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Heparin And Carboxymethylchitosan Metal Nanoparticles: An Evaluation Of Their Cytotoxicity

Adriana Bava, Francesca Cappellini, Elisa Pedretti, Federica Rossi, Enrico Caruso, Elena Vismara, Maurizio Chiriva-Internati, Giovanni Bernardini, Rosalba Gornati

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In the search for noninvasive diagnostic techniques and new therapies, “nanosystems”, which are capable of binding and targeting bioactive molecules, are becoming increasingly important. In this context, biocompatible coatings are gaining interest, not only for their biological effects but also because they are considered capable to mask nanoparticle toxicity. In this work, we have compared the toxicity of nanoparticles coated with heparin and carboxymethylchitosan in the SKOV-3 cell line. Our results indicate that heparin and carboxymethylchitosan coatings do not guarantee the decrease of nanoparticle intrinsic toxicity which is often envisaged. Nonetheless, these coatings provide the opportunity for further functionalization with a variety of biomolecules for their use in theranostics.