Online citations, reference lists, and bibliographies.
← Back to Search

Cognitive Deficits In Depression: Possible Implications For Functional Neuropathology

M. Austin, Philip Mitchell, G. Goodwin
Published 2001 · Psychology, Medicine

Save to my Library
Download PDF
Analyze on Scholarcy Visualize in Litmaps
Share
Reduce the time it takes to create your bibliography by a factor of 10 by using the world’s favourite reference manager
Time to take this seriously.
Get Citationsy
Background While depression is known to involve a disturbance of mood, movement and cognition, its associated cognitive deficits are frequently viewed as simple epiphenomena of the disorder. Aims To review the status of cognitive deficits in depression and their putative neurobiological underpinnings. Method Selective computerised review of the literature examining cognitive deficits in depression and their brain correlates. Results Recent studies report both mnemonic deficits and the presence of executive impairment – possibly selective for set-shifting tasks – in depression. Many studies suggest that these occur independent of age, depression severity and subtype, task ‘difficulty’, motivation and response bias: some persist upon clinical ‘recovery’. Conclusions M nemonic and executive deficits do not appear to be epiphenomena of depressive disorder. A focus on the interactions between motivation, affect and cognitive function may allow greater understanding of the interplay between key aspects of the dorsal and ventral aspects of the prefrontal cortex in depression.
This paper references
Philosophical transactions of the Royal Society of London. B
HighWire Press (1886)
10.1136/jnnp.23.1.56
A RATING SCALE FOR DEPRESSION
M. Hamilton (1960)
10.1001/ARCHPSYC.1963.01720160014002
THINKING AND DEPRESSION. I. IDIOSYNCRATIC CONTENT AND COGNITIVE DISTORTIONS.
A. Beck (1963)
10.1037/H0048608
MINIMAL EFFECTS OF SEVERE DEPRESSION ON COGNITIVE FUNCTIONING.
A. S. Friedman (1964)
10.1192/BJP.111.477.659
THE DIAGNOSIS OF DEPRESSIVE SYNDROMES AND THE PREDICTION OF E.C.T. RESPONSE.
M. Carney (1965)
Hedonic capacity: some conjectures.
P. Meehl (1975)
10.1016/0022-3956(75)90026-6
"Mini-mental state". A practical method for grading the cognitive state of patients for the clinician.
M. Folstein (1975)
10.1001/ARCHPSYC.1976.01770020055009
Memory Functions in Depression: Improvement With Antidepressant Medication
David E. Sternberg (1976)
10.1111/J.2044-8260.1976.TB00020.X
Choice reaction times in depressive states.
D. Byrne (1976)
10.1111/j.1600-0447.1977.tb06670.x
The influence of depression on memory
L. S. Strömgren (1977)
10.1037//0021-843X.86.1.84
Recognition memory in elderly patients with depression and dementia: a signal detection analysis.
E. Miller (1977)
10.1002/1097-4679(198007)36:3<647::AID-JCLP2270360306>3.0.CO;2-9
Motivational deficit in depression: people's expectations x outcomes' impacts.
C. Layne (1980)
10.1001/ARCHPSYC.1981.01780260044004
Cognitive processes in depression.
H. Weingartner (1981)
10.1001/ARCHPSYC.1982.04290050061012
Effort and cognition in depression.
R. Cohen (1982)
Cognitive and performance deficits in depression.
A. Raskin (1982)
10.1192/BJP.142.6.610
Effects of ECT and depression on various aspects of memory.
C. Frith (1983)
10.1016/0165-0327(83)90016-2
Neuropsychological dysfunctions in unipolar nonpsychotic major depressions.
A. Rush (1983)
10.1001/ARCHPSYC.1983.01790060073009
Thinking Disorder in Depression: Logic and Strategy in an Abstract Reasoning Task
E. Silberman (1983)
10.1016/0301-0511(84)90010-3
The relative sensitivities of heart rate and T-wave amplitude to stress: Comments on, and some alternative interpretations of, Penzien et al.'s results
J. Furedy (1984)
Neuropsychological test performance in depressed patients before and after drug therapy.
