Relationship Between Neointimal Thickness And Shear Stress After Wallstent Implantation In Human Coronary Arteries
J J Wentzel, Rob Krams, Johan C. H. Schuurbiers, Jan A. Oomen, Jeroen de Kloet, Wim J. van der Giessen, Patrick W. Serruys, C. T. J. Slager
Published 2001 · Medicine
Download PDFAnalyze on Scholarcy
BackgroundIn-stent restenosis by excessive intimal hyperplasia reduces the long-term clinical efficacy of coronary stents. Because shear stress (SS) is related to plaque growth in atherosclerosis, we investigated whether variations in SS distribution are related to variations in neointima formation. Methods and ResultsIn 14 patients, at 6-month follow-up after coronary Wallstent implantation, 3D stent and vessel reconstruction was performed with a combined angiographic and intravascular ultrasound technique (ANGUS). The bare stent reconstruction was used to calculate in-stent SS at implantation, applying computational fluid dynamics. The flow was selected to deliver an average SS of 1.5 N/m2. SS and neointimal thickness (Th) values were obtained with a resolution of 90° in the circumferential and 2.5 mm in the longitudinal direction. For each vessel, the relationship between Th and SS was obtained by linear regression analysis. Averaging the individual slopes and intercepts of the regression lines summarized the overall relationship. Average Th was 0.44±0.20 mm. Th was inversely related to SS: Th=(0.59±0.24)−(0.08±0.10)×SS (mm) (P <0.05). ConclusionsThese data show for the first time in vivo that the Th variations in Wallstents at 6-month follow-up are inversely related to the relative SS distribution. These findings support a hemodynamic mechanism underlying in-stent neointimal hyperplasia formation.
This paper references
In-stent neointimal proliferation correlates with the amount of residual plaque burden outside the stent: an intravascular ultrasound study.
Francesco Prati (1999)
Stent-induced intimal hyperplasia: are there fundamental differences between flexible and rigid stent designs?
Arthur B. Fontaine (1994)
Six-month clinical and angiographic outcome of the new, less shortening Wallstent in native coronary arteries.
Yukio Ozaki (1996)
Wentzel et al Neointimal Thickness and Shear Stress
Image segmentation and 3-D reconstruction of intravascular ultrasound
W Li (1993)
Effects of the non-Newtonian viscosity of blood on flows in a diseased arterial vessel. Part 1: Steady flows.
Young I. Cho (1991)
True 3-dimensional reconstruction of coronary arteries in patients by fusion of angiography and IVUS (ANGUS) and its quantitative validation.
C. T. J. Slager (2000)
Stent Restenosis Study Investigators. A randomized comparison of coronary stent placement and balloon angioplasty in the treatment of coronary artery disease
D Fischman (1994)
Arterial adaptations to altered blood flow.
Richard D. Brownlee (1991)
Long-term endothelial dysfunction is more pronounced after stenting than after balloon angioplasty in porcine coronary arteries.
Heleen M. M. van Beusekom (1998)
Analysis of Changes in Reactivity of Rabbit Arteries and Veins Two Weeks after Induction of Hypertension by Coarctation of the Abdominal Aorta
John Althorp Bevan (1975)
Quantitative angiographic follow-up of the coronary Wallstent in native vessels and bypass grafts (European experience--March 1986 to March 1990).
B H Strauss (1992)
for the Stent Restenosis Study Investigators. A randomized comparison of coronary stent placement and balloon angioplasty in the treatment of coronary artery disease
D Fischman (1994)
Finite Element Methods and Navier-Stokes Equations
C. Cuvelier (1986)
A randomized comparison of coronary-stent placement and balloon angioplasty in the treatment of coronary artery disease. Stent Restenosis Study Investigators.
David L Fischman (1994)
Effects of the non-Newtonian viscosity of blood on flows in a diseased arterial vessel, part I: steady flows. Biorheology
YI Cho (1991)
Shear stress regulation of artery lumen diameter in experimental atherogenesis.
Christopher K. Zarins (1987)
Image segmentation and 3 - D reconstruction of intravascular ultrasound images
Investigation of endogenous nitric oxide vascular function in the carotid artery of cholesterol-fed rabbits.
David W. Laight (1996)
Chronic endothelin receptor antagonism preserves coronary endothelial function in experimental hypercholesterolemia.
Patricia J. M. Best (1999)
Endogenous cell seeding. Remnant endothelium after stenting enhances vascular repair.
C Rogers (1996)
Neointima formation following arterial placement of self-expanding stents of different radial force: Experimental results
Dierk Vorwerk (1994)
Low shear stress promotes intimal hyperplasia thickening
The Abdus Salam (1996)
Evaluation of endothelial shear stress and 3D geometry as factors determining the development of atherosclerosis and remodeling in human coronary arteries in vivo. Combining 3D reconstruction from angiography and IVUS (ANGUS) with computational fluid dynamics.
Rob Krams (1997)
Coronary stent implantation changes 3-D vessel geometry and 3-D shear stress distribution.
J J Wentzel (2000)
Increased blood flow inhibits neointimal hyperplasia in endothelialized vascular grafts.
