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COVID-19 And Alzheimer’s Disease: How One Crisis Worsens The Other

X. Xia, Yi Wang, Jialin C Zheng
Published 2021 · Medicine

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Alzheimer’s disease (AD) has emerged as a key comorbidity of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). The morbidity and mortality of COVID-19 are elevated in AD due to multiple pathological changes in AD patients such as the excessive expression of viral receptor angiotensin converting enzyme 2 and pro-inflammatory molecules, various AD complications including diabetes, lifestyle alterations in AD, and drug-drug interactions. Meanwhile, COVID-19 has also been reported to cause various neurologic symptoms including cognitive impairment that may ultimately result in AD, probably through the invasion of SARS-CoV-2 into the central nervous system, COVID-19-induced inflammation, long-term hospitalization and delirium, and post-COVID-19 syndrome. In addition, the COVID-19 crisis also worsens behavioral symptoms in uninfected AD patients and poses new challenges for AD prevention. In this review, we first introduce the symptoms and pathogenesis of COVID-19 and AD. Next, we provide a comprehensive discussion on the aggravating effects of AD on COVID-19 and the underlying mechanisms from molecular to social levels. We also highlight the influence of COVID-19 on cognitive function, and propose possible routes of viral invasion into the brain and potential mechanisms underlying the COVID-19-induced cognitive impairment. Last, we summarize the negative impacts of COVID-19 pandemic on uninfected AD patients and dementia prevention.
This paper references
10.1002/ANA.410050103
An explanation for the localization of herpes simplex encephalitis?
L. Davis (1979)
10.1017/S0317167100044115
"Limbic predilection in Alzheimer dementia: is reactivated herpesvirus involved?".
M. Ball (1982)
10.1016/0022-510X(82)90045-4
Alzheimer's disease Correlation of cortical choline acetyltransferase activity with the severity of dementia and histological abnormalities
G. Wilcock (1982)
10.1111/j.1532-5415.1988.tb01804.x
Are Alzheimer Patients Healthier?
G. Wolf-Klein (1988)
Are Alzheimer patients
GP Wolf-Klein (1988)
10.1046/j.1471-4159.2001.00338.x
Amyloid β peptides mediate hypoxic augmentation of Ca2+ channels
K. Green (2001)
The immune system and memory consolidation: a role for the cytokine IL-1beta.
C. Rachal Pugh (2001)
Amyloid beta peptides mediate hypoxic augmentation of ca(2+) channels
KN Green (2001)
10.1002/HIPO.10164
Learning modulation by endogenous hippocampal IL‐1: Blockade of endogenous IL‐1 facilitates memory formation
A. Depino (2004)
10.1016/j.neuroscience.2004.05.040
Modulation of hippocampal cell proliferation, memory, and amyloid plaque deposition in APPsw (Tg2576) mutant mice by isolation stress
H. Dong (2004)
10.1073/PNAS.0403812101
CD209L (L-SIGN) is a receptor for severe acute respiratory syndrome coronavirus.
