← Back to Search
Cardiovascular Risk Factors In Hematopoietic Cell Transplantation Survivors: Role In Development Of Subsequent Cardiovascular Disease.
S. Armenian, Can-Lan Sun, Tabitha Vase, K. Ness, E. Blum, L. Francisco, K. Venkataraman, Raynald A Samoa, F. Wong, S. Forman, S. Bhatia
Published 2012 · Medicine
Save to my Library
Download PDFAnalyze on Scholarcy
Hematopoietic cell transplantation (HCT) recipients may be at an increased risk of developing hypertension, diabetes, and dyslipidemia (referred to as cardiovascular risk factors [CVRFs]); and these factors can potentially increase the risk of cardiovascular disease (CVD). We examined the incidence and predictors of CVRFs and subsequent CVD in 1885 consecutive 1+year survivors of HCT performed at City of Hope between 1995 and 2004. Ten-year cumulative incidence of hypertension, diabetes, dyslipidemia, and multiple (≥ 2) CVRFs was 37.7%, 18.1%, 46.7%, and 31.4%, respectively. The prevalence of CVRFs was significantly higher among HCT recipients compared with the general population; contributed to largely by allogeneic HCT recipients. Older age and obesity at HCT were associated with increased risk of CVRFs. History of grade II-IV acute graft versus host disease was associated with an increased risk for hypertension (relative risk [RR] = 9.1, P < .01), diabetes (RR = 5.8, P < .01), and dyslipidemia (RR = 3.2, P < .01); conditioning with total body irradiation was associated with an increased risk of diabetes (RR = 1.5, P = .01) and dyslipidemia (RR = 1.4, P < .01). There was an incremental increase in 10-year incidence of CVD by number of CVRFs (4.7% [none], 7.0% [1 CVRF], 11.2% [≥ 2 CVRFs], P < .01); the risk was especially high (15.0%) in patients with multiple CVRFs and pre-HCT exposure to anthracyclines or chest radiation.
This paper references
Late mortality in survivors of autologous hematopoietic-cell transplantation: report from the Bone Marrow Transplant Survivor Study.
S. Bhatia (2005)
Endocrine complications of hematopoietic stem cell transplantation.
W. Chemaitilly (2007)
Prevalence and predictors of chronic health conditions after hematopoietic cell transplantation: a report from the Bone Marrow Transplant Survivor Study.
Can Sun (2010)
Hematopoietic stem-cell transplantation.
E. Copelan (2006)
Cardiac and cardiovascular consequences after haematopoietic stem cell transplantation
A. Tichelli (2008)
The preventive health behaviors of long-term survivors of cancer and hematopoietic stem cell transplantation compared with matched controls.
M. Bishop (2010)
Nonmalignant late effects and compromised functional status in survivors of hematopoietic cell transplantation.
N. Khera (2012)
Framingham risk score and prediction of lifetime risk for coronary heart disease.
D. Lloyd-Jones (2004)
Incidence and predictors of congestive heart failure after autologous hematopoietic cell transplantation.
S. Armenian (2011)
Life - time risk for developing congestive heart failure : the Framingham Heart Study
DM Lloyd-Jones (2002)
Abnormal insulin response to glucose following treatment for Wilms' tumor in childhood
A. Cicognani (1997)
Cardiovascular risk, cardiovascular events, and metabolic syndrome in renal transplantation: comparison of early steroid withdrawal and chronic steroids
A. Rike (2008)
[The progression from hypertension to congestive heart failure].
F. Palano (2011)
Case Definitions for Acute Coronary Heart Disease in Epidemiology and Clinical Research Studies: A Statement from the AHA Council on Epidemiology and Prevention
Russell V. Luepker (2003)
A Class of $K$-Sample Tests for Comparing the Cumulative Incidence of a Competing Risk
R. Gray (1988)
Assessment of cardiovascular risk by use of multiple-risk-factor assessment equations: a statement for healthcare professionals from the American Heart Association and the American College of Cardiology.
S. Grundy (1999)
Dyslipidemia after allogeneic hematopoietic stem cell transplantation: evaluation and management.
M. Griffith (2010)
Executive Summary of The Third Report of The National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, And Treatment of High Blood Cholesterol In Adults (Adult Treatment Panel III).
