Online citations, reference lists, and bibliographies.

Cytoreductive Surgery Combined With Hyperthermic Intraperitoneal Intraoperative Chemotherapy In The Treatment Of Advanced Epithelial Ovarian Cancer

A. Tentes, S. Kakolyris, D. Kyziridis, C. Karamveri
Published 2012 · Medicine

Cite This
Download PDF
Analyze on Scholarcy
Background/Aims. Intraperitoneal intraoperative hyperthermic chemotherapy (HIPEC) has been used in the treatment of ovarian cancer. The purpose of the study is to determine the efficacy of HIPEC after cytoreductive surgery in advanced ovarian cancer. Patients/Methods. From 2006 to 2010 patients with advanced ovarian cancer were enrolled in a prospective nonrandomized study to undergo cytoreductive surgery combined with HIPEC. Clinical and histopathological variables were correlated to hospital mortality, morbidity, survival, and recurrences. Results. The mean age of 43 women was 59.9 ± 13.8 (16–82) years. The hospital mortality and morbidity rate were 4.7% and 51.2%, respectively. Complete cytoreduction was possible in 69.8%. The overall 5-year survival rate was 54%. The prognostic indicators of survival were the extent of prior surgery (P = 0.048) and the extent of peritoneal dissemination (P = 0.011). The recurrence rate was 30.2%. Conclusions. Maximal cytoreductive surgery combined with HIPEC is a well-tolerated, feasible, and promising method of treatment in advanced ovarian cancer.
This paper references
Cytore - ductive surgery ( peritonectomy procedures ) combined with hyperthermic intraperitoneal chemotherapy ( HIPEC ) in the treatment of di ff use peritoneal carcinomatosis from ovarian
C. R. Rossi (2008)
Management of Peritoneal Surface Malignancy Using Inytraperitoneal Chemotherapy and Cytoreductive Surgery. A Manual for Physicians and Nurses
P H Sugarbaker (1998)
Improved survival in patients with peritoneal metastases from colorectal cancer: a preliminary study
H. Mahteme (2004)
Total Abdominal Colectomy
H. Kessler (2006)
Toxicity of cytoreductive surgery and hyperthermic intra-peritoneal chemotherapy.
V. Verwaal (2004)
Survival Analysis of Pseudomyxoma Peritonei Patients Treated by Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy
R. M. Smeenk (2007)
Current status and future strategies of cytoreductive surgery plus intraperitoneal hyperthermic chemotherapy for peritoneal carcinomatosis.
Hassan-Alaa-Hammed Al-Shammaa (2008)
Cytoreductive surgery in ovarian cancer
C. Pomel (2007)
Influence of local hyperthermia on the healing of small intestinal anastomoses in the rat
A. M. Kappas (1991)
Management of Peritoneal Surface Malignancy Using Inytraperitoneal Chemotherapy and Cytoreductive Surgery. A Manual for Physicians and Nurses, Ludann Company
P H Sugarbaker (1998)
Peritonectomy Procedures
P. Sugarbaker (2003)
Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy in peritoneal carcinomatosis from ovarian cancer
P. Piso (2004)
Management of peritoneal-surface malignancy: the surgeon’s role
P. Sugarbaker (1999)
Cytoreductive surgery followed by intraperitoneal hyperthermic perfusion
S. Kusamura (2006)
Cyclophosphamide and cisplatin compared with paclitaxel and cisplatin in patients with stage III and stage IV ovarian cancer.
W. Mcguire (1996)
Cytoreductive Surgery Followed by Intraperitoneal Hyperthermic Perfusion in the Treatment of Recurrent Epithelial Ovarian Cancer: A Phase II Clinical Study
M. Deraco (2001)
Secondary cytoreductive surgery for ovarian cancer.
T. Burke (1994)
Intraperitoneal heated chemotherapy affects healing of experimental colonic anastomosis: an animal study.
