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Deer Antlers – A Model Of Mammalian Appendage Regeneration: An Extensive Review

U. Kierdorf, H. Kierdorf
Published 2010 · Biology, Medicine

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Background: Compared with other vertebrate taxa, mammals possess a very limited capacity for appendage regeneration. The antlers of deer are an exception in that they are periodically lost and fully regenerated throughout the life of an individual. Objective: In this paper we compare certain aspects of antler regeneration with regenerative processes in other vertebrates. Methods: Review of the literature. Results: Recent studies suggest that antler regeneration is a stem cell-based process and that these stem cells are located in the pedicle periosteum. There is evidence that signaling pathways known to operate during appendage regeneration in other vertebrates are also activated during antler regeneration. There are, however, also differences between antlers and other systems of epimorphic regeneration. Thus, contrary to amphibian limb regeneration, signaling from the wound epidermis appears not to be of crucial importance for antler regeneration. Healing of the casting wound typically involves no or only minor scarring, making antlers interesting subjects for researchers attempting to reduce scar formation during wound healing in humans. The fact that despite their enormous growth rate the antlers of intact and castrated deer appear to be resistant to malignant transformation furthermore offers research opportunities for cancer biology. Conclusions: Studying antler renewal as an example of mammalian appendage regeneration may provide crucial information for regenerative medicine to achieve its ultimate goal of stimulating limb regeneration in humans. A deeper understanding of the developmental mechanisms involved in antler renewal can also be useful for controlling induced regeneration processes in mammals.
This paper references
Problems of antlerogenesis
RJ Goss (1970)
10.1016/j.semcdb.2009.04.009
Interrelation of immunity and tissue repair or regeneration.
S. Eming (2009)
10.1007/s00438-006-0190-0
Gene expression dynamics in deer antler: mesenchymal differentiation toward chondrogenesis
I. Gyurján (2006)
10.1111/j.1469-7580.2005.00464.x
Programmed cell death in the regenerating deer antler
M. Colitti (2005)
10.1016/S0093-3619(08)70911-0
Wnt-dependent de novo hair follicle regeneration in adult mouse skin after wounding
B. Thiers (2008)
10.1016/j.ydbio.2007.12.025
Development and regeneration of the neonatal digit tip in mice.
Manjong Han (2008)
10.1002/(SICI)1097-0185(19990501)255:1<69::AID-AR8>3.0.CO;2-R
Hard fallow deer antler: A living bone till antler casting?
H. Rolf (1999)
10.1098/RSTB.2004.1475
Scar-free healing: from embryonic mechanisms to adult therapeutic intervention.
M. Ferguson (2004)
10.1371/journal.pone.0000148
Nerve Growth Factor mRNA Expression in the Regenerating Antler Tip of Red Deer (Cervus elaphus)
Chunyi Li (2007)
10.1095/biolreprod.106.058172
Red Deer Cloned from Antler Stem Cells and Their Differentiated Progeny1
D. Berg (2007)
10.1007/BF02285354
Pedicle and first antler formation in deer: Anatomical, histological, and developmental aspects
U. Kierdorf (2005)
10.1038/nature08152
Cells keep a memory of their tissue origin during axolotl limb regeneration
M. Kragl (2009)
10.1002/AR.A.20148
Histological examination of antler regeneration in red deer (Cervus elaphus).
C. Li (2005)
Exploring the molecular mechanisms of antler regeneration
JS Price (2001)
10.1002/jez.b.21252
Development of a nude mouse model for the study of antlerogenesis--mechanism of tissue interactions and ossification pathway.
C. Li (2009)
10.1101/GAD.1540507
Advances in signaling in vertebrate regeneration as a prelude to regenerative medicine.
Cristi L. Stoick-Cooper (2007)
10.1177/154405910808700909
Tail Regeneration in Xenopus laevis as a Model for Understanding Tissue Repair
A-S Tseng (2008)
10.1002/AR.A.10082
Histological studies of bone formation during pedicle restoration and early antler regeneration in roe deer and fallow deer.
U. Kierdorf (2003)
10.1016/S0940-9602(11)80488-7
The macroscopic and microscopic structure of double-head antlers and pedicle bone of cervidae (Mammalia, Artiodactyla).
