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Trimethoprim, Creatinine And Creatinine-Based Equations

P. Delanaye, C. Mariat, E. Cavalier, N. Maillard, J. Krzesinski, C. White
Published 2011 · Medicine

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Co-trimoxazole is a frequently prescribed antibiotic worldwide. It is composed of both trimethoprim and sulfamethoxazol (Sfx) and is used in the treatment and prophylaxis of urinary tract and Pneumocystis jirovecii infections. The Sfx component appears to be nephrotoxic at high doses or doses inappropriately adjusted for glomerular filtration rate (GFR). The trimethoprim component, even at recommended doses, inhibits tubular creatinine secretion, leading to a rapid but ultimately reversible increase in serum creatinine independent of any changes in GFR. This translates into a falsely low estimated GFR when creatinine-based equations are used. This review focuses on evidence of the differential effects of trimethoprim and Sfx on serum creatinine concentrations and GFR and their relevance to clinical practice, with particular attention to kidney transplantation.
This paper references
Septrim/bactrim-reported adverse reactions, October 14, 1968–April
T Hanley (1969)
10.1001/jama.1980.03310040042025
Interstitial nephritis caused by trimethoprim-sulfamethoxazole in renal transplant recipients.
E. J. Smith (1980)
10.1002/cpt1978235553
Trimethoprim/sulfamethoxazole and renal function in transplant patients
R. Caterson (1978)
10.1093/NDT/GFM318
Chronic kidney disease stage in renal transplantation classification using cystatin C and creatinine-based equations.
C. White (2007)
10.1016/S0140-6736(79)90846-8
CO-TRIMOXAZOLE NEPHROTOXICITY
J. M. Richmond (1979)
Chronic kidney disease stage in renal transplantation classification using cystatin C and creatininebased equations
C White (2007)
[Serum creatinine concentration prior to and following trimethoprim-sulfamethoxazole (Bactrim) treatment].
Bonnie Horn (1974)
10.1016/S0140-6736(73)90251-1
Deterioration in renal function in association with co-trimoxazole therapy.
S. Kalowski (1973)
Kincaid-Smith P: Co-trimoxazole nephrotoxicity
JM Richmond (1979)
10.1111/j.1365-2125.1981.tb01293.x
The effect of co-trimoxazole on serum creatinine.
B. Dijkmans (1981)
10.1515/CCLM.2008.336
Cystatin C: current position and future prospects
S. Séronie-Vivien (2008)
10.1093/infdis/128.Supplement_3.S584
Absorption and urinary execretion of trimethoprim, sulfamethoxazole, and trimethoprim-sulfamethoxazole: results with single doses in normal young adults and preliminary observations during therapy with trimethoprim-sulfamethoxazole.
M. Bach (1973)
10.1016/S0140-6736(78)90486-5
EFFECT OF CO-TRIMOXAZOLE ON NORMAL CREATININE CLEARANCE
D. Shouval (1978)
following co-trimoxazole therapy
(1989)
10.1016/S0163-4453(80)90626-X
Co-trimoxazole, creatinine and renal function.
B. Trollfors (1980)
10.1111/j.1600-6143.2007.02117.x
Beta‐Trace Protein‐Based Equations for Calculation of GFR in Renal Transplant Recipients
U. Pöge (2008)
Septrim / bactrim - reported adverse reactions , October 14 , 1968 – April 14 , 1969
T Hanley (1969)
patients. Lancet 1984;i:1016–1017
JF Thompson (1984)
10.1093/ndt/gfq123
Creatinine-based GFR predicting equations in renal transplantation: reassessing the tubular secretion effect.
N. Maillard (2010)
10.2165/00003495-198223060-00001
Trimethoprim: A Review of its Antibacterial Activity, Pharmacokinetics and Therapeutic Use in Urinary Tract Infections
R. Brogden (1982)
Schweiz Med Wochenschr
(1974)
10.1023/B:PHAM.0000029286.45788.ad
Creatinine Transport by Basolateral Organic Cation Transporter hOCT2 in the Human Kidney
Y. Urakami (2004)
10.1007/BF00548773
Steady state pharmacokinetics of trimethoprim 300 mg once daily in healthy volunteers assessed by two independent methods
B. Odlind (1984)
10.1053/j.ajkd.2008.02.308
Performance of creatinine-based estimates of GFR in kidney transplant recipients: a systematic review.
