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Cortical Spreading Depression As A Target For Anti-migraine Agents

Cinzia Costa, A. Tozzi, I. Rainero, L. Cupini, P. Calabresi, C. Ayata, P. Sarchielli
Published 2013 · Medicine

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Spreading depression (SD) is a slowly propagating wave of neuronal and glial depolarization lasting a few minutes, that can develop within the cerebral cortex or other brain areas after electrical, mechanical or chemical depolarizing stimulations. Cortical SD (CSD) is considered the neurophysiological correlate of migraine aura. It is characterized by massive increases in both extracellular K+ and glutamate, as well as rises in intracellular Na+ and Ca2+. These ionic shifts produce slow direct current (DC) potential shifts that can be recorded extracellularly. Moreover, CSD is associated with changes in cortical parenchymal blood flow.CSD has been shown to be a common therapeutic target for currently prescribed migraine prophylactic drugs. Yet, no effects have been observed for the antiepileptic drugs carbamazepine and oxcarbazepine, consistent with their lack of efficacy on migraine. Some molecules of interest for migraine have been tested for their effect on CSD. Specifically, blocking CSD may play an enabling role for novel benzopyran derivative tonabersat in preventing migraine with aura. Additionally, calcitonin gene-related peptide (CGRP) antagonists have been recently reported to inhibit CSD, suggesting the contribution of CGRP receptor activation to the initiation and maintenance of CSD not only at the classic vascular sites, but also at a central neuronal level. Understanding what may be lying behind this contribution, would add further insights into the mechanisms of actions for “gepants”, which may be pivotal for the effectiveness of these drugs as anti-migraine agents.CSD models are useful tools for testing current and novel prophylactic drugs, providing knowledge on mechanisms of action relevant for migraine.
This paper references
10.1111/j.1365-2796.2003.01296.x
Regulated expression and subcellular localization of HMGB1, a chromatin protein with a cytokine function
S. Mueller (2004)
10.1152/PHYSREV.2001.81.3.1065
Mechanisms of spreading depression and hypoxic spreading depression-like depolarization.
G. Somjen (2001)
10.1007/s101940050001
The debut of The Journal of Headache and Pain
J. Odeberg (2000)
10.1093/BRAIN/AWH716
Cortical spreading depression and peri-infarct depolarization in acutely injured human cerebral cortex.
M. Fabricius (2006)
10.1007/s11910-010-0099-1
Cortical Spreading Depression and Migraine
K. Eikermann-Haerter (2010)
10.1016/0006-8993(88)90690-7
Evidence for a role of the N-methyl-d-aspartate (NMDA) receptor in cortical spreading depression in the rat
R. Marrannes (1988)
10.1016/j.neuron.2009.01.027
Enhanced Excitatory Transmission at Cortical Synapses as the Basis for Facilitated Spreading Depression in CaV2.1 Knockin Migraine Mice
A. Tottene (2009)
10.1038/jcbfm.1991.18
Regional Cerebral Blood Flow during Spreading Cortical Depression in Conscious Rats
R. Duckrow (1991)
10.1016/S0006-8993(01)02196-5
Optical recording of spreading depression in rat neocortical slices
I. Világi (2001)
10.1016/S0006-8993(01)02557-4
Spreading depression in human neocortical slices
A. Gorji (2001)
10.1111/j.1468-2982.2008.01804.x
Randomized, Double-Blind, Placebo-Controlled, Proof-of-Concept Study of the Cortical Spreading Depression Inhibiting Agent Tonabersat in Migraine Prophylaxis
P. Goadsby (2009)
10.1097/01.WNR.0000175250.33159.A9
Topiramate inhibits cortical spreading depression in rat and cat: impact in migraine aura
S. Akerman (2005)
Neuropharmacology of spreading depression. In: Lehmenkuhler A, Grotemeyer KH, Tegtmeier F (eds) Migraine: Basic Mechanisms and Treatment
R Marrannes (1993)
10.1177/0333102412444015
Suppressive effect of chronic peroral topiramate on potassium-induced cortical spreading depression in rats
M. Unekawa (2012)
10.1152/CLASSICESSAYS.00031.2005
Aristides Leão's discovery of cortical spreading depression.
G. Somjen (2005)
10.1159/000117004
Anti-migraine compounds fail to modulate the propagation of cortical spreading depression in the cat.
H. Kaube (1994)
10.1177/0333102410388435
BI 44370 TA, an oral CGRP antagonist for the treatment of acute migraine attacks: Results from a phase II study
H. Diener (2011)
10.1016/J.BRAINRESREV.2004.05.005
Update on connexins and gap junctions in neurons and glia in the mammalian nervous system
J. Nagy (2004)
10.1080/13556210020077091
A putative sigma1 receptor antagonist NE‐100 attenuates the discriminative stimulus effects of ketamine in rats
M. Narita (2001)
10.1016/j.gene.2012.09.109
Matrix metalloproteinase (MMP)-2 gene polymorphisms affect circulating MMP-2 levels in patients with migraine with aura.
F. M. Gonçalves (2013)
[Testosterone therapy of headache].
B. Jonsson (1951)
Efficacy of danazol in the control of hormonal migraine.
