← Back to Search
Invited Review: Development Of Fat Emulsions
Published 1981 · Medicine
Download PDFAnalyze on Scholarcy
: The studies on the possibility of preparing IV fat emulsions began in the 1920's; since then, a very large number of emulsions with various fats and emulsifiers have been investigated. However, none of the early fat emulsions could be used safely in man. By the trial and error technique, a method was finally found to prepare soybean oil and egg yolk phospholipids to make a fat emulsion that had a low incidence of adverse reactions. A newly devised biological test system based on nutritional concepts was of crucial importance. It meant that any energy supplying nutrient should be tested in animals in relation to the energy requirement of the species used and not identical to the human dose/kg body weight as in the "classical" toxicity and tolerance tests. With the development of well-tolerated IV fat emulsions it has been possible to devise a TPN regimen that is adequate from a nutritional point of view as well as an adequate alternative to the ordinary oral food. This regimen, which can be administered by the peripheral route, means that the original aims for developing IV fat emulsions were finally achieved.
This paper references
Parenteral nutrition; the vasodepressor activity of soybean phosphatide preparations.
R. Geyer (1949)
The intravenous administration of fat
L. Holt (1935)
Definition of two Distinct Processes in Activation during Potassium-Induced Contractures of Frog's Skeletal Muscle
G. B. Frank (1965)
Nitrogen Balance in Patients Receiving Either Fat or Carbohydrate For Total Intravenous Nutritiion
A. Gazzaniga (1975)
Metabolic studies in total parenteral nutrition with lipid in man. Comparison with glucose.
K. N. Jeejee hoy (1976)
Study of complete parenteral alimentation on dogs.
H. Meng (1949)
The role of Intralipid in prolonged parenteral nutrition. I. As a caloric substitute for glucose.
J. W. Broviac (1976)
Availability of apolipoprotein CII in relation to the maximal removal capacity for an infused triglyceride emulsion in man.
D. Erkelens (1979)
Nutritional requirements of adult surgical patients.
D. Elwyn (1980)
Effect of insulin on metabolic response to injury.
S. Allison (1980)
The toxicity of low-molecular triglycerides.
A. Wretlind (1957)
Interchange of apolipoproteins between chylomicrons and high density lipoproteins during alimentary lipemia in man.
R. Havel (1973)
Urinary Output of Nitrogen as Influenced by Intravenous Injection of a Mixture of Amino-Acids
R. Elman (1938)
Composition, preparation and testing of an intravenous fat emulsion.
Meyer Ce (1957)
Pharmacological effects of fatty acids, triolein and cottonseed oil.
L. Oro (1961)
Glucose or fat as a nonprotein energy source? A controlled clinical trial in gastroenterological patients requiring intravenous nutrition.
J. Macfie (1981)
Long-term total parenteral nutrition with growth, development, and positive nitrogen balance.
S. Dudrick (1968)
Verhalten der Ölemulsionen verschiedener Dispersität nach intravenöser Darreichung mit besonderer Berück=sichtigung der Fettembolie der Lunge
G. Sato (1931)
This paper is referenced by
Liver-Specific Particulate Contrast Agents: An Overview
K. Ivancev (1993)
Emerging Nanomedicine Therapies to Counter the Rise of Methicillin-Resistant Staphylococcus aureus
Alan J Hibbitts (2018)
Physicochemical characterization of lipid nanoparticles and evaluation of their drug loading capacity and sustained release potential
K. Westesen (1997)
Classic Article: Commentary on “Metabolic Studies in Total Parenteral Nutrition with Lipid in Man. Comparison with Glucose
S. J. Miller (2001)
Novel strategies for the formulation and processing of poorly water‐soluble drugs
K. Göke (2018)
Composition of phospholipid fatty acids in red blood cell membranes of patients in intensive care units: effects of different intakes of soybean oil, medium-chain triglycerides, and black-currant seed oil.
M. Diboune (1992)
Effects of free glycerol contained in intravenous fat emulsion on plasma triglyceride determination.
T. Howdieshell (1995)
The prevention and treatment of intestinal failure-associated liver disease in neonates and children.
D. Nehra (2011)
MCT/LCT emulsion ameliorate liver fat deposition in insulin-treated diabetic rats receiving total parenteral nutrition.
S. Yeh (1998)
Investigation of the gel formation of phospholipid-stabilized solid lipid nanoparticles
K. Westesen (1997)
Preparation and characterization of highly stable lipid nanoparticles with amorphous core of tuneable viscosity.
Thomas Delmas (2011)
Intravascular metabolism of different fatty acids during lipid infusion in man.
V. Siderova (1993)
Formulation, preparation and evaluation of an intravenous emulsion containing Brucea javanica oil and Coix Seed oil for anti-tumor application.
Ye-ling Yu (2008)
A serendipitous voyage in the field of nutrition and metabolism in health and disease: a translational adventure
P. Soeters (2020)
Intravenous Lipid Emulsions: 2001
D. Driscoll (2001)
Tumour targeting: biological factors and formulation advances in injectable lipid nanoparticles
V. Shenoy (2005)
Physicochemical stability of all-in-one mixtures inclinical setting
D. Driscoll (1998)
Estudio aleatorio de dos emulsiones grasas diferentes en la nutrición parenteral total del enfermo quirúrgico desnutrido: efecto sobre la morbilidad infecciosa y la mortalidad
T. Grau (2003)
Hochstabile Liposomen aus perfluoralkylierten Glycerophosphocholinen
C. Santaella (1991)
An interfacial equilibria model for the electrokinetic properties of a fat emulsion
S. B. Hall (1991)
ASPEN Lipid Injectable Emulsion Safety Recommendations, Part 1: Background and Adult Considerations.
J. Mirtallo (2020)
Systematic review of clinical adverse events reported after acute intravenous lipid emulsion administration
B. Hayes (2016)
Fine vs. coarse complete all-in-one admixture infusions over 96 hours in rats: fat globule size and hepatic function.
D. Driscoll (2008)
Lipid metabolism: comparison of stress and nonstressed states.
D. Waitzberg (2005)
Intravenous fat emulsions in clinical practice.
K. Warshawsky (1992)
Solid lipid nanoparticles
W. Mehnert (2012)
New developments in fat emulsions.
Y. Carpentier (1990)
Cholesterol improves the utilization of parenteral lipid emulsions
W. Druml (2009)
Solid lipid nanoparticles for parenteral drug delivery.
S. Wissing (2004)
Parenteral Fish Oil as Monotherapy Prevents Essential Fatty Acid Deficiency in Parenteral Nutrition–dependent Patients
V. E. de Meijer (2010)
Innovative parenteral and enteral nutrition therapy for intestinal failure.
H. Le (2010)
Intravenous fat emulsion in clinical practice: nutrient and antidote.
Vesna Putić (2015)See more