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Iron Deficiency During Embryogenesis And Consequences For Oligodendrocyte Generation In Vivo

D Morath, Margot Mayer-Pröschel
Published 2002 · Biology, Medicine
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One of the hallmarks of the pathology of iron deficiency in children is neurological disabilities that are often associated with hypomyelination. It has been hypothesized that this amyelination is mainly due to a disruption of myelin generation during the early postnatal stages when oligodendrocytes mature to generate myelin producing cell. In addition to these suggestions, we have previously provided in vitro data showing that iron affects both the proliferation and differentiation of glial precursor cells leading to a disruption in the generation of oligodendrocytes. We now present evidence demonstrating in vivo that iron deficiency during pregnancy affects the iron levels of various brain tissues in the developing fetus and disrupts not only the proliferation of their glial precursor cells but also disturbs the generation of oligodendrocytes from these precursor cells. In addition, we show that iron deficiency during embryogenesis affects glial lineage cells in a tissue-specific manner. Our studies offer the possibility to begin to comprehend whether any effects that occur during embryogenesis might have an influence on the establishment of the pathological defects that occur as a consequence of iron deficiency.
This paper references
10.1016/0306-4522(90)90320-4
Altered cellular distribution of iron in the central nervous system of myelin deficient rats
James R. Connor (1990)
10.1016/S0163-6383(78)80027-7
Developmental scores of iron deficient infants and the effects of therapy
Alice Sterling Honig (1978)
The prevalence of anaemia in the world.
E. M. Demaeyer (1985)
10.1093/ajcn/68.3.683
Evidence of altered central nervous system development in infants with iron deficiency anemia at 6 mo: delayed maturation of auditory brainstem responses.
Manuel Roncagliolo (1998)
10.1016/0006-8993(76)90225-0
Myelin synthesis during postnatal nutritional deprivation and subsequent rehabilitation
Richard C. Wiggins (1976)
10.1016/0006-8993(92)91652-U
Iron and transferrrin uptake by brain and cerebrospinal fluid in the rat
Andrew Crowe (1992)
10.1007/s002850050119
A stochastic model of brain cell differentiation in tissue culture
Andrei Yu Yakovlev (1998)
10.1016/0165-3806(90)90103-6
Developmental changes in transferrin and iron uptake by the brain in the rat.
Edwin Michael Taylor (1990)
10.1073/pnas.95.7.3996
A tripotential glial precursor cell is present in the developing spinal cord.
Mahendra S. Rao (1998)
Dietary iron and the integrity of the developing rat brain: a study with the artificially-reared rat pup.
A E de los Monteros (2000)
10.1523/JNEUROSCI.22-01-00248.2002
The Tripotential Glial-Restricted Precursor (GRP) Cell and Glial Development in the Spinal Cord: Generation of Bipotential Oligodendrocyte-Type-2 Astrocyte Progenitor Cells and Dorsal–Ventral Differences in GRP Cell Function
Ninel Z. Gregori (2002)
10.1002/jnr.490290317
Oligodendrocytes and myelin sheaths in normal, quaking and shiverer brains are enriched in iron.
Steven M LeVine (1991)
10.1016/S0887-8994(01)00303-4
Iron and iron management proteins in neurobiology.
J R Connor (2001)
10.1006/dbio.1997.8597
Glial-restricted precursors are derived from multipotent neuroepithelial stem cells.
Mahendra S. Rao (1997)
10.1007/BF01148114
Molecular identity, distribution and heterogeneity of glial fibrillary acidic protein: an immunoblotting and immunohistochemical study of Schwann cells, satellite cells, enteric glia and astrocytes
Kristjan R Jessen (1984)
Iron deficiency decreases 2,3-cyclic nucleotide 3)phosphorylase activity in developing rats
JA Wiesinger (2000)
Iron and transferrin uptake by the brain and cerebral spinal fluid in the rat
A Crowe (1994)
10.1016/0165-3806(84)90056-7
The differentiation of oligodendrocytes in a serum-free hormone-supplemented medium.
P. Ann Eccleston (1984)
10.1016/0013-4694(76)90193-0
Postnatal development of human brainstem potentials during the first year of life.
Alan Salamy (1976)
10.1006/dbio.2002.0610
Oligodendrocyte precursor cells from different brain regions express divergent properties consistent with the differing time courses of myelination in these regions.
Jennifer Power (2002)
10.1046/j.1471-4159.1995.65010373.x
Iron regulation in the developing rat brain: effect of in utero ethanol exposure.
Michael W Miller (1995)
10.1093/jn/130.11.2821
Chronic marginal iron intakes during early development in mice result in persistent changes in dopamine metabolism and myelin composition.
Catherine L. Kwik-Uribe (2000)
10.1073/pnas.76.10.4913
Monoclonal antibody to a plasma membrane antigen of neurons.
George S. Eisenbarth (1979)
10.1093/jn/127.10.2030
Regional brain iron, ferritin and transferrin concentrations during iron deficiency and iron repletion in developing rats.
Keith M. Erikson (1997)
10.1016/S0300-483X(01)00373-0
Effect of dietary zinc deficiency on hematological and biochemical parameters and concentrations of zinc, copper, and iron in growing rats.
