. Serra (2007)
Genetic approaches in mice to understand Rel/NF-kappaB and IkappaB function: transgenics and knockouts.
S. Gerondakis (1999)
Nuclear factor kappaB and activating protein 1 are involved in differentiation-related resistance to oxidative stress in skeletal muscle cells.
M. Catani (2004)
NF-κB regulation: the nuclear response
A. Mankan (2009)
Selective inhibition of NF-kappaB activation by a peptide that blocks the interaction of NEMO with the IkappaB kinase complex.
M. J. May (2000)
Genetic analysis of p38 MAP kinases in myogenesis: fundamental role of p38α in abrogating myoblast proliferation
E. Perdiguero (2007)
Wnt signalling regulates myogenic differentiation in the developing avian wing
K. Anakwe (2003)
A nucleosomal function for IκB kinase-α in NF-κB-dependent gene expression
V. Anest (2003)
Down-regulation of transcription factors AP-1, Sp-1, and NF-kappa B precedes myocyte differentiation.
Sanna K. Lehtinen (1996)
Constitutive and interleukin-1-inducible phosphorylation of p65 NF-{kappa}B at serine 536 is mediated by multiple protein kinases including I{kappa}B kinase (IKK)-{alpha}, IKK{beta}, IKK{epsilon}, TRAF family member-associated (TANK)-binding kinase 1 (TBK1), and an unknown kinase and couples p65 to
H. Buss (2004)
The carboxyl-terminal region of IkappaB kinase gamma (IKKgamma) is required for full IKK activation.
C. Makris (2002)
FGF6 in myogenesis.
A. Armand (2006)
IKK-i/IKKϵ Controls Constitutive, Cancer Cell-associated NF-κB Activity via Regulation of Ser-536 p65/RelA Phosphorylation*
Mazhar Adli (2006)
Functional activity of myogenic HLH proteins requires hetero-oligomerization with E12/E47-like proteins in vivo
A. Lassar (1991)
Expression of Either NF‐κB p50 or p52 in Osteoclast Precursors Is Required for IL‐1‐Induced Bone Resorption
L. Xing (2003)
Deficiency of T2K leads to apoptotic liver degeneration and impaired NF‐κB‐dependent gene transcription
M. Bonnard (2000)
β-TrCP binding and processing of NF-κB2/p100 involve its phosphorylation at serines 866 and 870
Chunyang Liang (2006)
The p50-p50 NF-κB complex as a stimulus-specific repressor of gene activation
X. Tong (2004)
Regulation of muscle mass by myostatin.
S. Lee (2004)
NF-kappaB-YY1-miR-29 regulatory circuitry in skeletal myogenesis and rhabdomyosarcoma.
H. Wang (2008)
IkappaB kinase promotes tumorigenesis through inhibition of forkhead FOXO3a.
M. C. Hu (2004)
Wnt7a activates the planar cell polarity pathway to drive the symmetric expansion of satellite stem cells.
F. Le Grand (2009)
The formation of skeletal muscle: from somite to limb
M. Buckingham (2003)
Distinct signaling pathways regulate transformation and inhibition of skeletal muscle differentiation by oncogenic Ras
C. Weyman (1997)
NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses.
S. Ghosh (1998)
IκB Kinases Phosphorylate NF-κB p65 Subunit on Serine 536 in the Transactivation Domain*
H. Sakurai (1999)
Nuclear Factor κB-inducing Kinase and IκB Kinase-α Signal Skeletal Muscle Cell Differentiation*
J. Canicio (2001)
The combined absence of the transcription factors Rel and RelA leads to multiple hemopoietic cell defects.
M. Grossmann (1999)
Protein turnover in skeletal muscle of tumour-bearing transgenic mice overexpressing the soluble TNF receptor-1.
M. Llovera (1998)
IKK-i, a novel lipopolysaccharide-inducible kinase that is related to IkappaB kinases.
T. Shimada (1999)
Insulin restores differentiation of Ras-transformed C2C12 myoblasts by inducing NF-κB through an AKT/P70S6K/p38-MAPK pathway
R. Conejo (2002)
Nuclear factor kappa-B blockade reduces skeletal muscle degeneration and enhances muscle function in Mdx mice
S. Messina (2006)
Inflammatory cytokines inhibit myogenic differentiation through activation of nuclear factor-kappaB.
