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Different Impacts Of Blood Pressure Variability On The Progression Of Cerebral Microbleeds And White Matter Lesions

Wenhong Liu, Ran Liu, Wei Sun, Qing Peng, Weiwei Zhang, En Qing Xu, Yan Cheng, Meiping Ding, Yansheng Li, Zhen Hong, Jiang Wu, Jinsheng Zeng, Chen Yao, Yining Huang
Published 2012 · Medicine
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Background and Purpose— Cerebral microbleeds (CMB) and white matter lesions (WML) are cerebral small vessel diseases. Hypertension is considered the most important risk factor. Its mechanism is not yet clarified. Our study assessed the association of blood pressure variability (BPV) with CMB and WML progression. Methods— Patients with a history of ischemic stroke within 1 to 6 months were consecutively recruited and followed-up for 12 to 18 months. Blood pressure was measured monthly and controlled to a target level. BPV was quantified by the maximum, standard deviation, coefficient of variation, successive variation, standard deviation independent of mean, and successive variation independent of mean. Magnetic resonance imaging was performed at baseline and the end of the study. CMB and WML were rated using Microbleed Anatomic Rating Scale and Age-Related White Matter Changes scales, respectively. Multiple logistic analyses assessed BPV associations with CMB and WML development. Results— Of 720 patients recruited, 500 and 584 had follow-up results for CMB and WML, respectively; 13.2% and 48.1% showed CMB and WML progression, respectively, over a median of 14 months. Patients with CMB had a higher mean, maximum, standard deviation, coefficient of variation, successive variation, standard deviation independent of the mean, and successive variation independent of the mean in either systolic blood pressure or diastolic blood pressure (P<0.05). Systolic blood pressure variability was an independent risk factor for deep and infratentorial CMB progression, whereas diastolic blood pressure variability was independently associated with CMB development in deep regions. WML progression was not significantly associated with BPV between visits. Conclusion— BPV independently predicts CMB progression in deep and infratentorial regions. Clinical Trial Registration Information— URL: http://www.clinicaltrials.gov. Unique identi-fier: NCT00202020.
This paper references
Spatial distribution of whitematter hyperintensities in Alzheimer disease , cerebral amyloid angiopathy , and healthy aging
CM Holland (2008)
10.1016/S1474-4422(09)70013-4
Cerebral microbleeds: a guide to detection and interpretation
Steven M. Greenberg (2009)
10.1161/STROKEAHA.109.558049
Brain Microbleeds Relate to Higher Ambulatory Blood Pressure Levels in First-Ever Lacunar Stroke Patients
J Staals (2009)
10.1161/01.STR.32.6.1318
A New Rating Scale for Age-Related White Matter Changes Applicable to MRI and CT
L O Wahlund (2001)
10.1016/S1474-4422(10)70104-6
Cerebral small vessel disease: from pathogenesis and clinical characteristics to therapeutic challenges
Leonardo Pantoni (2010)
10.1177/0194599814545472
Patients
Richard M Rosenfeld (2014)
10.1016/S0140-6736(10)60308-X
Prognostic significance of visit-to-visit variability, maximum systolic blood pressure, and episodic hypertension
Peter M. Rothwell (2010)
10.1016/S1474-4422(08)70094-2
Cilostazol as an alternative to aspirin after ischaemic stroke: a randomised, double-blind, pilot study
Yining Huang (2008)
10.1161/HYPERTENSIONAHA.107.100610
Brain Microbleeds Are Associated With Ambulatory Blood Pressure Levels in a Hypertensive Population
Léon H.G. Henskens (2008)
The relationship between visit- tovisit variability in systolic blood pressure 2922 Stroke November 2012 and allcause mortality in the general population: findings from NHANES
P Muntner (1988)
10.1161/STROKEAHA.110.595181
Prevalence and Risk Factors of Cerebral Microbleeds: An Update of the Rotterdam Scan Study
Mariëlle M. F. Poels (2010)
10.1212/WNL.0b013e3181c34a7d
The Microbleed Anatomical Rating Scale (MARS)
Simone M. Gregoire (2009)
10.1159/000091536
Age, Hypertension, and Lacunar Stroke Are the Major Determinants of the Severity of Age-Related White Matter Changes
Anna Maria Basile (2006)
10.1161/01.STR.0000132193.35955.69
White Matter Hyperintensity on Cranial Magnetic Resonance Imaging: A Predictor of Stroke
Lewis H. Kuller (2004)
Visit- tovisit variability in blood pressure over a 1-year period is a marker of left ventricular diastolic dysfunction in treated hypertensive patients
H Masugata (2011)
The relationship between visit-to-visit variability in systolic blood pressure Stroke
P Muntner (2012)
10.1016/S0140-6736(10)60309-1
Limitations of the usual blood-pressure hypothesis and importance of variability, instability, and episodic hypertension
Peter M. Rothwell (2010)
Variability Impact on CMB and WML
Liu
10.1161/STROKEAHA.107.498535
Progression of White Matter Hyperintensities and Incidence of New Lacunes Over a 3-Year Period: The Leukoaraiosis and Disability Study
Alida A. Gouw (2008)
10.1161/01.CIR.96.1.308
Hemodynamic patterns of age-related changes in blood pressure. The Framingham Heart Study.
