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Development And Validation Of A Subject-specific Finite Element Model Of The Functional Spinal Unit To Predict Vertebral Strength

C. Lee, P. Landham, R. Eastell, M. Adams, P. Dolan, L. Yang
Published 2017 · Medicine, Materials Science

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Finite element models of an isolated vertebral body cannot accurately predict compressive strength of the spinal column because, in life, compressive load is variably distributed across the vertebral body and neural arch. The purpose of this study was to develop and validate a patient-specific finite element model of a functional spinal unit, and then use the model to predict vertebral strength from medical images. A total of 16 cadaveric functional spinal units were scanned and then tested mechanically in bending and compression to generate a vertebral wedge fracture. Before testing, an image processing and finite element analysis framework (SpineVox-Pro), developed previously in MATLAB using ANSYS APDL, was used to generate a subject-specific finite element model with eight-node hexahedral elements. Transversely isotropic linear-elastic material properties were assigned to vertebrae, and simple homogeneous linear-elastic properties were assigned to the intervertebral disc. Forward bending loading conditions were applied to simulate manual handling. Results showed that vertebral strengths measured by experiment were positively correlated with strengths predicted by the functional spinal unit finite element model with von Mises or Drucker–Prager failure criteria (R2 = 0.80–0.87), with areal bone mineral density measured by dual-energy X-ray absorptiometry (R2 = 0.54) and with volumetric bone mineral density from quantitative computed tomography (R2 = 0.79). Large-displacement non-linear analyses on all specimens did not improve predictions. We conclude that subject-specific finite element models of a functional spinal unit have potential to estimate the vertebral strength better than bone mineral density alone.
This paper references
10.1243/09544110260216577
Patient-specific spine models. Part 1: Finite element analysis of the lumbar intervertebral disc—a material sensitivity study
M. Fagan (2002)
10.1016/S0021-9290(03)00308-7
Neural arch load-bearing in old and degenerated spines.
P. Pollintine (2004)
10.1016/S8756-3282(99)00216-1
Lumbar vertebral body compressive strength evaluated by dual-energy X-ray absorptiometry, quantitative computed tomography, and ashing.
E. Ebbesen (1999)
10.1016/j.bone.2009.09.032
Biomechanical effects of teriparatide in women with osteoporosis treated previously with alendronate and risedronate: results from quantitative computed tomography-based finite element analysis of the vertebral body.
Y. Chevalier (2010)
QCT-based finite element models predict the human vertebral apparent strength and stiffness significantly better than DXA
E Dall’Ara (2012)
10.1016/j.jbiomech.2015.09.006
Vertebroplasty reduces progressive ׳creep' deformity of fractured vertebrae.
J. Luo (2016)
10.1097/00007632-198403000-00003
Stress analysis of the lumbar disc-body unit in compression. A three-dimensional nonlinear finite element study.
S. A. Shirazi-Adl (1984)
10.1007/s00198-011-1568-3
QCT-based finite element models predict human vertebral strength in vitro significantly better than simulated DEXA
E. Dall’Ara (2011)
10.1016/S0045-7949(02)00400-5
Finite element model of a lumbar spinal motion segment to predict circadian variation in stature
R. Natarajan (2003)
10.1097/00007632-200107150-00010
Osteoporosis Changes the Amount of Vertebral Trabecular Bone at Risk of Fracture but Not the Vertebral Load Distribution
J. Homminga (2001)
10.1007/s005860050058
The relationship between height, shape and histological changes in early degeneration of the lower lumbar discs
U. Berlemann (1998)
10.1098/rsta.2010.0074
Predicting the yield of the proximal femur using high-order finite-element analysis with inhomogeneous orthotropic material properties
Z. Yosibash (2010)
10.1097/BRS.0000000000000905
Pathogenesis of Vertebral Anterior Wedge Deformity: A 2-Stage Process?
P. Landham (2015)
10.1002/JOR.1100180502
Biomechanical consequences of an isolated overload on the human vertebral body
D. Kopperdahl (2000)
10.1007/s001980070066
Vertebral Fracture Definition from Population-Based Data: Preliminary Results from the Canadian Multicenter Osteoporosis Study (CaMos)
S. Jackson (2000)
10.1002/(SICI)1097-4636(199722)38:2<155::AID-JBM10>3.0.CO;2-C
Properties of acrylic bone cement: state of the art review.
G. Lewis (1997)
10.1097/00007632-198005000-00007
The Resistance to Flexion of the Lumbar Intervertebral Joint
M. Adams (1980)
10.1115/1.2895413
Fracture prediction for the proximal femur using finite element models: Part II--Nonlinear analysis.
J. C. Lotz (1991)
10.1016/0021-9290(94)90054-X
Differences between the tensile and compressive strengths of bovine tibial trabecular bone depend on modulus.
T. M. Keaveny (1994)
10.1097/00007632-199605150-00009
Is the Nucleus Pulposus a Solid or a Fluid? Mechanical Behaviors of the Nucleus Pulposus of the Human Intervertebral Disc
J. Iatridis (1996)
Oncemonthly oral ibandronate improves biomechanical determinants of bone strength in women with postmenopausal osteoporosis
EMK Lewiecki (2009)
10.1016/J.BONE.2006.11.021
Mechanical efficacy of vertebroplasty: influence of cement type, BMD, fracture severity, and disc degeneration.
Jin Luo (2007)
10.1016/j.bone.2009.11.036
Is kyphoplasty better than vertebroplasty in restoring normal mechanical function to an injured spine?
Jin Luo (2010)
