Online citations, reference lists, and bibliographies.
← Back to Search

The Treatment Of Breast Cancer Using Liposome Technology

S. Brown, David R. Khan
Published 2012 · Medicine
Referenced 1 time by Citationsy Users

Cite This
Download PDF
Analyze on Scholarcy
Share
Liposome-based chemotherapeutics used in the treatment of breast cancer can in principle enhance the therapeutic index of otherwise unencapsulated anticancer drugs. This is partially attributed to the fact that encapsulation of cytotoxic agents within liposomes allows for increased concentrations of the drug to be delivered to the tumor site. In addition, the presence of the phospholipid bilayer prevents the encapsulated active form of the drug from being broken down in the body prior to reaching tumor tissue and also serves to minimize exposure of the drug to healthy sensitive tissue. While clinically approved liposome-based chemotherapeutics such as Doxil have proven to be quite effective in the treatment of breast cancer, significant challenges remain involving poor drug transfer between the liposome and cancerous cells. In this review, we discuss the recent advancements made in the development of liposome-based chemotherapeutics with respect to improved drug transfer for use in breast cancer therapy.
This paper references
10.1016/S0168-3659(99)00248-5
Tumor vascular permeability and the EPR effect in macromolecular therapeutics: a review.
H. Maeda (2000)
10.1016/S0168-3659(03)00201-3
Polymer vesicles in vivo: correlations with PEG molecular weight.
P. Photos (2003)
10.1016/S1072-7515(00)00768-7
Is this a practical approach?
R. Wallace (2001)
10.2147/TCRM.S3348
Pegylated liposomal doxorubicin in the management of ovarian cancer
G. Ferrandina (2010)
10.1038/sj.bjc.6600344
A phase I dose-escalating study of DaunoXome, liposomal daunorubicin, in metastatic breast cancer
K. O'Byrne (2002)
10.1016/S1055-3290(96)80016-1
Liposomal doxorubicin (Doxil).
D. Porche (1996)
10.1016/j.jconrel.2011.02.009
Efficient tumor regression by a single and low dose treatment with a novel and enhanced formulation of thermosensitive liposomal doxorubicin.
T. Tagami (2011)
10.3322/CA.2007.0003
Application of Nanotechnology in Cancer Therapy and Imaging
X. Wang (2008)
10.2165/00003495-199700542-00004
Prevention Strategies for Mycobacterium avium-intracellulare Complex (MAC) Infection
D. L. Cohn (2012)
10.1016/S1055-3290(96)80007-0
The chapter's role in educating ANAC members.
H. Melroe (1996)
10.1081/CNV-100103136
Pegylated Liposomal Doxorubicin: Metamorphosis of an Old Drug into a New Form of Chemotherapy
A. Gabizon (2001)
Targeting tumor microvessels using doxorubicin encapsulated in a novel thermosensitive liposome.
Q. Chen (2004)
10.1126/SCIENCE.1095833
Drug Delivery Systems: Entering the Mainstream
T. Allen (2004)
10.1016/S0360-3016(96)00389-6
Thermosensitive liposomes: extravasation and release of contents in tumor microvascular networks.
M. H. Gaber (1996)
10.1023/A:1016091314940
Effects of Polyethyleneglycol Chain Length and Phospholipid Acyl Chain Composition on the Interaction of Polyethyleneglycol-phospholipid Conjugates with Phospholipid: Implications in Liposomal Drug Delivery
F. Bedu-Addo (2004)
10.1093/ANNONC/MDH092
Phase I and pharmacokinetic study of MCC-465, a doxorubicin (DXR) encapsulated in PEG immunoliposome, in patients with metastatic stomach cancer.
Y. Matsumura (2004)
10.2165/00003495-199700544-00004
Liposomes. Opportunities in drug delivery.
T. Allen (1997)
10.1016/j.nano.2010.10.004
Delivery of siRNA into breast cancer cells via phage fusion protein-targeted liposomes.
D. Bedi (2011)
Optimizing liposomes for delivery of chemotherapeutic agents to solid tumors.