E. Lichten (1991)
10.1016/S0304-3940(02)01120-5
Blockade of voltage-gated calcium channels in rat inhibits repetitive cortical spreading depression
F. Richter (2002)
10.1016/0006-8993(93)91412-L
Analysis of potential shifts associated with recurrent spreading depression and prolonged unstable spreading depression induced by microdialysis of elevated K+ in hippocampus of anesthetized rats
O. Herreras (1993)
Impact of migraine attacks on the blood-brain barrier.
Hong-mei Gao (2010)
10.1007/3-211-27208-9_1
Depolarisation phenomena in traumatic and ischaemic brain injury.
A. Strong (2005)
10.1007/s00424-010-0802-8
CaV2.1 channelopathies
D. Pietrobon (2010)
10.1002/ANA.410280610
Timing and topography of cerebral blood flow, aura, and headache during migraine attacks
J. Olesen (1990)
Pietrobon D (2010) Cav2.1 channelopathies
10.1016/S0006-8993(00)02233-2
NMDA-induced changes in a cortical network in vivo are prevented by AMPA
J. Addae (2000)
10.1017/S0317167100041688
Suppression of spreading depression of Leão in neocortex by an N-methyl-D-aspartate receptor antagonist.
R. Mclachlan (1992)
10.1002/ANA.410430108
Perfusion‐weighted imaging defects during spontaneous migrainous aura
F. Michael Cutrer (1998)
10.1212/01.WNL.0000130338.62037.CC
Migraine prevalence in male to female transsexuals on hormone therapy
T. Pringsheim (2004)
10.1523/JNEUROSCI.0511-10.2010
Activation of Meningeal Nociceptors by Cortical Spreading Depression: Implications for Migraine with Aura
Xichun Zhang (2010)
10.3181/00379727-207-2320204
Endothelin-1–Induced Spreading Depression in Rats Is Associated with a Microarea of Selective Neuronal Necrosis
J. Dreier (2007)
10.1111/j.1468-2982.2009.01976.x
Neurological Mechanisms of Migraine: Potential of the Gap-Junction Modulator Tonabersat in Prevention of Migraine
P. Durham (2009)
10.4161/chan.5.2.14149
Role of different voltage-gated Ca2+ channels in cortical spreading depression: Specific requirement of P/Q-type Ca2+ channels
A. Tottene (2011)
10.1073/pnas.1215435109
Critical role of calcitonin gene-related peptide receptors in cortical spreading depression
A. Tozzi (2012)
10.1007/bf00999905
Transient changes in energy metabolites and intracellular pH during spreading depression in the chick retina.
F. A. de Azeredo (1991)
10.1038/nm.2333
The role of spreading depression, spreading depolarization and spreading ischemia in neurological disease
J. Dreier (2011)
10.1046/j.1468-2982.1990.1003147.x
Ovarian Steroid Levels in Migraine With and Without Aura
S. Nagel-Leiby (1990)
10.1177/03331024850050S222
The Effects of Flunarizine in Experimental Models Related to the Pathogenesis of Migraine
A. Wauquier (1985)
10.1016/0166-2236(96)10046-1
Control of gap-junctional communication in astrocytic networks
C. Giaume (1996)
10.1523/JNEUROSCI.23-09-03588.2003
Functional Hemichannels in Astrocytes: A Novel Mechanism of Glutamate Release
Zu-Cheng Ye (2003)
10.1056/NEJM198403153101114
Danazol and migraine.
G. Calton (1984)
10.1111/j.1468-2982.2009.01974.x
Tonabersat, a Gap-Junction Modulator: Efficacy and Safety in Two Randomized, Placebo-Controlled, Dose-Ranging Studies of Acute Migraineceph
S. Silberstein (2009)
10.1074/jbc.M109.004804
The Pannexin 1 Channel Activates the Inflammasome in Neurons and Astrocytes*
William R. Silverman (2009)
10.1046/j.1468-2982.1997.1702109.x
Lamotrigine versus Placebo in the Prophylaxis of Migraine with and Without aura
T. Steiner (1997)
10.1111/j.1526-4610.1994.hed3403160.x
Magnesium Content of Mononuclear Blood Cells in Migraine Patients
V. Gallai† (1994)
10.1111/j.0953-816X.2004.03289.x
Energy failure in astrocytes increases the vulnerability of neurons to spreading depression
Xiao-Yuan Lian (2004)
10.1152/JN.1944.7.6.359
SPREADING DEPRESSION OF ACTIVITY IN THE CEREBRAL CORTEX
A. A. P. Leão (1944)
10.1111/j.1468-2982.1998.1809644.x
Migraine with Aura Shows Gadolinium Enhancement Which is Reversed Following Prophylactic Treatment
G. Arnold (1998)
10.1586/14737175.8.5.759
Translational imaging studies of cortical spreading depression in experimental models for migraine aura
Justin M. Smith (2008)
10.1113/jphysiol.2010.188003
Insights into migraine mechanisms and CaV2.1 calcium channel function from mouse models of familial hemiplegic migraine
D. Pietrobon (2010)
10.1016/j.pain.2010.09.036
Dural afferents express acid-sensing ion channels: A role for decreased meningeal pH in migraine headache
Jin Yan (2011)
10.1212/01.wnl.0000297551.27191.70
Oxcarbazepine in migraine headache
S. Silberstein (2008)
10.1172/JCI21227
Cortical spreading depression activates and upregulates MMP-9.
