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Microsomal Epoxide Hydrolase, Endotoxin, And Lung Function Decline In Cotton Textile Workers.
Jing-qing Hang, W. Zhou, X. Wang, H. Zhang, B. Sun, Helian Dai, L. Su, D. Christiani
Published 2005 · Medicine
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Occupational exposure to endotoxin in organic dust may induce lung function decline. Microsomal epoxide hydrolase (mEH) detoxifies reactive oxygen species generated by endotoxin exposure, and polymorphisms of the mEH gene are associated with altered enzyme activity. We investigated the associations between mEH polymorphisms, endotoxin exposure, and lung function decline in a 20-year prospective study of 265 workers exposed to endotoxin and 234 control subjects. mEH Tyr113His and His139Arg polymorphisms were genotyped by the 5' nuclease assay, and data were analyzed using multivariate linear regression models, adjusting for important covariates. Overall, the annual decline rate of FEV1 was 29.47 ml during the 20-year follow-up. Endotoxin exposure was associated with faster lung function decline among genotypes associated with slower enzyme activity: estimates (SE) of annual FEV1 decline rates for endotoxin exposure were -2.33 (2.07), -2.81 (1.66), and -6.73 (2.83) ml for Tyr/Tyr, Tyr/His, and His/His genotype groups, respectively, for the Tyr113His polymorphism; and -1.82 (2.58) and -4.27 (1.33) ml for Arg/Arg + His/Arg and His/His genotypes, respectively, for the His139Arg polymorphism. We conclude that mEH polymorphisms modify the association between occupational endotoxin exposure and longitudinal lung function decline.
This paper references
Pulmonary function among cotton textile workers. A study of variability in symptom reporting, across-shift drop in FEV1, and longitudinal change.
D. Christiani (1994)
Chronic lipopolysaccharide exposure on airway function, cell infiltration, and nitric oxide generation in conscious guinea pigs: effect of rolipram and dexamethasone.
T. Toward (2001)
THE AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
R. A. Klocke (1994)
The role of endotoxin in grain dust-induced lung disease.
D. Schwartz (1995)
Gene polymorphism for microsomal epoxide hydrolase and susceptibility to emphysema in a Japanese population.
K. Takeyabu (2000)
Pulmonary function and symptoms after inhalation of endotoxin.
R. Rylander (1989)
Mechanisms of cell injury by activated oxygen species.
J. Farber (1994)
Dose-response relationship to inhaled endotoxin in normal subjects.
O. Michel (1997)
Epoxide hydrolase--polymorphism and role in toxicology.
C. J. Omiecinski (2000)
Impact of phase I or phase II enzyme polymorphisms on lymphocyte DNA adducts in subjects exposed to urban air pollution and environmental tobacco smoke.
P. Georgiadis (2004)
Applied Regression Analysis and Other Multivariable Methods
D. Kleinbaum (1978)
[Association between polymorphisms in the microsomal epoxide hydrolase (mEH) gene and chronic obstructive pulmonary disease].
D. Xiao (2003)
Longitudinal changes in pulmonary function and respiratory symptoms in cotton textile workers. A 15-yr follow-up study.
D. Christiani (2001)
Genetic susceptibility for emphysematous changes of the lung in Japanese.
A. Budhi (2003)
Reactive Oxygen and Nitrogen Species Differentially Regulate Toll-Like Receptor 4-Mediated Activation of NF-κB and Interleukin-8 Expression
Kieran A. Ryan (2004)
The Importance of Polymorphonuclear Leukocytes in Lipopolysaccharide-Induced Superoxide Anion Production and Lung Injury: Ex Vivo Observation in Rat Lungs
C. Tsuji (1998)
Determinants of longitudinal changer in spirometric functions among swine confinement operators and farm
DA Schwartz (1995)
Human peripheral lymphocytes as indicators of microsomal epoxide hydrolase activity in liver and lung.
C. J. Omiecinski (1993)
Effect of inhaled endotoxin on induced sputum in normal, atopic, and atopic asthmatic subjects
J. Nightingale (1998)
Epoxide hydrolases: biochemistry and molecular biology.
A. Fretland (2000)
Several functions of immune cells in mice changed by oxidative stress caused by endotoxin.
V. Víctor (2003)
Airborne endotoxin concentrations in various work areas within two cotton textile mills in the People's Republic of China.
S. Olenchock (1990)
Detection of polymorphisms at exons 3 (Tyr113-->His) and 4 (His139-->Arg) of the microsomal epoxide hydrolase gene using fluorescence PCR method combined with melting curves analysis.
F. Rodríguez (2002)
Genetic polymorphism of epoxide hydrolase and glutathione S-transferase in COPD
S. Cheng (2004)
Morphometric changes of the lung induced by inhaled bacterial endotoxin.
R. Lantz (1985)
Cotton dust and across-shift change in FEV1 as predictors of annual change in FEV1.
