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Iron Oxide Magnetic Nanoparticles: Characterization And Toxicity Evaluation ByIn VitroandIn VivoAssays

Alina Mihaela Prodan, Simona Liliana Iconaru, Carmen Steluta Ciobanu, Mariana Carmen Chifiriuc, Mihai Stoicea, Daniela Predoi

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The aim of this study was to evaluate the biological properties of iron oxide nanoparticles (IO-NPs) obtained in the aqueous suspension. The iron oxide nanoparticles were characterized by scanning electron microscopy (SEM) and transmission electron microscopy (TEM). The biocompatibility of the iron oxide was demonstrated by thein vitroquantification of HeLa cells viability using propidium iodide (PI) and fluorescein diacetate (FdA) and the MTT colorimetric assay. The toxicity of small size iron oxide nanoparticles was also evaluated by means of histological examination on male Brown Norway rats after intraperitoneal injection. At the tested concentrations, the nanoparticles proved to be not cytotoxic on HeLa cells. The rat’s behavior, as well as the histopathological aspect of liver, kidney, lung, and spleen tissues at 48 h after intraperitoneal injection did not present any modifications. Thein vivoandin vitroassays suggested that the IO-NPs could be further used for developing newin vivomedical applications.