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Different Reactivity And Structure Of The Prestenotic And Poststenotic Aorta In Human Coarctation. Implications For Baroreceptor Function.

J. Sehested, U. Baandrup, E. Mikkelsen
Published 1982 · Medicine

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In eight humans with coarctation, fresh aortic tissue was examined pharmacodynamically. In four of these patients, and in 12 additional patients, the aorta above and below the coarctation was studied morphologically and compared with eight control aortas. By in vitro stimulation with potassium (127 mM), noradrenaline (18 microM), and prostaglandin F2 alpha (28 microM), postcoarctational aortic ring preparations showed a significantly greater contractility than precoarctational rings (p less than 0.05). Volumetric analysis showed significantly more collagen (P less than 0.01) and les smooth muscle mass (p less than 0.01) in the aorta above than below the coarctation. No significant differences were found between sections from the arch and distal to the ligamentum arteriosum in the normal aortas. We conclude that the precoarctational aortic wall is more rigid than the postcoarctational wall. This may influence baroreceptors in the upper vascular bed in such a way as to tolerate a higher pressure. This would explain the preoperative proximal hypertension, the paradoxic hypertension and the frequent lack of normalization of blood pressure postoperatively.
This paper references
The resistance to blood flow in the upper and lower limb vessels in patients with coarctation of the aorta.
Patterson Gc (1957)
10.1097/00000542-196505000-00023
Morphometry of the Human Lung
E. R. Weibel (1965)
10.1016/S0003-4975(10)66683-0
Coarctation of the aorta and hypertension.
W. Sealy (1967)
10.1111/J.1748-1716.1969.TB04394.X
Relationship between aortic diameter and aortic baroreceptor activity in normal and hypertensive rabbits.
H. Aars (1969)
10.1002/BJS.1800560308
Abnormal levels of catecholamine metabolites in a resected coarctation of the aorta
L. O'Gorman (1969)
10.1097/00132586-197004000-00003
Increased Sympathetic Nerve Activity Following Resection of Coarctation of the Thoracic Aorta
M. Goodall (1969)
10.1016/0014-2999(70)90027-0
Heterogeneity of drug receptors in different segments of rabbit thoracic aorta.
B. Altura (1970)
Peripheral and renal vein plasma renin activity in coarctation of the aorta.
W. Strong (1970)
10.1161/01.CIR.44.2.281
Influence of Aortic Coarctation on Pulsatile Hemodynamics in the Proximal Aorta
M. O'Rourke (1971)
An elastic stain
PJ Miller (1971)
Miller PJ: An elastic stain
(1971)
Hemodynamic risk factors: mechanical stress, architecture, medical nutrition, and the vulnerability of arteries to atherosclerosis
Glagov (1972)
10.1161/01.CIR.47.1.119
Prognosis of Surgically Corrected Coarctation of the Aorta: A 20‐Year Postoperative Appraisal
B. Maron (1973)
10.1161/01.RES.34.1.27
Systolic Hypertension During Submaximal Exercise After Correction of Coarctation of Aorta
F. James (1974)
10.1016/0002-9378(74)90689-9
The action of vasopressors on isolated uterine arteries.
D. Van Nimwegen (1974)
10.1152/JAPPL.1976.41.1.36
Baroreflex sensitivity and carotid sinus dimensions in dogs with coarctation.
L. Bonchek (1976)
10.1161/01.CIR.54.3.382
Pathogenesis of Paradoxical Hypertension after Coarctation Resection
A. Rocchini (1976)
10.1093/CVR/10.4.437
Effects of hypertension on the static mechanical properties and chemical composition of the rat aorta.
C. Berry (1976)
10.1159/000158110
On the measurement of vascular and respiratory smooth muscle responses in vitro.
C. Hooker (1977)
10.1111/J.1748-1716.1978.TB06286.X
Effects of dopaminergic agonists and antagonists on isolated cerebral blood vessels.
L. Edvinsson (1978)
10.1111/J.1600-0773.1978.TB02166.X
Effects of verapamil and nitroglycerin on contractile responses to potassium and noradrenaline in isolated human peripheral veins.
E. Mikkelsen (1978)
10.1161/01.CIR.57.3.598
Changes in Plasma Catecholamines and Dopamine Beta-Hydroxylase after Corrective Surgery for Coarctation of the Aorta
C. Benedict (1978)
10.1111/J.1600-0773.1978.TB02284.X
Contractile effects of prostaglandin F2alpha on isolated human peripheral arteries and veins.
E. Mikkelsen (1978)
Acta Pharmacol Toxicol
(1978)
Der arterielle Blutdruck nach operativer Behandlung der Aortenisthmusstenose Langzeitergebnisse bei 250 Patienten
H Kuhn (1979)
Baroreceptor function in experimental aortic coarctation before and after surgical repair
JA Bevan (1979)
Experimental hypertension : constric - tent ductus , and a common atrioventricular canal and tion of the aorta at various levels
H Goldblatt
AORTIC DIFFERENCES IN COARCTATION / Sehested et al . blood flow in the upper and lower limb vessels in patients with coarctation of the aorta
MF O'Rourke



