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Effects Of Perindopril-Based Lowering Of Blood Pressure On Intracerebral Hemorrhage Related To Amyloid Angiopathy: The PROGRESS Trial

Hisatomi Arima, Christophe Tzourio, Craig Evan Anderson, Mark Woodward, Marie-Germaine Bousser, Stephen MacMahon, Bruce Neal, John W. Chalmers
Published 2010 · Medicine
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Background and Purpose— Patients with cerebral amyloid angiopathy (CAA) are at high risk for intracerebral hemorrhage (ICH), but no effective prevention strategies have been established. The objective is to determine whether lowering of blood pressure (BP) provides protection for this high-risk patient group. Methods— This study is a subsidiary analysis of the PROGRESS trial—a randomized, placebo-controlled trial that established the beneficial effects of BP lowering in patients with cerebrovascular disease; 6105 patients were randomly assigned to either active treatment (perindopril for all participants plus indapamide for those with neither an indication for nor a contraindication to a diuretic) or matching placebo. Outcomes were probable CAA-related ICH as defined by the Boston criteria, probable hypertension-related ICH, and unclassified ICH. Results— Over a mean follow-up of 3.9 years, 16 probable CAA-related ICH, 51 probable hypertension-related ICH, and 44 unclassified ICH occurred. Active treatment reduced the risk of CAA-related ICH by 77% (95% CI, 19%–93%), that of hypertension-related ICH by 46% (95% CI, 4%–69%), and that of unclassified ICH by 43% (95% CI, −5%–69%). There was no evidence of differences in the magnitude of the effects of treatment among different types of ICH (P homogeneity=0.4). Conclusions— BP-lowering treatment is likely to provide protection against all types of ICH.
This paper references
10.1097/00005072-197107000-00015
Pathological observations in hypertensive cerebral hemorrhage.
Fisher Cm (1971)
10.1016/S0002-9440(10)65616-7
Cerebral Amyloid Angiopathy : Amyloid β Accumulates in Putative Interstitial Fluid Drainage Pathways in Alzheimer’s Disease
Roy O. Weller (1998)
PATHOLOGICAL OBSERVATIONS IN HYPERTENSIVE CEREBRAL HEMORRHAGE
Christine M. Fisher (1971)
10.1161/01.STR.18.2.311
Cerebral amyloid angiopathy. A critical review.
H V Vinters (1987)
10.1212/WNL.56.4.537
Clinical diagnosis of cerebral amyloid angiopathy: Validation of the Boston Criteria
Katherine A Knudsen (2001)
10.1161/01.STR.20.10.1407
Stroke--1989. Recommendations on stroke prevention, diagnosis, and therapy. Report of the WHO Task Force on Stroke and other Cerebrovascular Disorders.
Lippincott Williams Wilkins (1989)
WHO Task Force on Stroke. Recommendations on stroke prevention, diagnosis and therapy. Report of the WHO Task Force on Stroke and Other Cerebrovascular Disorders
(1989)
10.1002/ana.410300503
Cerebral amyloid angiopathy without and with cerebral hemorrhages: a comparative histological study.
Jean Paul G. Vonsattel (1991)
Spontaneous intracerebral hemorrhage.
Raul G. Nogueira (1992)
10.1111/j.1749-6632.2000.tb06366.x
Apolipoprotein E genotype and cerebral amyloid angiopathy-related hemorrhage.
Mark O McCarron (2000)
Apolipoprotein E epsilon 4 is associated with the presence and earlier onset of hemorrhage in cerebral amyloid angiopathy.
S. Greenberg (1996)
10.1212/01.wnl.0000308819.43401.87
APOE genotype, ethnicity, and the risk of cerebral hemorrhage
Christophe Tzourio (2008)
Randomised trial of a perindopril-based blood pressure lowering regimen among 6,105 individuals with previous stroke or transient ischaemic attack
Stephen MacMahon (2001)
10.1161/01.STR.27.8.1333
Apolipoprotein E ε4 Is Associated With the Presence and Earlier Onset of Hemorrhage in Cerebral Amyloid Angiopathy
S. Greenberg (1996)



This paper is referenced by
10.1016/j.nrl.2011.03.010
Clinical practice guidelines in intracerebral haemorrhage.
M. Rodríguez-Yáñez (2013)
10.1001/jama.2015.16017
Blood Pressure Control and Recurrence of Intracerebral Hemorrhage--Reply.
