← Back to Search
Lipid Nanocapsule-Based Gels For Enhancement Of Transdermal Delivery Of Ketorolac Tromethamine
J. Varshosaz, V. Hajhashemi, Sindokht Soltanzadeh
Published 2011 · Chemistry, Medicine
Download PDFAnalyze on Scholarcy
Previous reports show ineffective transdermal delivery of ketorolac by nanostructured lipid carriers (NLCs). The aim of the present work was enhancement of transdermal delivery of ketorolac by another colloidal carriers, lipid nanocapsules (LNCs). LNCs were prepared by emulsification with phase transition method and mixed in a Carbomer 934P gel base with oleic acid or propylene glycol as penetration enhancers. Permeation studies were performed by Franz diffusion cell using excised rat abdominal skin. Aerosil-induced rat paw edema model was used to investigate the in vivo performance. LNCs containing polyethylene glycol hydroxyl stearate, lecithin in Labrafac as the oily phase, and dilution of the primary emulsion with 3.5-fold volume of cold water produced the optimized nanoparticles. The 1% Carbomer gel base containing 10% oleic acid loaded with nanoparticles enhanced and prolonged the anti-inflammatory effects of this drug to more than 12 h in Aerosil-induced rat paw edema model.
This paper references
Minimising the Adverse Effects of Ketorolac
D. Reinhart (2000)
Potential of Cyclodextrin Complexation and Liposomes in Topical Delivery of Ketorolac: In Vitro and In Vivo Evaluation
M. Nagarsenker (2008)
New lipid nanocapsules exhibit sustained release properties for amiodarone.
Alf Lamprecht (2002)
Reorganization of lipid nanocapsules at air-water interface. I. Kinetics of surface film formation.
I. Minkov (2005)
Reorganization of lipid nanocapsules at air-water interface: Part 2. Properties of the formed surface film.
I. Minkov (2005)
Salting-out effect induced by temperature cycling on a water/nonionic surfactant/oil system.
N. Anton (2007)
Ketorolac. A reappraisal of its pharmacodynamic and pharmacokinetic properties and therapeutic use in pain management.
J. Gillis (1997)
Influence of Ultrasound on the Percutaneous Absorption of Ketorolac Tromethamine In Vitro Across Rat Skin
S. Tiwari (2004)
Long Circulating Poly(Ethylene Glycol)-Decorated Lipid Nanocapsules Deliver Docetaxel to Solid Tumors
M. Khalid (2006)
Lipid nanocapsules for dermal application: a comparative study of lipid-based versus polymer-based nanocarriers.
Mona M A Abdel-Mottaleb (2011)
Lipidic nanocapsules: preparation process and use as Drug Delivery Systems
B. Heurtault (2000)
Engineering Methods for Robust Product Design: Using Taguchi Methods in Technology and Product Development
W. Y. Fowlkes (1995)
Etoposide nanocarriers suppress glioma cell growth by intracellular drug delivery and simultaneous P-glycoprotein inhibition.
A. Lamprecht (2006)
Design of targeted lipid nanocapsules by conjugation of whole antibodies and antibody Fab' fragments.
A. Béduneau (2007)
Orthogonal Arrays and Linear Graphs-Tools for Quality Engineering, American Supplier Institute
G Taguchi (1987)
Formulation and Evaluation of Nanostructured Lipid Carrier (NLC)–based Gel of Valdecoxib
M. Joshi (2006)
Appendix A: Orthogonal Arrays and Linear Graphs: Tools for Quality Engineering
G. Taguchi (2007)
The influence of lipid nanocapsule composition on their size distribution.
B. Heurtault (2003)
Proniosomes as a drug carrier for transdermal delivery of ketorolac.
I. Alsarra (2005)
Evaluation of physicochemical properties, skin permeation and accumulation profiles of ketorolac fatty ester prodrugs.
K. Bhandari (2007)
Liquid crystals and emulsions in the formulation of drug carriers
P. Saulnier (2007)
A Novel Phase Inversion-Based Process for the Preparation of Lipid Nanocarriers
B. Heurtault (2004)
Preparation, characterization and in vitro release kinetics of clozapine solid lipid nanoparticles.
