Online citations, reference lists, and bibliographies.
Please confirm you are human
(Sign Up for free to never see this)
← Back to Search

Breast Liver Metastases – Incidence, Diagnosis And Outcome

A. L. Hoe, G. Royle, I. Taylor
Published 1991 · Medicine

Save to my Library
Download PDF
Analyze on Scholarcy
Share
Breast liver metastases are uncommon and have not been well reported. We studied the clinical outcome of 47 patients who developed liver metastases out of 912 breast cancer patients treated between 1982 and 1987, an incidence of 5.2%. The median disease free interval prior to clinical liver metastases was 20.2 months (range 4–192 months). The most frequent clinical presentations were hepatomegaly (70%) and abdominal pain (34%). The diagnosis was confirmed on ultrasound scan in 72.7% patients. Thirty-one patients (70.5%) received specific treatment with both hormone and chemotherapy but only six showed any evidence of objective response, the majority of whom had metastases only in the liver. The median survival of treated patients was 4 months and absence of jaundice, response to treatment and liver metastases only were associated with significantly better survival. In conclusion breast liver metastases usually present as a manifestation of disseminated disease and have an appalling prognosis. When they occur as an initial site the prognosis is better but very few patients overall respond to conventional treatment.
This paper references
10.1016/0305-7372(90)90075-Q
The pattern of metastases in human breast cancer: methodological aspects and influence of prognostic factors.
C. Kamby (1990)
10.1016/0002-9343(61)90112-7
Manifestations of metastatic tumors of the liver. A study of eighty-one patients subjected to needle biopsy.
L. Fenster (1961)
10.1002/1097-0142(19870415)59:8<1524::AID-CNCR2820590823>3.0.CO;2-9
Incidence and methodologic aspects of the occurrence of liver metastases in recurrent breast cancer
C. Kamby (1987)
10.1148/RADIOLOGY.149.1.6611929
Computed tomography, ultrasound, and scintigraphy of the liver in patients with colon or breast carcinoma: a prospective comparison.
P. Alderson (1983)
Secondary tumours of the liver
RA Willis (1973)
Incidence and methodological aspects of the occurrence of liver metastases in recurrent breast
T Nemato (1987)
10.1002/1097-0142(19810101)47:1<207::AID-CNCR2820470134>3.0.CO;2-6
Reporting results of cancer treatment
A. Miller (1981)
10.1002/1097-0142(196603)19:3<421::AID-CNCR2820190316>3.0.CO;2-V
Significance of liver metastasis in women with disseminated breast cancer undergoing endocrine ablative surgery
T. Nemoto (1966)
10.1200/JCO.1987.5.5.773
Clinical course of breast cancer patients with liver metastases.
J. Zinser (1987)
Breast Cancer: Metastatic Patterns and Their Prognosis
O. Salazar (1988)
10.1001/ARCHOTOL.1969.00770030216025
Reporting results.
T. Walsh (1969)
10.1177/0284185173014S33406
Treatment
A. Satterfield (1938)
Efficacy of peroperative liver function tests and ultrasound in detecting hepatic metastasis in carcinoma of the breast.
C. P. Clark (1988)
Tests for liver metastases in breast cancer: evaluation of liver scan and liver ultrasound.
L. De Rivas (1980)
10.1002/1097-0142(196911)24:5<861::AID-CNCR2820240502>3.0.CO;2-3
Classification of patients with disseminated cancer of the breast
S. Cutler (1969)
10.1002/BJS.1800711212
Detection of liver metastases. A prospective study comparing liver enzymes, scintigraphy, ultrasonography and computed tomography
R. H. Schreve (1984)
10.1038/bjc.1973.40
Am Autopsy Study of Some Routes of Dissemination of Cancer of the Breast
E. Viadana (1973)
10.1038/bjc.1977.1
Design and analysis of randomized clinical trials requiring prolonged observation of each patient. II. analysis and examples.
R. Peto (1977)
undergoing endocrine ablative surgery
E Viadana (1966)
The topographic distribution of liver metastases. Its relation to surgical and isotope diagnosis
A Ozarda (1962)
10.1007/978-1-4612-4380-9_25
Nonparametric Estimation from Incomplete Observations
E. L. Kaplan (1958)
10.1097/00000658-198204000-00017
A prospective study of hepatic imaging in the detection of metastatic disease.
T. Smith (1982)
Scintigraphic criteria for hepatic metastases from cancer of the colon and breast.
D. Drum (1976)
10.1136/gut.13.11.926
Alkaline phosphatase.
T. Warnes (1972)
Factors influencing survival in patients with untreated hepatic metastases.
B. Jaffe (1968)
UICC:TNM Classification of malignant tumours
P Hermanek (1987)
10.1136/bmj.1.4703.399
Hepatic Tumours
R. Willis (1951)