Y. Gursoy-Ozdemir (2004)
10.1117/1.1852556
Cortical spreading depression produces long-term disruption of activity-related changes in cerebral blood volume and neurovascular coupling.
Michael Guiou (2005)
10.1152/AJPLEGACY.1957.189.1.159
Electrical and vascular concomitants of spreading depression.
A. van Harreveld (1957)
10.1016/j.expneurol.2008.03.026
The impact of anesthetics and hyperoxia on cortical spreading depression
Chiho Kudo (2008)
10.1111/j.1600-0404.2005.00350.x
Headache and transient focal neurological symptoms during pregnancy, a prospective cohort
J. M. Ertresvåg (2005)
10.1002/ana.21815
High cortical spreading depression susceptibility and migraine‐associated symptoms in Cav2.1 S218L mice
A. M. van den Maagdenberg (2010)
10.1152/AJPHEART.1994.266.3.H1095
Calcitonin gene-related peptide promotes cerebrovascular dilation during cortical spreading depression in rabbits.
D. Colonna (1994)
10.1001/ARCHNEURPSYC.1941.02280200137007
PATTERNS OF CEREBRAL INTEGRATION INDICATED BY THE SCOTOMAS OF MIGRAINE
K. Lashley (1941)
10.1038/384560A0
Sensitization of meningeal sensory neurons and the origin of headaches
A. Strassman (1996)
フラボノイドのMatrix Metalloproteinase(MMP)に及ぼす影響(第2報)
町田尚子 (2006)
10.1046/j.1468-2982.2002.00364.x
Intravenous Magnesium Sulphate in the Acute Treatment of Migraine Without Aura and Migraine with Aura. A Randomized, Double-Blind, Placebo-Controlled Study
M. Bigal (2002)
10.1016/0013-4694(87)90213-6
Ketamine blockade of cortical spreading depression in rats.
N. Gorelova (1987)
10.1152/JN.1956.19.2.154
Mechanism of spreading cortical depression.
B. Grafstein (1956)
10.1046/j.1526-4610.1997.3710622.x
Positron Emission Tomography Studies in Headache
H. Diener (1997)
10.1093/BRAIN/118.1.307
Pathophysiology of the migraine aura: the spreading depression theory.
T. Olsen (1995)
10.1016/0006-8993(94)91835-X
Changes in energy metabolites, cGMP and intracellular pH during cortical spreading depression
Laura M. Gault (1994)
10.32388/o1w8x7
Familial hemiplegic migraine.
J. B. Hansen (2010)
10.1111/j.1468-2982.2009.02015.x
History of migraine with aura and cortical spreading depression from 1941 and onwards
P. Tfelt-Hansen (2010)
10.1517/13543784.2012.681044
CGRP receptor antagonists: an expanding drug class for acute migraine?
A. Negro (2012)
10.1111/j.1526-4610.1993.hed3307385.x
Migraine Without Aura and Reproductive Life Events: A Clinical Epidemiological Study in 1300 Women
F. Granella (1993)
10.1152/JN.1947.10.6.409
Further observations on the spreading depression of activity in the cerebral cortex.
A. A. P. Leo (1947)
10.1016/S1474-4422(04)00768-9
Oestrogen and attacks of migraine with and without aura
E. MacGregor (2004)
10.1152/CLASSICESSAYS.00032.2005
Dr. Bernice Grafstein's paper on the mechanism of spreading depression.
A. J. Strong (2005)
10.1016/0006-8993(95)00692-J
Tolerance to ketamine-induced blockade of cortical spreading depression transfers to MK-801 but not to AP5 in rats
A. Rashidy-pour (1995)
10.1038/jcbfm.2010.191
Clinical Relevance of Cortical Spreading Depression in Neurological Disorders: Migraine, Malignant Stroke, Subarachnoid and Intracranial Hemorrhage, and Traumatic Brain Injury
M. Lauritzen (2011)
10.1111/j.1526-4610.2011.01903.x
Sex‐Related Differences in Animal Models of Migraine Headache
H. Bolay (2011)
10.1016/S1474-4422(09)70135-8
Effects of tonabersat on migraine with aura: a randomised, double-blind, placebo-controlled crossover study
A. Hauge (2009)
10.1093/cercor/bhq018
Transient swelling, acidification, and mitochondrial depolarization occurs in neurons but not astrocytes during spreading depression.
Ning Zhou (2010)
10.1111/J.1468-2982.2004.00711.X
A Report on the Journal 2004
P. Goadsby (2004)
10.1002/ana.23653
Acid‐sensing ion channel 1: A novel therapeutic target for migraine with aura
P. Holland (2012)
[Disappearance of migraine crises in two patients with male infertility treated with human chorionic gonadotropin/human menopausal gonadotrophin].
O. Arango (1996)
10.1016/j.ejphar.2010.11.021
Effects of AMPA and clomethiazole on spreading depression cycles in the rat neocortex in vivo.