S. Grundy (2001)
Diabetes Mellitus in Long-Term Survivors of Pediatric Hematopoietic Cell Transplantation
P. Hoffmeister (2004)
Late mortality after allogeneic hematopoietic cell transplantation and functional status of long-term survivors: report from the Bone Marrow Transplant Survivor Study.
S. Bhatia (2007)
Late cardiovascular events after allogeneic hematopoietic stem cell transplantation: a retrospective multicenter study of the Late Effects Working Party of the European Group for Blood and Marrow Transplantation
A. Tichelli (2008)
Long-term survival and late deaths after allogeneic hematopoietic cell transplantation.
J. Wingard (2011)
Cardiovascular Toxicities of Immunosuppressive Agents
L. Miller (2002)
Impaired glucose tolerance and dyslipidaemia as late effects after bone-marrow transplantation in childhood
M. Taskinen (2000)
Different anthracycline derivates for reducing cardiotoxicity in cancer patients.
E. C. van Dalen (2006)
Diagnosis and Classification of Diabetes Mellitus
Vittorio Basevi (2011)
Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) final report.
S. Grundy (2002)
Long‐term survival and late relapse in 2‐year survivors of autologous haematopoietic cell transplantation for Hodgkin and non‐Hodgkin lymphoma
N. Majhail (2009)
Hypertension and diabetes mellitus in adult and pediatric survivors of allogeneic hematopoietic cell transplantation.
N. Majhail (2009)
Assessment of Cardiovascular Risk by Use of Multiple-Risk-Factor Assessment Equations
S. Grundy (1999)
ACC/AHA 2005 Guideline Update for the Diagnosis and Management of Chronic Heart Failure in the Adult
S. Hunt (2005)
Lifetime Risk for Developing Congestive Heart Failure: The Framingham Heart Study
D. Lloyd-Jones (2002)
High prevalence of metabolic syndrome after allogeneic hematopoietic cell transplantation
N. Majhail (2009)
CA 91010-3000; e-mail: firstname.lastname@example.org
Premature cardiovascular disease after allogeneic hematopoietic stem-cell transplantation.
A. Tichelli (2007)
Frequency of abnormal findings detected by comprehensive clinical evaluation at 1 year after allogeneic hematopoietic cell transplantation.
S. Lee (2009)
Cardiovascular Hospitalizations and Mortality Among Recipients of Hematopoietic Stem Cell Transplantation
E. Chow (2011)
Vascular endothelium as 'novel' target of graft-versus-host disease.
A. Tichelli (2008)
Diabetes, hypertension, and cardiovascular events in survivors of hematopoietic cell transplantation: a report from the bone marrow transplantation survivor study.
K. Baker (2007)
Moni - toring for cardiovascular disease in survivors of childhood cancer : report from the Cardiovascular Disease Task Force of the Children ’ s Oncology Group
SM Shankar (2008)
Hyperinsulinemia in children and adolescents after bone marrow transplantation.
R. Lorini (1995)
Monitoring for Cardiovascular Disease in Survivors of Childhood Cancer: Report From the Cardiovascular Disease Task Force of the Children's Oncology Group
S. Shankar (2008)
The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure: the JNC 7 report.
A. Chobanian (2003)
National Health and Nutrition Examination Survey Questionnaire
Late effects of hematopoietic cell transplantation among 10-year adult survivors compared with case-matched controls.
K. Syrjala (2005)
AHA/ACC scientific statement: Assessment of cardiovascular risk by use of multiple-risk-factor assessment equations: a statement for healthcare professionals from the American Heart Association and the American College of Cardiology.
S. Grundy (1999)
Prevalence of metabolic syndrome in long-term survivors of hematopoietic stem cell transplantation
C. Annaloro (2008)
Comparison of the severity of the chronic cardiotoxicity produced by doxorubicin in normotensive and hypertensive rats.
E. Herman (1985)
Diabetes mellitus after abdominal radiation therapy
C. Teinturier (1995)
This paper is referenced by
Cardiovascular Risk Factors in Survivors of Childhood Hematopoietic Cell Transplantation Treated with Total Body Irradiation: A Longitudinal Analysis.
