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Trend-based Analysis Of Retinal Nerve Fiber Layer Thickness Measured By Optical Coherence Tomography In Eyes With Localized Nerve Fiber Layer Defects.

Eun Ji Lee, Tae-Woo Kim, R. Weinreb, K. Park, S. Kim, D. Kim
Published 2011 · Medicine

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PURPOSE To evaluate the rate of change in retinal nerve fiber layer (RNFL) thickness measured by optical coherence tomography (OCT) in eyes with stable and progressive localized RNFL defects and to investigate, in a trend-based approach, the diagnostic capability of OCT in the detection of progressive RNFL thinning. METHODS The study included 153 glaucomatous eyes with localized RNFL defects. The patients were divided into nonprogressors (n = 77) and progressors (n = 76) on the basis of an evaluation of serial red-free photographs. The rates of progressive thinning in global, quadrant, and clock-hour OCT RNFL thicknesses were determined, by linear regression, and were compared between groups. Areas under receiver operating characteristic curves and sensitivities at fixed specificities were calculated for each parameter. RESULTS The rate of progressive RNFL thinning was significantly faster in progressors than in nonprogressors globally; in the inferior quadrant; in the 10, 11, 6, and 7 o'clock sectors; and in the affected quadrant and clock-hour sector thicknesses (all P ≤ 0.001). The rate of RNFL thinning in affected clock-hour sectors had the highest ability to discriminate between stable and progressive RNFL thinning with a sensitivity of 62% (95% confidence interval, 50%-73%) at a specificity ≥80%. Agreement between OCT and red-free photography was strongest when the criterion of -3.6 μm/year with P < 0.1 was used for each clock hour. CONCLUSIONS The rate of OCT RNFL thinning was significantly greater in patients with progressive localized RNFL defects than in those with stable localized defects. The data suggest that trend-based analysis of OCT RNFL thickness may be useful in glaucoma progression analysis and may complement other diagnostic tests.
This paper references
10.1167/IOVS.03-0692
Relationship between visual field sensitivity and retinal nerve fiber layer thickness as measured by scanning laser polarimetry.
P. Schlottmann (2004)
10.1136/bjo.2008.150698
Agreement between spectral-domain and time-domain OCT for measuring RNFL thickness
G. Vizzeri (2009)
10.1097/01.ijg.0000212218.96932.f7
Correlation Between Topographic Profiles of Localized Retinal Nerve Fiber Layer Defects as Determined by Optical Coherence Tomography and Red-Free Fundus Photography
J. Hwang (2006)
10.2307/1402915
Statistical methods for rates and proportions
J. Fleiss (1981)
10.1016/j.ophtha.2009.07.033
Screening for glaucoma in high-risk populations using optical coherence tomography.
Giséle Li (2010)
10.1167/iovs.09-3468
Evaluation of retinal nerve fiber layer progression in glaucoma: a study on optical coherence tomography guided progression analysis.
C. Leung (2010)
10.1016/S0002-9394(14)72385-2
Initial glaucomatous optic disk and retinal nerve fiber layer abnormalities and their progression.
A. Tuulonen (1991)
10.1016/j.ajo.2008.07.023
Agreement among glaucoma specialists in assessing progressive disc changes from photographs in open-angle glaucoma patients.
Henry D. Jampel (2009)
Clinical evaluation of the optic disc and retinal nerve fiber layer
P Airaksinen (1996)
10.1167/iovs.09-3715
Detection of glaucoma progression with stratus OCT retinal nerve fiber layer, optic nerve head, and macular thickness measurements.
F. Medeiros (2009)
10.1016/S0161-6420(93)31598-8
Nerve fiber layer defects with normal visual fields. Do normal optic disc and normal visual field indicate absence of glaucomatous abnormality?
A. Tuulonen (1993)
10.1167/IOVS.05-1584
Optic disc and visual field progression in ocular hypertensive subjects: detection rates, specificity, and agreement.
N. Strouthidis (2006)
10.1016/S0161-6420(96)30410-7
Reproducibility of nerve fiber layer thickness measurements using optical coherence tomography.
J. Schuman (1996)
10.1016/J.OPHTHA.2006.08.046
Determinants of normal retinal nerve fiber layer thickness measured by Stratus OCT.
D. Budenz (2007)
10.1001/ARCHOPHT.1991.01080010079037
Clinically detectable nerve fiber atrophy precedes the onset of glaucomatous field loss.
A. Sommer (1991)
10.1016/J.OPHTHA.2007.01.023
Normal age-related decay of retinal nerve fiber layer thickness.
R. Parikh (2007)
10.1167/iovs.08-1682
Ability of Stratus OCT to detect progressive retinal nerve fiber layer atrophy in glaucoma.
Eun Ji Lee (2009)
10.1001/ARCHOPHT.1977.04450120055003
The nerve fiber layer in the diagnosis of glaucoma.
A. Sommer (1977)
Fundoscopy of nerve fiber layer defects in glaucoma.
W. Hoyt (1973)
10.1097/IJG.0b013e318193c29f
Comparison of Retinal Nerve Fiber Layer Thickness Values Using Stratus Optical Coherence Tomography and Heidelberg Retina Tomograph-III
J. Moreno-Montañés (2009)
10.1016/S0161-6420(82)34798-3
The onset and evolution of glaucomatous visual field defects.
W. Hart (1982)
10.1016/j.ophtha.2010.01.046
Quantitative assessment of diffuse retinal nerve fiber layer atrophy using optical coherence tomography: diffuse atrophy imaging study.
Jin Wook Jeoung (2010)
10.1167/IOVS.05-0294
Comparative study of retinal nerve fiber layer measurement by StratusOCT and GDx VCC, I: correlation analysis in glaucoma.
C. Leung (2005)
10.1001/ARCHOPHT.123.4.464
Optical coherence tomography longitudinal evaluation of retinal nerve fiber layer thickness in glaucoma.
G. Wollstein (2005)



