Online citations, reference lists, and bibliographies.
← Back to Search

Emerging Technologies Of Polymeric Nanoparticles In Cancer Drug Delivery

E. Brewer, J. Coleman, A. Lowman
Published 2011 · Materials Science

Cite This
Download PDF
Analyze on Scholarcy
Share
Polymeric nanomaterials have the potential to improve upon present chemotherapy delivery methods. They successfully reduce side effects while increasing dosage, increase residence time in the body, offer a sustained and tunable release, and have the ability to deliver multiple drugs in one carrier. However, traditional nanomaterial formulations have not produced highly therapeutic formulations to date due to their passive delivery methods and lack of rapid drug release at their intended site. In this paper, we have focused on a few "smart" technologies that further enhance the benefits of typical nanomaterials. Temperature and pH-responsive drug delivery devices were reviewed as methods for triggering release of encapsulating drugs, while aptamer and ligand conjugation were discussed as methods for targeted and intracellular delivery, with emphases on in vitro and in vivo works for each method.
This paper references
10.1021/AC0707075
Aptamer-functionalized gold nanoparticles for turn-on light switch detection of platelet-derived growth factor.
C. Huang (2007)
10.1016/S0169-409X(01)00200-9
Biodegradable microspheres for vitreoretinal drug delivery.
R. Herrero-Vanrell (2001)
10.1002/ANIE.200250653
Design of environment-sensitive supramolecular assemblies for intracellular drug delivery: polymeric micelles that are responsive to intracellular pH change.
Y. Bae (2003)
10.1002/ADMA.200305622
Development of Organic‐Dye‐Doped Silica Nanoparticles in a Reverse Microemulsion
X. Zhao (2004)
10.1016/S0305-7372(02)80004-4
Pegylation: engineering improved pharmaceuticals for enhanced therapy.
G. Molineux (2002)
10.1021/JA0358854
Ultrasensitive DNA detection using highly fluorescent bioconjugated nanoparticles.
X. Zhao (2003)
10.1021/BM061051C
Synthesis and characterization of cationic micelles self-assembled from a biodegradable copolymer for gene delivery.
Y. Wang (2007)
10.1002/j.1552-4604.1996.tb04152.x
Doxorubicin Encapsulated in Liposomes Containing Surface‐Bound Polyethylene Glycol: Pharmacokinetics, Tumor Localization, and Safety in Patients with AIDS‐Related Kaposi's Sarcoma
D. Northfelt (1996)
10.1023/A:1016266523505
Physical Entrapment of Adriamycin in AB Block Copolymer Micelles
G. Kwon (2004)
10.1021/AC050312Q
Microfluidic system for studying the interaction of nanoparticles and microparticles with cells.
O. Farokhzad (2005)
Sterically stabilized pH-sensitive liposomes. Intracellular delivery of aqueous contents and prolonged circulation in vivo
V. A. Slepushkin (1997)
10.1093/nar/gkl388
Aptamer mediated siRNA delivery
Ted C. Chu (2006)
10.1016/S0005-2736(02)00399-1
A novel pH-sensitive liposome formulation containing oleyl alcohol.
J. Sudimack (2002)
10.1007/s00262-002-0266-6
Folate targeting of haptens to cancer cell surfaces mediates immunotherapy of syngeneic murine tumors
Y. Lu (2002)
10.1016/S0360-3016(96)00389-6
Thermosensitive liposomes: extravasation and release of contents in tumor microvascular networks.
M. H. Gaber (1996)
10.1211/0022357021771913
pH‐sensitive, serum‐stable and long‐circulating liposomes as a new drug delivery system
Myo-Sook Hong (2002)
10.1021/BI952547+
Interaction of fusogenic synthetic peptide with phospholipid bilayers: orientation of the peptide alpha-helix and binding isotherm.
R. Ishiguro (1996)
10.1016/S0168-3659(99)00248-5
Tumor vascular permeability and the EPR effect in macromolecular therapeutics: a review.
H. Maeda (2000)
10.1016/S0006-3495(95)80369-3
Range and magnitude of the steric pressure between bilayers containing phospholipids with covalently attached poly(ethylene glycol).
A. Kenworthy (1995)
Liposomal drug formulations. Rationale for development and what we can expect for the future.
T. Allen (1998)
10.1016/S0168-3659(02)00017-2
Efficient intracellular drug and gene delivery using folate receptor-targeted pH-sensitive liposomes composed of cationic/anionic lipid combinations.
