Online citations, reference lists, and bibliographies.
← Back to Search

Effect Of Salicylic Acid On The Activity Of Betamethasone-17,21-Dipropionate In The Treatment Of Erythematous Squamous Dermatoses

Robert Elic, L. Durocher, E. Kavalec
Published 1983 · Medicine

Cite This
Download PDF
Analyze on Scholarcy
Share
Forty adult out-patients with erythematous squamous dermatoses of the scalp were treated in this 21-day double-blind study with an alcohol base lotion containing either 0·05% betamethasone-17,21-dipropionate, 2% salicylic acid, 0·05% betamethasone-17,21-dipropionate + 2% salicylic acid or their respective placebo. The four treatments were assigned randomly to the patients according to a 2 × 2 orthogonal factorial design. Changes in severity of redness, scaling, pruritus and size of lesions were evaluated. Since very few patients presented with excoriation and lichenificatioh, these symptoms could not be ascertained. Results were assessed for significance by covariance analysis where initial status was used as regressor. A potentiation of the betamethasone-17,21-dipropionate activity by salicylic acid was observed for scaling. An additive effect was noted for redness and pruritus. According to the physician's global evaluation, patients treated with the combination drug showed a better evolution than those treated with placebo. The results suggest that addition of a keratolytic agent enhances the corticosteroid effect in the treatment of erythematous squamous dermatoses.
This paper references
10.1111/j.1365-2133.1976.tb02280.x
Atrophy of the skin
I. Sneddon (1976)
10.1136/bmj.1.5645.670
Adverse Effect of Topical Fluorinated Corticosteroids in Rosacea
I. Sneddon (1969)
10.1177/030006057500300602
Betamethasone-17,21-Dipropionate with Salicylic Acid, a Double-Blind Comparative Evaluation with Flumethasone-21-Pivalate with Salicylic Acid in the Treatment of Psoriasis
G. Eriksson (1975)
Treatment of psoriasis and other steroid responsive dermatoses . Trial of a new topical corticosteroid . Betamethasone dipropionate ( Diprosone )
S Bor (1974)
Efficacy and tolerance of betamethasone dipropionate plus salicylic acid in the treatment of psoriasis and other steroid responsive dermatoses
H Lindemayr (1981)
10.1111/j.1365-2133.1972.tb02225.x
ROSACEA‐LIKE DERMATITIS: CONTRAINDICATION OR INTOLERANCE, REACTION TO STRONG STEROIDS
G. Weber (1972)
10.1177/030006057600400204
Percutaneous Absorption of Betamethasone-17, 21-Dipropionate and Salicylic Acid during the Treatment of Psoriasis and Eczema
L. Gip (1976)
A new synthetic steroid betamethasone-17,21dipropionate (Diprosone). Clinical trials of dermatological patients
T Fredriksson (1974)
Side - effects of indiscriminate application of local corticosteroids
S LesterR (1977)
10.1159/000257894
The treatment of steroid-induced rosacea and perioral dermatitis.
I. Sneddon (1976)
Treatment of psoriasis and other chronic dermatoses with extracts of Rauwolfia serpentina.
N. M. Wrong (1956)
eds) Oxford: BlackwellScientificPublications
A Rook (1971)
Treatment of psoriasis of the scalp.
Hellier Ff (1968)
10.1111/j.1365-2133.1980.tb06590.x
Detection of the action of salicylic acid on the normal stratum corneum
D. L. Roberts (1980)
Topical use of betamethasone dipropionate in treatment of psoriasis
S WilkinsonD (1972)
Studies with betamethasone dipropionate plus salicylic acid ( Diprosalic ) in psoriasis
L Glp
Side effects of potent topical corticosteroids.
R. Jackson (1978)
10.1111/j.1365-2133.1976.tb00825.x
Studies on the effect of salicylic acid on normal skin
M. Davies (1976)
10.1038/JID.1952.72
The effect of topically applied compound F in selected dermatoses.
M. Sulzberger (1952)
Topical therapy. In: Textbook of Dermatology
psoriasis. La Semana Medica (1972)
10.1097/00000542-194105000-00013
The Pharmacological Basis of Therapeutics
L. Goodman (1941)
10.1159/000257895
Comparative study of triamcinolone acetonide and hydrocortisone 17-butyrate in rosacea with special regard to the rebound phenomenon.
M. Go (1976)
A clinical investigation of a new topical corticosteroid preparation: Betamethasone dipropionate with salicylicacid
G Landi (1977)
[Side effects of indiscriminate application of local corticoids (author's transl)].
F. Posternak (1977)
Evaluation of new potent steroids
R BStoughton (1977)
10.1136/bmj.1.3974.499
THE EXTRA PHARMACOPOEIA
Martindale. (1937)
Topical corticosteroid therapy in low dosage.
(1967)
10.5694/j.1326-5377.1973.tb118065.x
TOPICAL DRUG ADDICTION: ADVERSE EFFECTS OF FLUORINATED CORTICOSTEROID CREAMS AND OINTMENTS
J. Burry (1973)
10.1111/1523-1747.EP12680178
Assay of topical corticosteroids by suppression of experimental inflammation in humans.
K. Kaidbey (1974)