U. Kierdorf (1994)
Effects of retinoic acid on pedicle and first antler growth
L Damadama (1999)
10.1007/978-1-4613-8966-8_11
The Role of the Nervous System in the Growth of Antlers
G. Bubenik (1990)
10.1016/j.semcdb.2008.11.011
Improbable appendages: Deer antler renewal as a unique case of mammalian regeneration.
U. Kierdorf (2009)
10.1083/jcb.200509011
Salamander limb regeneration involves the activation of a multipotent skeletal muscle satellite cell population
J. I. Morrison (2006)
10.1002/JEZ.1402660305
Effects of an antiandrogen treatment on the antler cycle of male fallow deer (Dama dama L.).
U. Kierdorf (1993)
10.1038/220083A0
Inhibition of Growth and Shedding of Antlers by Sex Hormones
RICHARD J. Goss (1968)
10.1016/S0742-8413(99)00038-9
Treatment of the growing pedicle with retinoic acid increased the size of the first antlers in fallow deer (Dama dama L.).
U. Kierdorf (1999)
10.1016/S0070-2153(05)67001-9
Deer antlers as a model of Mammalian regeneration.
J. Price (2005)
Epimorphic regeneration in mammals
RJ Goss (1984)
10.1002/JEZ.1402640408
The mechanism of antler casting in the fallow deer.
Richard J. Goss (1992)
10.1002/AR.1092410302
Future directions in antler research
Richard J. Goss (1995)
10.1002/dvdy.20742
Evidence that the canonical Wnt signalling pathway regulates deer antler regeneration
J. Mount (2006)
The endocrine control of the antler cycle; in Brown RD (ed): Antler Development in Cervidae
GA Bubenik (1983)
10.1089/REJ.2005.8.141
Ontogenetic decline of regenerative ability and the stimulation of human regeneration.
D. Gardiner (2005)
Wound healing and antler regeneration; in Maibach HI, Rovee DT (eds): Epidermal Wound Healing
RJ Goss (1972)
10.1006/DBIO.2002.0816
A role for retinoic acid in regulating the regeneration of deer antlers.
S. P. Allen (2002)
10.1002/JEZ.1402590214
Induction of deer antlers by transplanted periosteum: III. Orientation
Richard J. Goss (1991)
10.1093/CARCIN/18.8.1439
Regeneration versus neoplastic growth.
R. Prehn (1997)
Deer Antlers: Regeneration, Function and Evolution
Richard J. Goss (1983)
Wound healing and antler regeneration
RJ Goss
10.1007/BF01901843
Experimentelle Untersuchungen zur Bildung der primären Stirnauswüchse beim Reh (Capreolus capreolus L.)
H. Hartwig (2005)
10.1097/00003086-198009000-00038
Prospects of regeneration in man.
Richard J. Goss (1980)
10.1002/AJA.1000710304
Studies on the growth of deer antlers. I. On the structure and histogenesis of the antlers of the virginia deer (Odocoileus virginianus borealis)
G. B. Wislocki (1942)
10.1002/dvdy.10239
Regeneration or scarring: An immunologic perspective
M. Harty (2003)
10.1371/journal.pone.0002064
Localization and Characterization of STRO-1+ Cells in the Deer Pedicle and Regenerating Antler
H. Rolf (2008)
10.1016/S0940-9602(11)80085-3
A light microscopic study of primary antler development in fallow deer (Dama dama)
H. Kierdorf (1995)
10.1006/DBIO.2001.0487
Tissue origins and interactions in the mammalian skull vault.
X. Jiang (2002)
10.1643/0045-8511(2007)7[1050:FILEDA]2.0.CO;2
FINS INTO LIMBS: EVOLUTION, DEVELOPMENT AND TRANSFORMATION
M. Laurin (2007)
10.1111/j.1469-7580.2005.00478.x
Deer antlers: a zoological curiosity or the key to understanding organ regeneration in mammals?
J. Price (2005)
10.1016/b978-0-12-369371-6.x5017-5
Regenerative biology and medicine.
D. Stocum (2002)
10.1007/s00441-006-0333-y
Identification of key tissue type for antler regeneration through pedicle periosteum deletion
C. Li (2006)
10.1002/AJA.1000840103
Observations on the blood supply of growing antlers.