S. Jeffers (2004)
10.1128/IAI.73.4.1907-1916.2005
Apoptosis, Pyroptosis, and Necrosis: Mechanistic Description of Dead and Dying Eukaryotic Cells
S. Fink (2005)
10.1038/nm1267
A crucial role of angiotensin converting enzyme 2 (ACE2) in SARS coronavirus–induced lung injury
K. Kuba (2005)
10.1128/MMBR.69.4.635-664.2005
Coronavirus Pathogenesis and the Emerging Pathogen Severe Acute Respiratory Syndrome Coronavirus
S. Weiss (2005)
10.1111/j.1365-2265.2005.02361.x
Post‐SARS sickness syndrome manifestations and endocrinopathy: how, why, and so what?*
G. Chrousos (2005)
10.1097/01.qai.0000219774.20174.64
Lopinavir/Ritonavir Induces the Hepatic Activity of Cytochrome P450 Enzymes CYP2C9, CYP2C19, and CYP1A2 But Inhibits the Hepatic and Intestinal Activity of CYP3A as Measured by a Phenotyping Drug Cocktail in Healthy Volunteers
R. Yeh (2006)
10.1016/j.virol.2006.01.049
Human coronavirus OC43 infection induces chronic encephalitis leading to disabilities in BALB/C mice
H. Jacomy (2006)
10.1523/JNEUROSCI.5173-06.2007
Corticotropin-Releasing Factor Receptors Differentially Regulate Stress-Induced Tau Phosphorylation
R. Rissman (2007)
10.1016/j.tins.2008.06.005
Neuronal calcium mishandling and the pathogenesis of Alzheimer's disease
I. Bezprozvanny (2008)
10.1371/journal.pone.0003637
Seropositivity to Herpes Simplex Virus Antibodies and Risk of Alzheimer's Disease: A Population-Based Cohort Study
L. Letenneur (2008)
10.1038/nm1782
Amyloid-β protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory
G. Shankar (2008)
10.1128/JVI.00737-08
Severe Acute Respiratory Syndrome Coronavirus Infection Causes Neuronal Death in the Absence of Encephalitis in Mice Transgenic for Human ACE2
J. Netland (2008)
10.1016/j.neuron.2008.07.013
Linking Calcium to Aβ and Alzheimer's Disease
K. Green (2008)
Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory
GM Shankar (2008)
Linking calcium to Abeta and Alzheimer's disease
KN Green (2008)
10.1073/pnas.0805453106
Selective targeting of perivascular macrophages for clearance of β-amyloid in cerebral amyloid angiopathy
C. Hawkes (2009)
10.1002/path.2449
Herpes simplex virus type 1 DNA is located within Alzheimer's disease amyloid plaques
M. Woźniak (2009)
10.1371/journal.pmed.1000180
Epidemiological Pathology of Dementia: Attributable-Risks at Death in the Medical Research Council Cognitive Function and Ageing Study
F. Matthews (2009)
10.1111/j.1750-3639.2009.00354.x
Chronic Cortical and Subcortical Pathology with Associated Neurological Deficits Ensuing Experimental Herpes Encephalitis
A. Armién (2009)
10.1016/j.nbd.2009.10.006
Inflammation, microglia, and alzheimer's disease
Brent D. Cameron (2010)
10.1002/glia.20967
Concomitant astroglial atrophy and astrogliosis in a triple transgenic animal model of Alzheimer's disease
M. Olabarria (2010)
10.1186/1756-6606-3-34
Sex- and brain region-specific acceleration of β-amyloidogenesis following behavioral stress in a mouse model of Alzheimer's disease
L. Devi (2010)
atrophy and astrogliosis in a triple transgenic animal model of Alzheimer ' s disease
CA Hawkes (2010)
10.1101/cshperspect.a004457
Alzheimer's disease.
D. Selkoe (2011)
10.1101/cshperspect.a006189
Neuropathological alterations in Alzheimer disease.
A. Serrano-Pozo (2011)
10.1073/pnas.1017033108
Soluble amyloid β-protein dimers isolated from Alzheimer cortex directly induce Tau hyperphosphorylation and neuritic degeneration
Ming Jin (2011)
10.1186/1471-2377-11-37
Chronic widespread musculoskeletal pain, fatigue, depression and disordered sleep in chronic post-SARS syndrome; a case-controlled study
H. Moldofsky (2011)
10.1016/j.ajpath.2011.02.012
Inflammation induced by infection potentiates tau pathological features in transgenic mice.
Michael Sy (2011)
Study of interleukin-6 production in Alzheimer's disease.
I. Cojocaru (2011)
10.1016/S1474-4422(10)70325-2
Apolipoprotein E in Alzheimer's disease and other neurological disorders
P. Verghese (2011)
10.1038/nature11283
A mutation in APP protects against Alzheimer’s disease and age-related cognitive decline
T. Jónsson (2012)
10.1186/cc12709
The Adult Respiratory Distress Syndrome Cognitive Outcomes Study: long-term neuropsychological function in survivors of acute lung injury
C. Carlson (2013)
10.1038/ni.2639
CD36 coordinates NLRP3 inflammasome activation by facilitating the intracellular nucleation from soluble to particulate ligands in sterile inflammation
F. Sheedy (2013)
10.1056/NEJMoa1211851
TREM2 variants in Alzheimer's disease.
