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High Macrophage Lipoprotein Lipase Expression And Secretion Are Associated In Inbred Murine Strains With Susceptibility To Atherosclerosis.

G. Renier, E. Skamene, J. Desanctis, D. Radzioch
Published 1993 · Biology, Medicine

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To test the possibility that variations in macrophage lipoprotein lipase (LPL) secretion may constitute one of the hereditary components of atherosclerosis, we evaluated LPL gene expression and secretion in macrophages harvested from inbred mouse strains differing in their susceptibility to the diet-induced development of atherosclerosis. Inflammatory peritoneal macrophages harvested from atherosclerosis-susceptible C57BL/6J mice showed twofold to threefold higher basal LPL mass, activity, and mRNA levels than those isolated from atherosclerosis-resistant C3H/HeN mice. We determined LPL secretion and gene expression in the susceptible C57BL/6J (B), resistant A/J (A), and A x B/B x A recombinant inbred strains of mice typed as atherosclerosis resistant (A-like) or atherosclerosis susceptible (B-like). Macrophage LPL secretion and mRNA expression were twofold higher in the susceptible C57BL/6J (B) mice than in the resistant A/J (A) mice. Significantly higher LPL secretion, activity, and gene expression were found in recombinant inbred mouse strains that typed B-like than in those typed A-like. These results indicate that susceptibility to atherosclerosis is associated in inbred mouse strains with high LPL secretion and mRNA levels, whereas lower LPL secretion and mRNA expression are observed in atherosclerosis-resistant mice. These observations suggest a contributive role for LPL in the development of atherosclerosis.
This paper references
Genetic and developmental regulation of the lipoprotein lipase gene: loci both distal and proximal to the lipoprotein lipase structural gene control enzyme expression.
T. Kirchgessner (1989)
Secretion of lipoprotein lipase by macrophages in culture.
J. C. Khoo (1981)
Effect of cholesterol feeding on arterial lipolytic activity in the rabbit.
J. Corey (1977)
Macrophages and smooth muscle cells express lipoprotein lipase in human and rabbit atherosclerotic lesions.
S. Ylä-Herttuala (1991)
Serum cholesterol lipoproteins and risk of coronary disease: The Framingham Study
W Kannel (1971)
Inbred mice and their hypbrids as an animal model for atherosclerosis research.
A. Roberts (1976)
The cholesteryl ester cycle in macrophage foam cells. Continual hydrolysis and re-esterification of cytoplasmic cholesteryl esters.
M. Brown (1980)
Schotz MC: Evidence for independent genetic regulation of heart and adipose lipoprotein lipase activity
O Ben-Zeev (1983)
Serum cholesterol, lipoproteins, and the risk of coronary heart disease. The Framingham study.
W. Kannel (1971)
A stable, radioactive substrate emulsion for assay of lipoprotein lipase.
P. Nilsson-ehle (1976)
Genetically determined susceptibility and resistance to diet-induced atherosclerosis in inbred strains of mice.
J. Stewart-Phillips (1988)
ATH-3, a new gene for atherosclerosis in the mouse.
J. Stewart-Phillips (1989)
dence for independent genetic regulation of heart and adipose lipoprotein lipase activity
O Ben-Zeev (1983)
Ath-2, a second gene determining atherosclerosis susceptibility and high density lipoprotein levels in mice.
B. Paigen (1989)
Genetic control of lipid transport in mice. II. Genes controlling structure of high density lipoproteins.
A. Lusis (1983)
Metabolism of the arterial wall and atherosclerosis
RW St. Clair (1976)
Atherosclerosis susceptibility differences among progenitors of recombinant inbred strains of mice.
B. Paigen (1990)
Hybridization of denatured RNA and small DNA fragments transferred to nitrocellulose.
P. Thomas (1980)
Kinetics of product inhibition and mechanisms of lipoprotein lipase activation by apolipoprotein C-II.
I. Posner (1987)
Genetic factors controlling structure and expression of apolipoproteins B and E in mice.
A. Lusis (1987)
Endocytic and Secretory Repertoire of the Lipid‐Loaded Macrophage
R. R. Montgomery (1989)
Arterial foam cells with distinctive immunomorphologic and histochemical features of macrophages.
T. Schaffner (1980)
Cholesteryl ester accumulation in macrophages resulting from receptor-mediated uptake and degradation of hypercholesterolemic canine beta-very low density lipoproteins.
J. Goldstein (1980)
Control of Lipoprotein Lipase Secretion by Macrophages: Effect of Macrophage Differentiation Agents
R. Goldman (1990)
Evidence for independent genetic regulation of heart and adipose lipoprotein lipase activity.
O. Ben-Zeev (1983)
Synthesis and regulation of lipoprotein lipase in the hippocampus.
O. Ben-Zeev (1990)
Antibody against human lipoprotein lipase.
J. Etienne (1987)
ZuVersmit DB: Effect of cholesterol feeding on arterial lipOtytic activity in the rabbit
JE Corey (1977)
Production and use of an inhibitory monoclonal antibody to human lipoprotein lipase.
I. Goldberg (1986)
Ath-1, a gene determining atherosclerosis susceptibility and high density lipoprotein levels in mice.
B. Paigen (1987)
Characterization of lipid-laden aortic cells from cholesterol-fed rabbits. IV. Investigation of macrophage-like properties of aortic cell populations.
S. Fowler (1979)
The role of lipoprotein lipase in the metabolism of triglyceride-rich lipoproteins by macrophages.
P. Lindqvist (1983)
[Genetic aspects of arteriosclerosis].
I. Shkhvatsabaia (1975)
Lipoprotein lipase secretion by human monocytes and rabbit alveolar macrophages in culture.
E. Mahoney (1982)
Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease.
J. Chirgwin (1979)
Effects of cytokines on the production of lipoprotein lipase in cultured human macrophages.
U. Querfeld (1990)
Dietary induced atherogenesis in swine. Morphology of the intima in prelesion stages.
R. Gerrity (1979)
An enzyme-linked immunoassay for lipoprotein lipase.
J. Goers (1987)
Modulation of lipoprotein lipase activity in mouse peritoneal macrophages by recombinant human tumor necrosis factor.
G. Friedman (1988)