C. M. Waldo (1949)
10.1002/JEZ.1402440112
Induction of deer antlers by transplanted periosteum. II: Regional competence for velvet transformation in ectopic skin
Richard J. Goss (1987)
10.1387/IJDB.8877452
The cellular basis of limb regeneration in urodeles.
A. Mescher (1996)
A proliferation gradient between proximal and msxb-expressing distal blastema directs zebrafish fin regeneration.
Alex Nechiporuk (2002)
10.1016/S0940-9602(98)80049-6
Effects of retinoic acid on pedicle and first antler growth in a fallow buck (Dama dama L.).
U. Kierdorf (1998)
10.1016/b978-0-12-369439-3.x5000-4
Principles of Regenerative Biology
B. Carlson (2007)
Wound repair. Overview and general considerations; in Clark RAF (ed): The Molecular and Cellular Biology of Wound Repair, ed
RAF Clark (1996)
10.1007/978-1-4613-8966-8_9
Of Antlers and Embryos
Richard J. Goss (1990)
10.1007/BF02242839
Der Doppelkopf, ein für das Verständnis der Folgegeweih-Bildung aufschlußreiches Naturexperiment
U. Kierdorf (2005)
Tumor-like growth of antlers in castrated fallow deer: an electron microscopic study.
Goss Rj (1990)
10.1002/JMOR.10546
Deer antler regeneration: Cells, concepts, and controversies
U. Kierdorf (2007)
10.1530/JRF.0.0710007
Endocrine control of antler growth in red deer stags.
J. Suttie (1984)
10.1002/JEZ.1402340305
Regrowth of amputated velvet antlers with and without innervation.
J. Suttie (1985)
10.1002/AR.A.20127
Histological structure of antlers in castrated male fallow deer (Dama dama).
U. Kierdorf (2004)
10.1006/DBIO.2001.0312
In vivo imaging indicates muscle fiber dedifferentiation is a major contributor to the regenerating tail blastema.
K. Echeverri (2001)
10.1016/S0940-9602(11)80485-1
Light microscopic observations on the ossification process in the early developing pedicle of fallow deer (Dama dama).
H. Kierdorf (1994)
Newbrey JW: Light microscopic studies of the ossification process in developing antlers; in Brown RD (ed): Antler Development in Cervidae
WJ Banks (1983)
10.1016/j.semcdb.2008.12.007
Repatterning in amphibian limb regeneration: A model for study of genetic and epigenetic control of organ regeneration.
Nayuta Yakushiji (2009)
10.2174/157488809789057446
Adult stem cells and mammalian epimorphic regeneration-insights from studying annual renewal of deer antlers.
C. Li (2009)
Morphobiologische Untersuchungen am Cerviden-Geweih. Werden, Wechsel und Wesen des Rehgehörns
GB Gruber (1937)
10.1002/jez.b.21210
Role of heterotypic tissue interactions in deer pedicle and first antler formation-revealed via a membrane insertion approach.
C. Li (2008)
10.1002/JEZ.A.352
Antler regeneration: a dependent process of stem tissue primed via interaction with its enveloping skin.
C. Li (2007)
10.1016/j.semcdb.2009.04.005
Regeneration: The origin of cancer or a possible cure?
Néstor J Oviedo (2009)
10.1007/BF02241565
Knochengeschwulst an Damhirschstange
H. Kierdorf (2005)
10.1007/978-1-4612-2782-3_123
State of Determination of the Antlerogenic Tissues with Special Reference to Double-head Formation
H. Kierdorf (1992)
10.1002/AR.1092390211
Light microscopic studies of pedicle and early first antler development in red deer (Cervus elaphus)
C. Li (1994)
10.1002/JEZ.1402350307
Induction of deer antlers by transplanted periosteum. I. Graft size and shape.
Richard J. Goss (1985)
10.1242/dev.01155
Cell lineage tracing during Xenopus tail regeneration
C. Gargioli (2004)



This paper is referenced by
10.1515/pjvs-2017-0095
Molecular cloning, expression, purification and osteoblasts proliferation activity of sika deer thymosin beta10.