D. Fromm (1984)
10.1016/0005-7916(85)90068-0
Measurement of reinforcement in depression: a pilot study.
J. Hughes (1985)
10.3109/00048678609158860
Cognitive Deficit in the Depressed Elderly: A Review of Some Basic Unresolved Issues
Anthony F Jorm (1986)
10.1001/ARCHPSYC.1986.01800030083008
Effortful and automatic cognitive processes in depression.
P. Roy-Byrne (1986)
10.1146/ANNUREV.NE.09.030186.002041
Parallel organization of functionally segregated circuits linking basal ganglia and cortex.
G. E. Alexander (1986)
10.1017/S0033291700011806
Verbal and non-verbal recall by depressed and euthymic affective patients.
A. Calev (1986)
10.1016/0165-0327(87)90077-2
Verbal memory deficits associated with major affective disorders: a comparison of unipolar and bipolar patients.
J. Wolfe (1987)
10.3109/00207458808990690
Executive functions in unipolar depression before and after electroconvulsive therapy.
B. Jones (1988)
10.1037//0022-006X.57.3.396
Motivational effects on neuropsychological functioning: comparison of depressed versus nondepressed individuals.
P. Richards (1989)
10.1002/1097-4679(198911)45:6<836::AID-JCLP2270450602>3.0.CO;2-#
Cognitive functioning in depression.
J. A. Sweeney (1989)
10.1016/0165-0327(89)90032-3
Cognitive impairments in depression.
M. Golinkoff (1989)
10.1017/S0033291700017025
Neuropsychological deficits and CT scan changes in elderly depressives.
M. A. Abas (1990)
10.1037/0096-3445.119.1.45
Remembering with and without awareness in a depressed mood: evidence of deficits in initiative.
P. Hertel (1990)
10.1016/S0079-6123(08)62678-3
Basal ganglia-thalamocortical circuits: parallel substrates for motor, oculomotor, "prefrontal" and "limbic" functions.
G. E. Alexander (1990)
10.1016/0165-0327(91)90038-T
Disappearance of memory deficits in outpatient depressives responding to imipramine.
E. Peselow (1991)
10.1093/CERCOR/1.1.62
The Wisconsin Card Sorting Test: theoretical analysis and modeling in a neuronal network.
S. Dehaene (1991)
10.1080/01688639108405103
Asymmetry of recall in depression.
D. Deptula (1991)
10.1016/0272-7358(92)90116-P
Mood-congruent recall of affectively toned stimuli: A meta-analytic review
G. Matt (1992)
10.1016/0165-0327(92)90089-O
Cognitive function in major depression.
M. Austin (1992)
10.1016/0165-0327(92)90032-2
Single photon emission tomography with 99mTc-exametazime in major depression and the pattern of brain activity underlying the psychotic/neurotic continuum.
M. Austin (1992)
10.1037/0021-843X.101.3.575
Affective valence and memory in depression: dissociation of recall and fragment completion.
E. Denny (1992)
10.1176/AJP.149.5.620
White matter hyperintensity signals in psychiatric and nonpsychiatric subjects.
F. W. Brown (1992)
10.1176/AJP.150.5.713
Neural correlates of self-induced dysphoria.
J. Pardo (1993)
10.1016/0165-0327(93)90014-B
State changes in brain activity shown by the uptake of 99mTc-exametazime with single photon emission tomography in major depression before and after treatment.
G. Goodwin (1993)
10.1017/S0033291700038873
Working memory in clinical depression: an experimental study.
S. Channon (1993)
10.1176/AJP.150.11.1693
The course of geriatric depression with "reversible dementia": a controlled study.
G. Alexopoulos (1993)
10.1016/0028-3932(93)90147-R
Investigations of the functional anatomy of attention using the stroop test
C. Bench (1993)
10.1136/jnnp.57.12.1518
Emotion-related learning in patients with social and emotional changes associated with frontal lobe damage.
E. Rolls (1994)
10.1016/0165-0327(94)90090-6
Diurnal variation of mood and neuropsychological function in major depression with melancholia.