This paper is referenced by
10.1038/s41371-021-00585-6
Multi-centre cross-sectional study on vascular remodelling in children following successful coarctation correction
Skaiste Sendzikaite (2021)
10.1186/s13019-020-01283-z
Primary and secondary aortopathy associated with adult congenital heart disease - retrospective study
I. Schusterová (2020)
10.4330/wjc.v12.i5.167
Management of adults with coarctation of aorta
P. Agasthi (2020)
10.1017/S104795112000205X
Is the burden of late hypertension and cardiovascular target organ damage in children and adolescents with coarctation of the aorta after early successful repair different to healthy controls?
Ayşe Ağbaş (2020)
10.1186/s41747-019-0102-9
The effects of age at correction of aortic coarctation and recurrent obstruction on adolescent patients: MRI evaluation of wall shear stress and pulse wave velocity
Joe F. Juffermans (2019)
10.1016/J.PPEDCARD.2019.02.001
Increased aortic wall stiffness is predictive of aortic dilation in adult patients following coarctation of the aorta repair
Abigail Starker (2019)
Numerical Modelling of Blood Flow for Coarctation of the Aorta: Pre- and Post-treatment Simulations
Dilan Pathirana (2019)
10.1093/ejcts/ezy257
Impact of complex congenital heart disease on the prevalence of arterial hypertension after aortic coarctation repair
U. Giordano (2019)
10.1177/2047487317737174
Increased arterial stiffness in children with congenital heart disease
A. Häcker (2018)
10.1186/s12947-018-0126-y
Are aortic coarctation and rheumatoid arthritis different models of aortic stiffness? Data from an echocardiographic study
G. Faganello (2018)
10.1111/joic.12460
Is hypertension the fate of aortic coarctation patients treated with Cheatham Platinum (CP) stent?
A. Baykan (2018)
10.5772/INTECHOPEN.79865
The Adult with Coarctation of the Aorta
A. Salahuddin (2018)
10.1016/j.carrev.2018.03.018
Effect of stent implantation on blood pressure control in adults with coarctation of the aorta.
Jennifer J van der Burg (2018)
10.1007/s00246-017-1739-x
Hypertension in Coarctation of the Aorta: Challenges in Diagnosis in Children
T. Vigneswaran (2017)
10.1111/chd.12406
Aortic stenting in the growing sheep causes aortic endothelial dysfunction but not hypertension: Clinical implications for coarctation repair
N. Maschietto (2017)
10.1017/S1047951117001019
Is the medical treatment for arterial hypertension after primary aortic coarctation repair related to age at surgery? A retrospective cohort study
Peter J Lillitos (2017)
10.1007/978-3-319-44691-2_24
Anomalies of the Aortic Arch: Aortic Coarctation and Interrupted Aortic Arch
A. Dabbagh (2017)
10.1007/s12576-016-0512-x
Pathology and molecular mechanisms of coarctation of the aorta and its association with the ductus arteriosus
U. Yokoyama (2016)
10.1586/17434440.2015.1090309
MRI as a tool for non-invasive vascular profiling: a pilot study in patients with aortic coarctation
M. Kelm (2016)
10.1016/j.ijcard.2015.09.034
Renal sympathetic denervation in uncontrolled arterial hypertension after successful repair for aortic coarctation.
P. Lurz (2016)
10.1055/S-0035-1564796
Hypertension in the Pediatric Intensive Care Unit.
Gokhan Olgun (2016)
10.1016/j.amjcard.2016.05.055
Noninvasive Assessment of Vascular Function in Postoperative Cardiovascular Disease (Coarctation of the Aorta, Tetralogy of Fallot, and Transposition of the Great Arteries).
Y. Mivelaz (2016)
10.1097/PCC.0000000000000621
Pediatric Cardiac Intensive Care Society 2014 Consensus Statement: Pharmacotherapies in Cardiac Critical Care Antihypertensives
D. Klugman (2016)
10.1007/978-3-319-34141-5_4
Coarctation of the aorta.
M. Boutsikou (2016)
Vascular Dysfunction in Patients with Coarctation of the Aorta
Dr. Shanmuga sundaram Rathakrishnan (2016)
10.1093/ehjci/jeu309
Arterial-left ventricular-left atrial coupling late after repair of aortic coarctation and interruption.
V. W. Li (2015)
10.1161/JAHA.115.002107
Frequent Dilatation of the Descending Aorta in Children With Hypoplastic Left Heart Syndrome Relates to Decreased Aortic Arch Elasticity
I. Voges (2015)
10.1016/j.ijcard.2015.02.011
Increased aortic blood pressure augmentation in patients with congenital heart defects - A cross-sectional study in 1125 patients and 322 controls.
J. Müller (2015)
10.1161/JAHA.115.001978
Persistent Aortic Arch Hypoplasia After Coarctation Treatment Is Associated With Late Systemic Hypertension
Sophie Quennelle (2015)
Estudo da integridade arterial em pacientes com coarctação da aorta, antes e após aortoplastia com implante de stent
J. Assef (2015)
10.6515/ACS20150127A
Atrial Functions and Aortic Elasticity in Children with Aortic Coarctation.
S. Demirpençe (2015)
10.1007/s10554-015-0827-3
Serial assessment of arterial structure and function in patients with coarctation of the aorta undergoing stenting
C. A. Jesus (2015)
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