R. Langen (2001)
Regulation of the RelA ( p 65 ) transactivation domain
John M O'Shea (2008)
Transforming growth factor-β and myostatin signaling in skeletal muscle
Helen D. Kollias (2008)
Induction of p100 Processing by NF-κB-inducing Kinase Involves Docking IκB Kinase α (IKKα) to p100 and IKKα-mediated Phosphorylation*
G. Xiao (2004)
Activation of an alternative NF-kappaB pathway in skeletal muscle during disuse atrophy.
R. B. Hunter (2002)
NF-κB Regulation of YY1 Inhibits Skeletal Myogenesis through Transcriptional Silencing of Myofibrillar Genes
H. Wang (2007)
Skeletal muscle formation in vertebrates.
M. Buckingham (2001)
Regulation of the immune system by NF-kappaB and IkappaB.
H. Liou (2002)
p38 pathway targets SWI-SNF chromatin-remodeling complex to muscle-specific loci
C. Simone (2004)
The lymphotoxin-beta receptor induces different patterns of gene expression via two NF-kappaB pathways.
E. Dejardin (2002)
Mediation of IGF-1-induced skeletal myotube hypertrophy by PI(3)K/Akt/mTOR and PI(3)K/Akt/GSK3 pathways
C. Rommel (2001)
Myogenic regulatory factors and the specification of muscle progenitors in vertebrate embryos.
M. Pownall (2002)
The Lymphotoxin-β Receptor Induces Different Patterns of Gene Expression via Two NF-κB Pathways
E. Dejardin (2002)
Idiopathic inflammatory myopathies and the classical NF-kappaB complex: current insights and implications for therapy.
K. Creus (2009)
The RIP kinases: crucial integrators of cellular stress.
E. Meylan (2005)
NIK and Cot cooperate to trigger NF-kappaB p65 phosphorylation.
T. Wittwer (2008)
Postrepression activation of NF-kappaB requires the amino-terminal nuclear export signal specific to IkappaBalpha.
T. T. Huang (2001)
Phosphorylation of serine 468 by GSK-3beta negatively regulates basal p65 NF-kappaB activity.
H. Buss (2004)
TNFα inhibits skeletal myogenesis through a PW1‐dependent pathway by recruitment of caspase pathways
D. Coletti (2002)
IKKβ phosphorylates p65 at S468 in transactivaton domain 2
R. Schwabe (2005)
The IκB Kinase Complex (IKK) Contains Two Kinase Subunits, IKKα and IKKβ, Necessary for IκB Phosphorylation and NF-κB Activation
E. Zandi (1997)
Wnt signaling and the activation of myogenesis in mammals
G. Cossu (1999)
Down-Regulation of Transcription Factors AP-1, Sp-1, and NF-κB Precedes Myocyte Differentiation
Sanna K. Lehtinen (1996)
A Novel IκB Protein, IκB-ζ, Induced by Proinflammatory Stimuli, Negatively Regulates Nuclear Factor-κB in the Nuclei*
Soh Yamazaki (2001)
Characterization of the IκB-kinase NEMO Binding Domain*
M. J. May (2002)
Signaling pathways weigh in on decisions to make or break skeletal muscle
D. Guttridge (2004)
IKKepsilon is part of a novel PMA-inducible IkappaB kinase complex.
R. Peters (2000)
IkappaB kinases phosphorylate NF-kappaB p65 subunit on serine 536 in the transactivation domain.
H. Sakurai (1999)
Missing Pieces in the NF-κB Puzzle
S. Ghosh (2002)
Regulation of NF-kappaB signaling by Pin1-dependent prolyl isomerization and ubiquitin-mediated proteolysis of p65/RelA.
A. Ryo (2003)
Cyclic mechanical strain inhibits skeletal myogenesis through activation of focal adhesion kinase, Rac‐1 GTPase, and NF‐kB transcription factor
A. Kumar (2004)
Phosphorylation of Serine 468 by GSK-3β Negatively Regulates Basal p65 NF-κB Activity*
H. Buss (2004)
The circuitry of a master switch: Myod and the regulation of skeletal muscle gene transcription
S. Tapscott (2005)
IKKε Is Part of a Novel PMA-Inducible IκB Kinase Complex
R. Peters (2000)
NEMO/IKK gamma-deficient mice model incontinentia pigmenti.
M. Schmidt-Supprian (2000)
TNF-alpha regulates myogenesis and muscle regeneration by activating p38 MAPK.