A. Moffoot (1994)
10.1017/S0033291700027008
The dissociation of explicit and implicit memory in depressed patients.
N. Bazin (1994)
10.1017/S0033291700028932
Cognitive function in depression: its relationship to the presence and severity of intellectual decline.
R. Brown (1994)
10.1192/BJP.164.3.316
Defining melancholia: properties of a refined sign-based measure.
G. Parker (1994)
10.1016/0165-0327(94)90071-X
Cognitive dysfunctions in recovered melancholic patients.
T. Marcos (1994)
Cognitive flexibility and empathy after frontal lobe lesion.
L. Grattan (1994)
10.1037//0021-843X.103.3.460
Reward fails to alter response bias in depression.
J. B. Henriques (1994)
Descartes' error: emotion, reason, and the human brain. avon books
A. Damasio (1994)
10.1159/000106735
Cambridge Neuropsychological Test Automated Battery (CANTAB): a factor analytic study of a large sample of normal elderly volunteers.
T. Robbins (1994)
10.1016/0165-0327(95)00032-I
An analysis of memory dysfunction in major depression.
J. Ilsley (1995)
10.1016/0165-0327(95)00021-E
Affective valence of words, explicit and implicit memory in clinical depression.
J. M. Danion (1995)
10.1016/0006-3223(94)00174-2
Subcortical hyperintensities on magnetic resonance imaging: Clinical correlates and prognostic significance in patients with severe depression
I. Hickie (1995)
10.1176/AJP.152.1.6
The contribution of neuropsychology to psychiatry.
R. Keefe (1995)
10.1017/S0033291700028105
Time course of prefrontal lobe dysfunction in severely depressed in-patients: a longitudinal neuropsychological study.
C. Trichard (1995)
10.1017/S0033291700034929
The anatomy of melancholia: does frontal-subcortical pathophysiology underpin its psychomotor and cognitive manifestations?
M. Austin (1995)
10.1017/S0033291700036187
Effects of major depression on the cognitive function of younger and older subjects.
A. Tarbuck (1995)
10.1016/0028-3932(94)00124-8
Fluid intelligence after frontal lobe lesions
J. Duncan (1995)
10.1073/PNAS.93.9.3908
Hippocampal atrophy in recurrent major depression.
Y. Sheline (1996)
10.1098/rstb.1996.0128
The orbitofrontal cortex.
E. Rolls (1996)
10.1016/0165-0327(96)00059-6
Neuropsychological deficits among older depressed patients with predominantly psychological or vegetative symptoms.
B. Palmer (1996)
10.1017/S0033291700035303
Neuropsychological impairments in unipolar depression: the influence of perceived failure on subsequent performance.
R. Elliott (1996)
10.1017/S0033291700035662
Cognitive performance in tests sensitive to frontal lobe dysfunction in the elderly depressed.
B. Beats (1996)
10.1176/AJP.153.10.1280
Cognition and white matter hyperintensities in older depressed patients.
I. Lesser (1996)
10.1016/0028-3932(95)00106-9
Face and voice expression identification in patients with emotional and behavioural changes following ventral frontal lobe damage
J. Hornak (1996)
10.1093/CERCOR/6.2.215
Failure to respond autonomically to anticipated future outcomes following damage to prefrontal cortex.
A. Bechara (1996)
10.1016/0165-0327(96)00027-4
Executive dysfunction in depression: the Wisconsin Card Sorting Test.
S. Channon (1996)
10.1038/380069A0
Dissociation in prefrontal cortex of affective and attentional shifts
R. Dias (1996)
[Frontal lobe dysfunction and depressive state: relation to endogenous character of depression].
O. Moreaud (1996)
10.1136/jnnp.63.1.74
Abnormal response to negative feedback in unipolar depression: evidence for a diagnosis specific impairment
R. Elliott (1997)
10.1097/00005053-199712000-00005
Cognitive impairment in the euthymic phase of chronic unipolar depression.
