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Magnetic Properties And Biological Activity Evaluation Of Iron Oxide Nanoparticles

Alina Mihaela Prodan, Simona Liliana Iconaru, Carmen Mariana Chifiriuc, Coralia Bleotu, Carmen Steluta Ciobanu, Mikael Motelica-Heino, Stanislas Sizaret, Daniela Predoi

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The aim of this study was to provide information about the biological properties of iron oxide nanoparticles (IO-NPs) obtained in an aqueous suspension. The IO-NPs were characterized by transmission electron microscopy (TEM). Analysis of hysteresis loops data at room temperature for magnetic IO-NPs sample indicated that the IO-NPs were superparamagnetic at room temperature. The calculated saturation magnetization for magnetic iron oxide wasMs= 18.1 emu/g. The antimicrobial activity of the obtained PMC-NPs was tested against Gram-negative (Pseudomonas aeruginosa1397,Escherichia coliATCC 25922), Gram-positive (Enterococcus faecalisATCC 29212,Bacillus subtilisIC 12488) bacterial as well as fungal (Candida krusei963) strains. The obtained results suggested that the antimicrobial activity of IO-NPs is dependent on the metallic ions concentrations and on the microbial growth state, either planktonic or adherent. The obtained IO-NPs exhibited no cytotoxic effect on HeLa cells at the active antimicrobial concentrations.