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Gold-silver Alloy Nanoshells: A New Candidate For Nanotherapeutics And Diagnostics
Dana E. Gheorghe, L. Cui, C. Karmonik, A. Brazdeikis, J. M. Peñaloza, J. K. Young, R. Drezek, M. Bikram
Published 2011 · Materials Science, Medicine
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We have developed novel gold-silver alloy nanoshells as magnetic resonance imaging (MRI) dual T1 (positive) and T2 (negative) contrast agents as an alternative to typical gadolinium (Gd)-based contrast agents. Specifically, we have doped iron oxide nanoparticles with Gd ions and sequestered the ions within the core by coating the nanoparticles with an alloy of gold and silver. Thus, these nanoparticles are very innovative and have the potential to overcome toxicities related to renal clearance of contrast agents such as nephrogenic systemic fibrosis. The morphology of the attained nanoparticles was characterized by XRD which demonstrated the successful incorporation of Gd(III) ions into the structure of the magnetite, with no major alterations of the spinel structure, as well as the growth of the gold-silver alloy shells. This was supported by TEM, ICP-AES, and SEM/EDS data. The nanoshells showed a saturation magnetization of 38 emu/g because of the presence of Gd ions within the crystalline structure with r1 and r2 values of 0.0119 and 0.9229 mL mg-1 s-1, respectively (Au:Ag alloy = 1:1). T1- and T2-weighted images of the nanoshells showed that these agents can both increase the surrounding water proton signals in the T1-weighted image and reduce the signal in T2-weighted images. The as-synthesized nanoparticles exhibited strong absorption in the range of 600-800 nm, their optical properties being strongly dependent upon the thickness of the gold-silver alloy shell. Thus, these nanoshells have the potential to be utilized for tumor cell ablation because of their absorption as well as an imaging agent.
This paper references
Standard X‐Ray Diffraction Powder Patterns
H. Swanson (1954)
Magnetic nanoparticles for gene and drug delivery
S. McBain (2008)
Surface chemistry of colloidal gold : deposition of lead and accompanying optical effects
P. Mulvaney (1992)
Monocrystalline iron oxide nanocompounds (MION): Physicochemical properties
T. Shen (1993)
Poly ( lglutamic acid ) Gd ( III )DOTA conjugate with a degradable spacer for magnetic resonance imaging
ZR Lu (2003)
Poly(ethylene glycol) Surface Coated Magnetic Particles
Christophe Flesch (2005)
Standard X-Ray Diffraction Powder Patterns
J. T. Connor (1955)
Magnetic core/shell Fe3O4/Au and Fe3O4/Au/Ag nanoparticles with tunable plasmonic properties.
Zhichuan Xu (2007)
Preferential site of Gd in Gd-doped Fe3O4 nanopowder.
Y. Kim (2011)
Immobilization of BSA on Silica-Coated Magnetic Iron Oxide Nanoparticle
C. H. Yu (2009)
Synthesis of Thermally Stable and Highly Active Bimetallic Au−Ag Nanoparticles on Inert Supports
X. Liu (2009)
Microchip Laser Feedback Interferometer with an Optical Path Multiplier
R. Zhou (2008)
Lanthanide (III)-doped magnetite nanoparticles Golden book of phase transitions
De Silva (2002)
Small multifunctional nanoclusters (nanoroses) for targeted cellular imaging and therapy.
L. Ma (2009)
Lipidbased nanoparticles for contrast-enhanced MRI and molecular imaging
WJM Mulder (2006)
Modifying the Surface Properties of Superparamagnetic Iron Oxide Nanoparticles through A Sol−Gel Approach
Y. Lu (2002)
Width of cluster plasmon resonances: Bulk dielectric functions and chemical interface damping.
Synthesis and characterization of ultra-small superparamagnetic iron oxide nanoparticles thinly coated with silica.
A. Bumb (2008)
Magnetic-plasmonic core-shell nanoparticles.