Guangfeng Shi (2002)
10.1056/NEJMCP042630
Lung cancer screening.
A. Ganti (2006)
10.1002/ijc.1578
Pegylated liposomal tumor necrosis factor‐α results in reduced toxicity and synergistic antitumor activity after systemic administration in combination with liposomal doxorubicin (Doxil®) in soft tissue sarcoma‐bearing rats
T. L. T. ten Hagen (2002)
Hyperthermia enables tumor-specific nanoparticle delivery: effect of particle size.
G. Kong (2000)
10.1023/A:1018908421434
Biodegradable Nanoparticles Containing Doxorubicin-PLGA Conjugate for Sustained Release
H. Yoo (2004)
10.1023/A:1011922819926
Stealth PLA-PEG Nanoparticles as Protein Carriers for Nasal Administration
M. Tobío (2004)
10.1038/bjc.1986.141
Studies on the in vivo disposition of adriamycin in human tumours which exhibit different responses to the drug.
J. Cummings (1986)
10.1183/2312508x.erm6815
Lung cancer.
H. Hansen (1990)
In vivo efficacy of paclitaxel-loaded thermosensitive biodegradable polymeric micelles, M.S. thesis, Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences, Utrecht
O. Soga (2006)
10.3109/02656739409010278
Endothelial cells and hyperthermia.
L. Fajardo (1994)
10.1093/clinchem/45.9.1628
Aptamers: an emerging class of molecules that rival antibodies in diagnostics.
S. Jayasena (1999)
10.1073/pnas.0909611107
DNA aptamer–micelle as an efficient detection/delivery vehicle toward cancer cells
Y. Wu (2009)
Selective tumor localization and improved therapeutic index of anthracyclines encapsulated in long-circulating liposomes.
A. Gabizon (1992)
10.2745/DDS.23.618
Biodegradable polymeric materials
Y. Ohya (2008)
10.1126/SCIENCE.364652
Design of liposomes for enhanced local release of drugs by hyperthermia.
M. Yatvin (1978)
10.3109/08982109309148213
Ph-sensitive liposomes
C. Yuichiro (1993)
10.1021/BM049955Q
Poly(N-(2-hydroxypropyl) methacrylamide mono/di lactate): a new class of biodegradable polymers with tuneable thermosensitivity.
O. Soga (2004)
10.1021/BC0498166
Preparation and biological characterization of polymeric micelle drug carriers with intracellular pH-triggered drug release property: tumor permeability, controlled subcellular drug distribution, and enhanced in vivo antitumor efficacy.
Y. Bae (2005)
10.1016/0168-3659(93)90172-2
Block copolymer micelles as vehicles for drug delivery
Kataoka Kazunori (1993)
10.1021/bc8001248
Aptamer-Targeted Gold Nanoparticles As Molecular-Specific Contrast Agents for Reflectance Imaging
D. Javier (2008)
10.1074/JBC.M305411200
Tumor Cell Killing Enabled by Listeriolysin O-liposome-mediated Delivery of the Protein Toxin Gelonin*
C. Provoda (2003)
10.1016/J.JCONREL.2004.12.009
Thermosensitive and biodegradable polymeric micelles for paclitaxel delivery.
O. Soga (2005)
10.1158/1078-0432.CCR-03-0035
Novel Temperature-Sensitive Liposomes with Prolonged Circulation Time
L. Lindner (2004)
Sterically stabilized liposomes in cancer therapy and gene delivery.
D. Lasic (1999)
10.1002/cmdc.200700121
Co‐Delivery of Hydrophobic and Hydrophilic Drugs from Nanoparticle–Aptamer Bioconjugates
L. Zhang (2007)
10.1016/J.BIOELECHEM.2004.04.011
Aptamer-based biosensors for the detection of HIV-1 Tat protein.
S. Tombelli (2005)
10.1038/NMAT1737
Co-delivery of drugs and DNA from cationic core–shell nanoparticles self-assembled from a biodegradable copolymer
Y. Wang (2006)
10.1016/S0168-3659(02)00088-3
Doxorubicin-conjugated biodegradable polymeric micelles having acid-cleavable linkages.
H. Yoo (2002)
10.1016/j.biomaterials.2009.03.006
Self-assembled oligopeptide nanostructures for co-delivery of drug and gene with synergistic therapeutic effect.
