Online citations, reference lists, and bibliographies.
← Back to Search

Anesthesia With EMLA® Cream For Botulinum A Toxin Injection Into Eyelids

M. Söylev, N. Koçak, B. Kuvaki, S. B. Özkan, E. Kir
Published 2002 · Medicine

Cite This
Download PDF
Analyze on Scholarcy
Share
We investigated the efficacy of an eutectic mixture of local anesthetics (EMLA®) in reducing the pain of a botulinum toxin injection into eyelids. 17 patients with facial dyskinesia (9 blepharospasm and 8 hemifacial spasm) who had been treated regularly with botulinum toxin injections received EMLA cream and placebo. The pain was assessed by the ophthalmologist and the patient. Injection with EMLA cream showed lower pain scores (mean 1.82 ± 2.13, median 1) than injection with placebo (8.76 ± 2.17; p = 0.0001). Percutaneous anesthesia induced by EMLA cream is an effective and safe method which improves the comfort in patients who need repeated botulinum toxin injections for their facial dyskinesia.
This paper references
10.1016/S0161-6420(95)30757-9
Long-term changes in duration of relief with botulinum toxin treatment of essential blepharospasm and hemifacial spasm.
J. Ainsworth (1995)
10.1093/BJA/57.3.326
Clinical study of a lignocaine-prilocaine cream to relieve the pain of venepuncture.
B. Hallén (1985)
10.1016/0304-3959(90)91088-Z
Evaluating the efficacy of EMLA in alleviating pain associated with lumbar puncture; comparison of open and double-blinded protocols in children
J. Kapelushnik (1990)
10.1136/jnnp.51.6.767
Blepharospasm: a review of 264 patients.
F. Grandas (1988)
10.1097/00002341-198601060-00010
The Use of Botulinum Toxin in the Medical Management of Benign Essential Blepharospasm
K. I. Perman (1986)
10.1093/BJA/57.10.997
Dermal effects of compositions based on the eutectic mixture of lignocaine and prilocaine (EMLA). Studies in volunteers.
H. Evers (1985)
10.1016/S0039-6257(97)81995-9
Botulinum-A toxin in the treatment of craniocervical muscle spasms: short- and long-term, local and systemic effects.
J. Dutton (1996)
10.1093/BJA/63.6.655
Vascular response of human skin after analgesia with EMLA cream.
P. Bjerring (1989)
10.1159/000310837
Chemodenervation in treatment of upper eyelid retraction.
S. Ozkan (1997)
10.1016/S0161-6420(88)32977-5
Long-term results and complications of botulinum A toxin in the treatment of blepharospasm.
J. Dutton (1988)
10.1016/0039-6257(91)90207-V
Botulinum A toxin (Oculinum) in ophthalmology.
M. Osako (1991)
10.1001/ARCHDERM.135.7.855
EMLA cream-induced eye injury.
J. R. McKinlay (1999)
10.1136/bjo.75.3.130
A double-masked evaluation of lignocaine-prilocaine cream (EMLA) used to alleviate the pain of retrobulbar injection.
P. Sunderraj (1991)
10.3928/1542-8877-19900501-08
Side effects of the use of botulinum toxin for treatment of benign essential blepharospasm and hemifacial spasm.
H. K. Kalra (1990)
10.1016/S0161-6420(87)33338-X
Effectiveness of botulinum toxin therapy for essential blepharospasm.
P. Engstrom (1987)
10.1111/j.1365-2044.1988.tb05539.x
Pain‐free injection in infants
C. S. Hopkins (1988)
10.1046/j.1365-2044.1999.00842.x
The effects of EMLA and a topical formulation of 4%amethocaine (Ametop) on pain associated with retrobulbar injection
J. Browne (1999)
10.1001/ARCHOPHT.1984.01040031184014
Treatment of blepharospasm with botulinum toxin. A preliminary report.
B. Frueh (1984)
10.1136/bjo.78.3.209
Percutaneous anaesthesia with a lignocaine-prilocaine cream (Emla) for eyelid skin surgery.
S. Gotsis (1994)
10.1097/00002341-198701000-00006
Treatment of Blepharospasm with High Dose Brow Injection of Botulinum Toxin
R. Kristan (1987)
10.1016/S0161-6420(97)30220-6
Blepharospasm and hemifacial spasm. Randomized trial to determine the most appropriate location for botulinum toxin injections.
J. Price (1997)
10.1097/00002341-198601060-00005
Treatment of Hemifacial Spasm with Botulinum A Toxin: Results and Rationale
R. Gonnering (1986)
10.1093/BJA/58.11.1242
Double-blind evaluation of a lignocaine-prilocaine cream (EMLA) in children. Effect on the pain associated with venous cannulation.
E. Maunuksela (1986)
Evaluating the efficacy of EMLA in alleviating pain with lumbar puncture; comparison of open and double-blinded protocols in children. Pain 1990;42:31–34
J Kapelushnik (1990)
10.1093/BJA/65.2.240
Double-blind comparison of topical lignocaine-prilocaine cream (EMLA) and lignocaine infiltration for arterial cannulation in adults.
M. Smith (1990)
10.1002/ANA.410320404
Hemifacial spasm: Evaluation by magnetic resonance imaging and magnetic resonance tomographic angiography
C. Adler (1992)