C. White (2008)
Hyperkalaemia and non-oliguric renal failure associated with trimethoprim 52 KDIGO clinical practice guideline for the care of kidney transplant recipients
Gw Smith (1994)
10.1007/BF00542173
Pharmacokinetic study of the new sulfamethopyrazine-trimethoprim combination (kelfiprim) in renal insufficiency
Alberto Cantaluppi (1984)
10.1016/0006-2952(85)90721-X
Uptake of trimethoprim by renal cortex.
W. Cacini (1985)
10.1097/00007691-198706000-00006
Effect of Trimethoprim on Serum Creatinine in Healthy and Chronic Renal Failure Volunteers
S. Myre (1987)
10.1097/00007691-198204000-00011
Effect of Co‐trimoxazole and Sulfamethoxazole on Serum Creatinine in Normal Subjects
M. T. Roy (1982)
10.5694/j.1326-5377.1976.tb141169.x
Deterioration in renal function in association with co-trimoxazole therapy.
R. Bailey (1976)
10.1038/ki.2009.377
KDIGO clinical practice guideline for the care of kidney transplant recipients: a summary.
B. Kasiske (2010)
10.1128/AAC.15.3.447
Clinical Pharmacology of Intravenously Administered Trimethoprim-Sulfamethoxazole
W. Grose (1979)
10.1177/106002809302700518
Drug-Induced Alterations in Serum Creatinine Concentrations
E. Hartshorn (1993)
10.1093/infdis/128.Supplement_3.S556
Pharmacokinetics of trimethoprim and sulfamethoxazole in normal subjects and in patients with renal failure.
Peter G. Welling (1973)
Clinical Pharmacology ofIntravenously Administered Trimethoprim-Sulfamethoxazole
Tililoo (1979)
10.1016/S0140-6736(84)90444-6
ADVERSE EFFECT OF TRIMETHOPRIM ON KIDNEY FUNCTION IN RENAL TRANSPLANT PATIENTS
G. Nyberg (1984)
The treatment of gonorrhoea in women with sulphamethoxazole-trimethoprim.
C B S Schofield (1969)
10.1111/j.1749-6632.1957.tb49682.x
Clinical toxicity of sulfonamides.
D. Lehr (1957)
10.1021/jm01241a004
5-BENZYL-2,4-DIAMINOPYRIMIDINES AS ANTIBACTERIAL AGENTS. I. SYNTHESIS AND ANTIBACTERIAL ACTIVITY IN VITRO.
B. Roth (1962)
10.1093/oxfordjournals.qjmed.a067754
Drug associated acute interstitial nephritis: clinical and pathological features and the response to high dose steroid therapy.
C. D. Pusey (1983)
10.1093/jac/17.1.123-a
Effect of trimethoprim on serum creatinine in patients with acute cystitis.
T. Sandberg (1986)
10.1136/bmj.308.6926.454b
DRUG POINTS:Hyperkalaemia and non-oliguric renal failure associated with trimethoprim
G. Smith (1994)
10.1093/ndt/9.12.1845
Effect of co-trimoxazole on plasma creatinine concentrations in renal transplant recipients.
T A Odutola (1994)
10.5414/CNP72331
Trimethoprim-sulfamethoxazole induced acute interstitial nephritis in renal allografts; clinical course and outcome.
J P Garvey (2009)
10.1111/j.1748-1716.1961.tb02225.x
Urinary excretion patterns for substances with simultaneous secretion and reabsorption by active transport.
F. Berglund (1961)
10.1016/S0022-5347(17)58716-9
Re: Effect of Trimethoprim-Sulfamethoxazole on the Renal Excretion of Creatinine in Man, by Fredrik Berglund, Johan Killander and Rolf Pompeius, J. Urol., 114: 802, 1975
Stuart S. Howards (1976)
10.1159/000185711
Acute tubular necrosis following co-trimoxazole therapy.
T. Rudra (1989)
10.1159/000151436
Formula-Based Estimates of the GFR: Equations Variable and Uncertain
P. Delanaye (2008)
10.1016/S0025-6196(12)62509-9
Antimicrobial agents in adult patients with renal insufficiency: initial dosage and general recommendations.