Stanley S. Franklin (1997)
10.1038/hr.2011.54
Visit-to-visit variability in blood pressure over a 1-year period is a marker of left ventricular diastolic dysfunction in treated hypertensive patients
H. Masugata (2011)
10.1161/01.STR.31.11.2665
Frequency and Location of Microbleeds in Patients With Primary Intracerebral Hemorrhage
Gudrun Roob (2000)
Prevalence and risk factors of cerebral microbleeds: the Rotterdam Scan Study
MW Vernooij (2008)
Histopathologic analysis of foci of signal loss on gradient-echo T2*-weighted MR images in patients with spontaneous intracerebral hemorrhage: evidence of microangiopathy-related microbleeds.
Franz Fazekas (1999)
10.1161/STROKEAHA.107.497438
Spatial Distribution of White-Matter Hyperintensities in Alzheimer Disease, Cerebral Amyloid Angiopathy, and Healthy Aging
C. M. Holland (2008)
10.1212/01.wnl.0000194266.55694.1e
Cerebral microbleeds on MRI
H. C. Koennecke (2006)
10.1212/01.WNL.0000142966.22886.20
White matter lesions, cognition, and recurrent hemorrhage in lobar intracerebral hemorrhage
Eric E Smith (2004)
10.1212/01.WNL.0000101463.50798.0D
Cerebral microbleeds are regionally associated with intracerebral hemorrhage
S. H. Lee (2004)
10.1161/HYPERTENSIONAHA.110.162255
The Relationship Between Visit-to-Visit Variability in Systolic Blood Pressure and All-Cause Mortality in the General Population: Findings From NHANES III, 1988 to 1994
P. Muntner (2011)



This paper is referenced by
10.1111/ene.12310
Visit-to-visit systolic blood pressure variability predicts all-cause and cardiovascular mortality after lacunar infarct.
K. M. Lau (2014)
10.1007/s11906-015-0537-1
Blood Pressure Variability: Assessment, Predictive Value, and Potential as a Therapeutic Target
Gianfranco Parati (2015)
10.1161/JAHA.118.010793
Association of Variability in Body Mass Index and Metabolic Health With Cardiometabolic Disease Risk
Todd R Sponholtz (2019)
10.1212/WNL.0000000000007093
Blood pressure, glycemic control, and white matter hyperintensity progression in type 2 diabetics
Adam de Havenon (2019)
10.3995/jstroke.10737
Review: The origin and clinical importance of cerebral microbleeds II
Toshio Imaizumi (2019)
10.1093/neuonc/nov128
The effects of anti-angiogenic therapy on the formation of radiation-induced microbleeds in normal brain tissue of patients with glioma.
Janine M. Lupo (2016)
10.1093/ajh/hpz068
Blood Pressure Variability is Associated with White Matter Lesion growth in Intracranial Atherosclerosis.
