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Effects Of Human Recombinant Macrophage Colony-stimulating Factor On The Secretion Of Lipoprotein Lipase From Macrophages.
N. Mori, T. Gotoda, S. Ishibashi, H. Shimano, K. Harada, T. Inaba, F. Takaku, Y. Yazaki, N. Yamada
Published 1991 · Biology, Medicine
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The effects of human recombinant macrophage colony-stimulating factor (M-CSF) on the secretion of lipoprotein lipase were studied in rat alveolar macrophages. Five nanograms per milliliter M-CSF significantly enhanced lipoprotein lipase secretion (threefold), and the maximal effect (10-fold) of M-CSF on lipoprotein lipase secretion was observed at a dose of 200 ng/ml M-CSF. The effect of M-CSF was time dependent but was not manifested during the first 8 hours of incubation. After 24 hours, its effects were evident and dose dependent. On blot hybridization of macrophage RNAs with human cDNA of lipoprotein lipase, a remarkable and dose-dependent increase in mRNA level (7.3-fold) was found in M-CSF-treated alveolar macrophages. The secretion of lipoprotein lipase was also enhanced in human monocyte-derived macrophages (2.6-fold), whereas the secretion from either THP-1 cells, P388 cells, or J774 cells was not significantly enhanced. These results indicate that the stimulation of lipoprotein lipase secretion after M-CSF treatment was evident in rat alveolar macrophages and human monocyte-derived macrophages on the basis of both enzyme activity and mRNA level; therefore, M-CSF may be involved in lipoprotein metabolism of macrophages through modulation of the secretion of lipoprotein lipase.
This paper references
Secretion of lipoprotein lipase by macrophages in culture.
J. C. Khoo (1981)
The c-fms proto-oncogene product is related to the receptor for the mononuclear phagocyte growth factor, CSF 1
C. Sherr (1985)
Macrophage colony-stimulating factor enhances the expression of Fc receptors on murine peritoneal macrophages.
D. M. Magee (1987)
Beyond cholesterol. Modifications of low-density lipoprotein that increase its atherogenicity.
D. Steinberg (1989)
The cfms proto - oncogene product is related to the receptor for the mononuclear phagocyte growth factor , CSF1
CJ Sherr (1985)
Stimulation of macrophage antibody-dependent killing of tumor targets by recombinant lymphokine factors and M-CSF.
I. Nakoinz (1988)
Effects of insulin on lipoprotein lipase activity in the rat heart and adipose tissue.
J. Borensztajn (1972)
Transcriptional activation of the lipoprotein lipase gene in macrophages by dexamethasone.
W. S. Domin (1991)
A stable, radioactive substrate emulsion for assay of lipoprotein lipase.
P. Nilsson-ehle (1976)
The human hematopoietic colony-stimulating factors.
S. Clark (1987)
Necessary and sufficient conditions for recruitment of macrophages into the cell cycle.
S. Dienstman (1978)
Enhanced lipoprotein lipase secretion from human monocyte-derived macrophages caused by hypertriglyceridemic very low density lipoproteins.
S. Ishibashi (1989)
Control of lipoprotein lipase secretion in mouse macrophages.
R. Goldman (1989)
Molecular cloning of a complementary DNA encoding human macrophage-specific colony-stimulating factor (CSF-1).
E. Kawasaki (1985)
Lipoprotein lipase in mouse peritoneal macrophages: the effects of insulin and dexamethasone.
M. Kawakami (1986)
Inhibition of TPA-induced monocytic differentiation in THP-1 human monocytic leukemic cells by staurosporine, a potent protein kinase C inhibitor.
N. Barendsen (1990)
Protein measurement with the Folin phenol reagent.
O. H. Lowry (1951)
Factors regulating the activities of the low density lipoprotein receptor and the scavenger receptor on human monocyte-macrophages.
A. Fogelman (1981)
Regulation of the secretion of lipoprotein lipase by mouse macrophages.