surement of the number of lumbar spinal movements in the sagittal plane in a 24 - hour period
A Rohlmann (2014)
10.1016/0268-0033(96)00008-3
The clinical biomechanics award paper 1995 Lower extremity joint loading during impact in running.
Gerald K. Cole (1996)
10.1016/S0167-8442(97)00032-3
Development and validation of a viscoelastic finite element model of an L2/L3 motion segment
J. Wang (1997)
10.1302/0301-620X.68B1.3941139
The stages of disc degeneration as revealed by discograms.
M. Adams (1986)
10.1016/J.JBIOMECH.2005.07.026
Analysis of the influence of disc degeneration on the mechanical behaviour of a lumbar motion segment using the finite element method.
A. Rohlmann (2006)
10.1016/0021-9290(94)90277-1
Bending and compressive stresses acting on the lumbar spine during lifting activities.
P. Dolan (1994)
10.1359/jbmr.070728
Structural Determinants of Vertebral Fracture Risk
L. J. Melton (2007)
10.1016/S0021-9290(99)00152-9
Prediction of femoral fracture load using finite element models: an examination of stress- and strain-based failure theories.
J. Keyak (2000)
10.1097/01.BRS.0000049923.27694.47
Finite Element Modeling of the Human Thoracolumbar Spine
M. Liebschner (2003)
10.1016/S1350-4533(01)00094-7
Prediction of fracture location in the proximal femur using finite element models.
J. Keyak (2001)
10.1016/0268-0033(94)90052-3
The clinical biomechanics award paper 1993 Posture and the compressive strength of the lumbar spine.
M. Adams (1994)
10.1016/S0021-9290(01)00011-2
Dependence of yield strain of human trabecular bone on anatomic site.
E. Morgan (2001)
10.1016/S0021-9290(03)00071-X
Trabecular bone modulus-density relationships depend on anatomic site.
E. Morgan (2003)
10.1007/s00586-014-3588-0
Measurement of the number of lumbar spinal movements in the sagittal plane in a 24-hour period
A. Rohlmann (2014)
10.1016/j.ejmp.2009.08.002
Noninvasive prediction of vertebral body compressive strength using nonlinear finite element method and an image based technique.
Ahad Zeinali (2010)
10.1115/1.2895412
Fracture prediction for the proximal femur using finite element models: Part I--Linear analysis.
J. C. Lotz (1991)
10.1016/J.BONE.2006.10.025
Comparison of quantitative computed tomography-based measures in predicting vertebral compressive strength.
J. Buckley (2007)
10.1210/jc.2008-1807
Once-monthly oral ibandronate improves biomechanical determinants of bone strength in women with postmenopausal osteoporosis.
E. Lewiecki (2009)
10.1016/S0021-9290(03)00257-4
Comparison of the elastic and yield properties of human femoral trabecular and cortical bone tissue.
Harun H. Bayraktar (2004)
10.1186/ar629
Degeneration of the intervertebral disc
J. Urban (2003)
10.1080/10255842.2011.556627
HR-pQCT-based homogenised finite element models provide quantitative predictions of experimental vertebral body stiffness and strength with the same accuracy as μFE models
D. Pahr (2012)
10.1016/J.JBIOMECH.2003.11.018
Simulated influence of osteoporosis and disc degeneration on the load transfer in a lumbar functional spinal unit.
A. Polikeit (2004)
10.1302/0301-620X.66B5.6501365
Disc space narrowing and the lumbar facet joints.
R. Dunlop (1984)
10.1016/S0736-0266(01)00185-1
Quantitative computed tomography estimates of the mechanical properties of human vertebral trabecular bone
D. Kopperdahl (2002)
10.1016/J.JBIOMECH.2006.08.003
Prediction of strength and strain of the proximal femur by a CT-based finite element method.
M. Bessho (2007)
A new, standardized approach to fracture risk interpretation.
R. Wasnich (1996)
10.1016/S0021-9290(97)00123-1
Prediction of femoral fracture load using automated finite element modeling.
J. Keyak (1998)
10.1359/jbmr.061011
Effects of Teriparatide and Alendronate on Vertebral Strength as Assessed by Finite Element Modeling of QCT Scans in Women With Osteoporosis
T. M. Keaveny (2007)
10.1002/JBMR.5650060302
Classification of vertebral fractures
R. Eastell (1991)
Finite element modeling of the human thoracolumbar
Liebschner MAK (2003)
10.1007/s00198-008-0750-8
Assessment of vertebral fracture risk and therapeutic effects of alendronate in postmenopausal women using a quantitative computed tomography-based nonlinear finite element method
K. Imai (2008)
10.1016/S8756-3282(03)00210-2
Finite element models predict in vitro vertebral body compressive strength better than quantitative computed tomography.
R. Crawford (2003)
10.1016/J.JBIOMECH.2004.07.039
Biomechanical comparison between fusion of two vertebrae and implantation of an artificial intervertebral disc.
Guilhem Denozière (2006)
10.1359/jbmr.060609
Intervertebral Disc Degeneration Can Predispose to Anterior Vertebral Fractures in the Thoracolumbar Spine
M. Adams (2006)
10.1016/j.spinee.2010.04.015
Restoration of compressive loading properties of lumbar discs with a nucleus implant-a finite element analysis study.
D. Strange (2010)
10.1016/S0268-0033(03)00142-6
Biomechanical responses of the intervertebral joints to static and vibrational loading: a finite element study.
J. Cheung (2003)
10.1016/S8756-3282(99)00098-8
The ability of three-dimensional structural indices to reflect mechanical aspects of trabecular bone.
D. Ulrich (1999)
10.1007/S007760200040
Mechanical analysis of the lumbar vertebrae in a three-dimensional finite element method model in which intradiscal pressure in the nucleus pulposus was used to establish the model
K. Goto (2002)
10.1097/01.brs.0000192236.92867.15
Effects of Degeneration on the Biphasic Material Properties of Human Nucleus Pulposus in Confined Compression
Wade Johannessen (2005)



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