Ted R. Kohler (1991)
Hemodynamic shear stress and its role in atherosclerosis.
Adel M. Malek (1999)
A comparison of balloonexpandable-stent implantation with balloon angioplasty in patients with coronary artery disease
P Serruys (1994)
Patterns and mechanisms of in-stent restenosis. A serial intravascular ultrasound study.
Rainer Hoffmann (1996)
Effects of changes in blood flow rate on cell death and cell proliferation in carotid arteries of immature rabbits.
Ari Cho (1997)
Relationship between plaque mass and neointimal hyperplasia after stent placement in Yucatan micropigs.
Bart Jgl de Smet (1997)
This paper is referenced by
Increased Plasmin and Serine Proteinase Activity During Flow-Induced Intimal Atrophy in Baboon PTFE Grafts
Richard D Kenagy (2002)
A Numerical Methodology to Fully Elucidate the Altered Wall Shear Stress in a Stented Coronary Artery
Etude de l'Ecoulement Sanguin dans des Fistules Arterio-Veineuses Reconstruites à Partir d'Images Médicales.
Zaher Kharboutly (2007)
Conformability in everolimus-eluting bioresorbable scaffolds compared with metal platform coronary stents in long lesions
Jiang Ming Fam (2017)
Difference in haemodynamic microenvironment in vessels scaffolded with Absorb BVS and Mirage BRMS: insights from a preclinical endothelial shear stress study.
Erhan Tenekecioglu (2017)
Alterations in regional vascular geometry produced by theoretical stent implantation influence distributions of wall shear stress: analysis of a curved coronary artery using 3D computational fluid dynamics modeling
John F. LaDisa (2006)
[Role of shear stress in atherosclerosis and restenosis after coronary stent implantation].
Rosaire Mongrain (2006)
Use of myocardial fractional flow reserve to identify predictors of poor prognosis after percutaneous coronary interventions
Marcelo Bastos Brito (2013)
Modificações na angulação coronária após implante de suporte vascular bioabsorvível e de stents de cromo-cobalto e aço inoxidável
Mateus Veloso e Silva (2013)
Selection of coronary stents.
Antonio Colombo (2002)
A comparison of the conformability of everolimus-eluting bioresorbable vascular scaffolds to metal platform coronary stents.
Josep Gómez-Lara (2010)
Swirling Flow Can Suppress Flow Disturbances in Endovascular Stents: A Numerical Study
Zengsheng Chen (2009)
The effect of shear stress on the onset and progression of atheromatous disease and on restenosis following transluminal therapies.
Michail I. Papafaklis (2005)
In vivo validation of CAAS QCA-3D coronary reconstruction using fusion of angiography and intravascular ultrasound (ANGUS).
Johan C. H. Schuurbiers (2009)
Two-year vessel healing after everolimus-eluting stent implantation: serial assessment by optical coherence tomography.
Yu Taniguchi (2015)
From Histology and Imaging Data to Models for In-Stent Restenosis
C. M. Amatruda (2014)
Computational modeling of arterial biomechanics
David A. Vorp (2001)
Changes in intraarticular pressure on the blood supply in the retinaculum of the femoral neck.
Jiong Mei (2019)
[The role of haemodynamic factors in the development of in-stent restenosis].
Jarosław P. Wasilewski (2012)
High-intensity Interval Training after Percutaneous Coronary Intervention
Peter Scott Munk (2010)
Quantitative Analysis of Stenting Effects on Cellular Response
Nii Armah Armah (2015)
Blood Flow and Arterial Disease
Nicolaas Westerhof (2010)
Invasive or non-invasive imaging for detecting high-risk coronary lesions?
Kush Patel (2017)
Impact of bifurcation dual stenting on endothelial shear stress.
Henry Y. Chen (2015)
Frontiers in intravascular imaging technologies.
Yasuhiro Honda (2008)
Estudio hemodinámico de diferentes técnicas de tratamiento de bifurcaciones coronarias: Modelo experimental y matemático
Fernández Díaz (2017)
Tribological Characteristics of Human Vascular Smooth Muscle Cells: The Implication of Disease State on Friction
Emily Clark (2020)
Pattern of instent neointimal formation compared to native atherosclerosis in the coronary bifurcation lesions: volumetric intravascular ultrasound analysis
Jianqiang Xu (2013)
Tissue coverage of a hydrophilic polymer-coated zotarolimus-eluting stent vs. a fluoropolymer-coated everolimus-eluting stent at 13-month follow-up: an optical coherence tomography substudy from the RESOLUTE All Comers trial
Juan Luis Gutiérrez-Chico (2011)
The effects of stenting on shear stress: relevance to endothelial injury and repair.
Kim van der Heiden (2013)
Luminal Flow Amplifies Stent-Based Drug Deposition in Arterial Bifurcations
Vijaya B. Kolachalama (2009)
Influencia de la tensión de cizallamiento en la reestenosis intra-stent: estudio in vivo con reconstrucción 3D y dinámica de fluidos computacional
Marcelo Sanmartín (2006)See more