Online citations, reference lists, and bibliographies.

Impact Of Prediagnosis Smoking, Alcohol, Obesity, And Insulin Resistance On Survival In Male Cancer Patients: National Health Insurance Corporation Study.

Sang Min Park, Min Kyung Lim, Soon Ae Shin, Young Ho Yun
Published 2006 · Medicine
Cite This
Download PDF
Analyze on Scholarcy
Share
PURPOSE Although many studies have demonstrated that smoking, alcohol, obesity, and insulin resistance are risk factors for cancer, the role of those factors on cancer survival has been less studied. PATIENTS AND METHODS The study participants were 14,578 men with a first cancer derived from a cohort of 901,979 male government employees and teachers who participated in a national health examination program in 1996. We obtained mortality data for those years from the Korean Statistical Office. We used a standard Poisson regression model to estimate the hazard ratio (HR) for survival in relation to smoking, alcohol, obesity, and insulin resistance before diagnosis. RESULTS Poor survival of all cancer combined (HR, 1.24; 95% CI, 1.16 to 1.33), cancer of the lung (HR, 1.45; 95% CI, 1.15 to 1.82), and cancer of the liver (HR, 1.36; 95% CI, 1.21 to 1.53) were significantly associated with smoking. Compared with the nondrinker, heavy drinkers had worse outcomes for head and neck (HR, 1.85; 95% CI, 1.23 to 2.79) and liver (HR, 1.25; 95% CI, 1.11 to 1.41) cancer, with dose-dependent relationships. Patients with a fasting serum glucose level above 126 mg/dL had a higher mortality rate for stomach (HR, 1.52; 95% CI, 1.25 to 1.84) and lung (HR, 1.48; 95% CI, 1.18 to 1.87) cancer. Higher body mass index was significantly associated with longer survival in head and neck (HR, 0.54; 95% CI, 0.39 to 0.74) and esophagus (HR, 0.44; 95% CI, 0.28 to 0.68) cancer. CONCLUSION Prediagnosis risk factors for cancer development (smoking, alcohol consumption, obesity, and insulin resistance) had a statistically significant effect on survival among male cancer patients.



