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Ceramic Nanovector Based On Layered Double Hydroxide: Attributes, Physiologically Relevant Compositions And Surface Activation

S. Dey, R. Sistiabudi
Published 2007 · Materials Science

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Abstract Since 2001, intercalated or biohybridised ceramics based on layered double (M2+,M3+) hydroxide nanoparticles (LDHN) have been evaluated as a passive vector for drug and non-viral gene delivery. This paper identifies the attributes of LDHN as a passive delivery platform, judiciously selects and discusses issues in synthesis of physiologically relevant compositions, and demonstrates surface activation of (Mg2+,Al3+) LDHN; the latter a critical first step in the surface functionalisation process for active targeting. After a description of the layered double hydroxide (LDH) structure and unique attributes of LDHN as a passive platform, the advantages and issues of a robust LDHN surface functionalisation process for active targeting are identified. Next, the judicious selection of physiological relevant (Mg2+,Fe3+) and (Zn2+,Fe3+) LDH compositions is made, and their synthesis by precipitation and potential difficulties are discussed. Finally, the surface activation of (Mg2+,Al3+) LDHN is demonstrated by a bimolecular, nucleophilic substitution type reaction using acryloyl chloride.
This paper references
10.1016/S0167-7799(97)01036-6
Biomedical applications of nanotechnology--implications for drug targeting and gene therapy.
S. Davis (1997)
10.5012/BKCS.2004.25.1.122
Intercalation of Vitamer into LDH and Their Controlled Release Properties
Jin-Ho Choy (2004)
Newer trace elements in nutrition.
W. Mertz (1971)
10.1039/A804557G
Preparation method for organic-inorganic layered compounds including fibrous materials by the reaction of Zn(OH)2 with organic compounds
Sumikazu Ogata (1998)
10.1016/J.JCONREL.2003.12.027
Nanobiohybrids as delivery vehicles for camptothecin.
Katherine M. Tyner (2004)
10.1016/J.BIOMATERIALS.2003.09.083
Layered double hydroxide as an efficient drug reservoir for folate derivatives.
J. Choy (2004)
10.1016/J.NUCLCARD.2004.09.002
Magnetic resonance molecular imaging with nanoparticles
G. Lanza (2004)
10.1002/mrm.20287
Quantitative “magnetic resonance immunohistochemistry” with ligand‐targeted 19F nanoparticles
A. Morawski (2004)
10.1016/J.BIOMATERIALS.2004.01.056
Inorganic delivery vector for intravenous injection.
Seo-Young Kwak (2004)
10.1039/B008680K
Cellular uptake behavior of [γ-32P] labeled ATP–LDH nanohybrids
J. Choy (2001)
10.1023/A:1020398624602
Design and Function of a Dendrimer-Based Therapeutic Nanodevice Targeted to Tumor Cells Through the Folate Receptor
A. Quintana (2004)
10.1016/0168-3659(95)00164-6
Biodegradable nanoparticles — From sustained release formulations to improved site specific drug delivery
J. Leroux (1996)
10.1038/nrc903
Ligand-targeted therapeutics in anticancer therapy
T. Allen (2002)
10.1073/pnas.152463399
Nanocrystal targeting in vivo
M. Akerman (2002)
10.1038/nrd1494
Nanosuspensions in drug delivery
Barrett E. Rabinow (2004)
10.1016/S1567-1739(02)00163-3
Intercalative route to heterostructured nanohybrids
Jin-Ho Choy (2002)
10.1016/J.JSSC.2004.08.006
Synthesis and characterization of layered double hydroxides (LDH) intercalated with non-steroidal anti-inflammatory drugs (NSAID)
M. Arco (2004)
10.1002/JPS.10498
Preparation of 1-hydroxyethylidene-1,1-diphosphonic acid-intercalated layered double hydroxide and its physicochemical properties.