Carly S Levin (2009)
Metallodielectric Colloidal Core−Shell Particles for Photonic Applications
and Christina Graf (2002)
Handbook of MRI Pulse Sequences
Wilson Fong (2004)
A new hydrosol of gold clusters
D. Duff (1993)
Surface Chemistry of Colloidal Gold: Deposition of Lead and Accompanying Optical Effects.
P. Mulvaney (1993)
PEG branched polymer for functionalization of nanomaterials with ultralong blood circulation.
G. Prencipe (2009)
Synthesis, characterization, and tunable optical properties of hollow gold nanospheres.
A. Schwartzberg (2006)
Synthesis and surface engineering of iron oxide nanoparticles for biomedical applications.
A. Gupta (2005)
Extracellular gadolinium-based contrast media: an overview.
M. Bellin (2008)
Molecular imaging and therapy of atherosclerosis with targeted nanoparticles
S. Wickline (2007)
Ag-Au-Ag heterometallic nanorods formed through directed anisotropic growth.
Daeha Seo (2008)
Elements of X-Ray Diffraction Addison-Wesley Publishing Company
B D Cullity (1967)
Multifunctional polymeric micelles as cancer-targeted, MRI-ultrasensitive drug delivery systems.
N. Nasongkla (2006)
Nanoscale Research Letters
Interfacial electron transfer in colloidal spinel iron oxide. Conversion of Fe3O4-γFe2O3 in aqueous medium
J. Jolivet (1988)
Interfacial electron transfer in colloidal spinel iron oxide. Conversion of Fe 3 O 4 into γ-Fe 2 O 3 in aqueous medium
Jp Jolivet (1988)
XJ: Handbook of MRI pulse sequences
MA Bernstein (2004)
Surface Plasmon Resonance and Field Enhancement of Au/Ag Alloyed Hollow Nanoshells
Functionalized Silica Coated Magnetic Nanoparticles With Biological Species for Magnetic Separation
C. Yu (2007)
Powder Diffraction File-Inorganic Compounds JCPDS International Center for Diffraction Data
Elements of X-ray diffraction
B. Cullity (1956)
Paramagnetic ultrasmall gadolinium oxide nanoparticles as advanced T1 MRI contrast agent: account for large longitudinal relaxivity, optimal particle diameter, and in vivo T1 MR images.
J. Park (2009)
Preparation, characterization, and optical properties of gold, silver, and gold-silver alloy nanoshells having silica
J-H Kim (2008)
The preparation of magnetic nanoparticles for applications in biomedicine
P. Tartaj (2003)
Metalloporphrin enhancement of magnetic resonance imaging of human tumor xenographs in nude mice
P Furmanski (1988)
Growth Mechanisms and Oxidation Resistance of Gold-Coated Iron Nanoparticles
Sung-Jin Cho (2005)
Gold encapsulation of star-shaped FePt nanoparticles
N. Pazos-Pérez (2010)
Limitations on the optical tunability of small diameter gold nanoshells.
Michael Rasch (2009)
A novel efficient Au–Ag alloy catalyst system: preparation, activity, and characterization
A. Wang (2005)
Linear optical properties of gold nanoshells
R. Averitt (1999)
Photo-thermal tumor ablation in mice using near infrared-absorbing nanoparticles.
D. O'Neal (2004)
Optical properties and SERS efficiency of tunable gold/silver nanoshells
M. Gellner (2009)
Ultrasmall mixed ferrite colloids as multidimensional magnetic resonance imaging, cell labeling, and cell sorting agents.
E. Groman (2007)
Lipid‐based nanoparticles for contrast‐enhanced MRI and molecular imaging
W. Mulder (2006)
Preparation of ultrafine silica-and PEGcoated magnetite particles. Colloid Surface A
Md Butterworth (2001)
CONDENSED MATTER: STRUCTURE, MECHANICAL AND THERMAL PROPERTIES: Surface Plasmon Resonance and Field Enhancement of Au/Ag Alloyed Hollow Nanoshells
L. Zhou (2008)
Toxicity of MRI and CT contrast agents.