Alessandro Biffi (2016)
Amyloid-related Disorders Update on Amyloid-associated Intracerebral Hemorrhage
Rebbeca Grys iewicz (2012)
Cerebral microbleeds as a marker of small vessel disease : new insights from neuro-imaging and clinical studies in stroke patients
Simone M. Gregoire (2014)
10.1159/000486554
Amyloid Angiopathy in Brain Hemorrhage: A Postmortem Neuropathological-Magnetic Resonance Imaging Study
Céline Guidoux (2018)
10.3389/fneur.2012.00085
Translating Basic Science Research to Clinical Application: Models and Strategies for Intracerebral Hemorrhage
Christopher C. Leonardo (2012)
Cerebral amyloid angiopathy-related inflammation and rapidly progressive dementia: first case report in Colombia
Carlos Hugo Zapata Zapata (2016)
10.1177/0271678X15606720
Experimental hypertension increases spontaneous intracerebral hemorrhages in a mouse model of cerebral amyloidosis
Giselle F Passos (2016)
10.1136/jnnp-2016-314386
Medical management of intracerebral haemorrhage
Floris H.B.M. Schreuder (2016)
10.1016/J.PRANEU.2018.02.001
Angiopathie amyloïde cérébrale sporadique
S Alamowitch (2018)
10.1109/IECBES.2016.7843435
MR image enhancement for ICH classification
Nor Shahirah binti Shaik Amir (2016)
10.1055/s-0033-1357489
Brain hemorrhages in cerebral amyloid angiopathy.
Masahito Yamada (2013)
10.1097/JNN.0000000000000380
Cerebral Amyloid Angiopathy: A Different Kind of Stroke.
Lisa A. Ruth-Sahd (2018)
10.7887/JCNS.28.758
脳神経外科医が知るべき抗血栓療法のリスク・ベネフィット・適応
Yasushi Okada (2019)
10.1016/J.NRLENG.2011.03.011
Clinical practice guidelines in intracerebral haemorrhage.
M. Rodríguez-Yáñez (2013)
10.1161/STROKEAHA.111.617225
Body Mass Index and Etiology of Intracerebral Hemorrhage
A. Biffi (2011)
10.5853/jos.2015.17.1.17
Cerebral Amyloid Angiopathy: Emerging Concepts
Masahito Yamada (2015)
10.11575/PRISM/28634
Vascular Reactivity by Blood Oxygen Level Dependent Functional MRI in Cerebral Amyloid Angiopathy: Comparison with Alzheimer's Disease and Assessment of Longitudinal Change
Aaron Switzer (2014)
10.1160/TH11-06-0439
Use of aspirin in Chinese after recovery from primary intracranial haemorrhage.
B Chong (2012)
10.1212/WNL.0000000000006938
Deciphering the causes of nontraumatic intracerebral hemorrhage
T. Tatlisumak (2019)
10.1007/s00415-017-8428-9
Erratum to: Convexity subarachnoid haemorrhage has a high risk of intracerebral haemorrhage in suspected cerebral amyloid angiopathy
D. Wilson (2017)
10.12659/AJCR.900498
Rapidly Sequential and Fatal Hemorrhaging in a Case of Cerebral Amyloid Angiopathy
Zachary B. Bulwa (2016)
10.1186/s12916-014-0206-2
The overlap between vascular disease and Alzheimer’s disease - lessons from pathology
Johannes Attems (2014)
10.3390/ijms21103435
Understanding the Pathophysiology of Cerebral Amyloid Angiopathy
Laura Gatti (2020)
10.3233/JAD-160013
Influence of Low-Dose Aspirin on Cerebral Amyloid Angiopathy in Mice.
Yorito Hattori (2016)
10.1016/j.jstrokecerebrovasdis.2019.104342
Long-Term Follow-Up of Cerebral Amyloid Angiopathy-Associated Intracranial Hemorrhage Reveals a High Prevalence of Atrial Fibrillation.
Johanna Kaiser (2019)
10.1002/14651858.CD007858.pub2
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Thomas P Zonneveld (2018)
10.1136/jnnp-2011-301308
Sporadic cerebral amyloid angiopathy revisited: recent insights into pathophysiology and clinical spectrum
Andreas Charidimou (2011)
10.1016/J.CMONC.2012.02.014
A patient with non-small cell lung cancer presenting with headaches and change in mental status
J. Mann (2012)
10.1272/MANMS.13.6
Cerebral Amyloid Angiopathy-related Inflammation Presenting with Amnesia as an Initial Symptom
Tomoaki Kumagai (2017)
Imaging markers of cerebral small vessel disease
Ebru Baykara (2018)
10.1007/s15027-012-0273-2
Blutdrucksenkung ist die beste Prävention
Sven Lerch (2012)
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