H A El Hendy (2001)
10.1046/j.1471-4159.1997.69020443.x
Transport of iron in the blood-brain-cerebrospinal fluid system.
Michael William Blackburn Bradbury (1997)
Monoclonal antibody A2B5, which detects cell surface antigens, binds to ganglioside GT3 (II3 (NeuAc)3LacCer) and to its 9-O-acetylated derivative.
Charles. Dubois (1990)
10.1016/S0169-328X(99)00011-X
Expression of ferritin protein and subunit mRNAs in normal and iron deficient rat brain.
T. M. Hansen (1999)
10.1006/dbio.2001.0352
Iron modulates the differentiation of a distinct population of glial precursor cells into oligodendrocytes.
D Morath (2001)
10.1093/jn/130.2.254
Variations in dietary iron alter brain iron metabolism in developing rats.
Domingo J. Piñero (2000)
10.1002/jnr.490370405
Isoforms of ferritin have a specific cellular distribution in the brain.
J R Connor (1994)
Sequence of myelination in the brain of the albino rat
Steven Jacobson (1963)
10.1016/S0140-6736(96)02341-0
Randomised study of cognitive effects of iron supplementation in non-anaemic iron-deficient adolescent girls
Ann Bruner (1996)
10.1042/bj3560883
Effect of iron deficiency on placental transfer of iron and expression of iron transport proteins in vivo and in vitro.
Lorraine Gambling (2001)
Effect of prenatal iron deficiency on myelination in rat pups.
G S Yu (1986)
10.1073/pnas.83.6.1955
Growth requirements in vitro of oligodendrocyte cell lines and neonatal rat brain oligodendrocytes.
Jane E. Bottenstein (1986)
10.1006/exnr.2001.7729
Embryonic-Derived Glial-Restricted Precursor Cells (GRP Cells) Can Differentiate into Astrocytes and Oligodendrocytes in Vivo
Juan Herrera (2001)
10.1126/science.7123245
Monoclonal antibody to 5-bromo- and 5-iododeoxyuridine: A new reagent for detection of DNA replication.
Howard G. Gratzner (1982)
10.1073/pnas.79.8.2709
Development of oligodendrocytes and Schwann cells studied with a monoclonal antibody against galactocerebroside.
Barbara Ranscht (1982)
10.1007/978-1-4471-1766-7_5
Importance of Fetal and Neonatal Iron: Adequacy for Normal Development of Central Nervous System
Edward C. Larkin (1990)
10.1002/cne.901690303
Electron microscopic autoradiographic studies of gliogenesis in rat optic nerve. I. Cell proliferation.
Robert P. Skoff (1976)
Effects of low-iron status and deficiency of essential fatty acids on some biochemical constituents of rat brain.
Oao Oloyede (1992)
10.1093/jn/126.3.693
Brain iron and behavior of rats are not normalized by treatment of iron deficiency anemia during early development.
Barbara T. Felt (1996)
10.1006/dbio.1997.8592
Neuroepithelial stem cells from the embryonic spinal cord: isolation, characterization, and clonal analysis.
Alok Kalyani (1997)
10.1159/000111186
Origins of spinal cord oligodendrocytes: possible developmental and evolutionary relationships with motor neurons.
William D. Richardson (1997)
10.1001/jama.1997.03540360041028
Prevalence of iron deficiency in the United States.
A C Looker (1997)
10.1016/S0022-3476(76)80250-8
Iron deficiency and behavior.
Ernesto Pollitt (1976)
Lozoff B: Brain iron and behavior of rats
BT Felt (1994)
10.1093/jn/131.2.311
Variations in dietary iron alter behavior in developing rats.
Domingo J. Piñero (2001)
10.1097/00062752-199603020-00007
Current issues in iron deficiency
Roy D. Baynes (1996)
10.1016/0006-8993(74)90698-2
Synthesis of myelin proteins during starvation.
Richard C. Wiggins (1974)
10.1007/978-1-4757-6066-8_5
In Vitro Studies of Oligodendroglial Lipid Metabolism
David Pleasure (1984)
10.1093/jn/131.2.568S
Iron biology in immune function, muscle metabolism and neuronal functioning.
John L. Beard (2001)
10.1093/jn/130.2.347S
Causes of iron and zinc deficiencies and their effects on brain.
Harold H. Sandstead (2000)
Prevalence of nutritional anemia in infancy and childhood with emphasis on developing countries.
Rodolfo F. Florentino (1984)
10.1007/978-1-4615-2554-7_24
Iron deficiency: the global perspective.
James D. Cook (1994)
10.1016/S0025-5564(99)00010-3
A stochastic model of temporally regulated generation of oligodendrocytes in cell culture.
Kenneth M. Boucher (1999)
Developmental discrepancies of the human brainstem auditory evoked response
K Hecox (1999)
10.1016/0378-3782(95)01639-K
Maturation of the auditory brainstem in low risk-preterm infants: a comparison with age-matched full term infants up to 6 years.