K. M. Hasebroock (2009)
A new hydrosol of gold clusters. 1. Formation and particle size variation
D. Duff (1993)
Golden book of phase transitions
A Bartos (2002)
Metalloporphyrin enhancement of magnetic resonance imaging of human tumor xenografts in nude mice.
P. Furmanski (1988)
The enhanced anisotropic properties of the Fe3−xMxO4 (M = Fe, Co, Mn) films deposited on glass surface from aqueous solutions at low temperature
T. Y. Kim (2003)
Superparamagnetism of magnetite nanoparticles: dependence on surface modification.
M. Mikhaylova (2004)
A new hydrosol of gold clusters. 2. A comparison of some different measurement techniques
D. Duff (1993)
Gold-coated iron nanoparticles for biomedical applications
M. Chen (2003)
Preparation of ultrafine silica- and PEG-coated magnetite particles
M. Butterworth (2001)
Monodispersed core-shell Fe3O4@Au nanoparticles.
L. Wang (2005)
Synthesis of colloidal silver iron oxide nanoparticles--study of their optical and magnetic behavior.
A. Kumar (2009)
Toxic Potential of Materials at the Nanolevel
A. Nel (2006)
Primer on gadolinium chemistry
A. Sherry (2009)
Functional Polymers Based on Dextran
T. Heinze (2006)
Analytical investigation of the chemical reactivity and stability of aminopropyl-grafted silica in aqueous medium.
M. Etienne (2003)
Sonochemical Design of Engineered Gold−Silver Nanoparticles
D. Radziuk (2008)
Preparation, characterization, and optical properties of gold, silver, and gold-silver alloy nanoshells having silica cores.
J. Kim (2008)
Iron oxides: From molecular clusters to solid. A nice example of chemical versatility
J. Jolivet (2006)
Smart hybrid magnetic self-assembled micelles and hollow capsules
S. Lecommandoux (2005)
RE: Primer on gadolinium chemistry
AD Sherry (2009)
Bi-functional gold-coated magnetite composites with improved biocompatibility.
Maria Arsianti (2011)
Lanthanide(III)-doped magnetite nanoparticles.
Channa R De Silva (2009)
Gold, palladium, and gold-palladium alloy nanoshells on silica nanoparticle cores.
Junhyun Kim (2009)
Gold nanostructures: engineering their plasmonic properties for biomedical applications.
Min Hu (2006)
Magnetic nanoparticles: synthesis, protection, functionalization, and application.
A. Lu (2007)
Poly(l-glutamic acid) Gd(III)-DOTA conjugate with a degradable spacer for magnetic resonance imaging.
Zheng-Rong Lu (2003)
Synergistic effect in an Au-Ag alloy nanocatalyst: CO oxidation.
Jun-hong Liu (2005)
Nanoengineering of optical resonances
S. Oldenburg (1998)
MR imaging in patients with suspected liver metastases: value of liver-specific contrast agent Gd-EOB-DTPA.
C. Zech (2007)
Magnetic nanoparticles for theragnostics.
V. Shubayev (2009)
Iron Oxides: from Molecular Clusters to Solid. A Nice Example of Chemical Versatility
J. Jolivet (2006)
HR: Poly(l-glutamic acid) Gd(III)-DOTA conjugate with a degradable spacer for magnetic resonance imaging
ZR Lu (2003)
Alloy Formation of Gold−Silver Nanoparticles and the Dependence of the Plasmon Absorption on Their Composition
and Zhong Lin Wang (1999)
Attachment of gold nanograins onto colloidal magnetite nanocrystals
D. Caruntu (2005)
Magnetic iron oxide nanoparticles for biorecognition: evaluation of surface coverage and activity.
Isaac Koh (2006)
Recent advances with liposomes as pharmaceutical carriers
V. Torchilin (2005)
Optimization of silica silanization by 3-aminopropyltriethoxysilane.