R. Van Scoy (1987)
NEPHROTOXICITY OF TRIMETHOPRIM AND COTRIMOXAZOLE IN RENAL ALLOGRAFT RECIPIENTS TREATED WITH CYCLOSPORINE
Thomas W. Trull (1983)
Kreatininkonzentration im Serum vor und unter Behandlung mit Trimethoprim-Sulfamethoxazol (Bactrim)
B Horn (1974)
A prospective, randomized, double-blind study of trimethoprim-sulfamethoxazole for prophylaxis of infection in renal transplantation. Side effects of trimethoprim-sulfamethoxazole, interaction with cyclosporine.
D. Maki (1992)
10.1093/NDT/GFM708
Estimated glomerular filtration rate as an end point in kidney transplant trial: where do we stand?
C. Mariat (2008)
10.1016/S0022-5347(17)67149-0
Effect of trimethoprim-sulfamethoxazole on the renal excretion of creatinine in man.
F. Berglund (1975)
Letter: Drug interference with creatinine assay.
A. Bye (1976)
10.1016/0041-008X(81)90422-1
The influence of trimethoprim, sulfamethoxazole, and creatinine on renal organic anion and cation transport in rat kidney tissue.
J. Lee (1981)
10.1111/j.1600-6143.2009.02834.x
Special Issue: KDIGO Clinical Practice Guideline for the Care of Kidney Transplant Recipients
Supporting Tables (2009)
10.1111/j.1464-410X.1985.tb06340.x
The effect of trimethoprim on serum creatinine.
J. Kastrup (1985)
10.1038/ki.1985.205
Limitations of creatinine as a filtration marker in glomerulopathic patients.
O. Shemesh (1985)
10.1016/S0140-6736(84)92352-3
NEPHROTOXICITY BY CO-TRIMOXAZOLE AND CYCLOSPORIN IN TRANSPLANTED PATIENTS
O. Ringden (1984)
10.2215/CJN.05631207
A comparison of change in measured and estimated glomerular filtration rate in patients with nondiabetic kidney disease.
Da-wei Xie (2008)
10.1159/000185747
Renal effects of trimethoprim in ciclosporin- and azathioprine-treated kidney-allografted patients.
K. Berg (1989)
10.1001/ARCHINTE.163.4.402
Trimethoprim-sulfamethoxazole revisited.
Philip A. Masters (2003)
10.1373/clinchem.2009.135111
Estimating glomerular filtration rate in kidney transplantation: is the new chronic kidney disease epidemiology collaboration equation any better?
C. White (2010)
10.1128/AAC.41.11.2466
Effects of moderate-dose versus high-dose trimethoprim on serum creatinine and creatinine clearance and adverse reactions.
O. Naderer (1997)
Rapid onset of co-trimoxazole induced interstitial nephritis.
M. Chandra (1985)
10.1159/000237984
Effect of co-trimoxazole on the glomerular filtration rate of healthy adults.
G. Kainer (1981)
10.1159/000167666
Acute granulomatous interstitial nephritis due to co-trimoxazole.
C. Cryst (1988)
Letter: Effect of trimethoprim sulfamethoxazole on the renal excretion of creatinine in man.
Stuart S. Howards (1976)
Letter: drug interference with creati
A Bye (1975)
10.1016/S0140-6736(75)92196-0
USE OF CO-TRIMOXAZOLE IN CHRONIC RENAL FAILURE
P. Tasker (1975)



This paper is referenced by
10.1002/JHET.3135
Synthesis, Tautomerism, and Antiradical Activity of Novel Pteridinetrione Derivatives
M. S. Kazunin (2018)
The Effect of Co-Trimoxazole on Serum Potassium Concentration : Safety Evaluation of a Randomised Controlled Trial Running Title : Effect of Co-Trimoxazole on Serum Potassium
Wei Yee Chan (2017)
10.1093/ndt/gfv026
Population-based dose-response curve of glomerular filtration rate to dietary protein intake.
M. Cirillo (2015)
10.1007/978-1-4939-9034-4
Principles and Practice of Transplant Infectious Diseases
A. Safdar (2019)
10.1093/ndt/gfs001
Cystatin C in HIV-infected patients: promising but not yet ready for prime time.
