Please confirm you are human (Sign Up for free to never see this)
← Back to Search
Soluble Intercellular Adhesion Molecule-1 (sICAM-1) And Interferon-gamma In Bronchoalveolar Lavage Fluid From Children With Airway Diseases.
C. Marguet, T. Dean, J. Warner
Published 2000 · Medicine
Save to my Library
Download PDFAnalyze on Scholarcy
We have previously described that in bronchoalveolar lavage fluid (BALF), eosinophils characterize asthma and neutrophils are more prominent in infantile wheeze. In this study, we hypothesized that intercellular adhesion molecule 1 (ICAM-1) and interferon-gamma (IFN-gamma) would have a role in promoting migration of both cell types into the airway. To investigate this, we measured soluble (s) ICAM-1 in 68 BALFs from infants and young children with various respiratory problems. Children with asthma were characterized by significantly raised sICAM compared with those with chronic cough without wheeze (p = 0.05) or control subjects with no lower airway pathology (p = 0.045). The levels correlated with disease severity (evaluated with a symptom score) and with lymphocyte numbers. IFN-gamma levels were also raised in children with asthma compared with those with chronic cough (p = 0.05), but there was no correlation with disease activity. Infantile wheeze was characterized by a linear correlation between sICAM-1 and IFN-gamma (r = 0.55; p = 0.002). sICAM-1 levels in infantile wheeze correlated with the severity of the disease and lymphocyte numbers. IFN-gamma levels were elevated in the wheezers treated with inhaled steroids compared with untreated infants (p = 0.03). Although sICAM-1 levels were increased in those with severe cough, no characteristic inflammatory profile was found in the group with chronic cough. Our study suggests that ICAM-1 and IFN-gamma play a role in the activity of the inflammatory process in asthma in childhood and possibly in some infant wheezers, in whom IFN-gamma may be one of the factors increasing the expression of ICAM-1. The role of IFN-gamma, a T helper-1 cytokine, in children with asthma remains to be fully understood.
This paper references
Elevated serum interferon-gamma in atopic asthma correlates with increased airways responsiveness and circadian peak expiratory flow variation.
N. T. ten Hacken (1998)
Asthma and wheezing in the first six years of life. The Group Health Medical Associates.
F. Martinez (1995)
P-selectin/ICAM-1 double mutant mice: acute emigration of neutrophils into the peritoneum is completely absent but is normal into pulmonary alveoli.
D. Bullard (1995)
Bacterial-induced release of inflammatory mediators by bronchial epithelial cells.
O. Khair (1996)
Predominant TH2-like bronchoalveolar T-lymphocyte population in atopic asthma.
D. Robinson (1992)
Bronchoalveolar lavage fluid cellularity and soluble intercellular adhesion molecule‐1 in children with colds
J. Grigg (1999)
Glucocorticosteroids affect functions of airway- and blood-derived human T-cell clones, favoring the Th1 profile through two mechanisms.
F. H. Krouwels (1996)
Asthma and inflammation.
A. B. Kay (1991)
Increased production of IFN-γ and cysteinyl leukotrienes in virus-induced wheezing
S. Schaik (1999)
Th2 cytokines exert a dominant influence on epithelial cell expression of the major group human rhinovirus receptor, ICAM-1.
A. Bianco (1998)
Lymphocyte subsets, sIL2‐R and sICAM‐1 in blood during allergen challenge tests in asthmatic children
M. Schmitt (1993)
Reduced Interferon- γ Production in Infants with Bronchiolitis and Asthma
P. Renzi (1999)
Correlation of bronchial eosinophil and mast cell activation with bronchial hyperresponsiveness in children with asthma.
A. Ferguson (1992)
Eosinophil adhesion in allergic inflammation.
A. Wardlaw (1994)
Cell infiltration, ICAM-1 expression, and eosinophil chemotactic activity in asthmatic sputum.
R. Louis (1997)
Differential patterns of circulating adhesion molecules in children with bronchial asthma and acute bronchiolitis
K. Øymar (1998)
IFN-gamma potentiates the release of TNF-alpha and MIP-1alpha by alveolar macrophages during allergic reactions.
R. Déry (1999)
ICAM-1 on epithelial cells in allergic subjects: a hallmark of allergic inflammation.
G. Canonica (1995)
Intercellular adhesion molecule-1 (ICAM-1) and endothelial leucocyte adhesion molecule-1 (ELAM-1) expression in the bronchial mucosa of normal and asthmatic subjects.
S. Montefort (1992)
Circulating adhesion molecules in asthma.
S. Montefort (1994)
Corticosteroids inhibit IL-12 production in human monocytes and enhance their capacity to induce IL-4 synthesis in CD4+ lymphocytes.
M. H. Blotta (1997)
The expression of intercellular adhesion molecule-1 and the beta 1-integrins in asthma.
N. Manolitsas (1994)
Soluble intercellular adhesion molecule-1 in the bronchoalveolar lavage fluid of normal children exposed to parental cigarette smoke.
J. Grigg (1999)
Is deficiency of interferon gamma production by allergen triggered cord blood cells a predictor of atopic eczema?
J. Warner (1994)
The role of ICAM-1 on T-cells in the pathogenesis of asthma.
L. Stanciu (1998)
T-cell cytokine profile evaluated at the single cell level in BAL and blood in allergic asthma.
N. Krug (1996)
Prednisolone treatment in asthma is associated with modulation of bronchoalveolar lavage cell interleukin-4, interleukin-5, and interferon-gamma cytokine gene expression.