H. Nakayama (2003)
10.1016/S0168-3659(03)00218-9
Drug delivery in polymeric micelles: from in vitro to in vivo.
N. Rapoport (2003)
10.1359/jbmr.1998.13.4.749
Magnesium Deficiency: A Cause of Heterogenous Disease in Humans
R. Rude (1998)
10.1016/J.BIOMATERIALS.2003.12.014
Covalently immobilized thrombomodulin inhibits coagulation and complement activation of artificial surfaces in vitro.
C. Sperling (2004)
10.1016/J.JCONREL.2004.07.035
Intercalation, delivery, and expression of the gene encoding green fluorescence protein utilizing nanobiohybrids.
Katherine M Tyner (2004)
10.1111/J.1151-2916.1991.TB07132.X
Bioceramics: From Concept to Clinic
L. Hench (1991)
10.1016/S0168-3659(03)00241-4
Nanoparticle drug delivery system for intravenous delivery of topoisomerase inhibitors.
J. Williams (2003)
10.1016/S1367-5931(02)00347-2
Dendritic polymer macromolecular carriers for drug delivery.
A. Patri (2002)
10.1016/S0273-2300(02)00020-X
Trace element risk assessment: essentiality vs. toxicity.
S. Goldhaber (2003)
10.1016/S0167-577X(03)00480-4
Acid fuchsin-interleaved Mg–Al-layered double hydroxide for the formation of an organic–inorganic hybrid nanocomposite
M. Hussein (2004)
10.1016/0168-3659(95)00169-7
Control of molecular polymorphisms by a structured carbohydrate / ceramic delivery vehicle — aquasomes
N. Kossovsky (1996)
10.1002/1097-4636(200105)55:2<151::AID-JBM1001>3.0.CO;2-D
Gene-expression profiling of human osteoblasts following treatment with the ionic products of Bioglass 45S5 dissolution.
I. D. Xynos (2001)
10.1002/(SICI)1097-4636(19991205)47:3<324::AID-JBM6>3.0.CO;2-Y
In vitro analysis of biodegradable polymer blend/hydroxyapatite composites for bone tissue engineering.
K. Marra (1999)
10.1021/CM980523U
Layered double hydroxide stability. 1. Relative stabilities of layered double hydroxides and their simple counterparts.
J. W. Boclair (1999)
10.1023/A:1014832530184
Synthesis and Structural Transformations of Hydrotalcite-like Materials Mg-Al and Zn-Al
R. V. Prikhod’ko (2001)
10.1021/BM0342032
Physical polymer matrices based on affinity interactions between peptides and polysaccharides.
Brandon L Seal (2003)
10.1039/F19817700665
Coprecipitated nickel–alumina catalysts for methanation at high temperature. Part 2.—Variation of total and metallic areas as a function of sample composition and method of pretreatment
L. Alzamora (1981)
The metabolic and molecular basis of acquired disease
R. Cohen (1990)
10.1002/APP.20936
Effect of hydrotalcite on the physical properties and drug-release behavior of nanocomposite hydrogels based on poly[acrylic acid-co-poly(ethylene glycol) methyl ether acrylate] gels
W. Lee (2004)
10.1021/CM020370H
Preparation of Layered Double-Hydroxide Nanomaterials with a Uniform Crystallite Size Using a New Method Involving Separate Nucleation and Aging Steps
Y. Zhao (2002)
10.1016/S0378-5173(02)00235-1
Development of hemoglobin aquasomes from spherical hydroxyapatite cores precipitated in the presence of half-generation poly(amidoamine) dendrimer.
A. Khopade (2002)
10.1016/0920-5861(91)80068-K
Hydrotalcite-type anionic clays: Preparation, properties and applications.
