Online citations, reference lists, and bibliographies.
Please confirm you are human
(Sign Up for free to never see this)
← Back to Search

Rationale And Design Of The Multinational Observational Study Assessing Insulin Use: The MOSAIc Study

J. Polinski, B. Curtis, J. Seeger, N. Choudhry, A. Zagar, W. Shrank
Published 2012 · Medicine

Save to my Library
Download PDF
Analyze on Scholarcy
Share
BackgroundAlthough consensus guidelines recommend insulin progression among patients with type 2 diabetes (T2DM) who fail to meet glycemic targets over time, many fewer patients are progressed than may benefit. We describe the rationale and design of the MOSAIc (Multinational Observational Study Assessing Insulin use) study, a multinational observational cohort study to identify patient-, physician, and health care environment-based factors associated with insulin progression for patients with T2DM in real-world practice.Methods/designWe will enroll 4,500 patients with T2DM taking initial insulin therapy for ≥3 months across 175 physician practice sites in 18 countries. Extensive demographic, clinical, and psychosocial data at the patient and physician level and practice site characteristics will be collected at baseline and regular intervals during a 24-month follow-up period. We will use a multivariable logistic regression model to identify predictors of insulin progression and highlight potential opportunities for health behavior intervention to improve insulin progression rates. Secondary outcomes include evaluating factors associated with glycemic control, hypoglycemia, and treatment adherence among patients who do and do not progress beyond their initial insulin therapy and exploring geographic heterogeneity in treatment.DiscussionPractice site and patient recruitment began in 2011 and baseline data will be available in late 2012. The MOSAIC study’s longitudinal observational design as well as the breadth and depth of data will be used to explore and quantify predictors of insulin progression and to identify potential opportunities for health behavior intervention in order to improve T2DM treatment and clinical outcomes.
This paper references
10.1111/J.1475-6773.2006.00637.X
Interpersonal processes of care survey: patient-reported measures for diverse groups.
A. Stewart (2007)
10.1016/0168-8510(90)90421-9
EuroQol--a new facility for the measurement of health-related quality of life.
A. Kasuya (1990)
10.4158/EP.17.S2.1
American Association of Clinical Endocrinologists Medical Guidelines for Clinical Practice for developing a diabetes mellitus comprehensive care plan.
Y. Handelsman (2011)
EuroQol : a new facility for the measurement of health-related quality of life
A. Williams (1990)
Type 2 diabetes care and insulin intensification: is a more multidisciplinary approach needed? Results from the MODIFY survey
RM Cuddihy (2011)
10.2307/3348165
World health statistics.
K. Stowman (1949)
10.1016/j.diabres.2008.06.010
Intensification lessons with modern premixes: from clinical trial to clinical practice.
S. Guler (2008)
10.2337/DIACARE.29.04.06.DC05-0053
Resistance to insulin therapy among patients and providers: results of the cross-national Diabetes Attitudes, Wishes, and Needs (DAWN) study.
M. Peyrot (2005)
Development and testing of a new measure of case mix for use in office practice.
S. Greenfield (1995)
10.2337/DIACARE.27.5.1047
Global prevalence of diabetes: estimates for the year 2000 and projections for 2030.
S. Wild (2004)
World Health Organization: Diabetes Programme
(2011)
Rationale and design of the multinational observational study assessing insulin use: the MOSAIc study
Polinski (2012)
10.2337/DIACARE.27.10.2306
A population-based study of diabetes and its characteristics during the fasting month of Ramadan in 13 countries: results of the epidemiology of diabetes and Ramadan 1422/2001 (EPIDIAR) study.
I. Salti (2004)
10.4158/EP11007.CO
The parathyroid glands: what the endocrine surgeon should know.
N. Perrier (2011)
10.2337/DIACARE.28.2.337
Quality of diabetes care in U.S. academic medical centers: low rates of medical regimen change.
R. Grant (2005)
10.1370/afm.722
Barriers to Self-Management and Quality-of-Life Outcomes in Seniors With Multimorbidities
E. Bayliss (2007)
10.1002/pdi.305
The DAWN (Diabetes Attitudes, Wishes and Needs) study
G. Alberti (2002)
Understanding the context of healthcare utilization: assessing environmental and provider-related variables in the behavioral model of utilization.
K. A. Phillips (1998)
Centers for Disease Control and Prevention: National Diabetes Fact Sheet
(2011)
10.2337/DIACARE.28.9.2130
The burden of mortality attributable to diabetes: realistic estimates for the year 2000.
G. Roglic (2005)
10.1377/hlthaff.2011.1040
Analysis & commentary: Global prevention and control of type 2 diabetes will require paradigm shifts in policies within and among countries.
K. M. Narayan (2012)
A framework for the study of access to medical care.
L. Aday (1974)
10.2337/DC08-2195
Medical Management of Hyperglycemia in Type 2 Diabetes: A Consensus Algorithm for the Initiation and Adjustment of Therapy: A Consensus Statement of the American Diabetes Association and the European Association for the Study of Diabetes
D. Nathan (2009)
10.1093/BIOMET/73.1.13
Longitudinal data analysis using generalized linear models
K. Liang (1986)
10.1093/QJMED/93.6.369
Poor glycaemic control in type 2 diabetes: a conspiracy of disease, suboptimal therapy and attitude.
T. Wallace (2000)
10.1038/sj.ijo.0802173
When oral agents fail: practical barriers to starting insulin
M. Korytkowski (2002)
10.1111/j.1742-1241.2010.02363.x
Expectations about and experiences with insulin therapy contribute to diabetes treatment satisfaction in insulin-naïve patients with type 2 diabetes
A. Naegeli (2010)
10.2337/diacare.21.5.706
The Reliability and Validity of a Brief Diabetes Knowledge Test
J. Fitzgerald (1998)
World Health Organization: World health statistics
(2011)
Type 2 diabetes. NICE Clinical Guideline 66
(2008)
10.1201/b15183-9
Endocrine disorders
L. Hordon (1991)
10.2337/DIACARE.23.7.943
The summary of diabetes self-care activities measure: results from 7 studies and a revised scale.
D. Toobert (2000)
A Population-Based Study of Diabetes and Its Characteristics During the Fasting Month of Ramadan in 13 Countries
Éric Bénard (2004)
International Diabetes Federation: Diabetes Atlas
(2011)
A population-based study of diabetes and its characteristics during the fasting month of ramadan in 13 countries. Diab Care
I Salti (2004)



