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Metabolic Relationships Among The Plasma Lipoproteins. Reciprocal Changes In The Concentrations Of Very Low And Low Density Lipoproteins In Man.

D. Wilson, R. Lees
Published 1972 · Chemistry, Medicine

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The changes in other plasma lipoproteins which accompany alterations in very low density lipoproteins (VLDL) were studied in 31 normal and hyperlipidemic men and women who underwent weight reduction, carbohydrate induction, or clofibrate treatment. Plasma lipids and individual lipoprotein cholesterol concentrations were measured serially during control and treatment periods. Low density lipoprotein (LDL) protein was determined by radial immunodiffusion. Oppositely directed changes in VLDL and LDL were found with each of the three metabolic perturbations. Changes in high density lipoprotein (HDL) cholesterol generally paralleled those in LDL but were less consistent. Two patients with type III hyperlipoproteinemia failed to demonstrate reciprocal increases in LDL despite more than 40% reduction in plasma glycerides or VLDL with weight reduction or clofibrate therapy. After clofibrate therapy, LDL increased in proportion to the absolute decrease in VLDL cholesterol during treatment. LDL protein changed relatively less than did LDL cholesterol. The mechanism for the interdependency of plasma VLDL and LDL concentrations over the long term is not known and may be the result of altered rates of interconversion of these lipoproteins, or to feedback inhibition by VLDL of LDL production and release.
This paper references
Physical and chemical properties of the low - density lipoproteins and their analysis by refractometry
J. M. Dietschy (1965)
10.1172/JCI105324
The nature of pre beta (very low density) lipoproteins.
R. Levy (1966)
10.1016/0002-9343(68)90165-4
Treatment of hyperlipidemias.
E. H. Strisower (1968)
10.1016/0005-2760(70)90122-0
Very low density lipoprotein subfractions in a subject with broad-beta disease (Type 3 hyperlipoproteinemia) and a subject with endogenous lipemia (Type IV). Chemical composition and electrophoretic mobility.
W. Hazzard (1970)
10.1111/j.1753-4887.1987.tb02699.x
Fat transport in lipoproteins--an integrated approach to mechanisms and disorders.
D. Fredrickson (1967)
10.1093/AJCN/2.5.336
The use of orally-fed liquid formulas in metabolic studies.
Edward H. Ahrens (1954)
10.1172/JCI103596
Studies on the metabolism of plasma proteins in the nephrotic syndrome. II. The lipoproteins.
D. Gitlin (1958)
Splanchnic metabolism in healthy young men given clofibrate
B. Wolfe (1970)
10.1172/JCI104202
Idiopathic hyperlipemia: metabolic studies in an affected family.
R. Havel (1960)
10.1172/JCI106448
Very low density lipoprotein triglyceride transport in type IV hyperlipoproteinemia and the effects of carbohydrate-rich diets.
S. Quarfordt (1970)
10.1016/0926-6542(64)90040-X
STUDIES OF THE COMPOSITION AND STRUCTURE OF SERUM LIPOPROTEINS: PHYSICAL-CHEMICAL CHARACTERIZATION OF PHOSPHOLIPID-PROTEIN RESIDUES OBTAINED FROM VERY-LOW-DENSITY HUMAN SERUM LIPOPROTEINS.
A. Gustafson (1964)
10.1016/B978-1-4831-9942-9.50008-5
Practical methods for plasma lipoprotein analysis.
F. Hatch (1968)
Plasma low density lipoprotein ( LDL ) : a remnant of very low density lipoprotein ( VLDL ) catabolism ?
N. K. Freeman (1970)
10.1126/science.169.3944.493
Immunoassay of Plasma Low-Density Lipoproteins
R. Lees (1970)
10.1056/NEJM197005212822105
Regulation of cholesterol metabolism.
J. Dietschy (1970)
Regulation of cholesterol metabolism in man.
R. Nicolaysen (1971)
10.1093/CLINCHEM/12.10.681
An improved automated determination of serum total cholesterol with a single color reagent.
W. Block (1966)
10.1172/JCI106206
Failure of bile acids to control hepatic cholesterogenesis: evidence for endogenous cholesterol feedback.
H. J. Weis (1969)
10.1016/S0368-1319(68)80025-0
Effect of nicotinic acid on plasma lipids in patients with hyperlipoproteinemia during the first week of treatment.
L. Carlson (1968)
Plasma low density lipoprotein ( LDL ) : a remnant of very low density lipoprotein ( VLDL ) catabolism ?
F. Glazier (1970)
10.1073/PNAS.64.3.1128
Functions and interrelationships of different classes of plasma lipoproteins.
A. Nichols (1969)