N. Wiradharma (2009)
Toxicity and antitumor activity against solid tumors of micelle-forming polymeric anticancer drug and its extremely long circulation in blood.
M. Yokoyama (1991)
10.3109/10611869909085491
Folate-targeted enzyme prodrug cancer therapy utilizing penicillin-V amidase and a doxorubicin prodrug.
J. Lu (1999)
10.1016/j.jconrel.2010.01.006
Triggered content release from optimized stealth thermosensitive liposomes using mild hyperthermia.
L. Li (2010)
10.1021/bi952547
Interaction of fusogenic synthetic peptide with phospholipid bilayers: orientation of the peptide alpha-helix and binding isotherm.
R. Ishiguro (1996)
Doxorubicinconjugated biodegradable polymeric micelles having acidcleavable linkages
H. S. Yoo (2002)
Efficacy of liposomes and hyperthermia in a human tumor xenograft model: importance of triggered drug release.
G. Kong (2000)
10.1016/J.JCONREL.2004.02.003
Folate receptor targeted biodegradable polymeric doxorubicin micelles.
H. Yoo (2004)
10.1016/S0168-3659(00)00280-7
In vitro and in vivo anti-tumor activities of nanoparticles based on doxorubicin-PLGA conjugates.
H. Yoo (2000)
10.1016/J.BIOMATERIALS.2004.06.024
Synthesis and characterization of the paclitaxel/MPEG-PLA block copolymer conjugate.
Xuefei Zhang (2005)
10.1056/NEJM199903113401004
Liposomal Amphotericin B for Empirical Therapy in Patients with Persistent Fever and Neutropenia
T. Walsh (1999)
Polymeric prodrugs.
M. Azori (1987)
Controlled release of bioactive agents from lactide/glycolide polymers
D. Lewis (1990)
Novel temperature-sensitive liposomes with prolonged circulation 10 Journal of Nanomaterials time
L. H. Lindner (2004)
10.1002/cmdc.200800030
Molecular Recognition of Small‐Cell Lung Cancer Cells Using Aptamers
H. W. Chen (2008)
10.1021/AC052015R
Aptamer-conjugated nanoparticles for selective collection and detection of cancer cells.
Joshua K Herr (2006)
10.1016/S0005-2736(99)00192-3
Effect of grafted polyethylene glycol (PEG) on the size, encapsulation efficiency and permeability of vesicles.
A. Nicholas (2000)
Nanoparticle-aptamer bioconjugates: a new approach for targeting prostate cancer cells
O. C. Farokhzad (2004)
10.1073/PNAS.92.8.3318
Delivery of antisense oligodeoxyribonucleotides against the human epidermal growth factor receptor into cultured KB cells with liposomes conjugated to folate via polyethylene glycol.
S. Wang (1995)
10.3109/09687687809064156
Interactions of phospholipid vesicles with murine lymphocytes. I. Vesicle-cell adsorption and fusion as alternate pathways of uptake.
L. Huang (1978)
10.1002/IJC.2910620215
Pharmacokinetics and anti‐tumor activity of vincristine encapsulated in sterically stabilized liposomes
T. Allen (1995)
10.1016/S0168-3659(01)00218-8
PEGylated PLGA nanoparticles as protein carriers: synthesis, preparation and biodistribution in rats.
Y. Li (2001)
10.1172/JCI9872
Less is more, regularly: metronomic dosing of cytotoxic drugs can target tumor angiogenesis in mice.
D. Hanahan (2000)
10.1016/0005-2736(91)90246-5
Liposomes containing synthetic lipid derivatives of poly(ethylene glycol) show prolonged circulation half-lives in vivo.
T. Allen (1991)
Characterization of the effect of hyperthermia on nanoparticle extravasation from tumor vasculature.
G. Kong (2001)
10.1016/J.BBAMEM.2007.05.021
In vitro stability and content release properties of phosphatidylglyceroglycerol containing thermosensitive liposomes.
M. Hossann (2007)
Liposomal amphotericin B for empirical therapy in patients with persistent fever and neutropenia. National Institute of Allergy and Infectious Diseases Mycoses Study Group.
T. Walsh (1999)
Acid production in glycolysis-impaired tumors provides new insights into tumor metabolism.
G. Helmlinger (2002)
10.1016/S0005-2736(01)00409-6
Targeted delivery and triggered release of liposomal doxorubicin enhances cytotoxicity against human B lymphoma cells.