This paper is referenced by
10.2217/EBO.11.27
Current treatment options in psoriasis: topical agents
Kristine B. Zitelli (2011)
10.2165/00128071-200405020-00001
Fixed-Dose Combination Therapy for Psoriasis
L. Guenther (2004)
10.3109/09546639809160546
A comparison of the efficacy and safety of the combination mometasone furoate 0.1 %/salicylic acid 5% ointment with each of its components in psoriasis
H. Katz (1998)
10.1046/j.1365-4362.1999.00500.x
The role of salicylic acid in the treatment of psoriasis
M. Lebwohl (1999)
10.1046/j.1365-2133.2000.04713.x
Topical preparations for the treatment of psoriasis: a systematic review
J. Mason (2002)
Status of combination drugs with betamethasone dipropionate and salicylic acid in the treatment of skin diseases
M. Pastuszka (2012)
10.1016/j.jpba.2009.05.015
Development and validation of a stability-indicating HPLC method for simultaneous determination of salicylic acid, betamethasone dipropionate and their related compounds in Diprosalic Lotion.
M. Shou (2009)
10.1046/j.0007-0963.2002.04713.x
Topical preparations for the treatment of psoriasis: a systematic review
James Mason (2000)
10.1016/B978-0-407-00316-3.50013-5
Chapter 6 – Therapeutic uses of the salicylates
K. Rainsford (1984)
10.1002/psb.1429
Topical treatments for scalp psoriasis: evidence‐based guide
Anup Jheeta (2016)
10.1016/j.jaad.2008.11.890
Treatment of severe scalp psoriasis: from the Medical Board of the National Psoriasis Foundation.
C. S. Chan (2009)
10.1007/978-3-319-95165-2_8
Classification of Erythematous - Squamous Skin Diseases Through SVM Kernels and Identification of Features with 1-D Continuous Wavelet Coefficient
Yeliz Karaca (2018)
10.1586/EDM.09.32
Optimizing topical therapy for psoriasis
K. Busse (2009)
10.1002/14651858.CD009687.pub2
Topical treatments for scalp psoriasis.
J. G. Schlager (2016)
10.1111/bjd.12393
Topical treatments for chronic plaque psoriasis of the scalp: a systematic review
A. Mason (2013)
Are topical keratolytic agents needed in the treatment of scalp psoriasis?
Divya Shokeen (2014)
10.1080/14656566.2018.1448788
Pharmacotherapeutic approaches for treating psoriasis in difficult-to-treat areas
D. Kivelevitch (2018)
10.1002/14651858.CD009446.pub2
Topical anti-inflammatory agents for seborrhoeic dermatitis of the face or scalp.
H. Kastarinen (2014)
10.1016/S0149-2918(98)80091-X
Mometasone furoate 0.1%-salicylic acid 5% ointment versus mometasone furoate 0.1% ointment in the treatment of moderate-to-severe psoriasis: a multicenter study.
J. Koo (1998)
10.2174/1874372200802010032
Assessing Treatment of Pruritic Scalp
C. Burkhart (2008)
10.1007/s40257-016-0222-4
Managing Scalp Psoriasis: An Evidence-Based Review
T. Wang (2016)
10.1007/s13555-015-0068-3
Keratolytics and Emollients and Their Role in the Therapy of Psoriasis: a Systematic Review
A. Jacobi (2015)
10.1002/14651858.CD005028.pub3
Topical treatments for chronic plaque psoriasis.
A. Mason (2013)
Semantic Scholar Logo Some data provided by SemanticScholar