Shuen-Ei Chen (2007)
IKKα Regulates the Mitotic Phase of the Cell Cycle by Modulating Aurora A Phosphorylation
S. Prajapati (2006)
Adult satellite cells and embryonic muscle progenitors have distinct genetic requirements
C. Lepper (2009)
Activated Notch Inhibits Myogenic Activity of the MADS-Box Transcription Factor Myocyte Enhancer Factor 2C
J. Wilson-Rawls (1999)
IκB‐ζ: An Inducible Regulator of Nuclear Factor‐κB
T. Muta (2006)
RIP2, a Checkpoint in Myogenic Differentiation
Barbara Munz (2002)
Differential biological activities of mammalian Id proteins in muscle cells.
I. Melnikova (1999)
Pax7 Is Required for the Specification of Myogenic Satellite Cells
P. Seale (2000)
The Mef2c gene is a direct transcriptional target of myogenic bHLH and MEF2 proteins during skeletal muscle development.
D. Wang (2001)
Role of TNF-{alpha} signaling in regeneration of cardiotoxin-injured muscle.
Shuen-Ei Chen (2005)
Glutathione depletion impairs myogenic differentiation of murine skeletal muscle C2C12 cells through sustained NF-kappaB activation.
E. Ardite (2004)
E1A-mediated inhibition of myogenesis correlates with a direct physical interaction of E1A12S and basic helix-loop-helix proteins.
D. Taylor (1993)
The Putative Oncoprotein Bcl-3 Induces Cyclin D1 To Stimulate G1 Transition
S. Westerheide (2001)
A Fourth IκB Protein within the NF-κB Signaling Module
S. Basak (2007)
Posttranslational modifications of NEMO and its partners in NF-κB signaling
Hélène Sebban (2006)
Cellular and Molecular Signatures of Muscle Regeneration: Current Concepts and Controversies in Adult Myogenesis
A. Wagers (2005)
Essential role of RelA Ser311 phosphorylation by ζPKC in NF‐κB transcriptional activation
Á. Durán (2003)
NF-kappaB-dependent expression of nitric oxide synthase is required for membrane fusion of chick embryonic myoblasts.
K. H. Lee (1997)
Selective inhibition of NF-κB activation by a peptide that blocks the interaction of NEMO with the IκB kinase complex
M. J. May (2000)
One Nucleotide in a κB Site Can Determine Cofactor Specificity for NF-κB Dimers
Thomas H Leung (2004)
Role for IκBα, but not c-Rel, in skeletal muscle atrophy
A. Judge (2007)
Phosphorylation of CBP by IKKalpha promotes cell growth by switching the binding preference of CBP from p53 to NF-kappaB.
Wei-Chien Huang (2007)
NAK is an IkappaB kinase-activating kinase.
Y. Tojima (2000)
Nuclear factor kappa B-inducing kinase and Ikappa B kinase-alpha signal skeletal muscle cell differentiation.
J. Canicio (2001)
IKKβ Suppression of TSC1 Links Inflammation and Tumor Angiogenesis via the mTOR Pathway
D. Lee (2007)
TNF receptor (TNFR)-associated factor (TRAF) 3 serves as an inhibitor of TRAF2/5-mediated activation of the noncanonical NF-kappaB pathway by TRAF-binding TNFRs.
J. Hauer (2005)
Pax-3 expression in segmental mesoderm marks early stages in myogenic cell specification.
B. Williams (1994)
Embryonic and fetal limb myogenic cells are derived from developmentally distinct progenitors and have different requirements for beta-catenin.
D. Hutcheson (2009)
NF-κB Functions in Stromal Fibroblasts to Regulate Early Postnatal Muscle Development*
Jason M. Dahlman (2009)
Transformation by activated ras or fos prevents myogenesis by inhibiting expression of MyoD1
A. Lassar (1989)
Inducibility of κ immunoglobulin enhancer-binding protein NF-κB by a posttranslational mechanism
R. Sen (1986)
Phosphorylation of CBP by IKKα Promotes Cell Growth by Switching the Binding Preference of CBP from p53 to NF-κB
W. Huang (2007)
Regulation of Toll/IL-1-receptor-mediated gene expression by the inducible nuclear protein IκBζ
M. Yamamoto (2004)
Interplay of IKK/NF-kappaB signaling in macrophages and myofibers promotes muscle degeneration in Duchenne muscular dystrophy.
Swarnali Acharyya (2007)
Sir2 regulates skeletal muscle differentiation as a potential sensor of the redox state.
M. Fulco (2003)
Are the IKKs and IKK-related kinases TBK1 and IKK-epsilon similarly activated?
T. Chau (2008)
Fibroblast growth factor and transforming growth factor beta repress transcription of the myogenic regulatory gene MyoD1.
T. Vaidya (1989)
Essential role of RelA Ser311 phosphorylation by zetaPKC in NF-kappaB transcriptional activation.
