Online citations, reference lists, and bibliographies.
← Back to Search

Changes In Lung Function After Surgery For Mesothelioma

T. Ploenes, T. Osei-Agyemang, Alexander Krohn, C. F. Waller, V. Duncker-Rohr, M. Elze, B. Passlick
Published 2013 · Medicine

Cite This
Download PDF
Analyze on Scholarcy
Background: The effect of pleurectomy/decortication or extrapleural pleuropneumonectomy on pulmonary function has not yet been evaluated. The aim of this study was to determine the parameters of pulmonary function before and after pleurectomy/decortication or extrapleural pleuropneumonectomy. Methods: We conducted a review of 48 patients with unilateral malignant pleural mesothelioma who underwent pleurectomy/decortication or extrapleural pleuropneumonectomy. Data including medical history, histology, survival, and pre- and postoperative pulmonary function were extracted from the medical database of the University Medical Center Freiburg, or sought by telephone interview with the general practitioner or patients. Results: 25 patients underwent extrapleural pleuropneumonectomy and 23 had pleurectomy/decortication. Pulmonary function was not significantly reduced in the pleurectomy/decortication group postoperatively. In the extrapleural pleuropneumonectomy group, the median preoperative total lung capacity of 4.8 L (77.7%) differed significantly from the postoperative total lung capacity of 3.5 L (55.3%; p < 0.0006). The median vital capacity was significantly reduced from 2.8 L (77.7%) preoperatively to 1.8 L (47.6%) postoperatively (p < 0.0002). Other parameters were also highly significantly reduced after extrapleural pleuropneumonectomy. Conclusions: Pleurectomy/decortication preserved good pulmonary function, whereas extrapleural pleuropneumonectomy significantly reduced pulmonary function, which may lead to dyspnea and influence the quality of life of these patients.
This paper references
Incidence of atrial fibrillation after extrapleural pneumonectomy vs. pleurectomy in patients with malignant pleural mesothelioma.
S. Neragi-Miandoab (2008)
Diffuse Pleural Mesothelioma and Asbestos Exposure in the North Western Cape Province
Tim J. Carter (2005)
Recommendations for Uniform Definitions of Surgical Techniques for Malignant Pleural Mesothelioma: A Consensus Report of the International Association for the Study of Lung Cancer International Staging Committee and the International Mesothelioma Interest Group
D. Rice (2011)
Prevention, early detection, and management of complications after 328 consecutive extrapleural pneumonectomies.
D. Sugarbaker (2004)
A proposed new international TNM staging system for malignant pleural mesothelioma from the International Mesothelioma Interest Group.
V. Rusch (1996)
A phase II trial of surgical resection and adjuvant high-dose hemithoracic radiation for malignant pleural mesothelioma.
V. Rusch (2001)
Standardisation of spirometry
M. Miller (2005)
Surgical treatment of mesothelioma: pleurectomy.
J. Roberts (1999)
Decortication in chronic pleural empyema - effect on lung function.
W. Rzyman (2002)
Forced Expiratory Volume in One Second as a Prognostic Factor in Advanced Non-small Cell Lung Cancer
J. Lee (2011)
Resection margins, extrapleural nodal status, and cell type determine postoperative long-term survival in trimodality therapy of malignant pleural mesothelioma: results in 183 patients.
D. Sugarbaker (1999)
Survival after conservative (palliative) management of pleural malignant mesothelioma
N. Merritt (2001)
Dyspnea in cancer patients: Etiology, resource utilization, and survival‐Implications in a managed care world
C. Escalante (1996)
Dyspnea in
CP Escalante
Survival after trimodality therapy for malignant pleural mesothelioma: Radical Pleurectomy, chemotherapy with Cisplatin/Pemetrexed and radiotherapy.
S. Boeluekbas (2011)
Extrapleural pneumonectomy or supportive care: treatment of malignant pleural mesothelioma?
S. Sharif (2011)
Individual versus standard quality of life assessment in a phase II clinical trial in mesothelioma patients: feasibility and responsiveness to clinical changes.
K. Ribi (2008)
Extra-pleural pneumonectomy versus no extra-pleural pneumonectomy for patients with malignant pleural mesothelioma: clinical outcomes of the Mesothelioma and Radical Surgery (MARS) randomised feasibility study
T. Treasure (2011)
Standardisation of the measurement of lung volumes
J. Wanger (2005)
Interpretative strategies for lung function tests
R. Pellegrino (2005)
Extrapleural pneumonectomy versus pleurectomy/decortication in the surgical management of malignant pleural mesothelioma: results in 663 patients.
R. Flores (2008)
Malignant mesothelioma in a cohort of asbestos insulation workers: clinical presentation, diagnosis, and causes of death.
J. Ribak (1988)
A Systematic Review of Extrapleural Pneumonectomy for Malignant Pleural Mesothelioma
C. Cao (2011)
Phase I to II study of pleurectomy/decortication and intraoperative intracavitary hyperthermic cisplatin lavage for mesothelioma.
W. Richards (2006)
Quantitative measurement of lung reexpansion in malignant pleural mesothelioma patients undergoing pleurectomy/decortication.
W. Sensakovic (2011)