T. Ishida (2001)
10.1038/35021219
Molecular mechanisms that confer antibacterial drug resistance
C. Walsh (2000)
Pharmacokinetics of pegylated liposomal doxorubicin: review of animal and human studies
A. Gabizon (2003)
10.1126/SCIENCE.8128245
Biodegradable long-circulating polymeric nanospheres.
R. Gref (1994)
10.1073/PNAS.73.11.3862
Investigation of phase transitions of lipids and lipid mixtures by sensitivity differential scanning calorimetry.
S. Mabrey (1976)
Characterization and anticancer activity of the micelle-forming polymeric anticancer drug adriamycin-conjugated poly(ethylene glycol)-poly(aspartic acid) block copolymer.
M. Yokoyama (1990)
10.1021/MA011198Q
Thermoresponsive Polymeric Micelles with Controlled Instability Based on Hydrolytically Sensitive N-Isopropylacrylamide Copolymers
D. Neradovic (2001)
pHsensitive, serum-stable and long-circulating liposomes as a new drug delivery system
M.-S. Hong (2002)
Pharmacological-toxicological expert report. CAELYX. (Stealth liposomal doxorubicin HCl).
P. Working (1996)
10.1016/S0168-3659(97)00039-4
Block copolymer micelles for drug delivery: Loading and release of doxorubicin
G. Kwon (1997)
10.1073/PNAS.0601755103
Targeted nanoparticle-aptamer bioconjugates for cancer chemotherapy in vivo.
O. Farokhzad (2006)
10.1038/42218
Biodegradable block copolymers as injectable drug-delivery systems
B. Jeong (1997)
10.1016/S0169-409X(96)00401-2
Polymeric micelles as new drug carriers
G. Kwon (1996)
10.1016/S0140-6736(00)02059-6
Comparison of radiotherapy alone with radiotherapy plus hyperthermia in locally advanced pelvic tumours: a prospective, randomised, multicentre trial
J. Zee (2000)
10.1021/AC062151B
Aptamer-conjugated nanoparticles for the collection and detection of multiple cancer cells.
J. Smith (2007)
10.1021/BM0502720
Novel fast degradable thermosensitive polymeric micelles based on PEG-block-poly(N-(2-hydroxyethyl)methacrylamide-oligolactates).
C. Rijcken (2005)
10.1023/A:1007529218802
Methotrexate Esters of Poly(Ethylene Oxide)-Block-Poly(2-Hydroxyethyl-L-Aspartamide). Part I: Effects of the Level of Methotrexate Conjugation on the Stability of Micelles and on Drug Release
Y. Li (2004)
10.1021/BC060401P
In vivo antitumor activity of the folate-conjugated pH-sensitive polymeric micelle selectively releasing adriamycin in the intracellular acidic compartments.
Y. Bae (2007)
Toxicity and antitumor activity 6 Journal of Nanomaterials against solid tumors of micelle-forming polymeric anticancer drug and its extremely long circulation in blood
M. Yokoyama (1991)
10.1016/0168-3659(94)90118-X
Enhanced tumor accumulation and prolonged circulation times of micelle-forming poly(ethylene oxide-aspartate) block copolymer-Adriamycin conjugates
G. Kwon (1994)
10.1016/J.JCONREL.2006.09.044
Significant enhancement of antitumor activity and bioavailability of intracellular pH-sensitive polymeric micelles by folate conjugation.
Y. Bae (2006)
10.1016/S0168-3659(99)00135-2
Enhanced folate receptor mediated gene therapy using a novel pH-sensitive lipid formulation.
J. Reddy (2000)
10.1023/A:1015908831507
Efficiency of Cytoplasmic Delivery by pH-Sensitive Liposomes to Cells in Culture
Chun-Jung Chu (2004)
10.1021/LA048354H
Physicochemical characterization of degradable thermosensitive polymeric micelles.
O. Soga (2004)
10.1093/JAC/49.SUPPL_1.81
Liposomal amphotericin B versus conventional amphotericin B in the empirical treatment of persistently febrile neutropenic patients.
P. Cagnoni (2002)
Investigation of phase transitions of lipids and lipid mixtures by high sensitivity differential scanning calorimetry ( lipid bilayers / membranes / phase diagrams / transition heat capacity curves )
S. Mabrey
Pharmacological-toxicological expert report. CAELYX. (Stealth liposomal doxorubicin HCl).
