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Immunohistochemical Localization Of S100 Beta In Human Nervous System Tumors By Using Monoclonal Antibodies With Specificity For The S100 Beta Polypeptide.

L J Van Eldik, R A Jensen, B A Ehrenfried, W O Whetsell

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The immunohistochemical localization of the calcium-binding protein, S100 beta, in human nervous system tumors has been examined by using a monoclonal antibody with specificity for the S100 beta polypeptide. S100 beta-specific immunoreactivity is detected in astrocytoma, glioblastoma, Schwannoma, ependymoma, and craniopharyngioma, whereas no reactivity is seen in oligodendroglioma, meningioma, neuroblastoma, or medulloblastoma. These data suggest that analysis of S100 beta localization with these monoclonal antibodies may be useful for research or diagnostic purposes.