This paper is referenced by
10.1097/IJG.0000000000000046
Rates and Patterns of Macular and Circumpapillary Retinal Nerve Fiber Layer Thinning in Preperimetric and Perimetric Glaucomatous Eyes
J. Na (2015)
10.1167/iovs.13-13776
Effect of diabetic macular edema on peripapillary retinal nerve fiber layer thickness profiles.
D. J. Hwang (2014)
10.1016/j.ophtha.2012.11.008
Long-term reproducibility of cirrus HD optical coherence tomography deviation map in clinically stable glaucomatous eyes.
Kyu Hwa Roh (2013)
Glaucoma Comparative Assessment for the Ability of Cirrus , RTVue , and 3 D-OCT to Diagnose Glaucoma
Azusa Akashi (2013)
10.1371/journal.pone.0185649
Usefulness of axonal tract-dependent OCT macular sectors for evaluating structural change in normal-tension glaucoma
Kazuko Omodaka (2017)
10.3109/02713683.2012.742913
Progression of Retinal Nerve Fiber Layer Thinning in Glaucoma Assessed by Cirrus Optical Coherence Tomography-guided Progression Analysis
J. Na (2013)
10.1007/s10384-017-0511-3
Patterns of glaucoma progression in retinal nerve fiber and macular ganglion cell-inner plexiform layer in spectral-domain optical coherence tomography
H. Kim (2017)
10.5005/jp-journals-10008-1108
Assessment of Structural Glaucoma Progression
A. Miki (2012)
10.1007/s10384-013-0276-2
Discrepancy between optic disc and nerve fiber layer assessment and optical coherence tomography in detecting glaucomatous progression
Jong Rak Lee (2013)
10.1167/iovs.10-6818
β-Zone parapapillary atrophy and the rate of retinal nerve fiber layer thinning in glaucoma.
Eun Ji Lee (2011)
10.1007/978-1-62703-164-6
Assessing Ocular Toxicology in Laboratory Animals
Andrea B. Weir (2013)
10.1007/s10384-019-00706-2
Machine learning classifiers-based prediction of normal-tension glaucoma progression in young myopic patients
J. Lee (2019)
10.5455/aim.2014.22.237-240
Predictive Values of Optical Coherence Tomography (OCT) Parameters in Assessment of Glaucoma progression
S. Kasumovic (2014)
10.1167/iovs.18-25296
Rates of Ganglion Cell-Inner Plexiform Layer Thinning in Normal, Open-Angle Glaucoma and Pseudoexfoliation Glaucoma Eyes: A Trend-Based Analysis.
Won June Lee (2019)
10.1016/j.ophtha.2014.01.017
Rates of retinal nerve fiber layer thinning in glaucoma suspect eyes.
A. Miki (2014)
10.1007/s10384-012-0181-0
Test–retest variability in structural parameters measured with glaucoma imaging devices
M. Araie (2012)
Effect of Peripapillary Vitreous Opacity on Retinal Nerve Fiber Layer Thickness Measurement Using Optical Coherence Tomography
Irmgard Behlau (2012)
10.3109/02713683.2016.1170855
Effects of Diabetic Macular Edema on Repeatability of Retinal Nerve Fiber Layer Thickness Measurements at the Macular and Peripapillary Area Using Swept-Source Optical Coherence Tomography
J. K. Min (2017)
structural and functional tools the glaucoma spectrum assessed by 5-year disease progression of patients across
Natasha Gautam Seth ()
10.1007/978-1-62703-164-6_3
Emerging Imaging Technologies for Assessing Ocular Toxicity in Laboratory Animals
T. Nork (2012)
10.3928/15428877-20110627-01
Clinical use of OCT in assessing glaucoma progression.
J. Kotowski (2011)
10.1111/ceo.13826
Determination of retinal nerve fibre layer and ganglion cell/inner plexiform layers progression rates using two optical coherence tomography systems: The PROGRESSA study
D. Saks (2020)
10.1016/bs.pbr.2015.04.011
How to detect progression in glaucoma.
J. Vianna (2015)
10.4172/2155-9570.1000247
Evaluation of Retinal Nerve Fiber Layer Thickness with Spectral Domain Oct in Primary Open Angle Glaucoma and Ocular Hypertension
Esra Şahlı (2012)
10.1167/iovs.15-17297
Location of Initial Visual Field Defects in Glaucoma and Their Modes of Deterioration.
J. Kim (2015)
10.1097/IJG.0b013e3182120700
Glaucoma Progression After the First-detected Optic Disc Hemorrhage by Optical Coherence Tomography
M. Suh (2012)
10.1136/bjophthalmol-2017-310731
5-year disease progression of patients across the glaucoma spectrum assessed by structural and functional tools
N. Seth (2017)
10.1111/ceo.12363
Regional structural vulnerability of the macula in patients with normal tension glaucoma
Kazuko Omodaka (2015)
10.1001/archophthalmol.2011.2517
Effect of peripapillary vitreous opacity on retinal nerve fiber layer thickness measurement using optical coherence tomography.
Y. H. Hwang (2012)
Association Between Electroretinogram-identified Vigabatrin Toxicity and Subsequent Visual Field Reduction
Ananthavalli Kumarappah (2014)
Glaucoma Longitudinal Analysis of Progression in Glaucoma Using Spectral-Domain Optical Coherence Tomography
Julia M. Wessel (2013)
10.1097/IJG.0b013e318264b941
Combining Information From 3 Anatomic Regions in the Diagnosis of Glaucoma With Time-Domain Optical Coherence Tomography
M. Wang (2014)
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