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Oxygen Insensitivity Of The Histochemical Assay Of Glucose-6-phosphate Dehydrogenase Activity For The Discrimination Between Nonmalignant And Malignant Cells.

B. V. Driel, C. J. Noorden
Published 1999 · Biology

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We review here the oxygen insensitivity of the histochemical assay of glucose-6-phosphate dehydrogenase (G6PDH) activity to detect cancer cells. This inexpensive and rapid assay can be performed within half an hour. Discrimination between cancerous and noncancerous cells is based on a combination of elevated G6PDH activity, decreased superoxide dismutase (SOD) activity, and decreased lipid peroxidation in cancer cells. The test discriminates between adenomas and carcinomas of the colon with a certainty of >80% and has a high prognostic value for survival of colon cancer patients. Pancreatitis and pancreatic cancer are discriminated with a certainty of 100%. Therefore, the test can be applied by pathologists to provide additional information in difficult cases of diagnosis of cancer and for prognosis.
This paper references
10.1002/PATH.1700350303
The classification of cancer of the rectum
C. Dukes (1932)
10.5694/j.1326-5377.1953.tb85044.x
Histochemistry: Theoretical and Applied
A. Pearse (1953)
10.1016/S0006-291X(72)80218-3
The occurrence of superoxide anion in the reaction of reduced phenazine methosulfate and molecular oxygen.
M. Nishikimi (1972)
10.1016/0005-2744(75)90059-5
Superoxide radicals and hydrogen peroxide formation in mitochondria from normal and neoplastic tissues.
O. Dionisi (1975)
10.1016/S0079-6336(76)80015-0
Tetrazolium salts and formazans.
F. P. Altman (1976)
10.1016/0009-2797(78)90090-X
Studies on the reduction of nitroblue tetrazolium chloride mediated through the action of NADH and phenazine methosulphate.
V. Ponti (1978)
10.1016/s0300-9629(80)80042-9
Enzyme Histochemistry: A Laboratory Manual
Z. Lojda (1979)
Role of superoxide dismutase in cancer: a review.
L. Oberley (1979)
10.1177/019262338201000206
Biological markers of preneoplastic foci and neoplastic nodules in rodent liver *
P. Bannasch (1982)
10.1007/978-1-4613-3403-3_26
The Microsomal NADPH Oxidation System in Lung Cancer
R. G. Butcher (1982)
10.1136/jcp.36.2.133
A modified tetrazolium reaction for identifying malignant cells from gastric and colonic cancer
K. Ibrahim (1983)
10.1177/32.9.6747280
Histochemical localization of NADP-dependent dehydrogenase activity with four different tetrazolium salts.
C. V. van Noorden (1984)
10.1016/S0079-6336(84)80001-7
Histochemistry and cytochemistry of glucose-6-phosphate dehydrogenase.
C. J. Noorden (1984)
10.1007/BF02889888
Characterization of epithelial cell islets in primary monolayer cultures of human breast carcinomas by the tetrazolium reaction for glucose 6-phosphate dehydrogenase
O. Petersen (1986)
10.1007/BF02889887
Effect of oxygen on the tetrazolium reaction for glucose 6-phosphate dehydrogenase in cryosections of human breast carcinoma, fibrocystic disease and normal breast tissue
O. Petersen (1986)
Cytochemical investigation of glucose-6-phosphate dehydrogenase activity in rat mammary tissue.
P. Smyth (1987)
10.1016/0003-2697(89)90288-1
The involvement of superoxide anions in the nitro blue tetrazolium chloride reduction mediated by NADH and phenazine methosulfate.
C. V. van Noorden (1989)
10.1016/0891-5849(90)90156-D
Free radicals, antioxidant enzymes, and carcinogenesis.
Y. Sun (1990)
10.1016/0092-8674(90)90186-I
A genetic model for colorectal tumorigenesis
E. Fearon (1990)
Quantitative cytochemical detection of malignant and potentially malignant cells in the colon.
A. Best (1990)
10.1016/0003-9861(91)90166-G
Target enzymes on hepatic dysfunction caused by dietary products of lipid peroxidation.
K. Kanazawa (1991)
10.1016/S0079-6336(11)80060-4
The tetrazolium-formazan system: design and histochemistry.
E. Seidler (1991)
10.1016/0277-5379(91)90264-E
Quantitative cytochemistry of glucose-6-phosphate dehydrogenase in benign and malignant breast tumours.
E. T. Barron (1991)
10.1016/s0021-9258(18)53699-1
Inactivation of glucose-6-phosphate dehydrogenase by 4-hydroxy-2-nonenal. Selective modification of an active-site lysine.
L. Szweda (1993)
10.1111/j.1749-6632.1993.tb38781.x
White Cell and Thrombocytie Disorders
G. Valet (1993)
Enzyme Histochemistry: A Laboratory Manual of Current Methods
C. J. Noorden (1993)
10.1016/s0021-9258(18)53264-6
Covalent attachment of 4-hydroxynonenal to glyceraldehyde-3-phosphate dehydrogenase. A possible involvement of intra- and intermolecular cross-linking reaction.
K. Uchida (1993)
10.1006/ABBI.1993.1161
Oxidative modification of glucose-6-phosphate dehydrogenase from Leuconostoc mesenteroides by an iron(II)-citrate complex.
L. Szweda (1993)
10.1016/S0065-1281(11)80007-3
On the mechanism of the multistep reduction of tetrazolium salts with special reference to the involvement of tetrazolium radicals.
E. Seidler (1994)
10.3892/IJO.5.6.1255
Overexpression of glucose-6-phosphate-dehydrogenase in rat hepatic preneoplasia and neoplasia.
H. Stumpf (1994)
10.1016/0891-5849(94)90079-5
Importance of Se-glutathione peroxidase, catalase, and Cu/Zn-SOD for cell survival against oxidative stress.
C. Michiels (1994)
10.1177/42.10.7930518
The histochemical G6PDH reaction but not the LDH reaction with neotetrazolium is suitable for the oxygen sensitivity test to detect cancer cells.
P. Griffini (1994)
10.1016/0891-5849(94)90189-9
In vitro modulation of antioxidant enzyme levels in normal hamster kidney and estrogen-induced hamster kidney tumor.
T. Oberley (1994)
Effects of n-3 and n-6 polyunsaturated fatty acid-enriched diets on lipid metabolism in periportal and pericentral compartments of female rat liver lobules and the consequences for cell proliferation after partial hepatectomy.
C. J. Noorden (1995)
10.1006/ABBI.1995.9931
The effect of detergents on the reduction of tetrazolium salts.
S. Liochev (1995)
10.1016/S0891-5849(97)00102-0
Expression of CuZn- and Mn-superoxide dismutase in human colorectal neoplasms.
B. E. Van Driel (1997)
10.1002/(SICI)1097-0320(19971215)30:6<275::AID-CYTO3>3.0.CO;2-F
Automated classification of patients with chronic lymphocytic leukemia and immunocytoma from flow cytometric three-color immunophenotypes.
G. Valet (1997)
10.1002/(SICI)1096-9896(199708)182:4<398::AID-PATH869>3.0.CO;2-X
Development of oxygen insensitivity of the quantitative histochemical assay of G6PDH activity during colorectal carcinogenesis
B. E. Van Driel (1997)
The oxygen insensitivity assay of G6PDH activity in human cancer pathology: clinical and chemical aspects
B. V. Driel (1998)