J. Addae (2011)
10.1111/j.1476-5381.1996.tb15283.x
Inhibition of cortical spreading depression by L‐701,324, a novel antagonist at the glycine site of the N‐methyl‐D‐aspartate receptor complex
T. Obrenovitch (1996)
10.1007/s11916-012-0255-1
Endogenous Mechanisms Underlying the Activation and Sensitization of Meningeal Nociceptors: The Role of Immuno-Vascular Interactions and Cortical Spreading Depression
D. Levy (2012)
10.1002/ana.22281
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy syndrome mutations increase susceptibility to spreading depression
K. Eikermann-Haerter (2011)
10.1111/j.1468-2982.2004.00858.x
Diffusion- and Perfusion-Weighted MR Imaging in Persistent Migrainous visual Disturbances
H. Jäger (2005)
10.1111/j.1468-2982.2009.02021.x
Cortical spreading depression-associated cerebral blood flow changes induced by mechanical stimulation are modulated by AMPA and GABA receptors
P. Holland (2010)
10.1016/J.TINS.2003.09.017
Central sensitization and LTP: do pain and memory share similar mechanisms?
Ru-Rong Ji (2003)
10.4049/jimmunol.179.12.8525
Selective Proinflammatory Activation of Astrocytes by High-Mobility Group Box 1 Protein Signaling1
M. Pedrazzi (2007)
10.1074/jbc.M109902200
Intercellular Calcium Signaling in Astrocytes via ATP Release through Connexin Hemichannels*
Charles E Stout (2002)
The Pharmacological basis of migraine therapy
W. Amery (1984)
10.1111/j.1526-4610.2008.01183.x
Cortical Spreading Edema in Persistent Visual Migraine Aura
D. Bereczki (2008)
Methyl testosterone for migraine of women; report of sixty cases.
R. C. Moehlig (1955)
10.1002/ana.20778
Suppression of cortical spreading depression in migraine prophylaxis
C. Ayata (2006)
10.1124/jpet.106.117101
Effects of Pan- and Subtype-Selective N-Methyl-d-aspartate Receptor Antagonists on Cortical Spreading Depression in the Rat: Therapeutic Potential for Migraine
M. Peeters (2007)
Neuropharmacology of spreading depression
R Marrannes (1993)
10.1152/JN.1975.38.4.822
Neuronal and glial activity during spreading depression in cerebral cortex of cat.
E. Sugaya (1975)
10.1007/978-3-540-79090-7_13
The role of peptides in central sensitization.
V. Seybold (2009)
Headache mechanisms.
H. Wolff (1946)
10.1586/ern.12.13
Pharmacological targeting of spreading depression in migraine
K. Eikermann-Haerter (2012)
MWA shows gadolinium enhancement which is reversed following prophylactic treatment
G Arnold (1998)
10.1016/j.neuroscience.2009.07.067
Patterns of neurotransmitter receptor distributions following cortical spreading depression
H. Haghir (2009)
Analysis of potential shifts associated with recurrent spreading depression and prolonged unstable SD induced by microdyalisis of elevated K+ in hippocampus of anesthetized rats
O Herreras (1993)
10.1016/S0092-8674(00)81373-2
Familial Hemiplegic Migraine and Episodic Ataxia Type-2 Are Caused by Mutations in the Ca2+ Channel Gene CACNL1A4
R. Ophoff (1996)
10.1111/j.1526-4610.1989.hed2909590.x
Low Brain Magnesium in Migraine
N. Ramadan (1989)
10.1016/j.jphysparis.2011.10.004
CaV2.1 voltage activated calcium channels and synaptic transmission in familial hemiplegic migraine pathogenesis
O. Uchitel (2012)
10.1016/0006-8993(93)91265-T
A brief hypoperfusion precedes spreading depression if nitric oxide synthesis is inhibited
R. Duckrow (1993)
10.1152/AJPHEART.1991.261.1.H96
Cortical blood flow changes during spreading depression in cats.
R. D. Piper (1991)
10.1111/j.1468-2982.2009.01982.x
Spreading Depression: From Serendipity to Targeted Therapy in Migraine Prophylaxis
C. Ayata (2009)
10.1016/0304-3959(83)90191-4
Headache Persistent oligemia of rat cerebral cortex in the wake of spreading depression: Ann. Neurol., 12 (1982) 469–474
M. Lauritzen (1983)
10.1111/j.1526-4610.2004.04048.x
Spatio‐temporal Imaging of Cortical Desynchronization in Migraine Visual Aura: A Magnetoencephalography Case Study
S. D. Hall (2004)
10.1046/j.1468-2982.1992.1201021.x
Serum and Salivary Magnesium Levels in Migraine and Tension-Type Headache. Results in a Group of Adult Patients
P. Sarchielli (1992)
10.1016/j.cca.2009.07.008
Different circulating metalloproteinases profiles in women with migraine with and without aura.
A. Martins-Oliveira (2009)
10.1002/ana.1293
Magnetoencephalographic fields from patients with spontaneous and induced migraine aura
Susan M. Bowyer (2001)
10.1152/JN.00321.2002
Spreading depression: imaging and blockade in the rat neocortical brain slice.
T. Anderson (2002)
10.1016/j.brainres.2008.07.014
Mechanically-induced cortical spreading depression associated regional cerebral blood flow changes are blocked by Na+ ion channel blockade
S. Akerman (2008)
10.1212/WNL.58.8.1308-A
Hyperperfusion with vasogenic leakage by fMRI in migraine with prolonged aura.