S. Behr (1986)
Lipoprotein lipase activity in cultured macrophage cell line J774(2) and its increase in variants deficient in adenylate cyclase and cyclic AMP-dependent protein kinase.
R. Melmed (1983)
NV: Antibody-dependent antitumor cytotoxicity by human monocytes cultured with recombinant macrophage colony-stimulating factor
DH Munn (1989)
The role of lipoprotein lipase in the metabolism of triglyceride-rich lipoproteins by macrophages.
P. Lindqvist (1983)
The reciprocal regulation of lipoprotein lipase activity and hormone-sensitive lipase activity in rat adipocytes.
R. Patten (1970)
Purification of mouse immunoglobulin heavy-chain messenger RNAs from total myeloma tumor RNA.
C. Auffray (1980)
Quantitative determination of serum triglycerides by the use of enzymes.
G. Bucolo (1973)
Human monocyte colony-stimulating factor enhances the clearance of lipoproteins containing apolipoprotein B-100 via both low density lipoprotein receptor-dependent and -independent pathways in rabbits.
H. Shimano (1990)
Monocyte colony-stimulating factor enhances uptake and degradation of acetylated low density lipoproteins and cholesterol esterification in human monocyte-derived macrophages.
S. Ishibashi (1990)
Human CSF-1: molecular cloning and expression of 4-kb cDNA encoding the human urinary protein.
G. Wong (1987)
High-cholesterol diet-induced lipoproteins stimulate lipoprotein lipase secretion in cultured rat alveolar macrophages.
N. Mori (1987)
Macrophage growth factor CSF-1 stimulates human monocyte production of interferon, tumor necrosis factor, and colony stimulating activity.
M. K. Warren (1986)
Effect of nutritional status on rat adipose tissue, muscle and post-heparin plasma clearing factor lipase activities: their relationship to triglyceride fatty acid uptake by fat-cells and to plasma insulin concentrations.
A. Cryer (1976)
Enzymatic determination of total serum cholesterol.
C. Allain (1974)
Modulation of colony-stimulating factor-1 receptors on macrophages by tumor necrosis factor.
J. H. Shieh (1989)
Lipoprotein lipase secretion by human monocyte-derived macrophages.
A. Chait (1982)
Apolipoprotein E and lipoprotein lipase secreted from human monocyte-derived macrophages modulate very low density lipoprotein uptake.
S. Ishibashi (1990)
Human monocytes in culture synthesize and secrete lipoprotein lipase.
P. Wang-Iverson (1982)
A new enzymatic method for determination of serum choline-containing phospholipids.
M. Takayama (1977)
Bacterial lipopolysaccharide suppresses the expression of lipoprotein lipase in murine macrophages: a process independent of tumor necrosis factor or interleukin 1.
O. Sopher (1987)
Antibody-dependent antitumor cytotoxicity by human monocytes cultured with recombinant macrophage colony-stimulating factor. Induction of efficient antibody-mediated antitumor cytotoxicity not detected by isotope release assays
D. Munn (1989)
Factors regulating macrophage production and growth. Purification and some properties of the colony stimulating factor from medium conditioned by mouse L cells.
E. R. Stanley (1977)
Serum cholesterol-lowering activity of granulocyte-macrophage colony-stimulating factor.
S. Nimer (1988)
Lipoprotein lipase activity in cultured macrophage cell line J7742 and its increase in variants deficient in adenylate cyclase and cyclic AMP-dependent protein kinase
R. Melmed (1983)
A simple, rapid, and sensitive DNA assay procedure.
C. Labarca (1980)
MAS: Modulation of colony-stimulating factor-1 receptors on macrophages by tumor necrosis factor
J Shieh (1989)
Stimulatory effects of purified macrophage colony-stimulating factor on murine resident peritoneal macrophages.
N. Ampel (1986)
The hemopoietic colony stimulating factors
D. Metcalf (1984)
SERUM CHOLESTEROL-LOWERING ACTIVITY OF HUMAN MONOCYTIC COLONY-STIMULATING FACTOR
K. Motoyoshi (1989)
Regulation of lipoprotein lipase. Induction by insulin.