A. Gagneux-Brunon (2012)
10.1111/bcp.13263
The effect of co‐trimoxazole on serum potassium concentration: safety evaluation of a randomized controlled trial
Wei Yee Chan (2017)
10.4285/JKSTN.2018.32.4.92
Proposal of a Selective Prophylaxis Strategy Based on Risk Factors to Prevent Early and Late Pneumocystis jirovecii Pneumonia after Renal Transplantation
Ho Lee (2018)
10.1016/j.jiac.2019.01.005
Efficacies of atovaquone, pentamidine, and trimethoprim/sulfamethoxazole for the prevention of Pneumocystis jirovecii pneumonia in patients with connective tissue diseases.
T. Kitazawa (2019)
10.3810/pgm.2014.05.2765
Anti-Diabetes Therapy: Safety Considerations for Patients With Impaired Kidney Function
J. McGill (2014)
10.1515/cclm-2018-0900
Impact of interactions between drugs and laboratory test results on diagnostic test interpretation – a systematic review
Jasmijn A. van Balveren (2018)
Revisiting co-trimoxazole for the treatment of tuberculosis
Noor Alsaad (2016)
10.2215/CJN.06470614
Estimating GFR in adult patients with hematopoietic cell transplant: comparison of estimating equations with an iohexol reference standard.
S. Hingorani (2015)
10.1159/000469669
Serum Creatinine: Not So Simple!
P. Delanaye (2017)
Protein intake and kidney function in the middle-age population : contrast between cross-sectional and longitudinal data
M. Torres-Salido (2014)
Dried Blood Spot Analysis for Therapeutic Drug Monitoring of Co-trimoxazole in Patients with Tuberculosis
Dijkstra (2018)
10.1093/ndt/gfu056
Protein intake and kidney function in the middle-age population: contrast between cross-sectional and longitudinal data.
M. Cirillo (2014)
10.1053/j.ajkd.2013.03.030
Tubular secretion of creatinine in autosomal dominant polycystic kidney disease: consequences for cross-sectional and longitudinal performance of kidney function estimating equations.
E. M. Spithoven (2013)
10.1007/s00467-013-2651-0
The interplay between drugs and the kidney in premature neonates
M. Schreuder (2013)
10.21037/JLPM.2018.08.01
Serum creatinine: advantages and pitfalls
A. Bargnoux (2018)
10.1097/TP.0b013e318288caa6
MDRD Versus CKD-EPI Equation to Estimate Glomerular Filtration Rate in Kidney Transplant Recipients
I. Masson (2013)
10.1002/9781118705308.CH23
Regulatory Science Perspectives on Transporter Studies in Drug Development
S. Lee (2014)
10.1159/000484956
Acute Kidney Injury: Diagnosis and Classification in Adults and Children.
Zaccaria Ricci (2018)
10.1111/nep.12201
Complications and outcomes of trimethoprim-sulphamethoxazole as chemoprophylaxis for pneumocystis pneumonia in renal transplant recipients.
N. Mitsides (2014)
10.3390/jcm8060781
Utilizing the Patient Care Process to Minimize the Risk of Vancomycin-Associated Nephrotoxicity
Ashley Selby (2019)
10.1093/ndt/gfv009
Chronic kidney disease and the risk of stroke: a systematic review and meta-analysis.
P. Masson (2015)
10.1111/ajt.14498
Taking the challenge: A protocolized approach to optimize Pneumocystis pneumonia prophylaxis in renal transplant recipients
K. Urbancic (2018)
10.1136/bmj.i679
Autosomal dominant polycystic kidney disease
R. Simms (2016)
10.1080/14787210.2017.1379395
Diagnostic challenges of kidney diseases in HIV-infected patients
R. Chazot (2017)
10.7573/dic.2019-11-1
HIV, drugs and the kidney
N. Wearne (2020)
10.1016/j.addr.2017.07.020
Evaluation of transporters in drug development: Current status and contemporary issues☆
Sue-Chih Lee (2017)
10.1111/1751-2980.12132
A randomized controlled study of trimethoprim‐sulfamethoxazole versus norfloxacin for the prevention of infection in cirrhotic patients
S. Lontos (2014)
Translational renal genetics
Anna I. Reznichenko (2012)
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