M. Smith (2002)
10.1016/j.conb.2005.05.010
Function and dysfunction of synaptic calcium channels: insights from mouse models
D. Pietrobon (2005)
10.1136/jnnp.2005.063750
Lamotrigine reduces migraine aura and migraine attacks in patients with migraine with aura
C. Lampl (2005)
10.1152/jn.00034.2010
Gain of function in FHM-1 Cav2.1 knock-in mice is related to the shape of the action potential.
C. G. Inchauspe (2010)
10.1152/JN.00028.2007
Distinct vascular conduction with cortical spreading depression.
K. C. Brennan (2007)
10.1016/j.tins.2003.09.008
New roles for astrocytes: Gap junction hemichannels have something to communicate
M. Bennett (2003)
10.1038/jcbfm.1992.32
The Effect of Glutamate Receptor Blockade on Anoxic Depolarization and Cortical Spreading Depression
M. Lauritzen (1992)
10.1152/AJPHEART.1995.269.1.H23
Arginine-nitric oxide pathway and cerebrovascular regulation in cortical spreading depression.
M. Fabricius (1995)
10.1111/j.1526-4610.2007.00818.x
Cortical Spreading Depression and Estrogen
K. Eikermann-Haerter (2007)
10.1038/nrneurol.2013.192
Cortical spreading depression and migraine
A. Charles (2013)
10.1002/1531-8249(200001)47:1<18::AID-ANA6>3.0.CO;2-N
Meningeal cells can communicate with astrocytes by calcium signaling
B. Grafstein (2000)
10.1016/j.neulet.2012.02.058
Propofol hemisuccinate suppresses cortical spreading depression
A. Dhir (2012)
10.1097/00001756-200007140-00013
Characterization of optical intrinsic signals and blood volume during cortical spreading depression
A. O'Farrell (2000)
10.1046/j.1468-2982.1993.1302094.x
Red Blood Cell Magnesium Levels in Migraine Patients
V. Gallai† (1993)
10.1177/0333102410368444
Calcitonin gene-related peptide triggers migraine-like attacks in patients with migraine with aura
J. B. Hansen (2010)
MWA shows gadolinium enhancement which is reversed following prophylactic treatment
SM Bowyer (1998)
10.1111/head.12038
Contributions of Epidemiology to Our Understanding of Migraine
K. Merikangas (2013)
10.1016/0006-8993(93)90376-X
Role of calcium channels in spreading depression in rat hippocampal slices
J. Jing (1993)
10.1136/jnnp.16.3.172
FAMILIAL HEMIPLEGIC MIGRAINE
C. Whitty (1955)
10.1016/j.brainres.2004.04.011
Astrocytes contribute to regulation of extracellular calcium and potassium in the rat cerebral cortex during spreading depression
Xiao-Yuan Lian (2004)
Functional neuroimaging: enhanced understanding of migraine pathophysiology.
F. M. Cutrer (2000)
10.1212/WNL.55.1.139
Aura in some patients with familial hemiplegic migraine can be stopped by intranasal ketamine
H. Kaube (2000)
10.1161/STROKEAHA.107.500710
Nitric Oxide Modulates Spreading Depolarization Threshold in the Human and Rodent Cortex
G. Petzold (2008)
10.1177/0333102410375626
TRPV1 receptor blockade is ineffective in different in vivo models of migraine
O. Summ (2011)
Sex - related differences in animal models of migraine
H Bolay (2011)
10.1002/DDR.430100210
Effects of flunarizine on rat cerebral cortex
K. H. Reid (1987)
10.1212/WNL.35.4.618
Migraine responsive to danazol
F. Vincent (1985)
10.1017/S1464793106007081
Physiological studies of cortical spreading depression.
J. Smith (2006)
10.1172/JCI36059
Genetic and hormonal factors modulate spreading depression and transient hemiparesis in mouse models of familial hemiplegic migraine type 1.
K. Eikermann-Haerter (2009)
10.1017/S1462399411002067
Calcitonin gene-related peptide in migraine: intersection of peripheral inflammation and central modulation.
Ann C Raddant (2011)
10.1212/WNL.0b013e3182824e66
A randomized controlled trial of intranasal ketamine in migraine with prolonged aura
S. Afridi (2013)
10.1016/S0306-4522(99)00446-7
Impaired neurotransmitter release and elevated threshold for cortical spreading depression in mice with mutations in the α1A subunit of P/Q type calcium channels
C. Ayata (1999)
10.1016/j.nbd.2010.10.014
Migraine preventive drugs differentially affect cortical spreading depression in rat
V. Bogdanov (2011)
10.1111/j.1526-4610.2008.01262.x
Tonabersat Inhibits Trigeminal Ganglion Neuronal‐Satellite Glial Cell Signaling
S. Damodaram (2009)
10.1152/JN.1944.7.6.391
PIAL CIRCULATION AND SPREADING DEPRESSION OF ACTIVITY IN THE CEREBRAL CORTEX
A. A. P. Leo (1944)
Positron emission tomography studies in
HC Diener (1997)
10.1111/j.1468-2982.2009.01940.x
Migraine and Genetic and Acquired Vasculopathies
A. Stam (2009)
10.1152/jn.1947.10.6.409
Further observations on the spreading depression of activity in the cerebral cortex.