R. Guerreiro (2013)
10.2174/1570159X11311020007
ACE2-Ang-(1-7)-Mas Axis in Brain: A Potential Target for Prevention and Treatment of Ischemic Stroke
T. Jiang (2013)
10.1016/j.neuron.2013.04.014
Alzheimer’s Disease Risk Gene CD33 Inhibits Microglial Uptake of Amyloid Beta
A. Griciuc (2013)
10.1016/S1474-4422(14)70136-X
Potential for primary prevention of Alzheimer's disease: an analysis of population-based data
S. Norton (2014)
10.1165/rcmb.2013-0087OC
The NLRP3 inflammasome is required for the development of hypoxemia in LPS/mechanical ventilation acute lung injury.
H. Jones (2013)
10.1007/s12035-015-9260-9
Angiotensin-(1-7) is Reduced and Inversely Correlates with Tau Hyperphosphorylation in Animal Models of Alzheimer’s Disease
T. Jiang (2016)
10.1016/j.biopsych.2014.05.006
Alzheimer’s Disease Risk Genes and Mechanisms of Disease Pathogenesis
Celeste M. Karch (2015)
10.1523/JNEUROSCI.3333-14.2015
Posttraumatic Stress Disorder-Like Induction Elevates β-Amyloid Levels, Which Directly Activates Corticotropin-Releasing Factor Neurons to Exacerbate Stress Responses
N. Justice (2015)
10.3233/JAD-142853
Herpes Simplex Virus Type 1 and Other Pathogens are Key Causative Factors in Sporadic Alzheimer’s Disease
S. Harris (2015)
10.1016/S1474-4422(15)70016-5
Neuroinflammation in Alzheimer's disease
M. Heneka (2015)
10.1016/j.cca.2016.07.013
Increased serum concentrations of transforming growth factor-β1 (TGF-β1) in patients with Guillain-Barré syndrome.
Kuo-Hsuan Chang (2016)
10.3233/JAD-160152
Microbes and Alzheimer's Disease.
R. Itzhaki (2016)
10.3233/JAD-160261
Nutritional Status of Patients with Alzheimer's Disease and Their Caregivers.
M. Tombini (2016)
10.1007/s10522-016-9659-3
Protective role of the apolipoprotein E2 allele in age-related disease traits and survival: evidence from the Long Life Family Study
A. Kulminski (2016)
10.1186/s13195-016-0217-7
Angiotensin-converting enzyme 2 is reduced in Alzheimer’s disease in association with increasing amyloid-β and tau pathology
P. Kehoe (2016)
10.1146/ANNUREV-VIROLOGY-110615-042301
Structure, Function, and Evolution of Coronavirus Spike Proteins.
Fang Li (2016)
TGF-beta1 factor in the cerebrovascular diseases of Alzheimer's disease
X Zhang (2016)
10.1111/psyg.12218
Serum tumour necrosis factor‐α and interleukin‐6 levels in Alzheimer's disease and mild cognitive impairment
Yo Sup Kim (2017)
10.1093/gerona/glw251
Physical Activity and Alzheimer’s Disease: A Systematic Review
R. Stephen (2017)
10.2174/1871527316666170303144817
Clinically Relevant Drug Interactions with Anti-Alzheimer's Drugs.
F. Caraci (2017)
10.1016/j.nlm.2018.06.006
IL-6 deficiency alters spatial memory in 4- and 24-month-old mice
I. Bialuk (2018)
10.1016/j.bcp.2018.01.047
Angiotensin 1‐7 ameliorates 6‐hydroxydopamine lesions in hemiparkinsonian rats through activation of MAS receptor/PI3K/Akt/BDNF pathway and inhibition of angiotensin II type‐1 receptor/NF‐&kgr;B axis
Mostafa A Rabie (2018)
10.1093/database/bay003
TISSUES 2.0: an integrative web resource on mammalian tissue expression
O. Palasca (2018)
10.1016/j.neuron.2018.05.023
Multiscale Analysis of Independent Alzheimer’s Cohorts Finds Disruption of Molecular, Genetic, and Clinical Networks by Human Herpesvirus
B. Readhead (2018)
10.1007/s11910-018-0863-1
Viral Hypothesis and Antiviral Treatment in Alzheimer’s Disease
D. Devanand (2018)
10.3389/fnagi.2018.00048
Molecular Mechanisms for Herpes Simplex Virus Type 1 Pathogenesis in Alzheimer’s Disease
S. Harris (2018)
10.3233/JAD-170786
Medical Comorbidity in Alzheimer's Disease: A Nested Case-Control Study.
