← Back to Search
Comprehensive Geriatric Assessment For Older Patients With Cancer.
M. Extermann, A. Hurria
Published 2007 · Medicine
Download PDFAnalyze on Scholarcy
PURPOSE During the last decade, oncologists and geriatricians have begun to work together to integrate the principles of geriatrics into oncology care. The increasing use of a comprehensive geriatric assessment (CGA) is one example of this effort. A CGA includes an evaluation of an older individual's functional status, comorbid medical conditions, cognition, nutritional status, psychological state, and social support; and a review of the patient's medications. This article discusses recent advances on the use of a CGA in older patients with cancer. METHODS In this article, we provide an update on the studies that address the domains of a geriatric assessment applied to the oncology patient, review the results of the first studies evaluating the use of a CGA in developing interventions to improve the care of older adults with cancer, and discuss future research directions. RESULTS The evidence from recent studies demonstrates that a CGA can predict morbidity and mortality in older patients with cancer. Accumulating data show the benefits of incorporating a CGA in the evaluation of older patients with cancer. Prospective trials evaluating the utility of a CGA to guide interventions to improve the quality of cancer care in older adults are justified. CONCLUSION Growing evidence demonstrates that the variables examined in a CGA can predict morbidity and mortality in older patients with cancer, and uncover problems relevant to cancer care that would otherwise go unrecognized.
This paper references
Effect of Nurse Case Management on the Treatment of Older Women with Breast Cancer
J. Goodwin (2003)
Impact of androgen deprivation therapy on physical and cognitive function, as well as quality of life of patients with nonmetastatic prostate cancer.
F. Joly (2006)
Family caregivers of elderly patients with cancer: understanding and minimizing the burden of care.
W. Haley (2003)
Lesauskaite V: The nutritional status of older men with advanced prostate cancer and factors affecting it
J Toliusiene (2004)
Prognostic effect of weight loss prior to chemotherapy in cancer patients. Eastern Cooperative Oncology Group.
W. Dewys (1980)
The nutritional status of older men with advanced prostate cancer and factors affecting it
J. Toliusiene (2004)
Prognostic importance of comorbidity in a hospital-based cancer registry.
J. Piccirillo (2004)
Depressive symptoms and physical decline in community-dwelling older persons.
B. Penninx (1998)
Preoperative assessment of surgical risk in oncogeriatric patients.
R. Audisio (2005)
A comprehensive geriatric intervention detects multiple problems in older breast cancer patients.
M. Extermann (2004)
Geriatric evaluation and management units in the care of the frail elderly cancer patient.
A. Rao (2005)
Extent and cost of informal caregiving for older Americans with symptoms of depression.
K. Langa (2004)
Intercommunity variations in the association between social ties and mortality in the elderly. A comparative analysis of three communities.
T. Seeman (1993)
Comprehensive assessment of the elderly cancer patient: the feasibility of self-report methodology.
S. Ingram (2002)
Gemcitabine plus vinorelbine versus vinorelbine alone in elderly patients with advanced non-small-cell lung cancer.
G. Frasci (2000)
Understanding the treatment preferences of seriously ill patients.
T. Fried (2002)
Physical and Mental Health Status of Older Long‐Term Cancer Survivors
N. Keating (2005)
What threshold for adjuvant therapy in older breast cancer patients?
M. Extermann (2000)
O8 Testing CGA components to predict 30 days surgery outcome in elderly cancer patient
H. Ramesh (2006)
The impact of age in the outcome of patients with advanced or recurrent cervical cancer after platinum-based chemotherapy.
E. Kastritis (2007)
Hyperinsulinaemia: a prospective risk factor for lethal clinical prostate cancer.
J. Hammarsten (2005)
Pretreatment quality of life and functional status assessment significantly predict survival of elderly patients with advanced non-small-cell lung cancer receiving chemotherapy: a prognostic analysis of the multicenter Italian lung cancer in the elderly study.
P. Maione (2005)
Comprehensive geriatric assessment predicts tolerance to chemotherapy and survival in elderly patients with advanced ovarian carcinoma: a GINECO study.
G. Freyer (2005)
20 Pharmacy services in a oncogeriatric unit
G. Lidouren (2006)
Comparative study of health status of older patients with and without cancer in a short stay unit [French
F Retornaz (2006)
Treatment for Breast Cancer in Patients with Alzheimer's Disease
S. N. Gorin (2005)
The abbreviated comprehensive geriatric assessment (aCGA): a retrospective analysis.
J. Overcash (2005)
Medium-term effects of chemotherapy in older cancer patients
B. Eberhardt (2005)
terns of care and survival in cancer patients with cognitive impairment
TR Fried (2004)
Detection of Older People at Increased Risk of Adverse Health Outcomes After an Emergency Visit: The ISAR Screening Tool
J. McCusker (1999)
ADVANCING GERIATRIC NURSING PRACTICE; A Specialized Home Care Intervention Improves Survival Among Older Post‐Surgical Cancer Patients
M. Mezey (2000)
Comorbidity and KPS are independent prognostic factors in stage I non-small-cell lung cancer.