Á. Durán (2003)
Regulation of Toll/IL-1-receptor-mediated gene expression by the inducible nuclear protein IkappaBzeta.
M. Yamamoto (2004)
Inducibility of kappa immunoglobulin enhancer-binding protein Nf-kappa B by a posttranslational mechanism.
R. Sen (1986)
The epigenetic network regulating muscle development and regeneration
D. Palacios (2006)
Tumor necrosis factor-α and muscle wasting: a cellular perspective
M. Reid (2001)
Chromatin: the interface between extrinsic cues and the epigenetic regulation of muscle regeneration.
Valentina Guasconi (2009)
Cellular and molecular regulation of muscle regeneration.
Sophie B. P. Chargé (2004)
Characterization of the Ikappa B-kinase NEMO binding domain.
M. J. May (2002)
Expression of the Bcl-3 proto-oncogene suppresses p53 activation.
David F. Kashatus (2006)
beta-TrCP binding and processing of NF-kappaB2/p100 involve its phosphorylation at serines 866 and 870.
Chunyang Liang (2006)
A temporal switch from notch to Wnt signaling in muscle stem cells is necessary for normal adult myogenesis.
A. Brack (2008)
Regulation of the RelA (p65) transactivation domain.
John M O'Shea (2008)
p38 and Extracellular Signal-Regulated Kinases Regulate the Myogenic Program at Multiple Steps
Z. Wu (2000)
Nuclear Factor (NF)-κB2 (p100/p52) Is Required for Normal Splenic Microarchitecture and B Cell–mediated Immune Responses
J. Caamaño (1998)
The RelA/p65 subunit of NF‐κB specifically regulates cyclin D1 protein stability: Implications for cell cycle withdrawal and skeletal myogenesis
Jason M. Dahlman (2009)
Insulin-like Growth Factor-II, Phosphatidylinositol 3-Kinase, Nuclear Factor-κB and Inducible Nitric-oxide Synthase Define a Common Myogenic Signaling Pathway*
P. Kaliman (1999)
IKK-1 and IKK-2: Cytokine-Activated IκB Kinases Essential for NF-κB Activation
F. Mercurio (1997)
Inducible Phosphorylation of NF-κB p65 at Serine 468 by T Cell Costimulation Is Mediated by IKKϵ*
I. Mattioli (2006)
NEMO/IKKγ-Deficient Mice Model Incontinentia Pigmenti
M. Schmidt-Supprian (2000)
The Carboxyl-Terminal Region of IκB Kinase γ (IKKγ) Is Required for Full IKK Activation
C. Makris (2002)
Activation of IKKalpha target genes depends on recognition of specific kappaB binding sites by RelB:p52 dimers.
G. Bonizzi (2004)
IKK/NF-κB regulates skeletal myogenesis via a signaling switch to inhibit differentiation and promote mitochondrial biogenesis
N. Bakkar (2008)
NF-kappaB mediates inhibition of mesenchymal cell differentiation through a posttranscriptional gene silencing mechanism.
R. Sitcheran (2003)
Post-translational modification of RelA(p65) NF-kappaB.
K. Campbell (2004)
The IkappaB kinase complex (IKK) contains two kinase subunits, IKKalpha and IKKbeta, necessary for IkappaB phosphorylation and NF-kappaB activation.
E. Zandi (1997)
Regulation of skeletal muscle gene expression by p38 MAP kinases.
F. Lluís (2006)
Transforming growth factor-beta and myostatin signaling in skeletal muscle.
Helen D. Kollias (2008)
Activation by IKKα of a Second, Evolutionary Conserved, NF-κB Signaling Pathway
U. Senftleben (2001)
Inhibitors of the proteasome block the myogenic differentiation of rat L6 myoblasts
S. Kim (1998)
Differential signaling through NFκB does not ameliorate skeletal myoblast apoptosis during differentiation
K. Dee (2003)
Insulin produces myogenesis in C2C12 myoblasts by induction of NF‐κB and downregulation of AP‐1 activities
R. Conejo (2001)
TWEAK, via its receptor Fn14, is a novel regulator of mesenchymal progenitor cells and skeletal muscle regeneration
M. Girgenrath (2006)
Alterations in NF-κB function in transgenic epithelial tissue demonstrate a growth inhibitory role for NF-κB
C. S. Seitz (1998)
Regulation and Function of IKK and IKK-Related Kinases
H. Häcker (2006)

This paper is referenced by
Canonical nuclear factor-κB signaling in satellite stem cell homeostasis and function.