S. Paradiso (1997)
10.1097/00001756-199703030-00048
Cingulate function in depression: a potential predictor of treatment response
H. Mayberg (1997)
10.1016/S0006-3223(96)00363-0
Subcortical hyperintensities on magnetic resonance imaging in patients with severe depression—A longitudinal evaluation
I. Hickie (1997)
10.1177/026988119701100204
Neuropsychological and neuroimaging evidence for the involvement of the frontal lobes in depression
G. Goodwin (1997)
10.1038/386608A0
Transient and sustained activity in a distributed neural system for human working memory
S. Courtney (1997)
10.1017/S0033291797005448
Neuropsychological function in young patients with unipolar major depression.
R. Purcell (1997)
10.1038/386824A0
Subgenual prefrontal cortex abnormalities in mood disorders
W. Drevets (1997)
Cognitive Neuroscience: The Biology of the Mind
M. Gazzaniga (1998)
10.1017/S0033291797006090
Late-onset depressive disorders: a preventable variant of cerebrovascular disease?
I. Hickie (1998)
10.1001/ARCHNEUR.1993.00540080076020
Frontal-subcortical circuits and human behavior.
J. Cummings (1998)
10.1017/S0033291798006862
Cognitive impairment in the euthymic phase of affective disorder.
L. Kessing (1998)
10.1136/jnnp.66.2.162
Executive function in depression: the role of performance strategies in aiding depressed and non-depressed participants
S. Channon (1999)
10.1017/S0033291798007880
Abnormal response to negative feedback in depression.
P. Shah (1999)
10.1017/S0033291799001233
Emotional bias and inhibitory control processes in mania and depression.
F. Murphy (1999)
10.1176/AJP.156.2.209
Functional MRI study of the cognitive generation of affect.
J. Teasdale (1999)
10.1017/s0033291798007788
Cognitive function in depression: a distinct pattern of frontal impairment in melancholia?
M. Austin (1999)
10.1176/AJP.156.5.675
Reciprocal limbic-cortical function and negative mood: converging PET findings in depression and normal sadness.
H. Mayberg (1999)
10.1176/AJP.156.3.438
Neuropsychological functioning and MRI signal hyperintensities in geriatric depression.
E. Kramer-Ginsberg (1999)
Mood Disorders Unit and Department of Liaison Psychiatry
Marie-Paule Austin



This paper is referenced by
10.1016/J.IJHM.2021.102868
Do job insecurity, anxiety and depression caused by the COVID-19 pandemic influence hotel employees’ self-rated task performance? The moderating role of employee resilience
T. Aguiar-Quintana (2021)
10.2147/NDT.S294722
Depressive-, Cognitive- or Stroke-Related Risk Factors of Post-Stroke Depression: Which One Could Better Help Clinicians and Patients?
Rebecca Perrain (2021)
10.1177/0031512521998281
Aerobic Exercise Mediates Neural Inefficiency Among Adolescents At Risk for Suicide
Eunbi Jeong (2021)
10.1016/J.JEOA.2021.100327
Objective and subjective memory: Impact on the financial behavior of older adults in the United States
S. Shin (2021)
10.3389/fpsyt.2021.670974
Threat-Modulation of Executive Functions—A Novel Biomarker of Depression?
J. Peräkylä (2021)
10.1016/j.jpsychires.2021.02.028
Ketamine specifically reduces cognitive symptoms in depressed patients: An investigation of associated neural activation patterns.
A. Stippl (2021)
10.1016/j.jpsychires.2021.01.034
Impaired fear learning and extinction, but not generalization, in anxious and non-anxious depression.
C. Wurst (2021)
10.1177/1474704921994028
Divergent Thinking in Survival Processing: Did Our Ancestors Benefit From Creative Thinking?