S. Firat (2002)
Comorbidity, disability, and geriatric syndromes in elderly cancer patients receiving home health care.
S. Koroukian (2006)
Patterns of Presentation, Diagnosis, and Treatment in Older Patients with Colon Cancer and Comorbid Dementia
S. Gupta (2004)
Cognitive Function of Older Patients Receiving Adjuvant Chemotherapy for Breast Cancer: A Pilot Prospective Longitudinal Study
A. Hurria (2006)
Frailty in older adults: evidence for a phenotype.
L. Fried (2001)
Comorbidity and functional status are independent in older cancer patients.
M. Extermann (1998)
Aging, frailty, and chemotherapy.
L. Balducci (2007)
Approach to the newly diagnosed colorectal cancer patient: Special considerations—Colorectal cancer in the elderly patient: Assessment and treatment, in Lichtman S (ed): CMP Healthcare Media
M Extermann (2005)
Can older cancer patients tolerate chemotherapy?
H. Chen (2003)
Studies of comprehensive geriatric assessment in patients with cancer.
M. Extermann (2003)
How many and which items of activities of daily living (ADL) and instrumental activities of daily living (IADL) are necessary for screening.
B. Roehrig (2007)
Pharmacy services in an oncogeriatric unit
G Lidouren (2006)
Approach to the newly diagnosed colorectal cancer patient : Special considerations — Colorectal cancer in the elderly patient : Assessment and treatment
D Johnson (2005)
Predictors of tolerance to chemotherapy in older cancer patients: a prospective pilot study.
M. Extermann (2002)
The assessment of clinical resources in a senior adult oncology program
D. Johnson (2006)
Telephone monitoring of distress in patients aged 65 years or older with advanced stage cancer
A. Kornblith (2006)
The impact of cancer on the physical function of the elderly and their utilization of health care
R. Stafford (1997)
Long‐term adjustment of survivors of early‐stage breast carcinoma, 20 years after adjuvant chemotherapy
A. Kornblith (2003)
Weight, Weight Change, and Mortality in a Random Sample of Older Community‐Dwelling Women
M. W. Reynolds (1999)
Effect of Depression on Diagnosis, Treatment, and Survival of Older Women with Breast Cancer
J. Goodwin (2004)
Fluorouracil plus Levamisole as Effective Adjuvant Therapy after Resection of Stage III Colon Carcinoma: A Final Report
C. Moertel (1995)
O14 Screening of elderly patient with cancer for early death risk. Results of a prospective multicentric study of 364 patients under chemotherapy
P. Soubeyran (2006)
Value of functional status as a predictor of mortality: results of a prospective study.
D. Reuben (1992)
Social networks, social support, and survival after breast cancer diagnosis.
C. Kroenke (2006)
Surgical mortality in patients with esophageal cancer: development and validation of a simple risk score.
E. Steyerberg (2006)
Fasting insulin and outcome in early-stage breast cancer: results of a prospective cohort study.
P. Goodwin (2002)
Predictive factors of survival in patients treated with definitive chemoradiotherapy for squamous cell esophageal carcinoma.
F. Di Fioré (2006)
Identifying a short functional disability screen for older persons.
D. Saliba (2000)
Developing a cancer‐specific geriatric assessment
A. Hurria (2005)
Effect of obesity on survival in epithelial ovarian cancer
J. Pavelka (2006)
Effects of social relationships on survival for women with breast cancer: a prospective study.
N. Waxler-Morrison (1991)
The Effect of Comorbidity on 3-Year Survival of Women with Primary Breast Cancer
W. Satariano (1994)
Interaction between comorbidity and cancer.
M. Extermann (2007)
Involuntary Weight Loss in Older Outpatients: Incidence and Clinical Significance
J. Wallace (1995)
The abbreviated comprehensive geriatric assessment (aCGA) for use in the older cancer patient as a prescreen: scoring and interpretation.
J. Overcash (2006)
Undertreatment strongly decreases prognosis of breast cancer in elderly women.
C. Bouchardy (2003)
Impact of diabetes mellitus on outcomes in patients with colon cancer.
J. Meyerhardt (2003)
Influence of concomitant medications on toxicity from chemotherapy in elderly patients. Focus on cytochrome P-450 inhibition and protein binding effects
K. J. Wallace (2005)
Patterns of care and survival in cancer patients with cognitive impairment.
L. J. Callen (2004)
Prognostic effect of weight loss prior tochemotherapy in cancer patients
W. Dewys (1980)
Prognostic factors in non-small cell lung cancer surgery.
O. Birim (2006)
31 The role of comprehensive geriatric assessment (CGA) in the management of stage 3 hepatocellular carcinoma in the elderly
C. H. Soejono (2006)
Effect of adjuvant breast cancer chemotherapy on cognitive function from the older patient’s perspective
A. Hurria (2006)
Geriatric syndromes in elderly patients admitted to an oncology-acute care for elders unit.
