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The Second Transferrin Receptor Regulates Red Blood Cell Production In Mice

Antonella Nai, Maria Rosa Lidonnici, Marco Rausa, Giacomo Mandelli, Alessia Pagani, Laura Silvestri, Giuliana Ferrari, Clara Camaschella

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Key Points TFR2, a gene mutated in hemochromatosis and a partner of the EPO receptor, limits erythropoiesis expansion in mice. Iron deficiency mimics TFR2 deletion in the erythroid compartment.