A. Leao (1947)
10.1073/pnas.071582498
Mechanisms of migraine aura revealed by functional MRI in human visual cortex
N. Hadjikhani (2001)
10.1016/S0896-6273(04)00085-6
A Cacna1a Knockin Migraine Mouse Model with Increased Susceptibility to Cortical Spreading Depression
A. M. Maagdenberg (2004)
The Prelude to the Migraine Attack
A. Wauquier (1987)
10.1111/j.1468-2982.2009.01975.x
Efficacy and Safety of Tonabersat, a Gap-Junction Modulator, in the Acute Treatment of Migraine: A Double-Blind, Parallel-group, Randomized Study
Cgh Dahlö (2009)
Cortical spreading depression as a target for anti-migraine agents
Costa (2013)
Methyl testosterone for migraine of women; report of sixty cases.
Moehlig Rc (1955)
10.1016/0006-8993(94)91234-3
Involvement of calcitonin gene-related peptide (CGRP) and nitric oxide (NO) in the pial artery dilatation elicited by cortical spreading depression
M. Wahl (1994)
10.3109/00207458108985795
Ion and transmitter movements during spreading cortical depression.
H. Tuckwell (1981)
10.1523/JNEUROSCI.23-30-09888.2003
Different Mechanisms Promote Astrocyte Ca2+ Waves and Spreading Depression in the Mouse Neocortex
O. Peters (2003)
10.1007/s11940-011-0155-4
New Agents for Acute Treatment of Migraine: CGRP Receptor Antagonists, iNOS Inhibitors
J. Hoffmann (2011)
Positron emission tomography studies in
R Dardis (1997)
10.1152/AJPHEART.00227.2003
ET-1 induces cortical spreading depression via activation of the ETA receptor/phospholipase C pathway in vivo.
J. Kleeberg (2004)
Role of magnesium in the pathogenesis and treatment of migraines.
A. Mauskop (1998)
Methyl testosterone for migraine of women.
Moehlig Rc (1949)
10.1016/S0006-8993(97)01359-0
Cortical spreading depression induces an LTP-like effect in rat neocortex in vitro
D. R. Footitt (1998)
10.1016/0006-8993(92)91353-G
The oligemic phase of cortical spreading depression is not blocked by tirilazad mesylate (U-74006F)
P. Goadsby (1992)
Nitric oxide modulates spreading depolarization threshold in the human and rodent cortex. Stroke
GC Petzold (2008)
10.4065/80.10.1326
Neuron-astrocyte interactions: partnership for normal function and disease in the central nervous system.
E. Benarroch (2005)
10.1016/0006-8993(87)91652-0
Systemic ketamine blocks cortical spreading depression but does not delay the onset of terminal anoxic depolarization in rats
Jose Hernándéz-Cáceres (1987)
10.1097/00001756-199807130-00006
Suppression of cortical spreading depressions after magnesium treatment in the rat
W. S. van der Hel (1998)
10.1111/j.1476-5381.1995.tb16624.x
Effects of Ca2+ channel blockers on cortical hypoperfusion and expression of c‐Fos‐like immunoreactivity after cortical spreading depression in rats
M. Shimazawa (1995)
10.1016/j.brainres.2005.09.048
Nitric oxide modulates calcium entry through P/Q-type calcium channels and N-methyl-d-aspartate receptors in rat cortical neurons
G. Petzold (2005)
Spreading cortical depression and antimigraine drugs
A Hansen (1984)
10.1016/j.jneuroim.2012.07.016
Specific matrix metalloproteinase 9 (MMP-9) haplotype affect the circulating MMP-9 levels in women with migraine
A. Martins-Oliveira (2012)
10.1016/S0006-8993(00)03191-7
Cortical spreading depression produces increased cGMP levels in cortex and brain stem that is inhibited by tonabersat (SB-220453) but not sumatriptan
S. J. Read (2001)
10.1111/j.1468-2982.2008.01556.x
Spreading Depression Enhances Human Neocortical Excitability in vitro
M. Berger (2008)
10.1097/01.WCB.0000137057.92786.F3
Pronounced Hypoperfusion during Spreading Depression in Mouse Cortex
C. Ayata (2004)
10.1046/j.1468-2982.1993.1303180.x
Cortical Spreading Depression Does Not Result in the Release of Calcitonin Gene-Related Peptide into the External Jugular Vein of the Cat: Relevance to Human Migraine
R. D. Piper (1993)
10.1016/S0006-8993(00)02400-8
Sumatriptan modifies cortical free radical release during cortical spreading depression: A novel antimigraine action for sumatriptan?
S. J. Read (2000)
10.1007/s11916-003-0075-4
Migraine genetics
E. Kors (2003)
10.1055/S-2004-813350
The International Classification of Headache Disorders: 2nd edition.
P. Westerhuis (2004)
10.1111/J.1748-1716.1992.TB09451.X
NMDA-receptor blockers but not NBQX, an AMPA-receptor antagonist, inhibit spreading depression in the rat brain.
B. Nellgård (1992)
10.22038/IJBMS.2012.4880
Effect of Cannabinoid Receptor Activation on Spreading Depression
H. Kazemi (2012)
The ionic and metabolic responses associated with neuronal depression of Leão's type in cerebral cortex and in hippocampal formation.
