Reducing Hypermuscularization Of The Transitional Segment Between Arterioles And Capillaries Protects Against Spontaneous Intracerebral Hemorrhage
Spontaneous deep intracerebral hemorrhage (ICH) is a devastating subtype of stroke without specific treatments. It has been thought that smooth muscle cell (SMC) degeneration at the site of arteriolar wall rupture may be sufficient to cause hemorrhage. However, deep ICHs are rare in some aggressive small vessel diseases that are characterized by significant arteriolar SMC degeneration. Here we hypothesized that a second cellular defect may be required for the occurrence of ICH.
We studied a genetic model of spontaneous deep ICH using
We identified in the normal cerebroretinal vasculature a novel segment between arterioles and capillaries, herein called the transitional segment (TS), which is covered by mural cells distinct from SMCs and pericytes. In
Our results suggest that hypermuscularization of the TS, through increased Notch3 activity, is involved in the occurrence of ICH in