This paper is referenced by
10.1097/IOP.0b013e3181b1e526
Comparison of Pain Scores With 30-Gauge and 32-Gauge Needles for Periocular Botulinum Toxin Type A Injections
David E Yomtoob (2009)
10.1097/SAP.0000000000000121
A Clinical Comparison of EMLA Cream and Ethyl Chloride Spray Application for Pain Relief of Forehead Botulinum Toxin Injection
Saime Irkoren (2015)
Vapocoolant Anesthesia for Cosmetic Facial Rejuvenation Injections: A Randomized, Prospective, Split-Face Trial
Matthew R. Zeiderman (2018)
10.1097/IOP.0b013e3181a145ca
Reduction of Pain and Anxiety Prior to Botulinum Toxin Injections With a New Topical Anesthetic Method
R. A. Weiss (2009)
Efficacy of EMLA Cream in Pain Reduction during Botulinum Toxin Injections for Facial Dystonias
M. Moin (2019)
10.1016/j.asj.2003.10.002
Easing Botox administration with EMLA cream.
B. Eppley (2004)
10.1034/j.1399-6576.2003.00125.x
EMLA® does not permit pain‐free retrobulbar injection *
B. Kuvaki (2003)
10.1016/j.amjsurg.2011.06.040
Do topical anesthetics reduce periareolar injectional pain before sentinel lymph node biopsy?
J. O'Connor (2011)
10.1007/978-3-030-29505-9
Atlas of Surgical Therapy for Migraine and Tension-Type Headache
E. Raposio (2020)
10.1097/01.sap.0000139563.51598.75
Evaluating the Effects of Ice Application on the Pain Felt During Botulinum Toxin Type-A Injections: A Prospective, Randomized, Single-Blind Controlled Trial
N. Sarıfakioğlu (2004)
10.1111/j.1468-1331.2006.01442.x
Botulinum toxin therapy of hemifacial spasm: comparing different therapeutic preparations
K. Frei (2006)
Minimal Invasive Cutaneous and Aesthetic Surgery
Lauren L. Levy ()
10.1097/SAP.0b013e318045a083
Bupivacaine-Induced Myotoxicity and Its Effect on Botulinum Toxin Paresis
M. T. Yen (2008)
10.1590/S0034-72802012000600004
Eficácia do resfriamento da pele no alívio da dor desencadeada pela injeção de toxina botulínica tipo A nas distonias faciais
P. Monteiro (2012)
10.1080/01676830600675392
“Cryoanalgesic Preparation” Before Local Anaesthetic Injection for Lid Surgery
S. Goel (2006)
10.2165/00128071-200506030-00001
Managing Adverse Events Associated with Botulinum Toxin Type A
U. Wollina (2005)
10.1016/J.OTC.2005.03.005
Botulinum toxin management of upper facial rhytidosis and blepharospasm.
S. Seiff (2005)
10.2147/JPR.S21787
Evaluation of pain associated with facial injections using CoolSkin® in rhytidectomy
F. Taghizadeh (2011)
10.1097/SAP.0b013e31812f6e0f
EMLA Cream Application Without Occlusive Dressing Before Upper Facial Botulinum Toxin Injection: A Randomized, Double-Blind, Placebo-Controlled Trial
M. Kashkouli (2008)
10.1007/s00266-004-0015-7
Interactıon of Botulınum Toxın Type A wıth Local Anesthetıc Agents: An Experımental Study with Rabbıts
Metin Görgü (2004)
10.1097/00055735-200310000-00003
Chemodenervation for facial dystonias and wrinkles
A. Harrison (2003)
10.1016/j.survophthal.2010.03.008
Review and update of involuntary facial movement disorders presenting in the ophthalmological setting.
A. Ross (2011)
10.1111/J.1524-4725.2006.32191.X
Pain Sensation during Intradermal Injections of Three Different Botulinum Toxin Preparations in Different Doses and Dilutions
G. Kranz (2006)
10.1097/IOP.0b013e31819946c4
High Versus Low Concentration Botulinum Toxin A for Benign Essential Blepharospasm: Does Dilution Make a Difference?
Michael H. Boyle (2009)
10.1097/01.iop.0000248989.33572.3c
Efficacy of Botulinum Toxin Type A After Topical Anesthesia
M. Sami (2006)
10.1590/S0034-72802011000200003
Eficácia da aplicação da pomada EMLA® no alivio da dor desencadeada pela injeção de toxina botulínica tipo A no tratamento do blefaroespasmo essencial benigno
Nadia Ajub Moysés (2011)
10.1007/s00702-016-1522-9
Botulinum toxin therapy: reduction of injection site pain by pH normalisation
D. Dressler (2016)
10.1016/j.bjps.2012.04.016
Botulinum neurotoxin A: a review.
M. Berry (2012)
10.1097/IOP.0b013e318030459c
Efficacy of Skin Cooling and EMLA Cream Application for Pain Relief of Periocular Botulinum Toxin Injection
O. Elibol (2007)
10.1007/s00702-010-0546-9
Difficulties with differentiating botulinum toxin treatment effects in essential blepharospasm
B. Wabbels (2010)
10.1097/01.iio.0000167165.25649.e7
Advanced Functional Oculofacial Indications of Botulinum Toxin
C. Lee (2005)
10.1007/978-3-030-29505-9_7
Botulinum Neurotoxin: Basic Facts, Physiology and Pharmacology
M. G. Berry (2020)
See more
Semantic Scholar Logo Some data provided by SemanticScholar