Alex R. Straughn (2018)
Regulation of Skeletal Muscle Formation and Regeneration by the Cellular Inhibitor of Apoptosis 1 (cIAP1) Protein
E. Enwere (2011)
Cyclin-dependent kinase (CDK) inhibitor drugs induce apoptosis in human neutrophils through regulation of critical survival proteins
N. Riley (2012)
The role of adipose and skeletal muscle derived cytokines in primary human myogenesis: implications for ageing skeletal muscle
Mary Frances O'Leary (2018)
Functional analysis of the EMT inducing transcription factor ZEB1 during malignant carcinoma progression
A. Gheldof (2011)
TGF-β Regulates miR-206 and miR-29 to Control Myogenic Differentiation through Regulation of HDAC4
C. Winbanks (2011)
IKKε Knockout Prevents High Fat Diet Induced Arterial Atherosclerosis and NF-κB Signaling in Mice
C. Cao (2013)
Smac Mimetic Compound Treatment Induces Tumour Regression and Skeletal Muscle Wasting
Jennifer Vineham (2014)
The potential cytoprotective influence of estradiol and fish oil supplementation on indices of exercise-induced muscle damage in females
Sarah K. McKinley-Barnard (2015)
Involvement of oxidative stress, nuclear factor kappa B and the ubiquitin proteasomal pathway in dysferlinopathy.
D. Rajakumar (2014)
NF-κB and p38 MAPK: Major regulators in skeletal muscle development
Y. Ma (2012)
Biomechanical Origins of Muscle Stem Cell Signal Transduction.
James B Morrissey (2016)
Hücre İçi Sinyal Yolaklari ve Klinik Yansimalari
N. Ceren (2010)
Punicalagin inhibited proliferation, invasion and angiogenesis of osteosarcoma through suppression of NF-κB signaling
T. Huang (2020)
Some Phenotypic Characteristics of Nematode Caenorhabditis Elegans Strains with Defective Functions of the Sestrin (cSesn) Gene
A. O. Zeltukhin (2018)
Genomics of the NF-κB signaling pathway: hypothesized role in ovarian cancer
K. L. White (2011)
Régulation du métabolisme musculaire par les facteurs de transcription SREBP-1 : rôle des MRFs, de SIRT1 et des céramides
Kévin Dessalle (2012)
NF-κB Signaling Pathways in Carcinogenesis
H. Nakshatri (2019)
Hemeoxygenase 1 partly mediates the anti-inflammatory effect of dieckol in lipopolysaccharide stimulated murine macrophages.
Taddesse Yayeh (2014)
Differential effects of toll-like receptor stimulation on mRNA-driven myogenic conversion of human and mouse fibroblasts.
Jaewoo Lee (2016)
The role of oxidative stress in skeletal muscle injury and regeneration: focus on antioxidant enzymes
M. Kozakowska (2015)
Ginsenoside Rg3 sensitizes hypoxic lung cancer cells to cisplatin via blocking of NF-κB mediated epithelial-mesenchymal transition and stemness.
J. Wang (2018)
Induction of ABCA1 expression is correlated with increased CREB phosphorylation and altered cytokine secretion
M. Zaid (2011)
Muscle wasting in rheumatoid arthritis: The role of oxidative stress
A. Stavropoulos-Kalinoglou (2014)
Effectiveness of Antioxidant Nutraceuticals in Attenuating Canonical NF-κB Signaling in Human Skeletal Muscle Resulting From Exercise-Induced Inflammation and Oxidative Stress
Sarah K McKinley (2014)
Therapies for acute respiratory distress syndrome: determination of the mechanisms of action of hypercapnia and the therapeutic efficacy of mesenchymal stromal cells
S. Horie (2016)
Controversies in TWEAK-Fn14 signaling in skeletal muscle atrophy and regeneration
A. Pascoe (2020)
Regulation of signal transduction by spatial parameters: a case in NF-κB oscillation.
K. Ichikawa (2015)
Expression of Gα(z) in C2C12 cells restrains myogenic differentiation.
H. Mei (2011)
Low-dose benzo(a)pyrene and its epoxide metabolite inhibit myogenic differentiation in human skeletal muscle-derived progenitor cells.
C. Chiu (2014)
肿瘤恶病质骨骼肌消耗机制的研究进展 Progress in Mechanism of Muscle Wasting in Cachexia
周宇 (2016)
Classical NF-κB Metabolically Reprograms Sarcoma Cells Through Regulation of Hexokinase 2
Priya Londhe (2018)
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