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Oxidative Stress: Harms And Benefits For Human Health

G. Pizzino, N. Irrera, M. Cucinotta, Giovanni Pallio, F. Mannino, V. Arcoraci, F. Squadrito, D. Altavilla, A. Bitto
Published 2017 · Biology, Medicine

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Oxidative stress is a phenomenon caused by an imbalance between production and accumulation of oxygen reactive species (ROS) in cells and tissues and the ability of a biological system to detoxify these reactive products. ROS can play, and in fact they do it, several physiological roles (i.e., cell signaling), and they are normally generated as by-products of oxygen metabolism; despite this, environmental stressors (i.e., UV, ionizing radiations, pollutants, and heavy metals) and xenobiotics (i.e., antiblastic drugs) contribute to greatly increase ROS production, therefore causing the imbalance that leads to cell and tissue damage (oxidative stress). Several antioxidants have been exploited in recent years for their actual or supposed beneficial effect against oxidative stress, such as vitamin E, flavonoids, and polyphenols. While we tend to describe oxidative stress just as harmful for human body, it is true as well that it is exploited as a therapeutic approach to treat clinical conditions such as cancer, with a certain degree of clinical success. In this review, we will describe the most recent findings in the oxidative stress field, highlighting both its bad and good sides for human health.
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Carvacrol and astaxanthin co-entrapment in beeswax solid lipid nanoparticles as an efficient nano-system with dual antioxidant and anti-biofilm activities
M. T. Shakeri (2019)
Toxicological analysis of aerosols derived from three electronic nicotine delivery systems using Normal human bronchial epithelial cells.
K. Pearce (2020)
Ellagic acid ameliorates lung damage in rats via modulating antioxidant activities, inhibitory effects on inflammatory mediators and apoptosis-inducing activities
Abdullah Aslan (2019)
Enterococcus faecalis milk fermentates display antioxidant properties and inhibitory activity towards key enzymes linked to hypertension and hyperglycaemia
K. Graham (2019)
Pre-Treatment of Pterostilbene Enhances H2O2-induced Cell Apoptosis Through Caspase-dependent Pathway in Human Keratinocyte Cells
Yi-Ching Cheng (2021)
Phytoradiotherapy: An Integrative Approach to Cancer Treatment by Combining Radiotherapy With Phytomedicines
Tyler Alfonzetti (2020)
Role of Oxidative Stress in Pathophysiology of Diseases
P. Maurya (2020)
Oxidative Stress: A Key Modulator in Neurodegenerative Diseases
Anju Singh (2019)
Copper(II) complexes of coumarin-derived Schiff base ligands: Pro- or antioxidant activity in MCF-7 cells?
Louise Maclean (2019)
Air pollution associated epigenetic modifications: Transgenerational inheritance and underlying molecular mechanisms.
A. Shukla (2019)
Different Antioxidant Efficacy of Two MnII-Containing Superoxide Anion Scavengers on Hypoxia/Reoxygenation-Exposed Cardiac Muscle Cells
M. Becatti (2019)
The Potential of Lactobacillus spp. for Modulating Oxidative Stress in the Gastrointestinal Tract
Yanzhuo Kong (2020)
Oxidative Stress: A Possible Trigger for Pelvic Organ Prolapse
R. Marcu (2020)
Antioxidant Activity of Methanol Extract Tetracera scanden L Merr Predicted Active Compound of Methanol Extract with GCMS NIST Library
M. Soleha (2020)
In vitro anti-inflammatory, antioxidant and qualitative phytochemical evaluation of the Phytexponent preparation of selected plants
Gervason Moriasi (2020)
Macrocycles and Supramolecules as Antioxidants: Excellent Scaffolds for Development of Potential Therapeutic Agents
Jung-Seop Lee (2020)
Flavones and Flavonols: Bioactivities and Responses Under Light Stress in Herbs
E. P. Gutiérrez-Grijalva (2020)
Current Trends of Bioactive Peptides—New Sources and Therapeutic Effect
A. Jakubczyk (2020)
Dietary Intake of Selenium in Relation to Pubertal Development in Mexican Children
Y. Liu (2019)
Protective Effects of Ursolic Acid on Osteoblastic Differentiation via Activation of IER3/Nrf2
S. Lee (2019)
Elevated Levels of Protein Carbonylation in Patients With Diabetic Nephropathy: Therapeutic and Diagnostic Prospects.
E. Almogbel (2019)
Oxidative Stress Markers Differ in Two Placental Dysfunction Pathologies: Pregnancy-Induced Hypertension and Intrauterine Growth Restriction
A. Zyguła (2020)
Beneficial effects of AOS-iron supplementation on intestinal structure and microbiota in IDA rats
Hong He (2020)
Effects of silymarin and mesenchymal stem cells on hematological and some biochemical changes induced by gamma radiation in albino rats
Z. M. Ashraf (2019)
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