D. Drummond (1999)
10.1080/10611860400011935
Polymeric micelles for delivery of poorly soluble drugs: Preparation and anticancer activity in vitro of paclitaxel incorporated into mixed micelles based on poly(ethylene glycol)-lipid conjugate and positively charged lipids
Junping Wang (2005)
10.1016/J.BBAMEM.2005.08.007
Lysolipid incorporation in dipalmitoylphosphatidylcholine bilayer membranes enhances the ion permeability and drug release rates at the membrane phase transition.
Jeffrey K. Mills (2005)
10.1016/j.bcp.2010.04.020
The benefits and challenges associated with the use of drug delivery systems in cancer therapy.
E. Cukierman (2010)
10.1021/JA066929M
Targeted drug delivery utilizing protein-like molecular architecture.
E. Rezler (2007)
10.1016/j.ijpharm.2009.03.018
Tumor-targeted PE38KDEL delivery via PEGylated anti-HER2 immunoliposomes.
Jie Gao (2009)
10.1111/j.1747-0285.2007.00610.x
Effects of Drug Hydrophobicity on Liposomal Stability
D. R. Khan (2008)
10.4161/cbt.6.7.4345
Enhanced in vivo antitumor efficacy of poorly soluble PDT agent, meso-tetraphenylporphine, in PEG-PE-based tumor-targeted immunomicelles
A. Roby (2007)
Stealth liposomes and tumor targeting: one step further in the quest for the magic bullet.
A. Gabizon (2001)
10.1007/s10549-010-1122-6
Transient over-expression of estrogen receptor-α in breast cancer cells promotes cell survival and estrogen-independent growth
R. Tolhurst (2010)
10.1016/S0167-7799(98)01220-7
Novel applications of liposomes.
D. Lasic (1998)
10.1016/0005-2736(92)90194-Q
Versatility in lipid compositions showing prolonged circulation with sterically stabilized liposomes.
M. Woodle (1992)
10.1016/S0959-8049(00)00029-0
Antitumour activity of cytotoxic liposomes equipped with selectin ligand SiaLe(X), in a mouse mammary adenocarcinoma model.
E. Vodovozova (2000)
10.1186/1471-2407-8-158
Vav3 oncogene activates estrogen receptor and its overexpression may be involved in human breast cancer
K. Lee (2008)
10.1158/0008-5472.CAN-07-5810
Targeted delivery of small interfering RNA: approaching effective cancer therapies.
K. Pirollo (2008)
10.1016/j.ijpharm.2008.01.041
Tumor-specific antibody-mediated targeted delivery of Doxil reduces the manifestation of auricular erythema side effect in mice.
T. Elbayoumi (2008)
10.1002/ANIE.200501793
17β‐Estradiol‐Associated Stealth‐Liposomal Delivery of Anticancer Gene to Breast Cancer Cells
B. S. Reddy (2005)
10.2174/156800910791190210
A novel cancer targeting approach based on estrone anchored stealth liposome for site-specific breast cancer therapy.
S. Paliwal (2010)
10.4172/1948-5956.1000024
The Use of Nanocarriers for Drug Delivery in Cancer Therapy
David R. Khan (2010)



This paper is referenced by
10.1016/j.jddst.2020.101721
Letrozole-loaded nonionic surfactant vesicles prepared via a slurry-based proniosome technology: Formulation development and characterization
Nada Khudair (2020)
10.1159/000341446
Induction of Apoptosis and Growth Arrest in Human Breast Carcinoma Cells by a Snake (Walterinnesia aegyptia) Venom Combined With Silica Nanoparticles: Crosstalk Between Bcl2 and Caspase 3
M. Alsadoon (2012)
10.2217/clp.14.48
Utilizing liposomes and lipid nanoparticles to overcome challenges in breast cancer treatment
Reyhaneh Varshochian (2014)
Liposomal clarithromycin delivery for the treatment of pseudomonal lung infection in cystic fibrosis.
M. Alhajlan (2013)
Liposomes generated from proliposomes for treatment of glioma using Momordica charantia extracts
Seema Rammurat Jaiswal (2013)
10.2217/nnm.15.110
Polymersomes and their applications in cancer delivery and therapy.