H. Glindmeyer (1994)
Determinants of longitudinal changes in spirometric function among swine confinement operators and farmers.
D. Schwartz (1995)
Association between polymorphism in gene for microsomal epoxide hydrolase and susceptibility to emphysema
C. A. Smith (1997)
Cotton dust and endotoxin exposure and long-term decline in lung function: results of a longitudinal study.
D. Christiani (1999)
A follow-up study of the grain elevator workers in the Port of Vancouver.
M. Chan-Yeung (1981)
Susceptibility genes for rapid decline of lung function in the lung health study.
A. Sandford (2001)
[Microsomal epoxide hydrolase gene polymorphism and susceptibility to chronic obstructive pulmonary disease in Han nationality of North China].
R. Zhang (2002)
Xenobiotic metabolism enzyme gene expression in human bronchial epithelial and alveolar macrophage cells.
J. Willey (1996)
Genetic susceptibility to chronic obstructive pulmonary disease in Koreans: combined analysis of polymorphic genotypes for microsomal epoxide hydrolase and glutathione S-transferase M1 and T1
J. Yim (2000)
Epoxide hydrolases: new tools for the synthesis of fine organic chemicals.
A. Archelas (1998)
Respiratory symptoms and cotton dust exposure; results of a 15 year follow up observation
X. Wang (2003)
Human microsomal epoxide hydrolase: genetic polymorphism and functional expression in vitro of amino acid variants.
C. Hassett (1994)
Variable airway responsiveness to inhaled lipopolysaccharide.
J. Kline (1999)
Microsomal epoxide hydrolase genotypes and chronic obstructive pulmonary disease in Japanese.
M. Yoshikawa (2000)
This paper is referenced by
Exposure–response relationship between endotoxin exposure and lung function impairment in cotton textile workers
M. Oldenburg (2007)
The effect of organic dust exposure on long-term change in lung function: a systematic review and meta-analysis
A. C. Bolund (2017)
Updates on the COPD gene list
Y. Bossé (2012)
Do genetic factors protect for early onset lung cancer? A case control study before the age of 50 years
A. Rosenberger (2007)
Oviductal Microsomal Epoxide Hydrolase (EPHX1) Reduces Reactive Oxygen Species (ROS) Level and Enhances Preimplantation Mouse Embryo Development1
Ana W. Y. Cheong (2009)
Biomarkers in Occupational Asthma
J. Domínguez-Ortega (2016)
Association between polymorphisms of microsomal epoxide hydrolase and COPD: Results from meta‐analyses
G. Hu (2008)
Frontiers in occupational and environmental lung disease research.
S. Muzaffar (2012)
The role of gene–environment interplay in occupational and environmental diseases: current concepts and knowledge gaps
Elizabeth Kwo (2017)
Emphysema in the Nonsmoker
Delano S. Fabro (2008)
Genetic susceptibility to occupational exposures
D. Christiani (2008)
Genome-wide interaction study of gene-by-occupational exposure and effects on FEV1 levels.
K. de Jong (2015)
Cotton dust lung diseases
A. J. Khan (2007)
Interactive effect of paraoxonase-1 Q192R polymorphism and smoking history on the lung function decline in grain workers.
Takayuki Seo (2008)
Cross-shift airway responses and long-term decline in FEV1 in cotton textile workers.
X. Wang (2008)
Gene-environment interaction from international cohorts: impact on development and evolution of occupational and environmental lung and airway disease.
Adam W. Gaffney (2015)
Genetics of lung function decline and COPD development
C. C. V. Diemen (2008)
Association between cytochrome P450 3A5 polymorphism and the lung function in Saskatchewan grain workers
Takayuki Seo (2008)
Association between paraoxonase-1 Q192R polymorphism and lung function among Saskatchewan grain handlers.
Seo Takayuki (2007)
Chronic Lung Function Decline in Cotton Textile Workers: Roles of Historical and Recent Exposures to Endotoxin
J. Shi (2010)
Longitudinal pulmonary functional loss in cotton textile workers: A 5-year follow-up study
H. Kahraman (2013)
A Large Scale Gene-Centric Association Study of Lung Function in Newly-Hired Female Cotton Textile Workers with Endotoxin Exposure
Ruyang Zhang (2013)
EPHX1 Gene Polymorphisms in Alcohol Dependence and their Distribution among the Indian Populations
L. V. Bhaskar (2013)
Pulmonary innate immune modulation in the pathogenesis of allergic asthma
S. Natarajan (2009)
Genetic polymorphism in metabolism and host defense enzymes: Implications for human health risk assessment
G. Ginsberg (2010)
Endotoxin and gender modify lung function recovery after occupational organic dust exposure: a 30-year study
P. Lai (2015)
Update in environmental and occupational medicine 2005.
T. Nawrot (2006)