D. Robinson (1993)
Role of elevated plasma soluble ICAM-1 and bronchial lavage fluid IL-8 levels as markers of chronic lung disease in premature infants.
S. Little (1995)
Bronchoalveolar lavage findings suggest two different forms of childhood asthma
E. Stevenson (1997)
The one-two of T helper cells: does interferon-gamma knock out the Th2 hypothesis for asthma?
M. Holtzman (1996)
Bronchoalveolar cell profiles in children with asthma, infantile wheeze, chronic cough, or cystic fibrosis.
C. Marguet (1999)
Viral infections and the development of asthma.
F. Martinez (1995)
Bronchial biopsy evidence for leukocyte infiltration and upregulation of leukocyte-endothelial cell adhesion molecules 6 hours after local allergen challenge of sensitized asthmatic airways.
S. Montefort (1994)
Third International Pediatric Consensus statement on the management of childhood asthma
J. Warner (1998)
Inhaled corticosteroids increase interleukin-10 but reduce macrophage inflammatory protein-1alpha, granulocyte-macrophage colony-stimulating factor, and interferon-gamma release from alveolar macrophages in asthma.
M. John (1998)
HLA-DR and ICAM-1 expression on bronchial epithelial cells in asthma and chronic bronchitis.
A. Vignola (1993)
Intercellular adhesion molecule-1 (ICAM-1) in the pathogenesis of asthma.
C. Wegner (1990)
This paper is referenced by
Official American Thoracic Society Clinical Practice Guidelines: Diagnostic Evaluation of Infants with Recurrent or Persistent Wheezing.
C. Ren (2016)
IL-3 , 5 and GM-CSF-induced Adhesion Molecule Expression on Eosinophils by p 38 MAPK and NF-κ B
C. Wong (2003)
The development of exhaled breath condensate: a noninvasive method of measuring airway inflammation
P.P.R. Rosias (2008)
IL‐25 regulates the expression of adhesion molecules on eosinophils: mechanism of eosinophilia in allergic inflammation
P. F. Cheung (2006)
CHAPTER 23 – Social Context as an Individual Difference in Psychoneuroimmunology
E. Chen (2007)
Update on the roles of distal airways in asthma
P. Burgel (2009)
Chronic Cough in Children
A. Chang (2014)
Staphylococcus aureus enterotoxins induce IL-8 secretion by human nasal epithelial cells
Garrett J O'Brien (2006)
The Effect of Vitamin C Supplementation on sICAM-1 in Asthmatic Study Participants
Lindsay Gnant (2014)
Early elevation of plasma soluble intercellular adhesion molecule-1 in pediatric acute lung injury identifies patients at increased risk of death and prolonged mechanical ventilation*
H. Flori (2003)
Delayed asthmatic response: a new phenotype of bronchial response to allergen challenge and soluble adhesion molecules in the serum.
Z. Pelikán (2011)
Pulmonary chemokines and their receptors differentiate children with asthma and chronic cough.
D. Hartl (2005)
Increased eosinophil cationic protein levels in bronchoalveolar lavage from wheezy infants
I. Azevedo (2001)
Serum concentrations of interferon‐γ and intercellular adhesion molecule‐1 eight years after an early respiratory syncytial virus infection
H. Juntti (2005)
[Upper airway cellular pattern in infants with acute bronchiolitis: neutrophils or eosinophils?].
P. Pitrez (2003)
Increased interleukin-4 and decreased interferon-gamma in exhaled breath condensate of children with asthma.
Sukhbir K Shahid (2002)
Inflammatory Features of Childhood Asthma
M. Krawiec (2005)
Association of respiratory syncytial virus infection with asthma and atopic allergy
H. Juntti (2008)
Blood Group Type, Intercellular Adhesion Molecule-1 (ICAM-1)and Angiotensin-2 Impact on COVID.19 Outcomes
Mosab Nouraldein Mohammed Hamad (2020)
MICROCIRCULATORY ALTERATIONS OF HEPATIC AND MESENTERIC MICROCIRCULATION IN ENDOTOXIN TOLERANCE
S. Lendemans (2008)
Effect of intense wrestling exercise on leucocytes and adhesion molecules in adolescent boys
D. Nemet (2004)
Difficult asthma in children: an analysis of airway inflammation.
J. de Blic (2004)
Inflammatory profile in nasal secretions of infants hospitalized with acute lower airway tract infections
P. M. Pitrez (2005)
sICAM-1 and TNF-α in Asthma and Rhinitis: Relationship with the Presence of Atopy
M. Ciebiada (2011)
L'école française des pédiatres asthmologues
G. Dutau (2003)
Thymic stromal lymphopoietin induces chemotactic and prosurvival effects in eosinophils: implications in allergic inflammation.
C. Wong (2010)
Intercellular adhesion molecule 1 and tumor necrosis factor alpha in asthma and persistent allergic rhinitis: relationship with disease severity.
M. Gorska-Ciebiada (2006)
Increased interleukin-4 and decreased interferon-γ levels in serum of children with asthma.
M. Lama (2011)
Adhesion Molecules and Smoking
M. Garabedian (2010)
Adhesion in Physiological, Benign and Malignant Proliferative States of the Endometrium: Microenvironment and the Clinical Big Picture
E. Rutherford (2018)
Serum and bronchial lavage fluid concentrations of IL-8, SLPI, sCD14 and sICAM-1 in patients with COPD and asthma.
C. Hollander (2007)
T cell cytokine production in childhood asthma
V. Brown (2005)See more