Ze D Jiang (1995)



This paper is referenced by
10.1523/JNEUROSCI.0708-13.2013
Neonatal E. Coli Infection Causes Neuro-Behavioral Deficits Associated with Hypomyelination and Neuronal Sequestration of Iron
Jacqueline C. Lieblein-Boff (2013)
10.1301/nr.2006.may.S34-S43
Long-lasting neural and behavioral effects of iron deficiency in infancy.
Betsy Lozoff (2006)
10.7916/D8902B0Q
Stressed Astrocytes: Insights on the Pathology of Alexander Disease
Eileen Guilfoyle (2013)
10.3345/KJP.2010.53.3.392
Relationship between iron deficiency anemia and febrile convulsion in infants
Youn Soo Jun (2010)
10.1016/j.bbi.2013.09.009
Do prenatal immune activation and maternal iron deficiency interact to affect neurodevelopment and early behavior in rat offspring?
Louise Harvey (2014)
10.1016/j.seizure.2009.01.008
Association between iron deficiency anemia and first febrile convulsion: A case–control study
Elham Bidabadi (2009)
Effects of nutrients (in food) on the structure and function of the nervous system: update on dietary requirements for brain. Part 2 : macronutrients.
J. M. Bourre (2006)
10.1007/s12098-015-1904-2
Fetal Effects of Maternal Iron Deficiency
Deepak Chawla (2015)
10.1093/jn/nxx036
Biomarkers of Nutrition for Development (BOND)-Iron Review.
Sean Lynch (2018)
Coli Infection Causes NeuroBehavioral Deficits Associated with Hypomyelination and Neuronal Sequestration of Iron
Jacqueline C. Lieblein-Boff (2013)
10.1007/s12035-016-0369-2
Iron Availability Compromises Not Only Oligodendrocytes But Also Astrocytes and Microglial Cells
María V Rosato-Siri (2016)
Brain iron levels in children with attention-deficit/hyperactivity disorder (ADHD): MRI study
Samuele Cortese (2009)
10.1201/9781420038750.ch5
Nutrition and Health
Gordon Ward Fuller (2001)
10.3389/fped.2019.00286
Prevalence of Anemia and Its Associated Risk Factors Among 6-Months-Old Infants in Beijing
Qinrui Li (2019)
10.3945/jn.110.135715
Mild maternal iron deficiency anemia during pregnancy and lactation in guinea pigs causes abnormal auditory function in the offspring.
Jean-Luc Jougleux (2011)
10.1007/978-1-60327-485-2_14
The Liabilities of Iron Deficiency
John L. Beard (2012)
10.1002/jnr.22348
Oligodendrogenesis in iron-deficient rats: effect of apotransferrin.
María V Rosato-Siri (2010)
10.1179/1476830513Y.0000000067
Mild iron deficiency anaemia during pregnancy and lactation in guinea pigs alters amplitudes and auditory nerve velocity, but not brainstem transmission times in the offspring's auditory brainstem response
Jean-Luc Jougleux (2014)
10.1111/j.1753-4887.2011.00432.x
Long-term brain and behavioral consequences of early iron deficiency.
Michael K. Georgieff (2011)
10.2510/colomb.
Funcionamiento intelectual y rendimiento escolar en niños con anemia y deficiencia de hierro
Gilda G Stanco (2007)
10.1201/9781420073522.CH8
Micronutrient Needs of the Developing Brain: Priorities and Assessment
A J Fuglestad (2009)
10.1080/1028415X.2017.1408946
Impact of maternal iron deficiency on the auditory functions in the young and adult guinea pig
Nora Shero (2019)
10.1038/s41430-019-0400-6
A systematic literature review of the relation between iron status/anemia in pregnancy and offspring neurodevelopment
Janet Janbek (2019)
10.1002/pmic.201600407
The Effects of Prenatal Iron Deficiency and Risperidone Treatment on the Rat Frontal Cortex:  A Proteomic Analysis.
Lorna A. Farrelly (2017)
10.1093/jn/133.10.3215
Perinatal iron deficiency alters the neurochemical profile of the developing rat hippocampus.
Raghavendra B Rao (2003)
10.15406/MOJT.2014.01.00001
Effect of olfactory manganese dose on motor coordination in iron-deficient rats
Siripan Phattanarudee (2014)
10.31274/ETD-180810-1297
Recurrent selection to alter seed phytic acid content and iron bioavailability in maize
Alyssa W. Beavers (2014)
10.1038/s41390-018-0204-8
Iron as a Model Nutrient for Understanding the Nutritional Origins of Neuropsychiatric Disease
Amanda K Barks (2018)
10.1371/journal.pone.0017483
Identifying a Window of Vulnerability during Fetal Development in a Maternal Iron Restriction Model
Camelia Mihăilă (2011)
10.3945/jn.114.206599
Biomarkers of Nutrition for Development-Folate Review.
Lynn B. Bailey (2015)
10.1007/s11011-012-9290-1
The conundrum of iron in multiple sclerosis – time for an individualised approach
Susan Janse van Rensburg (2012)
10.1080/10284150500499644
Perinatal nutritional iron deficiency reduces hippocampal synaptic transmission but does not impair short- or long-term synaptic plasticity
Matthew D. McEchron (2005)
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