J. Altarriba (2021)
10.2147/NSS.S297872
Does Napping Enhance the Consolidation of Clinically Relevant Information? A Comparison of Individuals with Low and Elevated Depressive Symptoms
Edwyn B L Lo (2021)
10.2139/ssrn.3792594
The Long-Term Effect of Air Pollution on Human Cognition: Evidence from China
Lanlin Ding (2021)
10.3389/fpsyt.2021.664859
Abnormality of Resting-State Functional Connectivity in Major Depressive Disorder: A Study With Whole-Head Near-Infrared Spectroscopy
Eisuke Sakakibara (2021)
University of Birmingham Cognitive performance in Idiopathic Intracranial Hypertension and relevance of intracranial pressure
Olivia Grech MRes (2021)
10.3390/brainsci11020147
A Systematic Review of Executive Function and Information Processing Speed in Major Depression Disorder
L. Nuño (2021)
10.1016/j.psychres.2021.113931
Set Shifting and Inhibition Deficits as Potential Endophenotypes for Depression
Huiting Liu (2021)
Psicologia: Teoria e Pesquisa
R. Mazzei (2021)
10.1016/j.jaac.2021.01.003
Editorial: Comprehensive Child and Adolescent Mental Health Assessment Should Include Objective Assessments of Neurocognition.
D. Coghill (2021)
10.1101/2021.04.01.21254686
A randomised control trial of the effects of home-based online attention training and working memory training on cognition and everyday function in a community stroke sample.
P. Peers (2021)
Individual Differences in Executive Functioning and Psycho-emotional Well-being and the Impact of Acute Exercise on Children and Youth with ADHD
Madeline C. Crichton (2021)
10.1590/0102.3772E37413
La Relación Entre Depresión y Deterioro Cognitivo en Personas Mayores Institucionalizadas en Residencias Españolas
José Antonio Camacho-Conde (2021)
Microsoft Word-BRAIN-2020-00737R_Supplement.docx
Yuen-Siang Ang (2021)
10.22159/AJPCR.2021.V14I3.40467
COMPARISON OF THE EFFECTS OF ANTIDEPRESSANTS ON COGNITION FUNCTIONS IN PATIENTS OF MAJOR DEPRESSIVE DISORDERS IN TERTIARY CARE HOSPITAL IN HARYANA
S. Rani (2021)
10.2147/NDT.S299840
Cognitive Impairment and Associated Factors Among Adult Hypothyroid Patients in Referral Hospitals, Amhara Region, Ethiopia: Multicenter Cross-Sectional Study
B. Mulat (2021)
10.1016/j.bbr.2020.112929
Central CRF and acute stress differentially modulate probabilistic reversal learning in male and female rats
C. Bryce (2021)
10.3390/ijms22052468
Neural Circuitry–Neurogenesis Coupling Model of Depression
Il Bin Kim (2021)
10.1177/1354067X211025704
“Don’t praise the day before the sunset”: Paremiology in the study of depressiveness
M. Wołońciej (2021)
10.1007/s10608-021-10238-0
Online Cognitive Control Training for Remitted Depressed Individuals: A Replication and Extension Study
Jasmien Vervaeke (2021)
10.1016/j.psychres.2020.113690
THE EFFECT OF SECOND-GENERATION ANTIDEPRESSANT TREATMENT ON THE EXECUTIVE FUNCTIONS OF PATIENTS WITH MAJOR DEPRESSIVE DISORDER: A META-ANALYSIS STUDY WITH STRUCTURAL EQUATION MODELS
E. Gudayol-Ferré (2021)
10.2139/SSRN.3792594
Pollution and the Decline in Human Cognition: Evidence from China
Lanlin Ding (2021)
10.1080/13651501.2020.1840595
Assessment of cognitive performances in major depressed patients: a 6-month follow-up study.
B. Suciu (2020)
10.1192/bjo.2020.114
Baseline predictors of cognitive change in the treatment of major depressive episode: systematic review
Zoe A Barczyk (2020)
10.1007/s11126-020-09733-6
Clinical Quest for Associated Cognitive Impairment in Major Depressed Patients
B. Suciu (2020)
10.1016/j.jad.2020.07.008
Cognitive remediation therapy for partially remitted unipolar depression: A single-blind randomized controlled trial.
Lena Listunova (2020)
See more
Semantic Scholar Logo Some data provided by SemanticScholar