This paper is referenced by
10.1200/JCO.2011.39.7356
Management of metabolic effects associated with anticancer agents targeting the PI3K-Akt-mTOR pathway.
Naifa L Busaidy (2012)
10.1007/s10620-009-0944-8
Colorectal Cancer Outcomes, Recurrence, and Complications in Persons With and Without Diabetes Mellitus: A Systematic Review and Meta-Analysis
Kelly B. Stein (2009)
10.1002/cncr.26151
Prognostic influence of metformin as first-line chemotherapy for advanced nonsmall cell lung cancer in patients with type 2 diabetes.
Ben-Xu Tan (2011)
10.7314/APJCP.2013.14.12.7685
Prevalence, awareness, control, and treatment of hypertension and diabetes in korean cancer survivors: a cross-sectional analysis of the fourth and fifth Korea national health and nutrition examination surveys.
Kyung-Hyun Choi (2013)
10.1155/2012/853487
Long-Term (10-Year) Gastrointestinal and Genitourinary Toxicity after Treatment with External Beam Radiotherapy, Radical Prostatectomy, or Brachytherapy for Prostate Cancer
Grant K. Hunter (2012)
10.2337/db10-0334
Diabetes, Insulin Use, and Cancer Risk: Are Observational Studies Part of the Solution–or Part of the Problem?
Jeffrey A. Johnson (2010)
10.1016/j.ctrv.2018.07.001
Tobacco smoking and survival after a prostate cancer diagnosis: A systematic review and meta-analysis.
Ellie Darcey (2018)
10.1371/journal.pone.0149886
Socioeconomic and Other Demographic Disparities Predicting Survival among Head and Neck Cancer Patients
Seung Hee Choi (2016)
10.1177/1534735420915275
Effects and Relative Factors of Adjunctive Chinese Medicine Therapy on Survival of Hepatocellular Carcinoma Patients: A Retrospective Cohort Study in Taiwan
Yu-Pei Liao (2020)
10.3389/fonc.2018.00281
The Impact of Serum Glucose, Anti-Diabetic Agents, and Statin Usage in Non-small Cell Lung Cancer Patients Treated With Definitive Chemoradiation
Nick A. Iarrobino (2018)
10.2147/CMAR.S192273
Preoperative fasting hyperglycemia is an independent prognostic factor for postoperative survival after gallbladder carcinoma radical surgery
Peng Zheng (2019)
10.3109/00016489.2014.906750
Factors associated with malnutrition in patients with head and neck cancer
Yukinori Takenaka (2014)
10.1071/PY18075
Patterns of alcohol consumption among people with major chronic diseases.
Thi Thu Le Pham (2019)
10.1016/j.jss.2015.05.059
Differential impact of obesity and diabetes mellitus on survival after liver resection for colorectal cancer metastases.
Sousana Amptoulach (2015)
10.1002/ijc.31049
Associations of alcohol intake, smoking, physical activity and obesity with survival following colorectal cancer diagnosis by stage, anatomic site and tumor molecular subtype
Harindra Jayasekara (2018)
10.1155/2015/810134
Clinical and Oncological Value of Preoperative BMI in Gastric Cancer Patients: A Single Center Experience
Costantino Voglino (2015)
10.1016/j.socscimed.2013.01.012
The poorer cancer survival among the unmarried in Norway: is much explained by comorbidities?
Øystein Kravdal (2013)
10.1177/175114371201300405
Glucose Control in Critical Care Oncology
Tim Cooksley (2012)
10.1097/MD.0000000000003305
Effect of Body Mass Index on Overall Survival of Pancreatic Cancer
Yu-qi Shi (2016)
10.1016/S0001-4079(19)31173-2
[Metabolic syndrome, non alcoholic hepatic steatopathy and hepatocellular carcinoma: so dangerous liaisons].
Olivier Rosmorduc (2014)
10.1007/978-3-319-24814-1_13
Nutrition and the Cancer Survivor
Mary Marian (2016)
10.3945/ajcn.115.127092
Alcohol consumption and survival of colorectal cancer patients: a population-based study from Germany.
Viola Walter (2016)
10.1200/JCO.2016.71.2026
Cigarette Smoking and Pancreatic Cancer Survival.
Chen Yuan (2017)
10.1038/bjc.2014.6
Influence of pre-diagnostic cigarette smoking on colorectal cancer survival: overall and by tumour molecular phenotype
Yuhua Zhu (2014)
10.1002/cncr.26114
Prediagnostic smoking history, alcohol consumption, and colorectal cancer survival: the Seattle Colon Cancer Family Registry.
Amanda I. Phipps (2011)
10.1007/978-1-4419-9911-5_5
Insulin, Insulin Resistance, and Cancer Associations
Lorraine L. Lipscombe (2011)
CMAR_A_233215 451..459
Nahla Ali Azzam (2020)
Alcohol consumption and survival of colorectal cancer patients : population-based study from Germany 1 , 2
Viola Walter (2016)
10.1158/1055-9965.EPI-08-0685
Socioeconomic Inequalities in Cancer Survival in New Zealand: The Role of Extent of Disease at Diagnosis
M. V. C. Jeffreys (2009)
Health Effects of Mild Alcohol Consumption in Koreans: Focus on cardiovascular disease
박지은 (2017)
10.1371/journal.pone.0095485
Diabetes Mellitus and Poorer Prognosis in Hepatocellular Carcinoma: A Systematic Review and Meta-Analysis
Yan-gang Wang (2014)
10.1002/9780470710449.CH23
Substance Addition and Gastrointestinal Malignancy
Jason Hedrick (2010)
See more
Semantic Scholar Logo Some data provided by SemanticScholar