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XPD Lys751Gln Polymorphism In The Etiology And Outcome Of Childhood Acute Myeloid Leukemia: A Children's Oncology Group Report.

P. Mehta, T. Alonzo, R. Gerbing, J. Elliott, T. A. Wilke, R. Kennedy, J. Ross, J. Perentesis, B. Lange, S. Davies
Published 2006 · Biology, Medicine

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Genetic polymorphisms result in interindividual variation in DNA repair capacity and may, in part, account for susceptibility of a cell to genotoxic agents and to malignancy. Polymorphisms in XPD, a member of the nucleotide excision repair pathway, have been associated with development of treatment-related acute myeloid leukemia (AML) and with poor outcome of AML in elderly patients. We hypothesized that XPD Lys751Gln polymorphism may play a role in causation of AML in children and, as shown in adults, may affect the outcome of childhood AML therapy. Genotyping of 456 children treated for de novo AML was performed at XPD exon 23. Genotype frequencies in patients were compared with healthy control subject frequencies, and patient outcomes were analyzed according to genotype. Gene frequencies in AML patients and healthy controls were similar. There were no significant differences in overall survival (P = .82), event-free survival (P = .78), treatment-related mortality (P = .43), or relapse rate (RR) (P = .92) between patients with XPD751AA versus 751AC versus 751CC genotypes, in contrast to reports in adult AML. These data, representing the only data in pediatric AML, suggest that XPD genotype does not affect the etiology or outcome of childhood AML.
This paper references
10.1177/000348947108000408
References
(1971)
The natural duration of cancer: Reports on Public Health and Medical Subjects
M. Greenwood (1926)
Molecular genetics of eukaryotic DNA excision repair.
J. Hoeijmakers (1990)
Modulation of nucleotide excision repair capacity by XPD polymorphisms in lung cancer patients.
M. Spitz (2001)
10.1007/978-1-4612-4380-9_25
Nonparametric Estimation from Incomplete Observations
E. L. Kaplan (1958)
10.1016/S0084-3954(07)70266-X
Mortality in Overweight and Underweight Children with Acute Myeloid Leukemia
J. Stockman (2006)
10.1038/sj.onc.1202862
Drug-induced apoptosis is delayed and reduced in XPD lymphoblastoid cell lines: possible role of TFIIH in p53-mediated apoptotic cell death
A. Robles (1999)
10.1016/0959-8049(94)00381-E
Human nucleotide excision repair syndromes: molecular clues to unexpected intricacies.
J. Hoeijmakers (1994)
A Xeroderma pigmentosum group D gene polymorphism predicts clinical outcome to platinum-based chemotherapy in patients with advanced colorectal cancer.
D. Park (2001)
10.1182/BLOOD.V89.9.3323
Acute myeloid leukemia in the elderly: assessment of multidrug resistance (MDR1) and cytogenetics distinguishes biologic subgroups with remarkably distinct responses to standard chemotherapy. A Southwest Oncology Group study.
C. Leith (1997)
10.1182/BLOOD-2004-06-2161
Genetic variation in XPD predicts treatment outcome and risk of acute myeloid leukemia following chemotherapy.
J. Allan (2004)
10.1093/JNCI/92.21.1764
Repair of tobacco carcinogen-induced DNA adducts and lung cancer risk: a molecular epidemiologic study.
Q. Wei (2000)
Efficient nucleotide excision repair of cisplatin, oxaliplatin, and Bis-aceto-ammine-dichloro-cyclohexylamine-platinum(IV) (JM216) platinum intrastrand DNA diadducts.
J. Reardon (1999)
10.1016/S0168-9525(01)02280-6
Trichothiodystrophy, a transcription syndrome.
E. Bergmann (2001)
10.1016/0165-1218(94)90028-0
Detection of hyperdiploidy and chromosome breakage in interphase human lymphocytes following exposure to the benzene metabolite hydroquinone using multicolor fluorescence in situ hybridization with DNA probes.
D. Eastmond (1994)
Asymptotically efficient rank invariant test procedure (with discussion).
R. Peto (1972)
10.3322/canjclin.52.6.363
The Difficult Problem of Acute Myeloid Leukemia in the Older Adult
R. Stone (2002)
10.1016/S0968-0004(96)10046-3
The multiple roles of transcription/repair factor TFIIH.
J. Svejstrup (1996)
Alberta Children's Hospital, Calgary, AB, Canada; All Children's Hospital, St Backus Children's Hospital at MHUMC, Savannah, GA; Baptist Children's Hospital British Columbia's Children's Hospital
Prognostic significance of karyotype in de novo adult acute myeloid leukemia. The BGMT group.
N. Dastugue (1995)
Nucleotide excision repair of melphalan monoadducts.