Dayan Ad (1996)
10.1016/S0168-3659(98)00129-1
Synthesis and characterisation of poly(D,L-lactic acid)-idoxuridine conjugate.
M. G. Rimoli (1999)
10.1016/0005-2736(73)90314-3
Phase transitions in phospholipid vesicles. Fluorescence polarization and permeability measurements concerning the effect of temperature and cholesterol.
D. Papahadjopoulos (1973)
10.1016/S0169-409X(02)00015-7
Poly(ethylene oxide)-block-poly(L-amino acid) micelles for drug delivery.
A. Lavasanifar (2002)
10.1080/096876899294814
Surface aggregation and membrane penetration by peptides: relation to pore formation and fusion.
S. Nir (1999)
10.1016/0169-409X(95)00023-Z
Chemistry of polyethylene glycol conjugates with biologically active molecules
S. Zalipsky (1995)
10.1007/S00216-007-1346-4
Aptamers: molecular tools for analytical applications
T. Mairal (2008)
10.1016/S0014-827X(02)00019-8
Improvement of physicochemical and biopharmaceutical properties of theophylline by poly(ethylene glycol) conjugates.
M. Zacchigna (2003)
10.1039/B500266D
Multifunctional polymeric micelles with folate-mediated cancer cell targeting and pH-triggered drug releasing properties for active intracellular drug delivery.
Y. Bae (2005)
10.1016/J.EJPS.2007.08.009
Long-circulating, pH-sensitive liposomes sterically stabilized by copolymers bearing short blocks of lipid-mimetic units.
D. Momekova (2007)
10.1097/00006534-196302000-00036
Selective Destruction of Cancers After Exposure to Heat
G. Crile (1962)
10.1007/978-1-59745-557-2_5
Cell-specific aptamers for targeted therapies.
L. Cerchia (2009)
10.1158/1078-0432.CCR-06-0226
Phase I Trial of Doxorubicin-Containing Low Temperature Sensitive Liposomes in Spontaneous Canine Tumors
M. Hauck (2006)
10.1016/J.JCONREL.2004.11.017
Polymeric micellar pH-sensitive drug delivery system for doxorubicin.
M. Hrubý (2005)
10.3109/08982109409037050
pH-Sensitive Liposomes
Chun-Jung Chu (1994)
10.1016/S0167-7799(98)01220-7
Novel applications of liposomes.
D. Lasic (1998)
10.1515/iupac.84.0180
Tissue engineering.
M. Sefton (1998)
10.1016/J.BIOMATERIALS.2007.08.047
Hydrolysable core-crosslinked thermosensitive polymeric micelles: synthesis, characterisation and in vivo studies.
C. Rijcken (2007)
Tissue engineering : Frontiers in biotechnology
R. Langer (1993)
10.1016/S0168-3659(00)00340-0
Biodegradable polymeric micelles composed of doxorubicin conjugated PLGA-PEG block copolymer.
H. Yoo (2001)
A new temperature-sensitive liposome for use with mild hyperthermia: characterization and testing in a human tumor xenograft model.
D. Needham (2000)
10.1016/j.biomaterials.2010.02.030
Prostate cancer cell death produced by the co-delivery of Bcl-xL shRNA and doxorubicin using an aptamer-conjugated polyplex.
Eunjung Kim (2010)
10.1038/nbt1223
Cell type–specific delivery of siRNAs with aptamer-siRNA chimeras
James O McNamara (2006)
10.1200/JCO.2007.25.18_SUPPL.10009
Regional hyperthermia (RHT) improves response and survival when combined with systemic chemotherapy in the management of locally advanced, high grade soft tissue sarcomas (STS) of the extremities, the body wall and the abdomen: A phase III randomised pros
R. Issels (2007)
10.1016/S0959-8049(01)00050-8
Randomised phase II trial of pegylated liposomal doxorubicin (DOXIL/CAELYX) versus doxorubicin in the treatment of advanced or metastatic soft tissue sarcoma: a study by the EORTC Soft Tissue and Bone Sarcoma Group.
I. Judson (2001)
10.1073/pnas.0809154105
Targeted delivery of cisplatin to prostate cancer cells by aptamer functionalized Pt(IV) prodrug-PLGA–PEG nanoparticles
Shanta Dhar (2008)
10.1073/PNAS.71.7.2684
Kinetics of the crystalline-liquid crystalline phase transition of dimyristoyl L-alpha-lecithin bilayers.