This paper is referenced by
Lipoprotein lipase increases lipoprotein binding to the artery wall and increases endothelial layer permeability by formation of lipolysis products.
J. Rutledge (1997)
A critical role for the Sp1-binding sites in the transforming growth factor-β-mediated inhibition of lipoprotein lipase gene expression in macrophages
S. A. Irvine (2005)
Lipoprotein lipase-dependent binding and uptake of low density lipoproteins by THP-1 monocytes and macrophages: possible involvement of lipid rafts.
E. Makoveichuk (2004)
Tetrahydrocurcumin: Beneficial Effects on HMG-CoA Reductase enzyme and Lipoprotein Lipase Enzymes in High-fat diet-induced Hypercholesteremia Rabbits
Gopinathanpillai Prasanth Kalavarasariel (2012)
Upregulation of Macrophage Endothelial Lipase by Toll-Like Receptors 4 and 3 Modulates Macrophage Interleukin-10 and -12 Production
X. Wang (2007)
The emergence of mouse models of atherosclerosis and their relevance to clinical research
J. Smith (1997)
Pathogenesis of Atherosclerotic Vascular Disease
B. J. Basha (2005)
Plasma and vessel wall lipoprotein lipase have different roles in atherosclerosis.
S. M. Clee (2000)
Lipoprotein Lipase Reduces Secretion of Apolipoprotein E from Macrophages*
M. Lucas (1997)
Lipoprotein lipase: from gene to atherosclerosis.
Y. Li (2014)
Low atherosclerotic response of a strain of rabbits to diet-induced hypercholesterolemia.
J. Thiery (1995)
High-Energy Diets, Fatty Acids and Endothelial Cell Function: Implications for Atherosclerosis
B. Hennig (2001)
Injury produces early rise in lipoprotein lipase activity in rabbit aorta.
J. P. Werba (1996)
Estudio comparativo de características metabólicas del m. Gluteus medius en equinos y bovinos
N. Hernández (2004)
Prostaglandins, Leukotrienes and Essential Fatty Acids
T. Hamazaki (2013)
Lipoprotein lipase: structure, function, regulation, and role in disease
J. R. Mead (2002)
Lipoprotein lipase, a key role in atherosclerosis?
J. R. Mead (1999)
Lipopolysaccharide regulation of lipoprotein lipase expression in murine macrophages.
M. Hill (1995)
Lipoprotein lipase correlates positively and hepatic lipase inversely with calcific atherosclerosis in homozygous familial hypercholesterolemia.
K. Dugi (1997)
Estudi de la lipoproteïna lipasa mitjançant eines proteòmiques. Possible participació de l'òxid nítric en la seva regulació
A. Torrequebrada (2009)
Proliferative Effect of Lipoprotein Lipase on Human Vascular Smooth Muscle Cells
J. Mamputu (2000)
Regulated expression of endothelial cell-derived lipase.
K. Hirata (2000)
Correction of hypertriglyceridemia and impaired fat tolerance in lipoprotein lipase-deficient mice by adenovirus-mediated expression of human lipoprotein lipase.
K. J. Excoffon (1997)
Effects of the heparin-mimicking compound RG-13577 on lipoprotein lipase and on lipase mediated binding of LDL to cells.
L. Neuger (2001)
Metabolism and Modification of Apolipoprotein B-Containing Lipoproteins Involved in Dyslipidemia and Atherosclerosis.
S. Morita (2016)
Induction of tumor necrosis factor alpha gene expression by lipoprotein lipase.
G. Renier (1994)
Binding of Low Density Lipoproteins to Lipoprotein Lipase Is Dependent on Lipids but Not on Apolipoprotein B*
J. Borén (2001)
Automated measurement of mouse apolipoprotein B: convenient screening tool for mouse models of atherosclerosis.
D. Levine (1997)
Direct regulatory effect of fatty acids on macrophage lipoprotein lipase: potential role of PPARs.
S. E. Michaud (2001)
Induction of tumor necrosis factor alpha gene expression by lipoprotein lipase requires protein kinase C activation.
G. Reiner (1994)
Gene-based therapeutic strategies for Human Lipoprotein Lipase (LPL) deficiency: Rationale and prospects for alteration of atherogenic risk
M. S. Lewis (1996)
Lipoprotein lipase and lipolysis: central roles in lipoprotein metabolism and atherogenesis.
I. Goldberg (1996)
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