V. Makrin (2005)
Survival effect of maximal cytoreductive surgery for advanced ovarian carcinoma during the platinum era: a meta-analysis.
R. Bristow (2002)
Cytoreductive Surgery and Intraperitoneal Chemohyperthermia for Chemoresistant and Recurrent Advanced Epithelial Ovarian Cancer: Prospective Study of 81 Patients
E. Cotte (2007)
Cytoreductive surgery and intraperitoneal chemohyperthermia for chemoresistant and recurrent advanced epithelial ovarian cancer: prospective 6 Journal of Oncology study of 81 patients
E. Cotte (1813)
Cytoreductive surgery (peritonectomy procedures) combined with hyperthermic intraperitoneal chemotherapy (HIPEC) in the treatment of diffuse peritoneal carcinomatosis from ovarian cancer
A. di Giorgio (2008)
Cancer of the ovary.
M. McKay (1994)
Prognostic Indicators for Patients Undergoing Cytoreductive Surgery and Perioperative Intraperitoneal Chemotherapy for Diffuse Malignant Peritoneal Mesothelioma†
T. Yan (2006)
Cytoreductive Surgery and Intraperitoneal Chemohyperthermia for Recurrent Peritoneal Carcinomatosis from Ovarian Cancer
C. Zanon (2004)
Carboplatin and paclitaxel in ovarian carcinoma: a phase I study of the Gynecologic Oncology Group.
M. Bookman (1996)
Long‐term survival in advanced ovarian carcinoma following cytoreductive surgery with standard peritonectomy procedures
A. Tentes (2006)
Intraperitoneal cisplatin and paclitaxel in ovarian cancer.
D. Armstrong (2006)
Long‐term results of cytoreductive surgery for advanced and recurrent epithelial ovarian cancers and papillary serous carcinoma of the peritoneum
M. Look (2003)
Total abdominal colectomy, pelvic peritonectomy, and end-ileostomy for the surgical palliation of mucinous peritoneal carcinomatosis from non-gynecologic cancer.
K. Stamou (2003)
Management of Peritoneal Surface Malignancy Using Inytraperitoneal Chemotherapy and Cytoreductive Surgery. A Manual for Physicians and Nurses, Ludann
P. H. Sugarbaker (1998)
Radical surgery-peritonectomy and intraoperative intraperitoneal chemotherapy for the treatment of peritoneal carcinomatosis in recurrent or primary ovarian cancer.
S. Rufián (2006)
Hyperthermic intraperitoneal intraoperative chemotherapy after cytoreductive surgery for the treatment of abdominal sarcomatosis
C. Rossi (2004)

This paper is referenced by
Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy in the treatment of ovarian cancer
John Spiliotis (2015)
Cytoreductive Surgery plus Hyperthermic Intraperitoneal Chemotherapy to Treat Advanced/Recurrent Epithelial Ovarian Cancer: Results from a Retrospective Study on Prospectively Established Database1
J. Sun (2016)
Cytoreduction and HIPEC after neoadjuvant chemotherapy in stage IIIC-IV ovarian cancer. Critical analysis in elderly patients.
P. Cascales-Campos (2014)
The use of heated intraperitoneal chemotherapy for the treatment of gynecologic carcinomatosis
Sarah K Goodrich (2014)
Cytoreductive Surgery in Combination with HIPEC in the Treatment of Peritoneal Sarcomatosis
C. Karamveri (2018)
Chemotherapy for intraperitoneal use: a review of hyperthermic intraperitoneal chemotherapy and early post-operative intraperitoneal chemotherapy.
Martin D. Goodman (2016)
Cytoreduction and HIPEC for peritoneal carcinomatosis of pancreatic cancer.
