Online citations, reference lists, and bibliographies.

An Evaluation Of The Importance Of Gastric Acid Secretion In The Absorption Of Dietary Calcium.

G. Bo-Linn, G. R. Davis, D. J. Buddrus, S. Morawski, C. S. Santa Ana, J. Fordtran
Published 1984 · Medicine, Chemistry
Cite This
Download PDF
Analyze on Scholarcy
Share
Since calcium solubility is a prerequisite to calcium absorption, and since solubility of calcium is highly pH-dependent, it has been generally assumed that gastric acid secretion and gastric acidity play an important role in the intestinal absorption of calcium from ingested food or calcium salts such as CaCO3. To evaluate this hypothesis, we developed a method wherein net gastrointestinal absorption of calcium can be measured after ingestion of a single meal. A large dose of cimetidine, which markedly reduced gastric acid secretion, had no effect on calcium absorption in normal subjects, and an achlorhydric patient with pernicious anemia absorbed calcium normally. This was true regardless of the major source of dietary calcium (i.e., milk, insoluble calcium carbonate, or soluble calcium citrate). Moreover, calcium absorption after CaCO3 ingestion was the same when intragastric contents were maintained at pH 7.4 (by in vivo titration) as when intragastric pH was 3.0. On the basis of these results, we conclude that gastric acid secretion and gastric acidity do not normally play a role in the absorption of dietary calcium. Other possible mechanisms by which the gastrointestinal tract might solubilize ingested calcium complexes and salts are discussed.



This paper is referenced by
The Effects on Nutrition, Metabolism and Infection by Proton Pump Inhibitors: Unsafe Perspective
Bong Ki Cha (2011)
10.1111/J.1753-4887.1994.TB01427.X
A review of calcium preparations.
D. Levenson (1994)
10.1097/01.meg.0000059184.46867.c7
The role of the intestine in bone homeostasis.
Julian R. F. Walters (2003)
10.1007/s00198-020-05278-3
Magnesium oxide and hip fracture in the elderly: a population-based retrospective cohort analysis
Yi-Feng Wu (2020)
Un inhibiteur de la pompe à protons pour tous
Nicolas Morin (2010)
10.4315/0362-028X.JFP-13-470
Inhibitory effects of deoxynivalenol on gastric secretion in rats.
Yuwei Wang (2014)
BIOAVAILABILITY OF MINERALS A N D TRACE ELEMENTS
Susan J. Fairweather-Tait (2005)
10.1172/JCI113283
Role of vitamin D-dependent and vitamin D-independent mechanisms in absorption of food calcium.
M S Sheikh (1988)
Nutrition and osteoporosis . Calcium and vitamin D
JM Quesada-Gómez (2012)
10.15406/jnhfe.2017.06.00214
Tricalcium citrate (TCC) and health
Michael de Vrese (2017)
Long-term proton pump inhibitor use and effect on risk of fractures
Hannah Messer (2018)
Hydrochloric Acid: Physiological Functions and Clinical Implications
Gregory S. Kelly (1997)
10.1136/gut.43.6.763
Effect of intravenous ranitidine and omeprazole on intestinal absorption of water, sodium, and macronutrients in patients with intestinal resection
Palle B Jeppesen (1998)
10.3177/jnsv.44.869
Effect of L-lactic acid on the absorption of calcium in gastrectomized rats.
Osamu Chonan (1998)
10.1503/cmaj.071330
Use of proton pump inhibitors and risk of osteoporosis-related fractures
L. Targownik (2008)
10.1053/j.gastro.2009.11.014
Proton-pump inhibitor use is not associated with osteoporosis or accelerated bone mineral density loss.
L. Targownik (2010)
10.1002/9781444346220.CH25
Medical Management of Gastroesophageal Reflux Disease
Philip O Katz (2012)
10.1007/BF01625450
Secondary hyperparathyroidism and osteopenia in women following gastric exclusion surgery for obesity
J. L. Shaker (1991)
Bioavailability of Nutrients and Other Bioactive Components from Dietary Supplements Factors Influencing the Measurement of Bioavailability , Taking Calcium as a Model 1
Robert Proulx Heaney (2001)
Effects of duration of proton pump inhibitor (PPI) therapy on markers of bone health in men and post-menopausal women
Zarina Pabin (2010)
10.1097/MOG.0b013e32835d9f8e
Intraluminal bioavailability of divalent cations
David H. Alpers (2013)
Hip Fracture Long-term Proton Pump Inhibitor Therapy and Risk of Correction
Y. Yang (2006)
10.1515/iss-2016-0028
Diagnosis and therapy of osteoporosis in geriatric trauma patients: an update
Deborah Schray (2016)
Chronic PPI Therapy and Calcium Metabolism
Yaning Yang (2015)
10.1111/1756-185X.12866
Proton pump inhibitors use and change in bone mineral density.
Abbas Arj (2016)
10.1080/07315724.2000.10718083
The Bioavailability of Dietary Calcium
L. Guéguen (2000)
10.1007/s11894-010-0103-6
Safety of Proton Pump Inhibitors: Current Evidence for Osteoporosis and Interaction with Antiplatelet Agents
David Alan Johnson (2010)
10.4065/mcp.2010.0636
Update on medications with adverse skeletal effects.
Caroline J Davidge Pitts (2011)
10.1097/MCG.0b013e3182333820
Recent safety concerns with proton pump inhibitors.
Joan Chen (2012)
Compositions comprenant des acétates du calcium, du magnésium, du zinc et de la vitamine D3 destinées à la prévention et l'amélioration de l'ostéoporose
Yun Kau Tam (2009)
10.1590/S0004-28032007000300016
The presence of Helicobacter pylori in postmenopausal women is not a factor to the decrease of bone mineral density.
Adriana Maria Kakehasi (2007)
10.1517/14740338.2011.586628
The relationship among proton pump inhibitors, bone disease and fracture
Laura E Targownik (2011)
See more
Semantic Scholar Logo Some data provided by SemanticScholar