T. Tsong (1974)
10.1074/JBC.M200429200
Functional Characterization of an Endosome-disruptive Peptide and Its Application in Cytosolic Delivery of Immunoliposome-entrapped Proteins*
E. Mastrobattista (2002)
10.1677/ERC.1.01045
Polymer-drug conjugates: towards a novel approach for the treatment of endrocine-related cancer.
R. Duncan (2005)
10.1007/s00425-002-0762-0
Antisense and chemical suppression of the nonmevalonate pathway affects ent-kaurene biosynthesis in Arabidopsis
K. Okada (2002)
10.1016/S0927-7765(99)00156-3
'Stealth' corona-core nanoparticles surface modified by polyethylene glycol (PEG): influences of the corona (PEG chain length and surface density) and of the core composition on phagocytic uptake and plasma protein adsorption.
Gref (2000)
10.1016/J.IJPHARM.2005.10.010
Opsonization, biodistribution, and pharmacokinetics of polymeric nanoparticles.
Donald E. Owens (2006)
10.1016/S0378-5173(02)00044-3
Targetability and intracellular delivery of anti-BCG antibody-modified, pH-sensitive fusogenic immunoliposomes to tumor cells.
T. Mizoue (2002)
10.1073/PNAS.85.18.6949
Liposome formulations with prolonged circulation time in blood and enhanced uptake by tumors.
A. Gabizon (1988)
10.1023/A:1018998203127
Biodistribution of Micelle-Forming Polymer–Drug Conjugates
G. Kwon (2004)
10.1016/S0168-3659(01)00263-2
N-isopropylacrylamide copolymers for the preparation of pH-sensitive liposomes and polymeric micelles.
J. Leroux (2001)
10.1016/0142-9612(91)90075-L
Surface modification of haemoglobin-containing liposomes with polyethylene glycol prevents liposome aggregation in blood plasma.
H. Yoshioka (1991)
10.1126/SCIENCE.1095833
Drug Delivery Systems: Entering the Mainstream
T. Allen (2004)
10.1002/CHEM.200305470
Structure-switching signaling aptamers: transducing molecular recognition into fluorescence signaling.
Razvan Nutiu (2004)
10.1200/JCO.1998.16.12.3720
Combination chemotherapy versus single-agent therapy as first- and second-line treatment in metastatic breast cancer: a prospective randomized trial.
H. Joensuu (1998)
10.1016/0169-409X(95)00028-6
Sterically stabilized liposome therapeutics
M. Woodle (1995)
Sterically stabilized liposomes in cancer therapy and gene delivery.
Lasic Dd (1999)
Nuclear delivery of doxorubicin via folate-targeted liposomes with bypass of multidrug-resistance efflux pump.
D. Goren (2000)
A new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs.
Y. Matsumura (1986)
10.1016/J.ADDR.2003.10.038
On the formulation of pH-sensitive liposomes with long circulation times.
S. Simões (2004)
10.1073/PNAS.0404806101
A rapid bioassay for single bacterial cell quantitation using bioconjugated nanoparticles.
X. Zhao (2004)
Self-assembled oligopeptide nanostructures for co-delivery of drug and gene 8 Journal of Nanomaterials with synergistic therapeutic effect
N. Wiradharma (2009)
Cellular localization of the folate receptor: potential role in drug toxicity and folate homeostasis.
S. Weitman (1992)
10.1016/0378-1119(89)90033-4
Amplification, mutation and selection of catalytic RNA.
G. F. Joyce (1989)



This paper is referenced by
10.1016/J.RADMEAS.2013.04.015
Luminescence enhancement in CeF3/ZnO nanocomposites for radiation detection
Sunil K. Sahi (2013)
10.15275/rusomj.2017.0302
Systems for the delivery of chemotherapeutic drugs, new approaches and perspective
А. Д. Халахакун (2017)
10.1016/B978-0-12-396983-5.00024-7
Polymeric Biomaterials in Nanomedicine
Brittany L. Banik (2014)
10.33380/2305-2066-2019-8-1-43-57
КЛЕТОЧНЫЕ НОСИТЕЛИ КАК СИСТЕМЫ ДОСТАВКИ ПРОТИВООПУХОЛЕВЫХ ЛЕКАРСТВЕННЫХ СРЕДСТВ (ОБЗОР)
Ольга Валерьевна Тринеева (2019)
Rapid synthesis and characterization of Gold and Silver nanoparticles using exopolysaccharides and metabolites of Wesiella confusa as an antibacterial agent against Esherichia coli
B. Adebayo-Tayo (2019)
10.1016/j.ejpb.2020.08.013
Nanoparticle-based immunotherapy of breast cancer using recombinant Helicobacter pylori proteins.