Jen-Hung Wang (2018)
10.1111/acel.12802
Aging and Alzheimer’s disease: Comparison and associations from molecular to system level
Xian Xia (2018)
10.1002/jpen.1021
Malnutrition Identified by Academy of Nutrition and Dietetics/American Society for Parenteral and Enteral Nutrition Is Associated With More 30‐Day Readmissions, Greater Hospital Mortality, and Longer Hospital Stays: A Retrospective Analysis of Nutrition Assessment Data in a Major Medical Center
Lauren M Hudson (2018)
Angiotensin 1-7 ameliorates 6-hydroxydopamine lesions in hemiparkinsonian rats through activation of MAS receptor/PI3K/Akt/BDNF pathway and inhibition of angiotensin II type-1 receptor/NF-kappaB axis
MA Rabie (2018)
10.1016/j.bbadis.2019.165647
HHV-6A infection dysregulates autophagy/UPR interplay increasing beta amyloid production and tau phosphorylation in astrocytoma cells as well as in primary neurons, possible molecular mechanisms linking viral infection to Alzheimer's disease.
M. Romeo (2019)
10.1007/s40266-019-00648-x
Ginkgo biloba Extract (EGb761), Cholinesterase Inhibitors, and Memantine for the Treatment of Mild-to-Moderate Alzheimer’s Disease: A Network Meta-Analysis
Onnita Thancharoen (2019)
10.1186/s12985-019-1182-0
Coronavirus envelope protein: current knowledge
D. Schoeman (2019)
10.15252/embj.2018101064
Systemic inflammation impairs microglial Aβ clearance through NLRP3 inflammasome
Darío Tejera (2019)
10.3390/v12010014
Human Coronaviruses and Other Respiratory Viruses: Underestimated Opportunistic Pathogens of the Central Nervous System?
M. Desforges (2019)
10.3390/ijms20235939
Apolipoprotein C1: Its Pleiotropic Effects in Lipid Metabolism and Beyond
E. Fuior (2019)
10.1155/2019/9171424
Theories of Aging and the Prevalence of Alzheimer's Disease
Kaynara Trevisan (2019)
10.1080/14787210.2019.1656064
Herpes simplex virus type 1 and Alzheimer’s disease: link and potential impact on treatment
R. Mancuso (2019)
10.3389/fncel.2019.00264
Glutaminase C Regulates Microglial Activation and Pro-inflammatory Exosome Release: Relevance to the Pathogenesis of Alzheimer’s Disease
Ge Gao (2019)
10.3390/cells9010094
Host Calcium Channels and Pumps in Viral Infections
Xingjuan Chen (2019)
10.1111/acel.12869
Independent associations of TOMM40 and APOE variants with body mass index
A. Kulminski (2018)
10.3390/biom10010040
Alzheimer’s Disease Pharmacotherapy in Relation to Cholinergic System Involvement
G. Stanciu (2019)
10.1186/s13195-019-0552-6
HHV-6A infection induces amyloid-beta expression and activation of microglial cells
D. Bortolotti (2019)
Ginkgo biloba extract (EGb761), cholinesterase inhibitors, and memantine for the treatment of mild-tomoderate Alzheimer's disease: a network meta-analysis
O Thancharoen (2019)
Alzheimer's disease pharmacotherapy in relation to cholinergic system involvement. Biomolecules
GD Stanciu (2019)
10.3389/fpsyt.2020.578015
Behavioral and Psychological Effects of Coronavirus Disease-19 Quarantine in Patients With Dementia
(2020)
10.1093/cid/ciaa449
Detectable Serum Severe Acute Respiratory Syndrome Coronavirus 2 Viral Load (RNAemia) Is Closely Correlated With Drastically Elevated Interleukin 6 Level in Critically Ill Patients With Coronavirus Disease 2019
Xiaohua Chen (2020)
10.1101/2020.10.22.349415
Broad transcriptional dysregulation of brain and choroid plexus cell types with COVID-19
Andrew C. Yang (2020)
10.1080/07391102.2020.1822208
Molecular basis of the potential interaction of SARS-CoV-2 spike protein to CD147 in COVID-19 associated-lymphopenia
M. Helal (2020)
10.1016/S0140-6736(20)30937-5
Endothelial cell infection and endotheliitis in COVID-19
(2020)
10.1038/s41430-020-0642-3
Prevalence of malnutrition and analysis of related factors in elderly patients with COVID-19 in Wuhan, China
Tao Li (2020)
10.1007/s00405-020-05965-1
