Online citations, reference lists, and bibliographies.
← Back to Search

Mechanisms Of Arterial Remodeling In Hypertension: Coupled Roles Of Wall Shear And Intramural Stress.

J. Humphrey
Published 2008 · Chemistry, Medicine

Save to my Library
Download PDF
Analyze on Scholarcy Visualize in Litmaps
Share
Reduce the time it takes to create your bibliography by a factor of 10 by using the world’s favourite reference manager
Time to take this seriously.
Get Citationsy
Diverse data collected over the past 4 decades suggest the existence of a mechanical homeostasis across multiple length and time scales in the vasculature. For example,1 stress fibers within endothelial and vascular smooth muscle cells appear to disassemble and then reassemble in a mechanically preferred manner when perturbed from a normal value of mechanical stress or strain; focal adhesions in smooth muscle cells and fibroblasts tend to increase in area in response to local increases in mechanical loading so as to maintain the stress constant at a preferred value; fibroblasts tend to increase the tractions that they exert on the extracellular matrix when external loads are decreased from a preferred value, thus suggesting an attempt to enforce a “tensional homeostasis”; vascular smooth muscle cells tend to relengthen to their normal, preferred values when an arteriole is forced into a vasoconstricted state for an extended period; and arteries tend to decrease in caliber in response to sustained decreases in flow-induced wall shear stress, to increase in thickness in response to sustained increases in pressure-induced circumferential stress, and to lengthen in response to extension-induced increases in axial stress. Although changes in the cytoskeleton and integrins occur within minutes, changes at the cell-cell and cell-matrix levels occur over hours, and those at the vessel level occur over days to weeks or months. Hence, despite marked differences in length scales (dimensions from nanometers to centimeters) and time scales (durations from minutes to months), mechanobiological control mechanisms in the vasculature tend to restore values of stress or strain toward preferred (homeostatic) values in response to diverse perturbations from normal.2–5 Biomechanics and mechanobiology thus play key roles in vascular development, tissue maintenance in maturity, normal adaptations, aging, disease progression, and responses to injury or clinical interventions. A current challenge in hypertension research is to …
This paper references
10.1115/1.2891128
Effect of hypertension on elasticity and geometry of aortic tissue from dogs.
R. Vaishnav (1990)
10.1016/0022-4804(90)90202-D
Longitudinal retractive force in pressurized dog and human arteries.
P. Dobrin (1990)
10.1152/AJPCELL.1992.263.2.C389
Physiological fluid shear stress causes downregulation of endothelin-1 mRNA in bovine aortic endothelium.
A. Malek (1992)
10.1002/JCP.1041510106
Cyclical strain effects on production of vasoactive materials in cultured endothelial cells
J. A. Carosi (1992)
10.1152/PHYSREV.1995.75.3.519
Flow-mediated endothelial mechanotransduction.
P. F. Davies (1995)
10.1161/01.ATV.15.10.1781
Synergistic effects of fluid shear stress and cyclic circumferential stretch on vascular endothelial cell morphology and cytoskeleton.
S. Zhao (1995)
10.1152/AJPCELL.1995.269.6.C1371
Regulation of endothelial cell nitric oxide synthase mRNA expression by shear stress.
M. Uematsu (1995)
10.1172/JCI118181
Cyclic strain upregulates nitric oxide synthase in cultured bovine aortic endothelial cells.
M. Awolesi (1995)
10.1006/JMCC.1996.0023
The effects of endothelin-1 on collagen type I and type III synthesis in cultured porcine coronary artery vascular smooth muscle cells.
M. Rizvi (1996)
10.1161/01.RES.79.3.541
In vivo collagen turnover following experimental balloon angioplasty injury and the role of matrix metalloproteinases.
B. Strauss (1996)
10.1006/JMCC.1996.0480
Nitric oxide modulates basal and endothelin-induced coronary artery vascular smooth muscle cell proliferation and collagen levels.
M. Rizvi (1997)
10.1159/000025570
Stretch-Induced Collagen Synthesis in Cultured Smooth Muscle Cells from Rabbit Aortic Media and a Possible Involvement of Angiotensin II and Transforming Growth Factor-β
Qing Li (1998)
10.1159/000025568
Pulsatile Stretch and Shear Stress: Physical Stimuli Determining the Production of Endothelium-Derived Relaxing Factors
R. Busse (1998)
10.1161/01.ATV.19.8.1843
Angiotensin II stimulates collagen synthesis in human vascular smooth muscle cells. Involvement of the AT(1) receptor, transforming growth factor-beta, and tyrosine phosphorylation.