This paper is referenced by
Prolonged post-recurrence survival following pleurectomy/decortication for malignant pleural mesothelioma.
Yuichiro Kai (2019)
Quality of life after surgery for pleural malignant mesothelioma – methodological considerations
Emanuela Taioli (2016)
A systematic review and meta-analysis of surgical treatments for malignant pleural mesothelioma.
C. Cao (2014)
The Role of Surgery in Malignant Pleural Mesothelioma
Levon Toufektzian (2015)
Diaphragm and lung–preserving surgery with hyperthermic chemotherapy for malignant pleural mesothelioma: A 10‐year experience
M. Ambrogi (2018)
Poor Prognostic Factors in Patients with Malignant Pleural Mesothelioma Classified as Pathological Stage IB According to the Eighth Edition TNM Classification
T. Takuwa (2018)
[Malignant pleural mesothelioma: new aspects of medical therapy].
S. Kurz (2014)
Physical function and health-related quality of life in patients undergoing surgical treatment for malignant pleural mesothelioma
T. Tanaka (2017)
Treatment of malignant pleural mesothelioma: lessons learned and quo vadis?
S. Boeluekbas (2018)
History of Pleural Surgical Treatment
Dharmaraj Chauhan (2019)
Sustained preservation of pulmonary function after pleurectomy/ decortication: should it be the main reason to perform surgery in malignant pleural mesothelioma patients?
S. Ozer (2019)
Turning back the Wheel: Inducing Mesenchymal to Epithelial Transition via Wilms Tumor 1 Knockdown in Human Mesothelioma Cell Lines to Influence Proliferation, Invasiveness, and Chemotaxis
T. Plönes (2016)
Trimodality strategy for treating malignant pleural mesothelioma: results of a feasibility study of induction pemetrexed plus cisplatin followed by extrapleural pneumonectomy and postoperative hemithoracic radiation (Japan Mesothelioma Interest Group 0601 Trial)
S. Hasegawa (2015)
Surgery for malignant pleural mesothelioma: why, when and what?
L. Lang-Lazdunski (2014)
Current surgical strategies for malignant pleural mesothelioma
T. Takuwa (2015)
Systematic review of quality of life following pleurectomy decortication and extrapleural pneumonectomy for malignant pleural mesothelioma
R. Schwartz (2018)
Absence of amplification of the FGFR1-gene in human malignant mesothelioma of the pleura: a pilot study
T. Ploenes (2013)
Pleural mesothelioma: management updates and nursing initiatives to improve patient care
Rebecca H Lehto (2014)
British Thoracic Society Guideline for the investigation and management of malignant pleural mesothelioma
I. Woolhouse (2018)
Short‐term outcomes of pleurectomy decortication and extrapleural pneumonectomy in mesothelioma
M. V. van Gerwen (2018)
Should Lung-Sparing Surgery Be the Standard Procedure for Malignant Pleural Mesothelioma?
Y. Ichiki (2020)
Effects of extended pleurectomy and decortication on quality of life and pulmonary function in patients with malignant pleural mesothelioma.
D. Burkholder (2015)
Surgery in the treatment of malignant pleural mesothelioma: recruitment into trials should be the default position
A. Datta (2013)
Semantic Scholar Logo Some data provided by SemanticScholar