G. Somjen (1984)
Interaction of ketamine with mu2 opioid receptors in SH-SY5Y human neuroblastoma cells.
K. Hirota (1999)
10.1177/0333102411422383
Effect of cortical spreading depression on basal and evoked traffic in the trigeminovascular sensory system
G. Lambert (2011)
10.1177/0333102411430267
The trigeminovascular system does not require a peripheral sensory input to be activated – migraine is a central disorder Focus on ‘Effect of cortical spreading depression on basal and evoked traffic in the trigeminovascular sensory system’
P. Goadsby (2012)
10.1016/S0028-3908(03)00082-0
Effects of the nitric oxide donor, DEA/NO on cortical spreading depression
M. Wang (2003)
10.1002/ANA.410120510
Persistent oligemia of rat cerebral cortex in the wake of spreading depression
Martin Lauritzen (1982)
10.1016/0006-8993(87)90682-2
Change of cerebrovascular reactivity after cortical spreading depression in cats and rats
M. Wahl (1987)
10.1586/ern.09.103
CSD, BBB and MMP-9 elevations: animal experiments versus clinical phenomena in migraine
V. Gupta (2009)
10.1111/j.1526-4610.2012.02262.x
Two Mechanisms Involved in Trigeminal CGRP Release: Implications for Migraine Treatment
P. Durham (2013)
10.1073/pnas.192242399
Familial hemiplegic migraine mutations increase Ca2+ influx through single human CaV2.1 channels and decrease maximal CaV2.1 current density in neurons
A. Tottene (2002)
10.1016/j.expneurol.2012.05.002
Effect of systemic kynurenine on cortical spreading depression and its modulation by sex hormones in rat
V. Chauvel (2012)
10.1038/jcbfm.2010.92
Gabapentin Suppresses Cortical Spreading Depression Susceptibility
U. Hoffmann (2010)
10.1111/j.1471-4159.2007.04788.x
High mobility group box 1 protein is released by neural cells upon different stresses and worsens ischemic neurodegeneration in vitro and in vivo
G. Faraco (2007)
10.1016/s1474-4422(04)00904-4
Functional neuroimaging of headaches.
M. Sánchez del Río (2004)
10.1111/j.1526-4610.2006.00599.x
Low‐Dose Topiramate Versus Lamotrigine in Migraine Prophylaxis (The Lotolamp Study)
P. Gupta (2007)
Einhäupl KM (1998) MWA shows gadolinium enhancement which is reversed following prophylactic treatment
G Arnold (1998)
10.1111/J.1468-2982.1999.1901064.X
Effectiveness of Lamotrigine in the Prophylaxis of Migraine with Aura: an Open Pilot Study
G. D’Andrea (1999)
10.1016/j.jneuroim.2011.05.013
Trigeminal satellite cells express functional calcitonin gene-related peptide receptors, whose activation enhances interleukin-1β pro-inflammatory effects
A. Corato (2011)
10.1016/j.neuropharm.2012.10.018
Anesthetic effects on susceptibility to cortical spreading depression
Chiho Kudo (2013)
10.1111/j.1526-4610.2010.01672.x
Brain Apparent Water Diffusion Coefficient Magnetic Resonance Image During a Prolonged Visual Aura
R. Belvís (2010)
10.1152/JN.00729.2001
Multiwavelength optical intrinsic signal imaging of cortical spreading depression.
Alyssa M Ba (2002)
10.1371/journal.pgen.1002129
Increased Susceptibility to Cortical Spreading Depression in the Mouse Model of Familial Hemiplegic Migraine Type 2
Loredana Leo (2011)
10.1006/exnr.2001.7809
Diffusion-Weighted MRI Used to Detect in Vivo Modulation of Cortical Spreading Depression: Comparison of Sumatriptan and Tonabersat
D. P. Bradley (2001)
10.1126/science.1231897
Spreading Depression Triggers Headache by Activating Neuronal Panx1 Channels
Hulya Karatas (2013)
10.1111/j.1468-2982.2003.00706.x
Familial Hemiplegic Migraine: Follow-up Findings of Diffusion-Weighted Magnetic Resonance Imaging (MRI), Perfusion-MRI and [99mTc] HMPAO-SPECT in a Patient with Prolonged Hemiplegic Aura
S. Oberndorfer (2004)
10.1002/ANA.410090406
Focal hyperemia followed by spreading oligemia and impaired activation of rcbf in classic migraine
J. Olesen (1981)
10.1001/ARCHNEUR.56.5.548
Functional MRI-BOLD of visually triggered headache in patients with migraine.
Y. Cao (1999)
10.1111/j.1468-2982.1999.1901058.x
Lamotrigine in the Prophylactic Treatment of Migraine Aura— A Pilot Study
C. Lampl (1999)
10.1002/ana.21779
Androgenic suppression of spreading depression in familial hemiplegic migraine type 1 mutant mice
K. Eikermann-Haerter (2009)
10.1093/brain/awp338
Biphasic direct current shift, haemoglobin desaturation and neurovascular uncoupling in cortical spreading depression.