Olfactory and gustatory dysfunctions as a clinical presentation of mild-to-moderate forms of the coronavirus disease (COVID-19): a multicenter European study
J. Lechien (2020)
10.1007/s12035-020-02177-w
Neurobiochemical Cross-talk Between COVID-19 and Alzheimer’s Disease
M. Rahman (2020)
10.1016/j.paed.2020.12.003
SARS-CoV-2 paediatric inflammatory syndrome
C. Evans (2020)
10.1038/s41591-020-0822-7
Estimating clinical severity of COVID-19 from the transmission dynamics in Wuhan, China
(2020)
10.1177/1533317520960875
Neuropsychological and Functional Impact of COVID-19 on Mild Cognitive Impairment
K. Padala (2020)
10.1002/jmv.25681
Emerging coronaviruses: Genome structure, replication, and pathogenesis
Y. Chen (2020)
10.3233/jad-200581
Neurobiology of COVID-19.
M. Fotuhi (2020)
10.3389/fpsyt.2020.00866
COVID-19 Epidemic in Argentina: Worsening of Behavioral Symptoms in Elderly Subjects With Dementia Living in the Community
G. Cohen (2020)
10.1007/s00134-020-05985-9
Angiotensin-converting enzyme 2 (ACE2) as a SARS-CoV-2 receptor: molecular mechanisms and potential therapeutic target
Haibo Zhang (2020)
10.1016/j.cplett.2020.138057
Neuroprotective immunity by essential nutrient “Choline” for the prevention of SARS CoV2 infections: An in silico study by molecular dynamics approach
Papia Chowdhury (2020)
10.1016/S2215-0366(20)30287-X
Neurological and neuropsychiatric complications of COVID-19 in 153 patients: a UK-wide surveillance study
A. Varatharaj (2020)
10.1007/s10072-020-04541-z
Neurological diseases as mortality predictive factors for patients with COVID-19: a retrospective cohort study
Jong-Moon Hwang (2020)
10.3389/fnana.2020.596439
Histological Evidence for the Enteric Nervous System and the Choroid Plexus as Alternative Routes of Neuroinvasion by SARS-CoV2
Felix Deffner (2020)
10.1038/S41591-020-0877-5
Clinical and virologic characteristics of the first 12 patients with coronavirus disease 2019 (COVID-19) in the United States
T. C. I. team (2020)
10.1016/S1474-4422(20)30308-2
Neuropathology of patients with COVID-19 in Germany: a post-mortem case series
J. Matschke (2020)
10.1126/science.abb2762
Structural basis for the recognition of SARS-CoV-2 by full-length human ACE2
(2020)
10.1016/j.cell.2020.05.034
Structural Basis for RNA Replication by the SARS-CoV-2 Polymerase
Quan Wang (2020)
10.1016/j.bbrc.2020.03.044
Single cell RNA sequencing of 13 human tissues identify cell types and receptors of human coronaviruses
F. Qi (2020)
10.1016/S2213-8587(20)30272-2
Associations of type 1 and type 2 diabetes with COVID-19-related mortality in England: a whole-population study
E. Barron (2020)
10.1056/NEJMc2008597
Neurologic Features in Severe SARS-CoV-2 Infection
J. Helms (2020)
10.1002/trc2.12091
COVID‐19, physical (in‐)activity, and dementia prevention
P. Müller (2020)
10.1016/j.mehy.2020.110055
Into the looking glass: Post-viral syndrome post COVID-19
R. Perrin (2020)
10.1016/j.jinf.2020.03.037
The pathogenesis and treatment of the `Cytokine Storm' in COVID-19
Q. Ye (2020)
10.1038/s41581-020-00356-5
COVID-19-associated acute kidney injury: consensus report of the 25th Acute Disease Quality Initiative (ADQI) Workgroup
M. Nadim (2020)
10.1093/gerona/glaa131
APOE e4 Genotype Predicts Severe COVID-19 in the UK Biobank Community Cohort
Chia-Ling Kuo (2020)
10.1007/s00384-020-03785-7
Fecal-oral transmission of SARS-CoV-2: review of laboratory-confirmed virus in gastrointestinal system
D. Cuicchi (2020)
10.1016/S0140-6736(20)30755-8
Dementia care during COVID-19
Huali Wang (2020)
10.3390/cells9051267
A Structural View of SARS-CoV-2 RNA Replication Machinery: RNA Synthesis, Proofreading and Final Capping
M. Romano (2020)
10.1001/jama.2020.12839
Pathophysiology, Transmission, Diagnosis, and Treatment of Coronavirus Disease 2019 (COVID-19): A Review.
