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Apoptosis: The Biochemistry And Molecular Biology Of Programmed Cell Death.

R. A. Schwartzman, J. Cidlowski
Published 1993 · Biology, Medicine

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I. Introduction DEATH, along with growth and differentiation, is a critical part of the life cycle of a cell. Homeostatic control of cell number is thought to be the result of the dynamic balance between cell proliferation and cell death. It is only in the past few years, however, that attention has been focused on the physiological occurrence of cell death and its role in homeostasis. Researchers have become increasingly more aware during this time that this type of “natural” death, which is now called apoptosis or programmed cell death, is a widespread phenomenon that plays a crucial role in a myriad of physiological and pathological processes. This review first briefly covers some historical perspective on the discovery of apoptotic cell death, the characteristic morphology that accompanies this process, and the numerous cell types and mediators with which programmed cell death is associated. The bulk of the review discusses our current understanding of the biochemical and molecular mechanisms by which...
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Doxorubicin induces male germ cell apoptosis in rats
Kazutoshi Shinoda (1999)
Peroxidation of linoleic acid and its relation to aging and age dependent diseases
G. Spiteller (2001)
Glutamate induces apoptosis in anterior pituitary cells through group II metabotropic glutamate receptor activation.
C. Caruso (2004)
Avaliação dos efeitos da exposição experimental ao herpesvírus bovino tipo 5 em embriões bovinos produzidos in vitro
Mariana Pontes Carvalho Brenner (2012)
Apoptotic cell death in retinal degenerations
C. Remé (1998)
Molecular mechanisms of metal toxicity and carcinogenesis
S. Wang (2004)
Tau phosphorylation during apoptosis of human SH-SY5Y neuroblastoma cells
P. Mookherjee (2001)
In vivo monitoring of therapy-induced apoptotic process in patients with chronic lymphocytic leukemia and acute non-lymphoblastic leukemia
R. G. Brajuskovic (2002)
Prenatal ve postnatal alkol kullanımı sonucunda rat beyinlerinde oluşan nörodejenerasyonun betain ve/veya omega-3 uygulanmasıyla önlenmesinin araştırılması
Kevser Kuşat Ol (2014)
Photopheresis after cardiac transplantation induces apoptosis.
K. Schuerfeld (1999)
Morphological analysis of germ cell apoptosis during postnatal testis development in normal and Hsp70‐2 knockout mice
C. Mori (1997)
Apoptosis and cancer risk assessment.
T. Goldsworthy (1996)
Immunohistochemical analysis of the microanatomy of primate ovary.
F. Khan-dawood (1996)
Programmed cell death of the prothoracic glands of Manduca sexta during pupal-adult metamorphosis.
J. Dai (1997)
Use of rainbow trout primary epidermal cell cultures as an alternative to immortalized cell lines in toxicity assessment : A study with nonoxynol
K. Dowling (1999)
DNA cleavage in rat liver nuclei activated by Mg2+ or Ca2+ + Mg2+ is inhibited by a variety of structurally unrelated inhibitors.
K. Cain (1994)
Effects of vinblastine and colchicine on male rat meiosis in vivo: Disturbances in spindle dynamics causing micronuclei and metaphase arrest
M. Kallio (1995)
Ultrastructural studies of complement mediated cell death: a biological reaction model to plasma membrane injury
J. Papadimitriou (1994)
Defining Apoptosis: Players and Systems
G. Erickson (1997)
Cisplatin-induced apoptotic cell death in Mongolian gerbil cochlea
S. A. Alam (2000)
Combinatorial nanocarrier based drug delivery approach for amalgamation of anti-tumor agents in bresat cancer cells: an improved nanomedicine strategies
C. Murugan (2016)
Essential Oil from Carpesium abrotanoides L. Induces Apoptosis via Activating Mitochondrial Pathway in Hepatocellular Carcinoma Cells
Q. Wang (2018)
Dietary Fats, Lipids, Hormones, and Tumorigenesis
D. Heber (1996)
Inactivated Tianjin strain, a novel genotype of Sendai virus, induces apoptosis in HeLa, NCI-H446 and Hep3B cells
J. Chen (2016)
Manganese Superoxide Dismutase (MnSOD) and Its Importance in Mitochondrial Function and Cancer
Aaron K. Holley (2016)
The timing of Drosophila salivary gland apoptosis displays an l(2)gl-dose response
R. Farkaš (2000)
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