A. Tentes (2018)
Experience of Hipec and Cytoreductive Surgery in Klaipeda University Hospital
Vitalijus Eismontas (2013)
Security and efficiency of a closed-system, turbulent-flow circuit for hyperthermic intraperitoneal chemotherapy after cytoreductive ovarian surgery: perioperative outputs
Javier Pascual-Ramírez (2014)
Hemodynamic Monitoring During Heated Intraoperative Intraperitoneal Chemotherapy Using the FloTrac/Vigileo System.
Christos Mavroudis (2015)
Wstępna ocena przydatności dootrzewnowej perfuzyjnej chemioterapii w warunkach hipertermii (HIPEC) u chorych z nowotworowym rozsiewem wewnątrzotrzewnowym
Beata Śpiewankiewicz (2013)
Intraperitoneal Chemotherapy from Armstrong to HIPEC: Challenges and Promise
Ramez N. Eskander (2013)
Ascites do not affect the rate of complete cytoreductive surgery and prognosis in patients with primary ovarian cancer with ascites treated with hyperthermic intraperitoneal chemotherapy.
Mingchen Ba (2019)
A critical appraisal of hyperthermic intraperitoneal chemotherapy (HIPEC) in the treatment of advanced and recurrent ovarian cancer.
L. Chiva (2015)
Intraperitoneal chemotherapy against peritoneal carcinomatosis: current status and future perspective.
Joji Kitayama (2014)
Current Indications, Techniques and Results of Cytoreductive Surgery with Hyperthermic Intraperitoneal Chemotherapy for Intra-Abdominal Malignancies
Meagan Wademan (2012)
Management of peritoneal surface malignancy: a review of the recent literature.
E. Halkia (2014)
V. Eismontas (2013)
Consolidation hyperthermic intraperitoneal chemotherapy for the treatment of advanced stage ovarian carcinoma: a 3 year experience
A. Mendivil (2017)
Hyperthermic Intraperitoneal Chemotherapy (HIPEC) as Primary Treatment of Ovarian Cancer: A Review of the Current Literature
Samira Zirak-Schmidt (2018)
Ovarian cancer, version 2.2013: Featured updates to the NCCN guidelines
R. Morgan (2013)
The cost of cytoreductive surgery and perioperative intraperitoneal chemotherapy in the treatment of peritoneal malignancy in one Greek institute.
A. Tentes (2012)
Place des résections pelviennes élargies associées à une chimiothérapie hyperthermique intra-péritonéale dans le traitement de la carcinose péritonéale
Julien Coget (2013)
Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy in epithelial ovarian cancer: State of the art
Ramez N. Eskander (2013)
Intraperitoneal chemotherapy in ovarian cancer: a review of tolerance and efficacy
D. L. Chan (2012)
Hyperthermic intraperitoneal chemotherapy (HIPEC) and cytoreductive surgery (CRS) in ovarian cancer: A systematic review and meta-analysis.
Y. R. Huo (2015)
Zasady stosowania dootrzewnowej chemioterapii w hipertermii (HIPEC) w leczeniu nowotworów złośliwych powierzchni otrzewnej w połączeniu z zabiegami cytoredukcyjnymi: zalecenia krajowe Polish clinical practice guideline on Hyperthermic Intraperitoneal Chemotherapy (HIPEC) with Cytoreductice Surgery (
Piotr Rutkowski (2014)
An overview and update of hyperthermic intraperitoneal chemotherapy in ovarian cancer
Eelco de Bree (2020)
Prognostic Significance of Sugarbaker’s Peritoneal Cancer Index for the Operability of Ovarian Carcinoma
Bjoern Lampe (2015)
The role of cytoreductive surgery in advanced ovarian cancer: the general surgeon's perspective.
K. Romanidis (2014)
Long non-coding RNA ENST00000457645 reverses cisplatin resistance in CP70 ovarian cancer cells.
H. Yan (2017)
Lack of significant intraoperative coagulopathy in patients undergoing cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (HIPEC) indicates that epidural anaesthesia is a safe option
O. Korakianitis (2015)
See more
Semantic Scholar Logo Some data provided by SemanticScholar