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Insulin Degradation: Progress And Potential.

W. Duckworth, R. Bennett, F. G. Hamel
Published 1998 · Biology, Medicine

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Insulin degradation is a regulated process that plays a role in controlling insulin action by removing and inactivating the hormone. Abnormalities in insulin clearance and degradation are present in various pathological conditions including type 2 diabetes and obesity and may be important in producing clinical problems. The uptake, processing, and degradation of insulin by cells is a complex process with multiple intracellular pathways. Most evidence supports IDE as the primary degradative mechanism, but other systems (PDI, lysosomes, and other enzymes) undoubtedly contribute to insulin metabolism. Recent studies support a multifunctional role for IDE, as an intracellular binding, regulatory, and degradative protein. IDE increases proteasome and steroid hormone receptor activity, and this activation is reversed by insulin. This raises the possibility of a direct intracellular interaction of insulin with IDE that could modulate protein and fat metabolism. The recent findings would place intracellular insulin-IDE interaction into the insulin signal transduction pathway for mediating the intermediate effects of insulin on fat and protein turnover.
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Endocrinologie First announcement: The 42 nd Journées Internationales d'Endocrinologie Clinique will be held in Paris on April 29 -30, 1999 and will be devoted to: "Hormones, heart and vessels
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The dissociation and degradation of internalized insulin occur in the endosomes of rat hepatoma cells.
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INSULIN DEGRADATION olysis by insulin in isolated rat hepatocytes: possible role of internalized hormone
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Van Der Veen EA 1990 Effect of the insulin degradation inhibitors bacitracin and chloroquine on insulin binding data to H35 rat hepatoma cells
Cp De Vries
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Cn Jones
Identification and isolation of a cytosolic proteolytic complex containing insulin degrading enzyme and the multicatalytic proteinase.
R. Bennett (1994)
Kinetics of insulin internalization and processing in adipocytes: Effects of insulin concentration
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Human insulin-degrading enzyme shares structural and functional homologies with E. coli protease III.
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Regulation of insulin, epidermal growth factor, and transforming growth factor-alpha levels by growth factor-degrading enzymes.
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Hepatic metabolism of insulin.
W. Duckworth (1988)
High performance liquid chromatographic analysis of insulin degradation by rat skeletal muscle insulin protease.
F. G. Hamel (1986)
Ultrastructural evidence for the accumulation of insulin in nuclei of intact 3T3-L1 adipocytes by an insulin-receptor mediated process.
R. M. Smith (1987)

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