A. Mohabati Mobarez (2020)
10.1007/978-1-4939-0706-9
Molecular mechanisms and physiology of disease
N. Maulik (2014)
10.1016/B978-0-323-46144-3.00029-5
Nanotherapy: a next generation hallmark for combating cancer
Avinash P. Ingle (2017)
Nanoparticle Drug Delivery for Cancer Therapy: An Update
V. Ahuja (2018)
10.22159/IJAP.2017V9I6.21674
FORMULATION AND EVALUATION OF POLYMERIC NANOSUSPENSION OF NARINGENIN
R. Sumathi (2017)
10.1039/C5RA01811K
Curcumin-loaded, folic acid-functionalized magnetite particles for targeted drug delivery
M. Salem (2015)
FABRICATION OF DUAL DRUG LOADED POLYMERIC NANOSUSPENSION: INCORPORATING ANALYTICAL HIERARCHY PROCESS AND DATA ENVELOPMENT ANALYSIS IN THE SELECTION OF A SUITABLE METHOD
C. Moorthi (2013)
10.4155/tde-2016-0058
Design of novel chemotherapeutic delivery systems for colon cancer therapy based on oral polymeric nanoparticles.
B. Mishra (2017)
An innovative epigenetic strategy for retinoblastoma treatment
N. Ilaria (2017)
10.2147/IJN.S61670
Nanotechnology-based drug delivery systems for treatment of oral cancer: a review
G. Calixto (2014)
10.1155/2012/143524
Glucan Particles for Macrophage Targeted Delivery of Nanoparticles
E. Soto (2012)
10.2217/fon.12.139
Polymer nanoparticulate drug delivery and combination cancer therapy.
Pengxiao Cao (2012)
10.1007/s10570-015-0710-3
Orthogonal analysis for rechargeable antimicrobial finishing of plasma pretreated cotton
Chang-E Zhou (2015)
Formulation and evaluation of novel vancomycin loaded lipidpolymer hybrid nanoparticles for effective antibiotic therapy.
Nasreen. Seedat (2015)
10.1166/JBN.2014.1890
Nanotechnological strategies for vaginal administration of drugs--a review.
P. B. da Silva (2014)
10.1021/acs.langmuir.7b01273
Near-Infrared Responsive Gold-Layersome Nanoshells.
A. Abbasi (2017)
10.1155/2014/939378
Nanotechnology in Cancer Drug Delivery and Selective Targeting
K. B. Sutradhar (2014)
10.11159/IJTAN.2014.006
Clathrate Hydrate Formation and Micellization of Tetrabutylammonium 10-Undecenoate
Clifford E. Larrabee (2014)
Étude toxicologique de nanoparticules polymériques véhicules de S-nitrosoglutathion
Ramia Safar (2015)
10.1016/j.carbpol.2013.12.069
Augmenting protein release from layer-by-layer functionalized agarose hydrogels.
Daniel A Lynam (2014)
10.1177/0192623318770608
Gold Nanoparticle Toxicity in Mice and Rats: Species Differences
J. Bahamonde (2018)
Improving practices in nanomedicine through near real-time pharmacokinetic analysis
Isidro B. Magaña (2015)
10.1016/j.jconrel.2015.01.014
Functionalized nanoscale β-1,3-glucan to improve Her2+ breast cancer therapy: In vitro and in vivo study.
Zahra Nasrollahi (2015)
10.1002/EJIC.201100545
Polymer Conjugates of Photoinducible CO‐Releasing Molecules
Nadine E. Brückmann (2011)
10.1016/B978-0-323-52725-5.00003-4
Conspectus on Nanotechnology in Oral Cancer Diagnosis and Treatment
Ravindran Ankathil (2017)
10.1002/btm2.10049
Virus‐like particles: Next‐generation nanoparticles for targeted therapeutic delivery
M. Rohovie (2017)
10.4018/JNN.2017010101
Drug-Nanoparticle Composites: A Predictive Model for Mass Loading
N. Sizochenko (2017)
See more
Semantic Scholar Logo Some data provided by SemanticScholar