Bum Joon Kim (2019)
10.1097/HJH.0000000000000838
SBP, DBP, and pulse blood pressure variability are temporally associated with the increase in pulse wave velocity in a model of aortic stiffness
Marc Isabelle (2016)
10.1016/j.neurol.2019.12.009
Imaging of the aging brain and development of MRI signal abnormalities.
H. Chabriat (2020)
10.1179/1743132815Y.0000000087
Combined clopidogrel–aspirin treatment for high risk TIA or minor stroke does not increase cerebral microbleeds
Zhiming Wang (2015)
10.1161/JAHA.116.004350
China Stroke Primary Prevention Trial: Visit‐to‐Visit Systolic Blood Pressure Variability Is an Independent Predictor of Primary Stroke in Hypertensive Patients
Xi Men (2017)
10.3995/JSTROKE.10510
Microbleeds による脳卒中再発予測:脳卒中タイプでの違い
俊雄 今泉 (2017)
10.1111/epi.12113
Acute cerebral microbleeds in refractory status epilepticus.
Sang-Beom Jeon (2013)
[Cerebral microbleeds in cerebrovascular and neurodegenerative diseases].
A. V. Arablinskii (2013)
10.1159/000358513
Carotid Artery Calcification Is Associated with Deep Cerebral Microbleeds
Pil-Wook Chung (2014)
A prospective evaluation of the long-term clinical associations of neurocardiovascular instability in older people
Claire McDonald (2014)
10.1016/j.atherosclerosis.2014.04.015
Visit-to-visit blood pressure variability as a prognostic marker in patients with cardiovascular and cerebrovascular diseases--relationships and comparisons with vascular markers of atherosclerosis.
Kui Kai Lau (2014)
Unraveling the heterogeneity of cerebral small vessel disease. From local to remote effects
E.M.C. van Leijsen (2018)
10.1007/978-3-319-40501-8_3
Arterial Stiffness and Blood Pressure Variability
Paolo Salvi (2017)
10.1111/ijs.12607
High Rate of Microbleed Formation following Primary Intracerebral Hemorrhage
Jason Mackey (2015)
10.3988/jcn.2016.12.2.129
Considerations When Subtyping Ischemic Stroke in Asian Patients
Oh Young Bang (2016)
10.1007/s12975-018-0639-6
High Circulatory Phosphate Level Is Associated with Cerebral Small-Vessel Diseases
Chih-Ping Chung (2018)
10.1016/j.jstrokecerebrovasdis.2017.06.040
Racial Difference in Cerebral Microbleed Burden among Ischemic Stroke Patients.
S. Shahjouei (2017)
10.1161/HYPERTENSIONAHA.113.02735
Blood Pressure, Internal Carotid Artery Flow Parameters, and Age-Related White Matter Hyperintensities
Benjamin S. Aribisala (2014)
10.1016/j.jstrokecerebrovasdis.2014.05.030
Effect of blood pressure variability on cardiovascular outcome in diabetic and nondiabetic patients with stroke.
Bu-xing Chen (2014)
10.1016/j.jns.2016.01.015
Longitudinal relationship between chronic kidney disease and distribution of cerebral microbleeds in patients with ischemic stroke
Qing Peng (2016)
10.3390/diagnostics10010018
Cerebral Microbleeds in a Stroke Prevention Clinic
A-Hyun Cho (2019)
10.1093/ajh/hpt167
Visit-to-visit blood pressure variability, silent cerebral injury, and risk of stroke.
Mina Nagai (2013)
10.1152/ajpheart.00780.2016
Cerebral microhemorrhages: mechanisms, consequences, and prevention.
Zoltan Ungvari (2017)
10.1042/CS20160384
Disease progression and regression in sporadic small vessel disease-insights from neuroimaging.
Esther M C van Leijsen (2017)
10.3389/fphys.2014.00120
Arterial pressure and cerebral blood flow variability: friend or foe? A review
Caroline A. Rickards (2014)
10.1371/journal.pone.0129917
Effect of Carotid Artery Stenting on Cognitive Function in Patients with Internal Carotid Artery Stenosis and Cerebral Lacunar Infarction: A 3-Year Follow-Up Study in China
Zhang Xia (2015)
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