D. F. Grant (1998)
10.1016/S0140-6736(86)92674-7
PRINCIPAL RESULTS OF THE MEDICAL RESEARCH COUNCIL'S 8th ACUTE MYELOID LEUKAEMIA TRIAL
J. Rees (1986)
ERCC2 and biomarkers of DNA damage in human blood mononuclear cells
(2000)
10.1182/BLOOD.V98.5.1302
Attempts to improve treatment outcomes in acute myeloid leukemia (AML) in older patients: the results of the United Kingdom Medical Research Council AML11 trial.
A. Goldstone (2001)
10.1093/emboj/16.21.6559
Mechanism of open complex and dual incision formation by human nucleotide excision repair factors
E. Evans (1997)
10.1016/S0959-437X(96)90006-4
TFIIH: a key component in multiple DNA transactions.
J. Hoeijmakers (1996)
10.1016/S0027-5107(97)00106-1
Predisposing genes and increased chromosome aberrations in lung cancer cigarette smokers.
N. Conforti-froes (1997)
10.1073/pnas.061408298
Methylenetetrahydrofolate reductase (MTHFR) polymorphisms and risk of molecularly defined subtypes of childhood acute leukemia
J. Wiemels (2001)
10.1016/S0921-8777(97)00057-8
Seasonal variation of DNA damage and repair in patients with non-melanoma skin cancer and referents with and without psoriasis.
P. Møller (1998)
10.1016/S0140-6736(02)02524-2
HOSPITAL FOR SICK CHILDREN.
J. Morgan (1884)
10.1128/MCB.23.2.754-761.2003
Nucleotide Excision Repair- and Polymerase η-Mediated Error-Prone Removal of Mitomycin C Interstrand Cross-Links
H. Zheng (2003)
Different removal of ultraviolet photoproducts in genetically related xeroderma pigmentosum and trichothiodystrophy diseases.
E. Eveno (1995)
10.1093/CARCIN/21.5.965
Polymorphisms in the DNA repair genes XRCC1 and ERCC2 and biomarkers of DNA damage in human blood mononuclear cells.
E. Duell (2000)
10.1093/NAR/29.21.4257
Repair of triplex-directed DNA alkylation by nucleotide excision repair.
A. Ziemba (2001)
Polymorphisms in genes encoding drugs and xenobiotic metabolizing enzymes, DNA repair enzymes, and response to treatment of childhood acute lymphoblastic leukemia.
M. Krajinovic (2002)
10.1101/GAD.10.10.1219
The XPB and XPD DNA helicases are components of the p53-mediated apoptosis pathway.
X. Wang (1996)
10.1093/CARCIN/BGG115
Association of the DNA repair gene XPD Asp312Asn polymorphism with p53 gene mutations in tobacco-related non-small cell lung cancer.
Weimin Gao (2003)
10.1200/JCO.1999.17.11.3569
Management of acute myeloid leukemia in elderly patients.
W. Hiddemann (1999)
10.1214/AOMS/1177730491
On a Test of Whether one of Two Random Variables is Stochastically Larger than the Other
H. B. Mann (1947)
10.1200/JCO.2004.04.016
Pilot study of idarubicin-based intensive-timing induction therapy for children with previously untreated acute myeloid leukemia: Children's Cancer Group Study 2941.
B. Lange (2004)
Polymorphisms in DNA repair genes and associations with cancer risk.
E. Goode (2002)
The natural duration of cancer: Reports on Public Health and Medical Subjects, 33. London, United Kingdom: Her Majesty's Stationery Office
M Greenwood
10.1136/BMJ.2.3320.266
THE NATURAL DURATION OF CANCER
W. S. Lazarus-Barlow (1924)
10.1002/j.1460-2075.1994.tb06522.x
The ERCC2/DNA repair protein is associated with the class II BTF2/TFIIH transcription factor.
L. Schaeffer (1994)
Analysis of genetic polymorphism in NQO1, GST-M1, GST-T1, and CYP3A4 in 469 Japanese patients with therapy-related leukemia/ myelodysplastic syndrome and de novo acute myeloid leukemia.
T. Naoe (2000)
10.1016/S0027-5107(98)00059-1
Variation in DNA repair is a factor in cancer susceptibility: a paradigm for the promises and perils of individual and population risk estimation?
H. Mohrenweiser (1998)
Functional significance of XPD polymorphic variants: attenuated apoptosis in human lymphoblastoid cells with the XPD 312 Asp/Asp genotype.
H. Şeker (2001)
10.1038/365852A0
Human xeroderma pigmentosum group D gene encodes a DMA helicase
P. Sung (1993)
10.1101/GAD.859501
The xeroderma pigmentosum group D (XPD) gene: one gene, two functions, three diseases.
A. Lehmann (2001)
10.1214/AOS/1176350951
A Class of $K$-Sample Tests for Comparing the Cumulative Incidence of a Competing Risk
R. Gray (1988)
10.2307/2344317
Asymptotically Efficient Rank Invariant Test Procedures
R. Peto (1972)
10.1128/9781555816704.ch7
Nucleotide Excision Repair
A. Roger (2006)
XPB and XPD helicases are components of the p53- mediated apoptosis pathway
Xw Wang (1996)



This paper is referenced by
10.1016/j.hoc.2008.01.001
The genetics of cancer survivorship.