Joshua C. Chang (2010)
10.1007/s00234-011-0946-z
Perfusion-weighted MR imaging in persistent hemiplegic migraine
I. Mourand (2011)
10.1016/S0165-0173(99)00083-1
Perspectives on spreading depression
H. Martins-Ferreira (2000)



This paper is referenced by
10.3390/brainsci9070172
Upregulation of IL-1 Receptor Antagonist in a Mouse Model of Migraine
Salvo Danilo Lombardo (2019)
10.1186/s10194-017-0770-x
De novo exonic duplication of ATP1A2 in Italian patient with hemiplegic migraine: a case report
S. Gagliardi (2017)
10.1007/s10072-019-03838-y
Does the migraine attack start in the cortex and is the cortex critical in the migraine process?
P. Barbanti (2019)
10.3390/ijerph15040587
Association between Cervical Spondylosis and Migraine: A Nationwide Retrospective Cohort Study
W. Lin (2018)
10.1007/978-3-319-47810-4_13
Temporal Excitation Patterns on the Cerebral Cortex as a Result of Migraine Modeling
J. Kroos (2017)
Sensibilité à l'ischémie cérébrale chez les patients migraineux : évaluation par tomodensitométrie cérébrale de perfusion
I. Francillard (2017)
10.1007/s11739-015-1208-6
Fathoming the kynurenine pathway in migraine: why understanding the enzymatic cascades is still critically important
M. Curto (2015)
Investigation of Migraine-related Intracerebral White Matter Lesions
Komáromy Hedvig (2019)
10.1186/s10194-016-0711-0
Genetic and biochemical changes of the serotonergic system in migraine pathobiology
C. Gasparini (2016)
10.1177/1941874415583118
Episodic Aphasia Associated With Cortical Spreading Depression After Subdural Hemorrhage Evacuation
N. H. Shah (2016)
10.3390/brainsci9020026
Potential Application of Optogenetic Stimulation in the Treatment of Pain and Migraine Headache: A Perspective from Animal Studies
Sufang Liu (2019)
10.1007/s40263-018-0555-z
Refining the Benefit/Risk Profile of Anti-Epileptic Drugs in Headache Disorders
M. Marmura (2018)
10.1097/WNP.0000000000000275
Spreading Depolarizations: A Therapeutic Target Against Delayed Cerebral Ischemia After Subarachnoid Hemorrhage.
David Y. Chung (2016)
10.1007/s11940-019-0558-1
Current Status of Antiepileptic Drugs as Preventive Migraine Therapy
Simy K. Parikh (2019)
10.2147/DDDT.S117166
Nitroglycerin enhances the propagation of cortical spreading depression: comparative studies with sumatriptan and novel kynurenic acid analogues
L. Knapp (2017)
10.1152/jn.00632.2015
Triptans disrupt brain networks and promote stress-induced CSD-like responses in cortical and subcortical areas.
L. Becerra (2016)
10.1177/0271678X17747188
Perivascular neurotransmitters: Regulation of cerebral blood flow and role in primary headaches
S. D. Frederiksen (2019)
10.1007/978-3-319-06886-2_3
Aura Without Migraine
Miguel J. A. Láinez (2015)
10.1007/s10072-017-2970-1
High asymmetric dimethylarginine, symmetric dimethylarginine and L-arginine levels in migraine patients
A. Reyhani (2017)
10.1007/s10072-020-04992-4
Retinal nerve fiber layer changes in migraine: a systematic review and meta-analysis
XiaoGuang Lin (2021)
10.1159/000448473
Hemiplegic Migraine Presenting with Prolonged Somnolence: A Case Report
C. Saleh (2016)
10.1016/j.ncl.2019.07.008
An Update: Pathophysiology of Migraine.
P. Goadsby (2019)
10.1186/s10194-019-1038-4
Current and emerging evidence-based treatment options in chronic migraine: a narrative review
E. Agostoni (2019)
10.2174/1389200217666151222155043
Brain Aging and Disorders of the Central Nervous System: Kynurenines and Drug Metabolism.
N. Török (2016)
10.1021/acs.joc.7b00845
Palladium-Mediated Synthesis of a Near-Infrared Fluorescent K+ Sensor.
H. Bandara (2017)
10.1016/j.camwa.2017.05.013
A computational multiscale model of cortical spreading depression propagation
L. Gerardo-Giorda (2017)
10.1007/S40267-019-00602-2
Consider using selected antiepileptics to reduce the frequency of various types of headaches
Adis Medical Writers (2019)
10.1177/0333102416681588
Pro-nociceptive migraine mediator CGRP provides neuroprotection of sensory, cortical and cerebellar neurons via multi-kinase signaling
P. Abushik (2017)
10.3389/fncel.2016.00156
The Revolution in Migraine Genetics: From Aching Channels Disorders to a Next-Generation Medicine
S. Pellacani (2016)
10.1080/01616412.2018.1428406
Arguments against the role of cortical spreading depression in migraine
P. Borgdorff (2018)
10.1101/2019.12.20.884247
Functional NHE1 expression is critical to blood brain barrier integrity and sumatriptan blood to brain uptake
Erika Liktor-Busa (2019)
10.1179/1476830514Y.0000000148
Effects of garlic extract on spreading depression: In vitro and in vivo investigations
Claudia Marschollek (2017)
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