Online citations, reference lists, and bibliographies.

Primary Carcinoid Tumors At Atypical Sites: Surgery Is Mandatory And Size Determines Survival—an Egyptian Study

Karim Moustafa, Gamal M. Saied
Published 2019 · Medicine
Cite This
Download PDF
Analyze on Scholarcy
Share
BackgroundCarcinoids at atypical sites are rare and mostly asymptomatic. In the majority, they show normal levels of serotonin and its metabolites in plasma and urine, resulting in a relatively late diagnosis and hence guarded prognosis. The relatively large size and repeated local recurrences are features of carcinoids at atypical locations and may direct the attention to its possible existence.Patients and methodsA report of six cases of carcinoid tumors in the breast, abdominal paravertebral region, duodenum, ovary, and stomach is given. Blood serotonin, plasma, and urine 5-hydroxyindole acetic acid were determined for cases suspected to have carcinoid syndrome. Those presented with a mass were radiologically studied by CT or MRI, and if a biopsy was taken (or the mass removed), keratin, CEA, and chromogranin for argentaffin reaction were studied. Follow-up was for 15 months, and a second surgery was done for the two cases (1 and 5).ResultsExcept for case 4, all patients were females. The symptoms and clinical findings in the six cases were vague and did not raise the possibility of a carcinoid. Repeated local recurrence was the clue for the diagnosis. The enrolled six cases had no common features that may point or suggest the presence of neither carcinoid tumor nor syndrome. Also, there was no relation between the site and size of the tumor and the detection of the manifestations of carcinoid syndrome. Additionally, in one case (case 1), the originally non-functioning lesion turned active when recurrence happened.ConclusionCarcinoid tumors at atypical sites are low-grade malignant neoplasms with a good long-term prognosis if correctly managed. Routine aggressive resection or even debulking is the treatment of choice whenever possible, even in recurrent cases. The survival of patients depends basically on the tumor size and/or the presence of distant metastases. Treatment by somatostatin analogy is usually mandatory if carcinoid syndrome is present.
This paper references
Carcinoids and their variant endocrinomas. An analysis of 11842 reported cases.
Jun Soga (2003)
10.1016/j.amjsurg.2006.09.016
Raf-1 activation in gastrointestinal carcinoid cells decreases tumor cell adhesion.
David Yü Greenblatt (2007)
A comparison of paraganglioma, carcinoid tumor, and small-cell carcinoma of the larynx.
Paul B Googe (1988)
10.1378/chest.115.2.598
Coronary spasm and cardiac arrest from carcinoid crisis during laser bronchoscopy.
Atul C. Mehta (1999)
[Multiple endocrine neoplasia type 1: recent developments and guidelines for DNA diagnosis and periodic clinical monitoring].
Koen M.A. Dreijerink (2000)
10.1016/j.surg.2006.07.033
Operative resection of primary carcinoid neoplasms in patients with liver metastases yields significantly better survival.
Babak Givi (2006)
10.1136/adc.60.3.269
Carcinoid syndrome: an unusual cause of diarrhoea.
Mary D. King (1985)
10.1002/ijc.1473
Familial carcinoid tumors and subsequent cancers: a nation-wide epidemiologic study from Sweden.
Kari Hemminki (2001)
10.1056/nejm199903183401107
Carcinoid tumors.
M. Kulke (1999)
Carcinoid metastasis to the brain. Cancer
R Hlatky (2004)
Medical progress : Carcinoid tumors
Matthew H. Kulke (1999)
10.1007/s00428-006-0250-1
TNM staging of foregut (neuro)endocrine tumors: a consensus proposal including a grading system
G. Rindi (2006)
10.1002/cncr.20659
Carcinoid metastasis to the brain.
R. Hlatký (2004)
10.1007/978-1-4419-1664-8_1
MEN1 clinical background.
Péter Igaz (2009)
10.1177/000456320203900605
Evaluation of Whole Blood Serotonin and Plasma and Urine 5-Hydroxyindole Acetic Acid in Diagnosis of Carcinoid Disease
Rachel S. Carling (2002)
10.1186/1477-7819-2-3
A primary pancreatic carcinoid tumour with unusual clinical complaints: A case report
Olivier Saint-Marc (2004)
10.1002/(SICI)1096-911X(200003)34:3<218::AID-MPO12>3.0.CO;2-9
Metastatic appendiceal carcinoid tumor in a child.
Andrea Volpe (2000)
New, rationally-based chemotherapy combination appears highly effective in patients with treatment-resistant neuroendocrine tumors
RL Fine (2014)
10.1093/annonc/mdv041
Pulmonary neuroendocrine (carcinoid) tumors: European Neuroendocrine Tumor Society expert consensus and recommendations for best practice for typical and atypical pulmonary carcinoids.
M. Caplin (2015)
10.3747/CO.V17I6.669
Metastatic carcinoid presenting as a breast lesion.
Holly L Geyer (2010)
10.1016/j.jnci.2016.06.003
Primary ovarian carcinoid: A report of two cases and a decade registry.
I. Metwally (2016)
10.1097/MPA.0b013e31828e34a4
Consensus guidelines for the management and treatment of neuroendocrine tumors.
P. Kunz (2013)
10.1002/cncr.11105
A 5-decade analysis of 13,715 carcinoid tumors.
Irvin Mark Modlin (2003)
10.1136/jclinpath-2015-203551
Neuroendocrine tumours in rare sites: differences in nomenclature and diagnostics—a rare and ubiquitous histotype
Elia Guadagno (2016)
10.1186/1752-1947-5-45
Long-term follow-up after en bloc resection and reconstruction of a solitary paraganglioma metastasis in the first lumbar vertebral body: a case report
Alexander von Richter (2011)
10.1043/1543-2165(2003)127<1200:NTCANC>2.0.CO;2
Neuroendocrine tumors (carcinoid and neuroendocrine carcinoma) presenting at extra-appendiceal sites in childhood and adolescence.
R. Broaddus (2003)



Semantic Scholar Logo Some data provided by SemanticScholar