F. Cavani (1991)
10.1016/0304-5102(82)85035-9
C1-C6 Alcohols from synthesis gas on copper-cobalt catalysts
P. Courty (1982)
10.1016/S0167-2738(02)00714-2
Bio-LDH nanohybrid for gene therapy
Seo-Young Kwak (2002)
10.1016/J.JPCS.2003.10.047
Intercalative route to heterostructured nanohybrid
Jin-Ho Choy (2004)
10.1016/J.MATERRESBULL.2004.04.016
Preparation and intercalation chemistry of magnesium–iron(III) layered double hydroxides containing exchangeable interlayer chloride and nitrate ions
W. Meng (2004)
10.1016/J.JPCS.2003.09.019
In vitro release of citrate anions intercalated in magnesium aluminium layered double hydroxides
Jairo Tronto (2004)
10.1016/S0169-409X(02)00022-4
Chemistry for peptide and protein PEGylation.
M. Roberts (2002)
10.1126/SCIENCE.1064126
Tumor Therapy with Targeted Atomic Nanogenerators
M. McDevitt (2001)
10.1016/0168-7336(88)80089-5
Synthesis of hydrotalcite-like compounds and their physico-chemical properties
T. Sato (1988)
10.1007/BF02062519
Alcohol formation from synthesis gas: A thermodynamic study
A. Marchi (1986)
10.1016/S0142-9612(01)00043-6
Relationship between complement activation, cellular uptake and surface physicochemical aspects of novel PEG-modified nanocapsules.
V. Mosqueira (2001)
10.1016/0167-2738(86)90067-6
Synthesis of anionic clay minerals (mixed metal hydroxides, hydrotalcite)
W. T. Reichle (1986)
10.1016/S0168-3659(01)00555-7
A new synthesis of galactose-poly(ethylene glycol)-polyethylenimine for gene delivery to hepatocytes.
K. Sagara (2002)
CRC Handbook of Chemistry and Physics
D. Lide (1996)
10.1016/J.JSSC.2004.03.041
Studies on the intercalation of naproxen into layered double hydroxide and its thermal decomposition by in situ FT-IR and in situ HT-XRD
M. Wei (2004)
10.1002/JPS.20054
Mg,Al layered double hydroxides with intercalated indomethacin: synthesis, characterization, and pharmacological study.
M. del Arco (2004)
10.1016/J.MOLMED.2004.04.003
Methods for targeting biologicals to specific disease sites.
A. Nissim (2004)
10.1016/S0378-5173(03)00128-5
Development of polymeric nanoparticulate drug delivery systems: evaluation of nanoparticles based on biotinylated poly(ethylene glycol) with sugar moiety.
I. Kim (2003)
10.1016/S1359-6446(03)02903-9
Nanotech approaches to drug delivery and imaging.
S. Sahoo (2003)
10.1002/(SICI)1099-0682(199810)1998:10<1439::AID-EJIC1439>3.0.CO;2-1
New Synthetic Routes to Hydrotalcite-Like Compounds − Characterisation and Properties of the Obtained Materials
U. Costantino (1998)
Function and regulation of transferrin and ferritin.
P. Ponka (1998)
10.1006/JSSC.1995.1282
Preparation of New Useful Materials by Surface Modification of Inorganic Layered Compound
H. Morioka (1995)
10.1126/SCIENCE.1067404
Third-Generation Biomedical Materials
L. Hench (2002)
10.7326/0003-4819-117-5-448_2
Casarett and Doull's toxicology : the basic science of poisons :companion handbook
Louis J. Casarett (1999)
10.1016/S0378-5173(02)00703-2
Circulation and biodistribution profiles of long-circulating PEG-liposomes of various sizes in rabbits.
V. Awasthi (2003)
10.1080/10587250108023703
Organic Anions of Pharmaceutical Interest Intercalated in Magnesium Aluminum LDHs by Two Different Methods
J. Tronto (2001)
10.2138/am-2002-5-604
Infrared and Raman study of interlayer anions CO32–, NO3–, SO42– and ClO4– in Mg/Al-hydrotalcite
J. T. Kloprogge (2002)
10.1023/A:1024911716152
“Smart” polymeric nanospheres as new materials for possible biomedical applications
Krzysztof Szczubiałka (2003)
10.1002/(SICI)1520-670X(2000)13:1<73::AID-JTRA9>3.0.CO;2-X
Iron metabolism: Physiology and pathophysiology
P. Ponka (2000)
10.1126/SCIENCE.8128245
Biodegradable long-circulating polymeric nanospheres.