Lijuan Guan (2015)
10.1007/978-981-15-5179-6_8
Green Synthesis of Nanoparticles and Their Application in Cancer Therapy
V. D. Matteis (2020)
10.7314/APJCP.2016.17.1.117
Combination between Taxol-Encapsulated Liposomes and Eruca sativa Seed Extract Suppresses Mammary Tumors in Female Rats Induced by 7,12 Dimethylbenz(α)anthracene.
N. Shaban (2016)
10.1155/2013/456409
Liposomal Doxorubicin in the Treatment of Breast Cancer Patients: A Review
J. Lao (2013)
10.1016/j.semcancer.2019.08.013
Nanomaterials multifunctional behavior for enlighten cancer therapeutics.
Seeta Rama Raju Ganji (2019)
Exploring Critical Vehicle Parameters for the Design of Multitargeted Nanoparticles for Cancer Specific Gene Delivery
R. Levine (2015)
10.1039/c5cc04643b
Multifunctional nanoparticles: recent progress in cancer therapeutics.
G. Seeta Rama Raju (2015)
10.1016/j.colsurfb.2018.07.013
Folate receptor-mediated celastrol and irinotecan combination delivery using liposomes for effective chemotherapy.
Zar Chi Soe (2018)
10.1016/B978-0-323-46142-9.00005-0
Multifunctional nanostructured biopolymeric materials for therapeutic applications
I. Armentano (2017)
10.1155/2019/4927312
Cancer Nanomedicine: A New Era of Successful Targeted Therapy
M. Z. El-Readi (2019)
10.1016/j.ejpb.2015.03.018
Advanced targeted therapies in cancer: Drug nanocarriers, the future of chemotherapy.
Edgar Pérez-Herrero (2015)
10.2217/nnm-2019-0459
HER-2/neu and MYC gene silencing in breast cancer: therapeutic potential and advancement in nonviral nanocarrier systems.
Jananee Padayachee (2020)
Formulation and efficacy of liposome-encapsulated azithromycin for pulmonary infection due to Pseudomonias Aeruginosa
Venkata Saran Tejaswi Solleti (2016)
10.20517/2572-8180.2017.25
Cytotoxic effects of tamoxifen in breast cancer cells
F. Hassan (2018)
10.22377/AJP.V12I01.2037
Liposomes as a Novel Drug Delivery System: Fundamental and Pharmaceutical Application
Anayatollah Salimi (2018)
10.1111/ajt.13878
Micro and Nano Material Carriers for Immunomodulation
E. Bracho-Sanchez (2016)
10.1007/s00280-016-3168-6
Trends on polymer- and lipid-based nanostructures for parenteral drug delivery to tumors
Elham Ajorlou (2016)
10.3390/pharmaceutics11110610
Development of Injectable PEGylated Liposome Encapsulating Disulfiram for Colorectal Cancer Treatment
M. Najlah (2019)
10.2217/clp.13.33
Recent approaches to overcoming multiple drug resistance in breast cancer using modified liposomes
Rassoul Dinarvand (2013)
10.1021/la400859e
Preparation and characterization of liposome-encapsulated plasmid DNA for gene delivery.
Rachel M. Levine (2013)
10.1002/btm2.10022
Targeting HPV‐infected cervical cancer cells with PEGylated liposomes encapsulating siRNA and the role of siRNA complexation with polyethylenimine
Rachel M. Levine (2016)
10.2147/IJN.S68861
Liposomes as nanomedical devices
G. Bozzuto (2015)
10.4172/2168-9652.1000E133
The Bright Future of Liposome Mediated Drug Delivery
Dandan Hu (2014)
10.1016/j.jconrel.2018.04.047
Image‐guided thermosensitive liposomes for focused ultrasound drug delivery: Using NIRF‐labelled lipids and topotecan to visualise the effects of hyperthermia in tumours
Miguel N. Centelles (2018)
10.1016/j.jddst.2020.102018
Smart nanocarriers-based drug delivery for cancer therapy: An innovative and developing strategy
S. Huda (2020)
Liposomal Paclitaxel: Recent Trends and Future Perspectives
Neeraj Sharma (2015)
10.1002/jat.3566
Liposomal encapsulation of silver nanoparticles enhances cytotoxicity and causes induction of reactive oxygen species‐independent apoptosis
A. Yusuf (2018)
See more
Semantic Scholar Logo Some data provided by SemanticScholar