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Studies On Effect Of PH On Cross-linking Of Chitosan With Sodium Tripolyphosphate: A Technical Note

Devika R. Bhumkar, Varsha B Pokharkar
Published 2008 · Medicine, Chemistry
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Summary and ConclusionsThe ionotropic gelation method for formation of crosslinked chitosan particles can be easily modified from ionic cross-linking to deprotonation by adjusting the pH of TPP. Chitosan was cross-linked ionically with TPP at lower pH and by deprotonation mechanism at higher pH. The swelling behavior of cross-linked chitosan appeared to depend on the pH of TPP. The ionically cross-linked chitosan showed higher swelling ability. Thus the nature of crosslinked chitosan can be tailor made to obtain the desired properties in terms of cross-linking density, crystallinity, and hydrophilicity.
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