This paper is referenced by
10.1111/1753-0407.12443
Exploring the role of the patient–physician relationship on insulin adherence and clinical outcomes in type 2 diabetes: Insights from the MOSAIc study
B. Linetzky (2017)
10.1007/s13300-016-0178-7
Cross-National Variation in Glycemic Control and Diabetes-Related Distress Among East Asian Patients Using Insulin: Results from the MOSAIc Study
I. Matsuba (2016)
10.1186/s40842-018-0059-2
Characteristics of insulin-Naïve people with type 2 diabetes who successfully respond to insulin glargine U100 after 24 weeks of treatment: a meta-analysis of individual participant data from 3 randomized clinical trials
M. Cummings (2018)
10.1080/03007995.2018.1448260
Comparative usability study of the dulaglutide single-use pen versus the insulin degludec FlexTouch® among self-injection-naïve patients with type 2 diabetes mellitus in Japan
T. Asakura (2018)
10.1111/dom.13622
A multinational observational study assessing insulin use: Understanding the determinants associated with progression of therapy
K. Ray (2019)
10.1111/ijcp.12251
Glycaemic control and implementation of the ADA/EASD‐2006 consensus algorithm in type 2 diabetes mellitus patients in primary care in Spain
F. Alvarez-Guisasola (2014)
10.1016/j.drudis.2014.07.011
Channeling postmarketing patient data into pharmaceutical regulatory systems.
Maria F. S. Barbosa (2014)
10.1002/pds.3704
A cross‐national comparison of 17 countries' insulin glargine drug labels
J. Polinski (2015)
10.1186/s13098-016-0157-1
Challenges associated with insulin therapy progression among patients with type 2 diabetes: Latin American MOSAIc study baseline data
B. Linetzky (2016)
10.1186/s12902-015-0044-z
Geographic patterns in patient demographics and insulin use in 18 countries, a global perspective from the multinational observational study assessing insulin use: understanding the challenges associated with progression of therapy (MOSAIc)
J. Polinski (2015)
Semantic Scholar Logo Some data provided by SemanticScholar