V. Venkateswarlu (2004)
Transdermal Delivery of Ketorolac Tromethamine: Effects of Vehicles and Penetration Enhancers
Y. A. Cho (2004)
Creveling, Engineering Methods for Robust Product Design Using Taguchi Methods in Technology and Product Development, Addison-Wesley
C.M.W.Y. Fowlkes (1995)
Stability of lipid excipients in solid lipid nanoparticles.
A. Radomska-Soukharev (2007)
Electrokinetic properties of noncharged lipid nanocapsules: Influence of the dipolar distribution at the interface
A. Vonarbourg (2005)
Investigation into the potential of iontophoresis facilitated delivery of ketorolac.
S. Tiwari (2003)
Brain targeting using novel lipid nanovectors.
A. Béduneau (2008)
Enhanced Oral Paclitaxel Bioavailability After Administration of Paclitaxel-Loaded Lipid Nanocapsules
S. Peltier (2006)
Aqueous-core lipid nanocapsules for encapsulating fragile hydrophilic and/or lipophilic molecules.
N. Anton (2009)
Lipid nanocapsules loaded with an organometallic tamoxifen derivative as a novel drug-carrier system for experimental malignant gliomas.
E. Allard (2008)
Lipid nanocapsules: a new platform for nanomedicine.
N. Huynh (2009)
Evaluation of alternative strategies to optimize ketorolac transdermal delivery
C. Puglia (2008)
This paper is referenced by
Current and emerging lipid-based systems for transdermal drug delivery.
S. K. Singla (2015)
Lipid Nanocapsules for Imatinib Delivery: Design, Optimization and Evaluation of Anticancer Activity Against Melanoma Cell Line
Mohammad Reza Molaahmadi (2019)
Obtaining of sol-gel ketorolac-silica nanoparticles: characterization and drug release kinetics
T. L. Goerne (2013)
Acyclovir lipid nanocapsules gel for oromucosal delivery: A preclinical evidence of efficacy in the chicken pouch membrane model
Darine Abozaid (2018)
Antibacterial action of lipid nanocapsules containing fatty acids or monoglycerides as co-surfactants.
A. Umerska (2016)
Preparation of Dacarbazine Lipid Nanocapsule Based Hydrogel as an Efficient Delivery System for Melanoma
Hend Mohamed Abdel-Bar (2019)
Lipid-based nanoparticles as novel drug delivery systems for antimicrobial agents
A. Rassouli (2019)
Advances in lipid-based colloid systems as drug carrier for topic delivery.
Yingjie Zhai (2014)
Liquid Crystalline Systems Based on Glyceryl Monooleate and Penetration Enhancers for Skin Delivery of Celecoxib: Characterization, In Vitro Drug Release, and In Vivo Studies.
Mariane de Cássia Lima Dante (2018)
Lipid nanoparticles comprising an antibiotic and their use in therapy
Amokrane Reghal (2014)
Design of topical nanostructured lipid carrier of silymarin and its effect on 7,12-dimethylbenz[a]anthracene (DMBA) induced cellular differentiation in mouse skin
Pooja Singh (2016)
Recent advances in ultrasound-based transdermal drug delivery
Brenden Cheong-Qi Seah (2018)
Production of novel vitamin D3 loaded lipid nanocapsules for milk fortification
A. Kiani (2017)
Lipid nanoparticles for topical application of drugs for skin diseases
S. Dey (2016)
Ketoprofen Microemulsion for Improved Skin Delivery and In Vivo Anti-inflammatory Effect
Ana Luisa Murbach Aliberti (2017)
Lipid nanocapsules for transdermal delivery of ropivacaine: in vitro and in vivo evaluation.
Yingjie Zhai (2014)
pH-sensitive interpenetrating polymer network microspheres of poly(vinyl alcohol) and carboxymethyl cellulose for controlled release of the nonsteroidal anti-inflammatory drug ketorolac tromethamine
Ebru Kondolot Solak (2016)
Liposomal systems as viable drug delivery technology for skin cancer sites with an outlook on lipid-based delivery vehicles and diagnostic imaging inputs for skin conditions'.
N. Akhtar (2016)
Curcumin-loaded lipid-hybridized cellulose nanofiber film ameliorates imiquimod-induced psoriasis-like dermatitis in mice.
N. Kang (2018)
Investigating Transdermal Delivery of Vitamin D3
A. Alsaqr (2015)