Kellie L. Flood (2006)
From bedside to bench: research agenda for frailty.
L. Fried (2005)
Body mass index and mortality among hospitalized patients.
F. Landi (2000)
Polypharmacy in the Older Patient With Cancer.
A pilot study of the vulnerable elders survey‐13 compared with the comprehensive geriatric assessment for identifying disability in older patients with prostate cancer who receive androgen ablation
S. Mohile (2007)
Greater influence of age than co-morbidity on primary treatment and complications of prostate cancer patients: an in-depth population-based study
S. Houterman (2006)
Lifestyle intervention development study to improve physical function in older adults with cancer: outcomes from Project LEAD.
W. Demark-Wahnefried (2006)
Comprehensive geriatric assessment adds information to Eastern Cooperative Oncology Group performance status in elderly cancer patients: an Italian Group for Geriatric Oncology Study.
L. Repetto (2002)
Prognostic importance of comorbidity in a hospitalbased cancer
JF Piccirillo (2004)
The Impact of the
Barbara L. Welther (2000)
Establishing a Case‐Finding and Referral System for At‐Risk Older Individuals in the Emergency Department Setting: The SIGNET Model
L. Mion (2001)
Weight Change in Old Age and its Association with Mortality
A. Newman (2001)
This paper is referenced by
Tratamento de leucemia e mieloide aguda no idoso
Rita João Portela Meira (2014)
Wertigkeit eines geriatrischen Assessments in der Chemotherapie der älteren onkologischen Patientin
R. Groh (2012)
Fighting diagnostic and therapeutic nihilism in the elderly with cancer.
E. Biskup (2019)
Untangling the complexities of depression diagnosis in older cancer patients.
M. Weinberger (2009)
Considerations for Elderly People Facing Colorectal Surgery
B. Rovena (2017)
Outcome and toxicity of radical radiotherapy or concurrent Chemoradiotherapy for elderly cervical cancer women
W. Wang (2017)
Comprehensive geriatric assessment for older adults admitted to hospital.
G. Ellis (2017)
Nutritional Risk in the Cancer Patient 65 and Older Undergoing Systemic Treatment Via Phase I Clinical Trials
A. C. Williams (2019)
Determinants of functional decline in older adults experiencing cancer (the INCAPAC study).
A. Galvin (2019)
Treatment of elderly patients with diffuse large B-cell lymphoma
T. Noesslinger (2016)
Impact of a pharmacist and geriatrician medication review on drug-related problems in older outpatients with cancer.
C. Choukroun (2020)
Comorbidities in the aging breast cancer population: are current assessments leading to improved outcomes?
W. McCaskill-Stevens (2011)
Management of Acute Myeloid Leukemia (AML) in Older Patients
Maya Abdallah (2020)
Management of central nervous system tumours in the elderly.
R. Rampling (2014)
Management of cancer in the older adult.
D. Kilari (2012)
A retrospective study of the impact of age on patterns of care for elderly patients with metastatic breast cancer
K. Hashimoto (2011)
Geriatric Evaluation Programs and Elderly Oncology Patients
Antonio Jirillo (2011)
Cancer du sein métastatique chez la femme âgée : de l’évaluation gériatrique à la décision thérapeutique
Gilles Freyer (2010)
Pharmacology of Chemotherapy
C. Steer (2013)
Respiratory Organ Aging and Cancer
Leah J Witt (2018)
Comparison of efficacy and safety of single-agent and doublet chemotherapy in advanced non-small cell lung cancer in the elderly: A meta-analysis.
G. D. Guetz (2010)
Use of hormonal therapy in senior breast cancer patients treated with or without radiotherapy.
S. Krotneva (2014)
Individualized Health Intervention: Behavioral Change and Quality of Life in an Older Rural Chinese Population
B. Zhou (2010)
The role of geriatric assessment prior to chemotherapy in elderly patients with cancer
Aaldrik Albertus Aaldriks (2015)
Breast cancer in women 80 years of age and older: A comprehensive analysis of an underreported entity
M. Vetter (2013)
The Prognostic Impact of Dose-attenuated R-CHOP Therapy for Elderly Patients with Diffuse Large B-cell Lymphoma
A. Tanimura (2018)
Evaluating the Older Patient with Cancer: Understanding Frailty and the Geriatric Assessment
S. Pal (2010)
Merckel cell carcinoma: The impact of multidisciplinary management
S. Miranda (2012)
Management of squamous cell carcinoma of the head and neck in the elderly: Review and recommendations
A. Weir (2012)
Predicting 5‐ and 10‐Year Survival in Older Women with Early‐Stage Breast Cancer: Self‐Rated Health and Walking Ability
Jessica A. Eng (2015)
Spezielle Aspekte bezogen auf Organsysteme nach geriatrisch klinischer Bedeutung
M. Wehling (2016)
Breast Cancer in the Older Adult
Emily J. Guerard (2016)See more