C. M. Ford (1999)
10.1007/0-387-23346-6_27
[Vascular remodeling].
S. Kim (2000)
10.1165/AJRCMB.22.1.F172
Adventitial fibroblasts: defining a role in vessel wall remodeling.
B. Strauss (2000)
10.1161/01.HYP.36.1.89
Blood flow regulates the development of vascular hypertrophy, smooth muscle cell proliferation, and endothelial cell nitric oxide synthase in hypertension.
H. Ueno (2000)
10.1115/1.1406131
Stress, strain, and mechanotransduction in cells.
J. Humphrey (2001)
10.1067/MVA.2001.112231
Molecular mechanisms of aortic wall remodeling in response to hypertension.
C. Xu (2001)
10.1016/S0008-6363(01)00399-6
Adhesion receptors of vascular smooth muscle cells and their functions.
E. Moiseeva (2001)
10.1016/S0006-3495(01)76184-X
In vivo control of soluble guanylate cyclase activation by nitric oxide: a kinetic analysis.
P. Condorelli (2001)
10.1146/ANNUREV.BIOENG.3.1.109
Can we model nitric oxide biotransport? A survey of mathematical models for a simple diatomic molecule with surprisingly complex biological activities.
D. Buerk (2001)
10.1161/HY09T1.096249
Vascular Remodeling in Hypertension: Roles of Apoptosis, Inflammation, and Fibrosis
H. Intengan (2001)
10.1186/1471-2261-2-11
Expression of TGF-β1 and β3 but not apoptosis factors relates to flow-induced aortic enlargement
Chengpei Xu (2002)
Expression of TGF-␤1 and ␤3 but not apoptosis factors relates to flow-induced aortic enlargement Extracellular matrix remodeling in hypertension
C Xu (2002)
10.1016/S0962-8924(03)00057-6
Fibroblast biology in three-dimensional collagen matrices.
F. Grinnell (2003)
10.1152/AJPHEART.00494.2002
Uniaxial strain upregulates matrix-degrading enzymes produced by human vascular smooth muscle cells.
K. Asanuma (2003)
10.1016/S0021-9290(03)00032-0
Cardiovascular solid mechanics. Cells, tissues, and organs
K. Hayashi (2003)
10.1161/01.HYP.0000146907.82869.f2
Upregulation of Vascular Arginase in Hypertension Decreases Nitric Oxide–Mediated Dilation of Coronary Arterioles
C. Zhang (2004)
10.1016/J.TCB.2004.10.003
TGF-β activation by traction?
J. Keski‐Oja (2004)
10.1152/PHYSREV.00041.2003
Molecular regulation of vascular smooth muscle cell differentiation in development and disease.
G. Owens (2004)
10.1161/01.HYP.0000164580.39991.3d
Structural and Genetic Bases of Arterial Stiffness
S. Laurent (2005)
10.1080/10739680590896054
Integrins and Regulation of the Microcirculation: From Arterioles to Molecular Studies using Atomic Force Microscopy
L. Martinez-Lemus (2005)
10.1038/ncpcardio0307
Large-artery stiffness, hypertension and cardiovascular risk in older patients
J. Blacher (2005)
10.1161/01.RES.0000174614.74469.83
Endothelin-1, via ETA Receptor and Independently of Transforming Growth Factor-&bgr;, Increases the Connective Tissue Growth Factor in Vascular Smooth Muscle Cells
Juan Rodríguez-Vita (2005)
10.1016/J.VPH.2005.03.004
Vascular endothelin in hypertension.
E. Schiffrin (2005)
10.1161/01.RES.0000153883.55971.81
Cross-Linking Vasomotor Tone and Vascular Remodeling: A Novel Function for Tissue Transglutaminase?
B. Langille (2005)
10.2174/1573402052952834
Extracellular Matrix Remodeling in Hypertension
H. Sasamura (2005)
: From arterioles to molecular studies using atomic force microscopy
F Grinnell (2005)
Transforming growth factor beta signaling, vascular remodeling, and hypertension.