J. Wang (2017)
10.1186/scrt71
The role of p21 in regulating mammalian regeneration
L. M. Arthur (2011)
10.1016/j.bone.2019.115046
Antlers - Evolution, development, structure, composition, and biomechanics of an outstanding type of bone.
T. Landete-Castillejos (2019)
10.1002/JWMG.780
Long‐term trends and correlates of antler anomalies in roe deer
Jan Húsek (2014)
10.1126/science.aax5182
Ruminants: Evolutionary past and future impact
Dai Fei Elmer Ker (2019)
10.1186/s11658-020-00234-9
Comparative transcriptome analysis of the main beam and brow tine of sika deer antler provides insights into the molecular control of rapid antler growth
Baojin Yao (2020)
10.1007/s00018-013-1303-7
The roles of endogenous retinoid signaling in organ and appendage regeneration
Nicola U. Blum (2013)
10.1177/0300985814528216
Antleroma in a Free-ranging White-tailed Deer (Odocoileus virginianus)
B. Munk (2015)
10.1002/art.34396
Heritability of articular cartilage regeneration and its association with ear wound healing in mice.
M. Rai (2012)
Biological Archetypes for Self-Healing Materials Matthew
J. Harrington (2015)
Plasticity of salamander skeletal muscle cells
Paula Borg (2012)
10.1089/ten.TEB.2015.0401
Looking Ahead to Engineering Epimorphic Regeneration of a Human Digit or Limb.
Lina M. Quijano (2016)
10.1002/cbin.10168
Effects of PTHrP on expression of MMP9 and MMP13 in sika deer antler chondrocytes
Shou-Tang Wang (2013)
10.3390/molecules22101793
The Regulatory Mechanism of MLT/MT1 Signaling on the Growth of Antler Mesenchymal Cells
Feifei Yang (2017)
10.1186/s13227-019-0124-7
Common themes in tetrapod appendage regeneration: a cellular perspective
Bess M. Miller (2019)
10.1007/s13258-014-0193-x
Identification of novel reference genes using sika deer antler transcriptome expression data and their validation for quantitative gene expression analysis
Meichen Liu (2014)
10.1007/12_2015_334
Biological Archetypes for Self-Healing Materials
Matthew J. Harrington (2015)
10.4161/cc.9.18.13119
Epimorphic regeneration in mice is p53-independent
L. M. Arthur (2010)
10.1111/joa.12091
The structure of pedicle and hard antler bone in the European roe deer (Capreolus capreolus): a light microscope and backscattered electron imaging study
U. Kierdorf (2013)
10.1016/j.pep.2016.06.005
Cloning, expression, purification, and characterization of the catalytic domain of sika deer MMP-13.
Xueliang Zhang (2016)
10.1089/scd.2014.0127
Periodontal ligament stem cells modulate root resorption of human primary teeth via Runx2 regulating RANKL/OPG system.
Bei Li (2014)
Deer Antler Supplements , Growth Factors and Possible Cancer Risks Borna
Ilić (2016)
10.1152/physiol.00028.2011
Physiological regeneration of skin appendages and implications for regenerative medicine.
C. Chuong (2012)
10.1002/9781118707449.CH6
Advances in Understanding Limb Regeneration in a Developmental and Evolutionary Context
Jessica A Lehoczky (2013)
10.1002/9783527699315.CH4
Biological Hard Tissues of CaPO4
S. Dorozhkin (2016)
10.3109/03008207.2015.1045139
Antlerogenic stem cells: molecular features and potential in rabbit bone regeneration
N. Dabrowska (2016)
10.1002/cbin.10724
13cRA regulates the differentiation of antler chondrocytes through targeting Runx3
H. Zhang (2017)
Understanding Positional Information During Zebrafish Fin Regeneration
Gregory Thomas Nachtrab (2013)
10.1007/s11676-014-0542-2
Full length cDNA cloning and expression analysis of annexinA2 gene from deer antler tissue
Li Hao (2014)
Angiogenesis During Multi-tissue Regeneration Following Tail Loss in the Leopard Gecko (Eublepharis macularius)
Samantha L Payne (2012)
Regenerating the brain : lessons from the Red Spotted Newt
Daniel A. Berg (2012)
REGENERATING THE BRA IN : LESSONS FROM THE RED SPOTTED
D. Berg (2012)
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