J. Allan (2008)
10.1158/1055-9965.EPI-07-2507
DNA Repair Gene XPD Polymorphisms and Cancer Risk: A Meta-analysis Based on 56 Case-Control Studies
F. Wang (2008)
10.1182/BLOOD-2006-05-022111
Polymorphisms in DNA repair genes and therapeutic outcomes of AML patients from SWOG clinical trials.
N. Kuptsova (2007)
10.1182/asheducation-2004.1.98
Acute myeloid leukemia.
M. O'donnell (2008)
10.1016/j.ejogrb.2009.06.007
Genetic polymorphisms in DNA repair gene APE1, XRCC1 and XPD and the risk of pre-eclampsia.
P. Vural (2009)
10.1002/ijc.25318
Genetic variations of DNA repair genes and their prognostic significance in patients with acute myeloid leukemia
J. Shi (2011)
A pilot pharmacogenomics study examining the influence of cytotoxic and metabolising genetic polymorphisms on chemotherapy toxicity and outcome in osteosarcoma
R. Windsor (2013)
10.1155/2014/213790
Polymorphism of XRCC1, XRCC3, and XPD Genes and Risk of Chronic Myeloid Leukemia
C. Banescu (2014)
10.5897/AJB10.1839
Polymorphisms of the DNA repair gene XPD (751) and XRCC1 (399) correlates with risk of hematological malignancies in Turkish population
A. Özcan (2011)
10.1016/j.gene.2014.01.049
The effect of XPD/ERCC2 Lys751Gln polymorphism on acute leukemia risk: a systematic review and meta-analysis.
D. Liu (2014)
10.2217/PGS-2016-0055
Pharmacogenomics and the treatment of acute myeloid leukemia.
J. E. Megías-Vericat (2016)
10.3109/10428190903582804
Acute myeloid leukemia outcome: role of nucleotide excision repair polymorphisms in intermediate risk patients
S. Strom (2010)
10.1007/s00277-015-2528-3
Association of XPD (Lys751Gln) and XRCC1 (Arg280His) gene polymorphisms in myelodysplastic syndrome
D. Joshi (2015)
10.2217/pme-2018-0077
Genetic variants of nucleotide excision repair pathway and outcomes of induction therapy in acute myeloid leukemia.
Z. Sharifi (2019)
10.1016/J.LEUKRES.2006.01.016
Influence of genetic polymorphisms on the risk of developing leukemia and on disease progression.
P. Bolufer (2006)
10.1007/978-3-642-13781-5_6
Pharmacogenetic and Pharmacogenomic Considerations in the Biology and Treatment of Childhood Leukemia
J. Yang (2011)
10.1007/s13277-016-4815-6
Influence of XPC, XPD, XPF, and XPG gene polymorphisms on the risk and the outcome of acute myeloid leukemia in a Romanian population
C. Bănescu (2016)
10.1016/j.fertnstert.2007.09.038
X-ray repair cross-complementing group 4 (XRCC4) promoter -1394( *)T-related genotype, but not XRCC4 codon 247/intron 3 or xeroderma pigmentosum group D codon 312, 751/promoter -114, polymorphisms are correlated with higher susceptibility to myoma.
Y. Hsieh (2008)
10.1016/J.DNAREP.2007.02.010
Common XPD (ERCC2) polymorphisms have no measurable effect on nucleotide excision repair and basal transcription.
J. P. Lainé (2007)
10.3389/fgene.2018.00218
Associations Between XPD Lys751Gln Polymorphism and Leukemia: A Meta-Analysis
Min Wen (2018)
10.3324/haematol.11203
Pediatric acute myeloid leukemia: towards high-quality cure of all patients
G. Kaspers (2007)
10.1179/102453311X13127324303399
DNA repair genes polymorphisms in multiple myeloma: no association with XRCC1 (Arg399Gln) polymorphism, but the XRCC4 (VNTR in intron 3 and G-1394T) and XPD (Lys751Gln) polymorphisms is associated with the disease in Turkish patients
S. Çifçi (2011)
10.3109/10428194.2014.974045
Polymorphisms in XPC, XPD and XPG DNA repair genes and leukemia risk in a Tunisian population
K. Douzi (2015)
10.2217/14622416.8.7.817
Pharmacogenomics of acute leukemia.
M. Ansari (2007)
10.5772/26145
The Association of the DNA Repair Genes with Acute Myeloid Leukemia: The Susceptibility and the Outcome After Therapy
C. Banescu (2011)
Risk effects of XRCC1 Arg399Gln and XPD Lys751Gln gene polymorphisms in de novo acute myeloid leukemia – A study from India
S. Santhi (2017)
10.1016/j.dnarep.2020.102951
DNA repair pathways as guardians of the genome: Therapeutic potential and possible prognostic role in hematologic neoplasms.
Elahe Rahimian (2020)
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