P. August (2006)
10.1016/J.CARDIORES.2005.08.002
Matrix metalloproteinases regulate migration, proliferation, and death of vascular smooth muscle cells by degrading matrix and non-matrix substrates.
A. Newby (2006)
10.1097/01.HJH.0000229464.09610.FF
Pulse pressure reduction and cardiovascular protection.
S. Laurent (2006)
10.1016/J.FREERADBIOMED.2006.05.009
Theoretical analysis of biochemical pathways of nitric oxide release from vascular endothelial cells.
K. Chen (2006)
10.1056/NEJMCIBR062143
Transforming Growth Factor β Signaling, Vascular Remodeling, and Hypertension
P. August (2006)
10.1016/J.CARDIORES.2005.12.002
Structure and function of matrix metalloproteinases and TIMPs.
H. Nagase (2006)
10.1016/J.ARTRES.2011.10.242
Molecular mechanisms of the vascular responses to haemodynamic forces.
S. Lehoux (2006)
10.1042/CS20060337
Arterial adaptations to chronic changes in haemodynamic function: coupling vasomotor tone to structural remodelling.
Dorota Dajnowiec (2007)
10.1152/AJPHEART.00304.2006
Cyclic strain-mediated matrix metalloproteinase regulation within the vascular endothelium: a force to be reckoned with.
P. Cummins (2007)
10.1002/path.2101
Ageing of the conduit arteries
S. Greenwald (2007)
10.1016/J.CELLSIG.2007.01.004
Mechanical stress-initiated signal transduction in vascular smooth muscle cells in vitro and in vivo.
C. Li (2007)
10.1016/J.JACC.2006.12.050
Mechanical factors in arterial aging: a clinical perspective.
M. O'Rourke (2007)
10.1016/J.JACC.2007.02.059
Role of endothelial shear stress in the natural history of coronary atherosclerosis and vascular remodeling: molecular, cellular, and vascular behavior.
Y. Chatzizisis (2007)
10.1161/HYPERTENSIONAHA.107.089631
Role of Matrix Metalloproteinases in Early Hypertensive Vascular Remodeling
M. Flamant (2007)
10.1161/HYPERTENSIONAHA.107.087049
Personalized medicine for high blood pressure.
S. Turner (2007)
10.1016/J.JBIOMECH.2006.04.011
Molecular basis of the effects of mechanical stretch on vascular smooth muscle cells.
J. Haga (2007)
10.1016/J.CARDIORES.2007.06.023
The role of the adventitia in vascular inflammation.
K. Maiellaro (2007)
10.1007/s12013-007-9002-3
Vascular Adaptation and Mechanical Homeostasis at Tissue, Cellular, and Sub-cellular Levels
J. Humphrey (2007)
: roles of apoptosis , inflammation , and fibrosis
D Dajnowiec (2007)
Aging of conduit arteries
SE Greenwald (2007)
10.1146/annurev.bioeng.10.061807.160439
Intracranial and abdominal aortic aneurysms: similarities, differences, and need for a new class of computational models.
J. Humphrey (2008)
Humphrey Biomechanics in Hypertension



This paper is referenced by
10.1101/2021.01.06.425577
Fibronectin-mediated inflammatory signaling through integrin α5 in vascular remodeling
Madhusudhan Budatha (2021)
Controlled Comparison of Simulated Hemodynamics across Tricuspid and Bicuspid Aortic Valves
Alexander D. Kaiser (2021)
10.1098/rspa.2020.0622
Complementary roles of mechanotransduction and inflammation in vascular homeostasis
M. Latorre (2021)
10.1007/s10439-021-02775-2
From Uniaxial Testing of Isolated Layers to a Tri-Layered Arterial Wall: A Novel Constitutive Modelling Framework.
A. Giudici (2021)
10.1098/rsif.2021.0336
Excessive adventitial stress drives inflammation-mediated fibrosis in hypertensive aortic remodelling in mice
B. Spronck (2021)
10.1007/978-3-030-63164-2_10
Mechanobiology of Arterial Hypertension
C. de Wit (2021)
10.1007/s00360-021-01353-1
Arterial wall thickening normalizes arterial wall tension with growth in American alligators, Alligator mississippiensis.