J. Howarter (2006)
Facile preparation of a new gadofullerene-based magnetic resonance imaging contrast agent with high 1H relaxivity.
C. Shu (2009)
In Standard X-Ray Diffraction Powder Patterns. Volume 539. USA: National Bureau of Standards
Gold nanoparticles: assembly, supramolecular chemistry, quantum-size-related properties, and applications toward biology, catalysis, and nanotechnology.
M. Daniel (2004)
Miscibilita fra gli ossidi salini di ferro e di manganese
V Montoro (1938)
Majetich SA: Gold-coated iron nanoparticles for biomedical applications
M Chen (2003)
Effect of Au coating on the magnetic and structural properties of Fe nanoclusters for use in biomedical applications: A density-functional theory study
Q. Sun (2006)
This paper is referenced by
Synthesis, Study, and Discrete Dipole Approximation Simulation of Ag-Au Bimetallic Nanostructures
Yang Hu (2016)
Animated Green Vitriol Can Transmute Copper (Cu) into Special Copper
Ramakrishnan Madhusoodanan (2012)
A prospective overview of the essential requirements in molecular modeling for nanomedicine design.
P. Kumar (2013)
Rapid and selective separation for mixed proteins with thiol functionalized magnetic nanoparticles
S. Lee (2012)
Synthesis of Cu–Ag nanoparticles by biological method
H. R. Ghorbani (2018)
Towards the Industrial Application of Spark Ablation for Nanostructured Functional Materials
T. Pfeiffer (2014)
Chloroplasts-mediated biosynthesis of nanoscale Au-Ag alloy for 2-butanone assay based on electrochemical sensor
Yixia Zhang (2012)
Fabrication of self-organized fcc-AuAg(001) alloy nanodots on MgO(001) substrates
Masao Kamiko (2019)
Author Correction: Sensitivity enhancement of flexible gas sensors via conversion of inkjet-printed silver electrodes into porous gold counterparts
Y. Fang (2018)
A facile one-pot green synthesis of reduced graphene oxide and its composites for non-enzymatic hydrogen peroxide sensor applications
G. G. Kumar (2014)
Synthesis of Bimetallic Nanoparticles (Au–Ag Alloy) Using Commelina nudiflora L. Plant Extract and Study its on Oral Pathogenic Bacteria
P. Kuppusamy (2017)
Monte Carlo Study on Does Enhancement Effect of Various Paramagnetic Nanoshells in Brachytherapy
T. Moghaddas (2014)
Metal nanoparticle‐hydrogel nanocomposites for biomedical applications – An atmospheric pressure plasma synthesis approach
H. Nolan (2018)
Synthesis of Composite Nanoparticles with Magnetic Properties
Henrik Winther Solemslie (2013)
Antitumor Activity of Alloy and Core-Shell-Type Bimetallic AgAu Nanoparticles
I. Shmarakov (2017)
Application of Nanoparticles on Diagnosis and Therapy in Gliomas
N. Hérnandez-Pedro (2013)
Multifunctional Nanoparticles for Theranostics and Imaging
Xue Xue (2014)
Gold silver alloy nanoparticles (GSAN): an imaging probe for breast cancer screening with dual-energy mammography or computed tomography.
P. Naha (2016)
A new ex vivo method to evaluate the performance of candidate MRI contrast agents: a proof-of-concept study
A. P. Candiota (2014)
Sensitivity enhancement of flexible gas sensors via conversion of inkjet-printed silver electrodes into porous gold counterparts
Y. Fang (2017)
Nanotechnology Based Treatments for Neurological Disorders from Genetics Perspective
Nicholas S. Kurek (2013)
Multi-modal MR imaging and magnetic hyperthermia study of Gd doped Fe3O4 nanoparticles for integrative cancer therapy
N. Thorat (2016)
NANO EXPRESS Open Access
J. Lorbeer (2014)