A. S. Garfinkel (1976)
This paper is referenced by
Effects of CSF-1 on cholesterol accumulation and efflux by macrophages.
W. Jessup (1997)
Effects of platelet-derived growth factor on the synthesis of lipoprotein lipase in human monocyte-derived macrophages.
T. Inaba (1995)
Induction of LDL receptor-related protein during the differentiation of monocyte-macrophages. Possible involvement in the atherosclerotic process.
Y. Watanabe (1994)
Lipoprotein lipase synergizes with interferon gamma to induce macrophage nitric oxide synthetase mRNA expression and nitric oxide production.
G. Renier (1995)
A Novel Role of Sp1 and Sp3 in the Interferon-γ-mediated Suppression of Macrophage Lipoprotein Lipase Gene Transcription*
T. Hughes (2002)
Impact of monocyte colony-stimulating factor upon beta-very low density lipoprotein (beta-VLDL) cholesterol metabolism in tetradecanoyl phorbol acetate-derived THP-1 cells.
I. Ishii (1994)
Transcriptional activation of the macrophage-colony stimulating factor gene by minimally modified LDL. Involvement of nuclear factor-kappa B.
T. Rajavashisth (1995)
Heterozygous osteopetrotic (op) mutation reduces atherosclerosis in LDL receptor- deficient mice.
T. Rajavashisth (1998)
Overexpression of Apolipoprotein E Prevents Development of Diabetic Hyperlipidemia in Transgenic Mice
K. Yamamoto (1995)
Physiological regulation of lipoprotein lipase.
S. Kersten (2014)
The pivotal role of lipoprotein lipase in atherosclerosis.
J. R. Mead (2002)
Role of oxidant injury on macrophage lipoprotein lipase (LPL) production and sensitivity to LPL.
G. Renier (1996)
Lipoprotein lipase, a key role in atherosclerosis?
J. R. Mead (1999)
Lipoprotein lipase: structure, function, regulation, and role in disease
J. R. Mead (2002)
Design of the START-trial: STimulation of ARTeriogenesis using subcutaneous application of GM-CSF as a new treatment for peripheral vascular disease. A randomized, double-blind, placebo-controlled trial
N. van Royen (2003)
Lipoprotein lipase: recent contributions from molecular biology.
J. Auwerx (1992)
Lipoprotein lipase: the regulation of tissue specific expression and its role in lipid and energy metabolism
Karina Preiss-Landl (2002)
Potent cholesterol-lowering effect by human granulocyte-macrophage colony-stimulating factor in rabbits. Possible implications of enhancement of macrophage functions and an increase in mRNA for VLDL receptor.
T. Ishibashi (1994)
Decrease in scavenger receptor expression in human monocyte-derived macrophages treated with granulocyte macrophage colony-stimulating factor.
M. A. van der Kooij (1996)
Role of Macrophage Colony‐Stimulating Factor in the Initial Process of Atherosclerosis
Y. Watanabe (1995)
Human Granulocyte‐Macrophage Colony‐Stimulating Factor Lowers the Levels of Plasma Cholesterol with an Increase in mRNA for Very Low Density Lipoprotein Receptor in Rabbits a
T. Ishibashi (1995)
Macrophage colony-stimulating factor regulates both activities of neutral and acidic cholesteryl ester hydrolases in human monocyte-derived macrophages.
T. Inaba (1993)
Global mRNA sequencing of human skeletal muscle: Search for novel exercise-regulated myokines
S. Pourteymour (2017)
Independent Regulation of Cholesterol Incorporation into Free Apolipoprotein-mediated Cellular Lipid Efflux in Rat Vascular Smooth Muscle Cells (*)
Q. Li (1995)
Immunological mechanisms in atherosclerosis
T. Yokota (1995)
Effects of granulocyte-macrophage colony-stimulating factor on the levels of VLDL and LDL receptor mRNAs in vivo.
T. Ishibashi (1996)