R. Gref (1994)
10.1002/JBM.820030106
Identification of rapid changes at plasma-solid interfaces.
L. Vroman (1969)
10.1016/S0304-4157(96)00014-7
The molecular mechanisms of the metabolism and transport of iron in normal and neoplastic cells.
D. Richardson (1997)
10.1557/MRS2004.14
Bio-Resorbable Nanoceramics for Gene and Drug Delivery
W. Kriven (2004)
10.1121/1.1810251
Acoustic characterization in whole blood and plasma of site-targeted nanoparticle ultrasound contrast agent for molecular imaging.
M. Hughes (2005)
10.1038/NMAT945
Nucleation of apatite crystals in vitro by self-assembled dentin matrix protein 1
Gen He (2003)
10.1039/b204076j
Intercalation chemistry of layered double hydroxides: recent developments and applicationsBasis of a presentation given at Materials Discussion No. 5, 22???25 September 2002, Madrid, Spain.
A. I. Khan (2002)
10.1016/0920-5861(92)85004-6
Effect op the preparation conditions on the reducibility of Cu-Co based oxides
A. Marchi (1992)
10.1038/nbt876
Small-scale systems for in vivo drug delivery
David A. LaVan (2003)
10.1016/S0378-5173(01)00629-9
Intercalation compounds of hydrotalcite-like anionic clays with antiinflammatory agents--I. Intercalation and in vitro release of ibuprofen.
V. Ambrogi (2001)



This paper is referenced by
10.1517/17425240903130585
Layered double hydroxide nanoparticles in gene and drug delivery
Katharina Ladewig (2009)
10.1016/j.jconrel.2011.06.004
Inorganic nanoparticles for cancer imaging and therapy.
Huang-Chiao Huang (2011)
Layereddoublehydroxide nanoparticlesingeneanddrug delivery
Katharina Ladewig (2009)
Synthesis and Characterization of Silver (Core)/Layered Double Hydroxides (Shell) Nanoparticles
W. Noh (2012)
10.1016/j.jcis.2015.07.073
Insights into the synthesis of layered double hydroxide (LDH) nanoparticles: Part 1. Optimization and controlled synthesis of chloride-intercalated LDH.
Xiaodi Sun (2015)
Chemical Processing Science of Ceramic Nanoparticles and Films for Biomedicine and Energy
Sun Zhou (2014)
10.1016/J.JCONREL.2011.07.005
WITHDRAWN: Inorganic nanoparticles for cancer imaging and therapy.
Huang-Chiao Huang (2011)
10.1016/j.jconrel.2013.03.034
Layered double hydroxides as drug carriers and for controlled release of non-steroidal antiinflammatory drugs (NSAIDs): a review.
V. Rives (2013)
The Synthesis and Characterization of Gold-Core/LDH-Shell Nanoparticles
Colton Rearick (2011)
10.4028/www.scientific.net/AMM.766-767.355
Investigation of Mechanical Properties of Nano Sized Clay/LDH Particle as Hybrid Nano Composite Material
S. Sivasaravanan (2015)
10.1515/ntrev-2012-0065
Applications of nanobioceramics to healthcare technology
J. Feng (2013)
10.1039/C5RA25814F
Layered double hydroxide and sulindac coiled and scrolled nanoassemblies for storage and drug release
M. A. Rocha (2016)
10.1016/J.VIBSPEC.2016.09.010
Modified drug release system based on Sulindac and layered double hydroxide: An in vivo Raman investigation ☆
O. Gil (2016)
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