This paper is referenced by
10.1007/s00270-011-0216-9
Abstracts of CIRSE (Cardiovascular and Interventional Radiological Society of Europe) 2011. September 10-14, 2011. Munich, Germany.
L. Tarantino (2011)
10.2147/CMAR.S178395
Incidence and prognostic factors of patients with synchronous liver metastases upon initial diagnosis of breast cancer: a population-based study
Hai-Yun Zhao (2018)
10.1007/s00270-011-0216-9
September 10-14 Munich, Germany CIRSE 2011
L. Tarantino (2011)
10.1007/s00330-009-1525-0
Transarterial chemoembolization (TACE) with mitomycin C and gemcitabine for liver metastases in breast cancer
T. Vogl (2009)
10.1002/bjs.4326
Interstitial laser thermotherapy for liver tumours
M. Nikfarjam (2003)
10.1016/j.breast.2011.12.014
Biopsy of liver metastasis for women with breast cancer: impact on survival.
E. Botteri (2012)
10.1590/S0100-39842002000600007
Contribuição da ultra-sonografia abdominal no seguimento de pacientes pós-tratamento do câncer mamário
A. C. Ferreira (2002)
10.1007/978-1-4419-0751-6_29
Embolic Therapy for the Treatment of Liver Metastases 27
R. Winokur (2013)
10.21037/TCR-20-1833
Stereotactic body radiotherapy (SBRT) for oligo-metastatic liver metastases from breast cancer, as an effective and safe alternative to surgery: a review
S. Aoki (2020)
10.1007/s10549-005-9117-4
Metastatic breast cancer with liver metastases: a registry analysis of clinicopathologic, management and outcome characteristics of 500 women
G. Pentheroudakis (2005)
10.3969/j.issn.2095-3941.2012.01.011
Serological Diagnosis of Liver Metastasis in Patients with Breast Cancer
R. Cao (2012)
ENZYMES AND ANTIOXIDANT AS BIOMARKERS IN BREAST CANCER
V. Pavithra (2014)
10.2217/fon-2017-0358
Experience with eribulin in patients with metastatic breast cancer and associated hepatic impairment: case studies.
Daniel Acosta-Eyzaguirre (2018)
10.1016/j.jvir.2010.01.046
Ablation of liver metastases: current status.
V. Flanders (2010)
10.2217/hep.14.40
A role for hepatic surgery in patients with liver metastatic breast cancer: review of literature.
N. Bacalbașa (2015)
10.1148/radiol.2533081968
Breast cancer liver metastases: US-guided percutaneous radiofrequency ablation--intermediate and long-term survival rates.
M. F. Meloni (2009)
10.1308/003588414X14055925059192
Surgical resection of a liver metastasis from breast cancer.
D. Selvakumar (2015)
10.1016/J.CTRV.2004.09.007
Liver metastases from breast cancer: management of patients with significant liver dysfunction.
M. Mano (2005)
10.1148/RADIOL.2332030454
Breast cancer metastases in liver: laser-induced interstitial thermotherapy--local tumor control rate and survival data.
M. Mack (2004)
10.1007/3-540-30036-8_50
Benigne und maligne Tumoren der Mamma
D. Oertli (2006)
10.21873/invivo.11425
Hepatic Arterial Infusion Chemotherapy Is a Feasible Treatment Option for Breast Cancer with Liver-predominant Metastatic Disease
Jui-Hu Hsiao (2018)
10.1016/j.breast.2017.02.003
Systematic review of early and long-term outcome of liver resection for metastatic breast cancer: Is there a survival benefit?
T. G. Yoo (2017)
10.1186/1471-2407-10-199
A long-term follow-up of the imatinib mesylate treatment for the patients with recurrent gastrointestinal stromal tumor (GIST): the liver metastasis and the outcome
J. Zhu (2009)
10.1046/J.1563-2571.2001.01033.X
Prognostic significance of liver metastases as first site of generalisation in patients with breast cancer--a retrospective analysis.
M. Baur (2001)
10.1111/j.1477-2574.2010.00282.x
Surgical management of breast cancer liver metastases.
Maria A. Cassera (2011)
10.2147/BCTT.S71781
BP-C1 in the treatment of patients with stage IV breast cancer: a randomized, double-blind, placebo-controlled multicenter study and an additional open-label treatment phase
S. Larsén (2014)
10.1007/s12282-011-0276-3
Improvement of survival and prospect of cure in patients with metastatic breast cancer
Y. Cheng (2011)
10.1016/j.ejso.2012.04.015
Resection of liver metastases in patients with breast cancer: survival and prognostic factors.
G. A. M. van Walsum (2012)
10.4999/UHOD.161574
Prognostic Factors In Breast Cancer Patients With Hepatic Metastases: Impact Of Molecular Subtype And Local Hepatic Treatment
O. Ates (2016)
10.2325/JBCS.12.26
Open-configuration MR-guided microwave thermocoagulation therapy for metastatic liver tumors from breast cancer
H. Abe (2005)
10.1055/S-0037-1608807
Liver Metastasis: Update on Thermal and Nonthermal Ablative Therapies
D. López (2017)
Breast Cancer: Targets and Therapy Dovepress
()
See more
Semantic Scholar Logo Some data provided by SemanticScholar