R. Filogonio (2021)
10.1038/s41371-021-00585-6
Multi-centre cross-sectional study on vascular remodelling in children following successful coarctation correction
Skaiste Sendzikaite (2021)
10.1161/CIRCRESAHA.121.318061
Arterial Stiffness and Cardiovascular Risk in Hypertension.
P. Boutouyrie (2021)
10.7150/ijbs.56247
Dickkopf-1 promotes Vascular Smooth Muscle Cell proliferation and migration through upregulating UHRF1 during Cyclic Stretch application
Tengfei Zheng (2021)
10.1007/978-3-030-46839-2_24
Clinical Utilization of Ultrasound in Vascular Disease
M. Novitch (2021)
10.1016/j.medengphy.2021.06.009
Sequential numerical simulation of vascular remodeling and thrombosis in unconventional hybrid repair of ruptured middle aortic syndrome.
Xiaoning Sun (2021)
10.3389/fcvm.2020.588692
Small Resistance Artery Disease and ACE2 in Hypertension: A New Paradigm in the Context of COVID-19
M. Galán (2020)
10.5772/intechopen.90404
Cerebral Vascular Tone Regulation: Integration and Impact of Disease
Brayden D Halvorson (2020)
10.1016/j.atherosclerosis.2020.11.031
Association of pulse wave velocity and pressure wave reflection with the ankle-brachial pressure index in Japanese men not suffering from peripheral artery disease.
Takamichi Takahashi (2020)
10.1016/j.actbio.2020.11.025
Comparison of Morphometric, Structural, Mechanical, and Physiologic Characteristics of Human Superficial Femoral and Popliteal Arteries.
M. Jadidi (2020)
10.1016/j.actbio.2020.10.035
Mechanical, Structural, and Physiologic Differences in Human Elastic and Muscular Arteries of Different Ages: Comparison of the descending thoracic aorta to the superficial femoral artery.
M. Jadidi (2020)
10.1111/1440-1681.13384
Reversion of cardiovascular remodelling in renovascular hypertensive 2K‐1C rats by renin–angiotensin system inhibitors
Jose W. Correa (2020)
10.1088/2516-1091/ab9a29
Biochemomechanics of the thoracic aorta in health and disease
Selda Sherifova and (2020)
10.1101/727800
Genetic Background Dictates Aortic Fibrosis in Hypertensive Mice
B. Spronck (2020)
10.1101/2020.11.27.401034
Human induced pluripotent stem cell-derived vessels as dynamic atherosclerosis model on a chip
A. Mallone (2020)
10.1007/978-3-030-40542-7_54
Introduction to the Molecular Basis of Liver Stiffness and Its Relation to Mechano-signaling
S. Mueller (2020)
10.1097/HJH.0000000000002508
Vascular consequences of inflammation: a position statement from the ESH Working Group on Vascular Structure and Function and the ARTERY Society.
L. Zanoli (2020)
10.2176/nmc.st.2020-0072
Hemodynamic and Histopathological Changes in the Early Phase of the Development of an Intracranial Aneurysm
H. Kataoka (2020)
Probing blood pressure and arterial stiffness noninvasively by guided axial waves.
G. Li (2020)
10.1016/j.cobme.2019.11.005
Modeling biological growth and remodeling: Contrasting methods, contrasting needs
M. Latorre (2020)
10.1039/d0sm00763c
Tensional homeostasis at different length scales.
D. Stamenović (2020)
10.1007/s10237-020-01315-6
Spatiotemporal remodeling of embryonic aortic arch: stress distribution, microstructure, and vascular growth in silico
S. S. Lashkarinia (2020)
10.1007/s00062-020-00892-4
Coiling of the Internal Carotid Artery is Associated with Hypertension in Patients Suspected of Stroke
Josephus L. M. van Rooij (2020)
10.1097/HJH.0000000000002400
Aortic remodeling is modest and sex-independent in mice when hypertension is superimposed on aging
B. Spronck (2020)
10.1016/bs.ctm.2020.08.008
Vascular smooth muscle stiffness and its role in aging.
A. Trache (2020)
10.3389/fphys.2020.00002
Multiscale Modeling Framework of Ventricular-Arterial Bi-directional Interactions in the Cardiopulmonary Circulation
Sheikh Mohammad Shavik (2020)
See more
Semantic Scholar Logo Some data provided by SemanticScholar