W. Wiersinga (2020)
10.1016/j.cellsig.2020.109721
Drugs targeting various stages of the SARS-CoV-2 life cycle: Exploring promising drugs for the treatment of Covid-19
R. Poduri (2020)
10.1111/psyg.12617
Recognition of the coronavirus disease 2019 pandemic and face mask wearing in patients with Alzheimer's disease: an investigation at a medical centre for dementia in Japan
R. Kobayashi (2020)
10.1126/science.abc1669
SARS-CoV-2 productively infects human gut enterocytes
M. Lamers (2020)
10.1002/ctm2.200
The noncoding and coding transcriptional landscape of the peripheral immune response in patients with COVID‐19
Hao Tang (2020)
10.32388/ysepj9
Concomitant
(2020)
10.1002/dmrr.3377
Obesity and diabetes as high‐risk factors for severe coronavirus disease 2019 (COVID‐19)
Yue Zhou (2020)
10.1093/cid/ciaa449
Detectable serum SARS-CoV-2 viral load (RNAaemia) is closely correlated with drastically elevated interleukin 6 (IL-6) level in critically ill COVID-19 patients
Xiaohua Chen (2020)
10.1016/j.scitotenv.2020.141946
Mapping community-level determinants of COVID-19 transmission in nursing homes: A multi-scale approach
M. Sugg (2020)
10.1021/acschemneuro.0c00335
CNS Penetration Ability: A Critical Factor for Drugs in the Treatment of SARS-CoV-2 Brain Infection
C. C. Danta (2020)
10.1038/s41591-020-0868-6
SARS-CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genes
W. Sungnak (2020)
10.3233/JAD-200937
Cognitive Impairment Is a Common Comorbidity in Deceased COVID-19 Patients: A Hospital-Based Retrospective Cohort Study.
P. Martín-Jiménez (2020)
10.1093/femspd/ftaa033
SARS, MERS and COVID-19: clinical manifestations and organ-system complications: a mini review
Jad Gerges Harb (2020)
10.1016/S0140-6736(20)30566-3
Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study
(2020)
10.1001/jamaneurol.2020.1127
Neurologic Manifestations of Hospitalized Patients With Coronavirus Disease 2019 in Wuhan, China.
L. Mao (2020)
10.1038/s41421-020-0147-1
Comparative genetic analysis of the novel coronavirus (2019-nCoV/SARS-CoV-2) receptor ACE2 in different populations.
Yanan Cao (2020)
10.2991/jegh.k.200721.001
Population Risk Factors for COVID-19 Mortality in 93 Countries
M. J. Hashim (2020)
10.1016/j.nbd.2020.105131
The SARS-CoV-2 spike protein alters barrier function in 2D static and 3D microfluidic in-vitro models of the human blood–brain barrier
Tetyana P. Buzhdygan (2020)
10.3389/fphar.2020.00396
Modeling and Targeting Alzheimer’s Disease With Organoids
A. Papaspyropoulos (2020)
10.1056/NEJMc2009787
Large-Vessel Stroke as a Presenting Feature of Covid-19 in the Young
T. Oxley (2020)
10.1016/j.jhazmat.2020.123771
Multi-route transmission potential of SARS-CoV-2 in healthcare facilities
Baihuan Feng (2020)
10.4103/ijpvm.IJPVM_114_20
Possible Neurological and Mental Outcomes of COVID-19 Infection: A Hypothetical Role of ACE-2\Mas\BDNF Signaling Pathway
M. Motaghinejad (2020)
10.1038/s41574-020-00435-4
COVID-19 and diabetes mellitus: from pathophysiology to clinical management
Soo Lim (2020)
10.1016/j.bbrc.2020.02.071
Structure analysis of the receptor binding of 2019-nCoV
Y. Chen (2020)
10.1056/NEJMoa2001316
Early Transmission Dynamics in Wuhan, China, of Novel Coronavirus–Infected Pneumonia
(2020)
10.1016/j.cels.2020.10.003
Large-Scale Multi-omic Analysis of COVID-19 Severity
K. Overmyer (2020)
10.1001/jama.2020.4683
Case-Fatality Rate and Characteristics of Patients Dying in Relation to COVID-19 in Italy.