This paper is referenced by
10.1002/ELAN.201600767
A Novel Superoxide Anion Biosensor for Monitoring Reactive Species of Oxygen Released by Cancer Cells
B. P. Crulhas (2017)
10.1016/j.acthis.2009.03.003
Renal cell carcinoma and oxidative stress: The lack of peroxisomes.
W. Frederiks (2010)
10.1007/s10637-009-9237-5
Silibinin ameliorates oxidative stress induced aberrant crypt foci and lipid peroxidation in 1, 2 dimethylhydrazine induced rat colon cancer
N. Sangeetha (2010)
10.1369/jhc.6A7068.2006
Loss of Peroxisomes Causes Oxygen Insensitivity of the Histochemical Assay of Glucose-6-Phosphate Dehydrogenase Activity to Detect Cancer Cells
W. Frederiks (2007)
10.3171/JNS.2007.106.2.299
Prolonged survival of mice with established intracerebral glioma receiving combined treatment with peroxisome proliferator-activated receptor-gamma thiazolidinedione agonists and interleukin-2-secreting syngeneic/allogeneic fibroblasts.
A. Spagnolo (2007)
10.1016/J.MEHY.2007.03.017
Reactive oxygen species in cancer, too much or too little?
Fuxiong Lu (2007)
10.1111/J.1365-313X.2006.02682.X
A spatiotemporal analysis of enzymatic activities associated with carbon metabolism in wild-type and mutant embryos of Arabidopsis using in situ histochemistry.
S. Baud (2006)
10.1016/J.ACTHIS.2006.08.001
Methimazole increases H2O2 toxicity in human thyroid epithelial cells.
N. L. Landex (2006)
10.1016/J.ACTHIS.2004.12.002
Glucose-6-phosphate dehydrogenase activity in monolayer cultures of thyroid epithelial cells: TSH and inhibition of nitrogen oxide synthase affect the enzyme activity and the oxygen sensitivity of the histochemical assay.
L. Kayser (2005)
10.1023/B:CLIN.0000037706.13747.5e
Inhibition of experimental hepatic metastasis by targeted delivery of catalase in mice
M. Nishikawa (2004)
10.1023/A:1004043206422
Ito Cell Morphology, α-smooth Muscle Actin and Collagen Type IV Expression in the Liver of Patients with Gastric and Colorectal Tumors
M. Gulubova (2000)
10.1177/002215540104900503
Oxygen Insensitivity of the Histochemical Assay of Glucose-6-phosphate Dehydrogenase Activity for the Detection of (Pre)Neoplasm in Rat Liver
J. D. Jong (2001)
10.1038/35030140
Superoxide dismutase as a target for the selective killing of cancer cells
P. Huang (2000)
10.1007/s004180050410
Glucose-6-phosphate dehydrogenase cytochemistry using a copper ferrocyanide method and its application to rapidly frozen cells
T. Ishibashi (1999)
Differential diagnosis of chronic pancreatitis and pancreatic cancer in brush cytology specimens.
B. E. Van Driel (1999)
10.1002/(SICI)1097-0320(19990815)38:4<176::AID-CYTO4>3.0.CO;2-#
Prognostic estimation of survival of colorectal cancer patients with the quantitative histochemical assay of G6PDH activity and the multiparameter classification program CLASSIF1.
B. E. Van Driel (1999)
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