This paper is referenced by
10.3109/00365518109090519
Changes in plasma high density lipoproteins and lipolytic enzymes after long-term, heavy ethanol consumption
R. Ekman (1981)
10.1172/JCI109564
Metabolic fate of chylomicron phospholipids and apoproteins in the rat.
A. Tall (1979)
10.1007/BF02536163
Compositional changes and apoprotein A-I metabolism of plasma high density lipoprotein in estrogenized chicks
B. H. Cho (2006)
10.1007/BF00252761
High-density lipoprotein cholesterol and apolipoprotein A-I levels at diagnosis in patients with non-insulin dependent diabetes
K. Taylor (2004)
10.1016/B978-0-12-024918-3.50008-3
Effects of hypolipidemic drugs on bile acid metabolism in man.
T. Miettinen (1981)
10.1016/0021-9150(79)90037-6
Changes in plasma lipoproteins accompanying diet therapy in obese diabetics.
B. Howard (1979)
10.1001/JAMA.1987.03390040118029
Decrease in plasma high-density lipoprotein cholesterol levels at puberty in boys with delayed adolescence. Correlation with plasma testosterone levels.
R. Kirkland (1987)
10.1007/BF01651267
Lipoproteinveränderungen unter Clofibrat bei Typ IV-Hyperlipoproteinämien
P. Weisweiler (2005)
10.1016/0021-9150(81)90019-8
High density lipoprotein cholesterol, insulin and obesity in Samoans.
C. Hornick (1981)
10.7326/0003-4819-80-2-143
Moderate ethanol ingestion and plasma triglyceride levels. A study in normal and hypertriglyceridemic persons.
H. Ginsberg (1974)
10.1016/0021-9150(76)90013-7
Relationships between plasma lipoprotein cholesterol concentrations and the pool size and metabolism of cholesterol in man.
N. Miller (1976)
10.1002/cpt1976193352
One‐year trials with halofenate, clofibrate, and placebo
Carlos A. Dujovne (1976)
10.5551/JAT1973.2.3_197
正常血漿脂質家兎のリポ蛋白質代謝に及ぼす Elastase の影響
山崎 晴一郎 (1974)
10.1016/0005-2760(74)90144-1
Metabolic interrelationships between the lipids of very low, low and high density lipoproteins in the squirrel monkey
D. Illingworth (1974)
10.1016/B978-0-433-22880-6.50019-9
The Epidemiology of the Plasma Cholesterol
N. Myant (1981)
10.1007/978-1-4684-4268-7_13
Plasma Lipoprotein Changes Induced by Diets and Drugs
C. Sirtori (1982)
10.1016/0026-0495(81)90114-1
Effect of a high carbohydrate diet on apoprotein-B catabolism in man.
H. Ginsberg (1981)
10.1016/0091-7435(83)90265-7
Atherosclerosis and apoproteins B and A-I.
P. Kwiterovich (1983)
10.1172/JCI111643
Apolipoprotein A and B (Sf 100-400) metabolism during bezafibrate therapy in hypertriglyceridemic subjects.
J. Shepherd (1984)
10.1161/01.ATV.7.3.292
Lack of Sex Differences in High Density Lipoproteins in Pima Indians: Studies of Obesity, Lipase Activities, and Steroid Hormones
B. Howard (1987)
10.1016/0026-0495(75)90050-5
Immunoassay of human plasma apolipoprotein B.
J. Albers (1975)
10.1172/JCI113806
Dietary polyunsaturated fats of the W-6 and W-3 series reduce postprandial lipoprotein levels. Chronic and acute effects of fat saturation on postprandial lipoprotein metabolism.
M. Weintraub (1988)
10.1111/j.1365-2362.1978.tb00822.x
Metabolic regulation of plasma high density Iipoprotein concentrations
E. A. Nikkilä (1978)
10.1016/0021-9681(78)90027-9
High density lipoprotein--key to anti-atherogenesis.
R. Eaton (1978)
10.1136/bmj.281.6243.770
Changes in plasma high-density lipoprotein cholesterol concentration after weight reduction in grossly obese subjects.
D. Streja (1980)
Metabolism of plasma triglycerides in hypothyroidism and hyperthyroidism in man.
J. J. Abrams (1981)
10.1016/0002-8703(83)90385-X
Exercise training improves lipoprotein lipid profiles in patients with coronary artery disease.
G. Heath (1983)
10.1080/00325481.1991.11701084
Hypertriglyceridemia. Examining its role in coronary heart disease.
S. Grundy (1991)
10.4044/JOMA1947.93.5-6_555
A cardiovascular epidemiologic survey in three different areas in Okayama prefecture (Sakuto-cho, Sanyo-cho and Osafune-cho) in 1980
Shoichi Haraoka (1981)
10.1007/BF03029197
Serum lipoprotein subfractions before and during low-calorie diet in obese women
D. Sommariva (1985)
10.1016/0378-5122(83)90005-1
Long-term post-menopausal hormone therapy and serum HDL-C, total cholesterol and triglycerides.
S. Vilska (1983)
10.1016/S0025-7125(16)32109-5
Individualization of treatment of hyperlipoproteinemic disorders.
D. Azarnoff (1974)
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