G. Onder (2020)
10.3390/v12040372
Virology, Epidemiology, Pathogenesis, and Control of COVID-19
Yuefei Jin (2020)
10.1016/j.jinf.2020.06.072
Elevation of ACE2 as a SARS-CoV-2 entry receptor gene expression in Alzheimer's disease
Key-Hwan Lim (2020)
10.3233/JAD-200832
Awareness of the COVID-19 Outbreak and Resultant Depressive Tendencies in Patients with Severe Alzheimer's Disease.
A. Tsugawa (2020)
10.1126/science.abe9403
Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms
D. E. Gordon (2020)
10.1038/s41577-020-0399-x
SARS-CoV-2 on the neural battleground
C. E. Pavillet (2020)
10.1128/JVI.00127-20
Receptor Recognition by the Novel Coronavirus from Wuhan: an Analysis Based on Decade-Long Structural Studies of SARS Coronavirus
Y. Wan (2020)
10.1056/NEJMoa2002032
Clinical Characteristics of Coronavirus Disease 2019 in China
W. Guan (2020)
10.1021/acschemneuro.0c00122
Evidence of the COVID-19 Virus Targeting the CNS: Tissue Distribution, Host–Virus Interaction, and Proposed Neurotropic Mechanisms
A. Baig (2020)
10.1126/sciadv.abc5801
Non-neuronal expression of SARS-CoV-2 entry genes in the olfactory system suggests mechanisms underlying COVID-19-associated anosmia
David H. Brann (2020)
10.1111/jth.14820
Abnormal coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia
D. Arachchillage (2020)
10.1016/j.stem.2020.09.016
Human Pluripotent Stem Cell-Derived Neural Cells and Brain Organoids Reveal SARS-CoV-2 Neurotropism Predominates in Choroid Plexus Epithelium
Fadi Jacob (2020)
10.1111/ijcp.13596
The Another Side of COVID‐19 in Alzheimer’s Disease Patients: Drug‐Drug Interactions
Nisa Balli (2020)
10.3233/JAD-200940
Death Rate Due to COVID-19 in Alzheimer's Disease and Frontotemporal Dementia.
J. Matias‐Guiu (2020)
10.1093/braincomms/fcaa069
The cognitive consequences of the COVID-19 epidemic: collateral damage?
K. Ritchie (2020)
10.1186/s12929-020-00703-5
Insights to SARS-CoV-2 life cycle, pathophysiology, and rationalized treatments that target COVID-19 clinical complications
I. Trougakos (2021)
10.1016/j.nut.2020.111016
Obesity, malnutrition, and trace element deficiency in the coronavirus disease (COVID-19) pandemic: An overview
D. Fedele (2020)
10.1084/jem.20202135
Neuroinvasion of SARS-CoV-2 in human and mouse brain
E. Song (2021)
10.1016/j.arr.2020.101205
Aging in COVID-19: Vulnerability, immunity and intervention
Yiyin Chen (2020)
SARS-CoV-2 paediatric inflammatory syndrome. Paediatr Child Health (Oxford)
C Evans (2021)
Serum tumour necrosis factor-alpha and interleukin-6 levels in Alzheimer's disease and mild cognitive impairment. Psychogeriatrics
YS Kim (2021)
Human pluripotent stem cell-derived neural cells and brain organoids reveal SARS
F Jacob



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