D. Friedman (2017)
Genetics of Anthracycline Cardiomyopathy in Cancer Survivors
S. Bhatia (2020)
Risk factors for diabetes mellitus and impaired glucose tolerance following allogeneic hematopoietic stem cell transplantation in pediatric patients with hematological malignancies
K. Hirabayashi (2014)
Title Cardiac Complications in the Adult Bone Marrow Transplant Patient Permalink
Mirela Tuzovic (2019)
Chapter 18 – Total Body Irradiation
C. Barker (2016)
Clinicopathologic characteristics of secondary squamous cell carcinoma of head and neck in survivors of allogeneic hematopoietic stem cell transplantation for hematologic malignancies
C. Chaulagain (2018)
Efficacy of low-dose zoster prophylaxis in patients undergoing allogeneic hematopoietic cell transplantation
Kristen Mascarenhas (2019)
Differences in health behaviour between recipients of allogeneic haematopoietic SCT and the general population: a matched control study
M. Kirsch (2014)
Nutritional issues and body weight in long-term survivors of allogeneic blood and marrow transplant (BMT) in NSW Australia
J. Smith (2016)
Cardiac Toxic Chemotherapy and Cancer Survivorship
D. Szalda (2017)
Management of endocrino-metabolic dysfunctions after allogeneic hematopoietic stem cell transplantation
M. Vantyghem (2014)
Cardiac Toxicities in the Era of Precision Medicine: Underlying Risk Factors, Targeted Therapies, and Cardiac Biomarkers.
A. Blaes (2018)
Psychosocial Response to New-Onset Diabetes as a Long-Term Effect of Allogeneic Hematopoietic Stem Cell Transplantation
Jill M Olausson (2017)
Dyslipidemia and lipid-lowering treatment in a hematopoietic stem cell transplant cohort: 25 years of follow-up data.
Melanie Premstaller (2018)
Cardiac Complications in the Adult Bone Marrow Transplant Patient
Mirela Tuzovic (2019)
Early and progressive insulin resistance in young, non‐obese cancer survivors treated with hematopoietic stem cell transplantation
C. Bizzarri (2015)
Late Effects after Allogeneic Hematopoietic Stem Cell Transplantation
S. Hashmi (2013)
Hematopoietic Cell Transplants: Concepts, Controversies, and Future Directions
H. Lazarus (2017)
Influence of conventional cardiovascular risk factors and lifestyle characteristics on cardiovascular disease after hematopoietic cell transplantation.
E. Chow (2014)
Cardiac complications in childhood cancer survivors treated with anthracyclines.
V. Franco (2015)
Impact of a lifestyle modification program on the metabolic syndrome and associated risk factors in long-term survivors of stem cell transplantation
E. Smith (2016)
Treatment-related cardiotoxicity in survivors of childhood cancer
S. Lipshultz (2013)
Cost‐effectiveness of a lifestyle modification program in long‐term survivors of hemopoietic stem cell transplantation
L. Gao (2017)
Evaluation of Cardiac Parameters in Bone Marrow Transplant Patients: Effect of Pulmonary Artery Pressure on Survival Kemik İliği Nakli Yapılan Hastalarda Kardiyak Parametrelerin Değerlendirilmesi: Pulmoner Arter Basıncının Sağkalıma Etkisi
Ali Caner Özdöver (2019)
Late Effects Surveillance Recommendations among Survivors of Childhood Hematopoietic Cell Transplantation: A Children's Oncology Group Report.
E. Chow (2016)
Metabolic syndrome and cardiovascular disease following hematopoietic cell transplantation: screening and preventive practice recommendations from CIBMTR and EBMT
Z. DeFilipp (2017)
Chronic disease burden and frailty in survivors of childhood HSCT: a report from the St. Jude Lifetime Cohort Study.
H. Eissa (2017)
Age at Exposure to Radiation Determines Severity of Renal and Cardiac Disease in Rats.
Marek Lenarczyk (2019)
Survivorship After Allogeneic Transplantation—Management Recommendations for the Primary Care Provider
A. Tichelli (2015)
Left Ventricular Systolic Function in Long-Term Survivors of Allogeneic Hematopoietic Stem Cell Transplantation
R. Massey (2020)
Metabolic syndrome induced by anticancer treatment in childhood cancer survivors
Hee Won Chueh (2017)
Premature coronary artery disease following allogeneic stem cell transplantation: an NHLBI Cohort Study
K. Doucette (2018)See more